Cellules souches
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les cellules souches et leurs voies de signalisation, affectant leur capacité à s'auto-renouveler et à se différencier. Ces inhibiteurs sont essentiels dans la recherche axée sur le contrôle du comportement des cellules souches, la compréhension des processus de développement et le développement de thérapies pour des maladies comme le cancer, où les cellules souches sont censées jouer un rôle clé. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de cellules souches pour soutenir vos recherches en médecine régénérative, biologie du développement et oncologie.
226 produits trouvés pour "Cellules souches"
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TGFβRI-IN-1
CAS :TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Formule :C20H14D3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.4CJJ300
CAS :CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formule :C30H33N3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :435.6Ref: TM-T62483
2mg35,00€5mg51,00€10mg90,00€25mg164,00€50mg259,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)57,00€BRD0209
CAS :BRD0209 is a highly selective and potent GSK3 inhibitor.
Formule :C22H25N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :347.45JAK3/BTK-IN-2
CAS :JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Formule :C25H32N8O2Degré de pureté :99.64% - 99.87%Couleur et forme :SolidMasse moléculaire :476.57Chromenone 1
CAS :Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Formule :C18H10F3N3O2Degré de pureté :99.83% - 99.93%Couleur et forme :SolidMasse moléculaire :357.29Ref: TM-T61301
1mg52,00€5mg111,00€10mg162,00€25mg235,00€50mg330,00€100mg452,00€200mg607,00€1mL*10mM (DMSO)113,00€VT103
CAS :VT103, an oral TEAD1 palmitoylation inhibitor, shows promise against various cancers by disrupting YAP/TAZ-TEAD interactions.Formule :C18H17F3N4O2SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :410.41Ref: TM-T62077
1mg112,00€5mg268,00€10mg424,00€25mg735,00€50mg1.071,00€100mg1.549,00€200mg2.097,00€1mL*10mM (DMSO)295,00€TEAD-IN-2
CAS :TEAD-IN-2 is a potent and bifunctional TEAD inhibitor to induce TEAD protein degradation via the ubiquitination pathway, with anticancer potential.Formule :C16H18BrF3N2OCouleur et forme :SolidMasse moléculaire :391.23GSK-3β inhibitor 12
CAS :GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFormule :C14H13N3OSDegré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :271.34AF-2112
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.
Formule :C21H18FNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.37JA310
CAS :JA310 is a highly selective inhibitor of the MST3 kinase, demonstrating significant cellular potency with an EC50 value of 106 nM [1].Formule :C17H19N7OCouleur et forme :SolidMasse moléculaire :337.38BIP-135
CAS :BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.
Formule :C21H13BrN2O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :421.24CID-5056270
CAS :CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma
Formule :C17H13N3O3SDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :339.37SJ000063181
CAS :SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.
Formule :C14H14ClFN2O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :296.72FzM1
CAS :FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formule :C21H16N2O2SDegré de pureté :99.37% - 99.89%Couleur et forme :SolidMasse moléculaire :360.43Ref: TM-T24076
1mg42,00€5mg64,00€10mg99,00€25mg188,00€50mg328,00€100mg528,00€500mg1.130,00€1mL*10mM (DMSO)62,00€MSC-4106
CAS :MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.
Formule :C18H12F3N3O2Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :359.3TT-10
CAS :TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.
Formule :C11H10FN3OS2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :283.35LEQ506
CAS :LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.Formule :C25H32N6ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :432.56Ref: TM-T11838
1mg64,00€5mg145,00€10mg210,00€25mg338,00€50mg455,00€100mg610,00€200mg823,00€1mL*10mM (DMSO)160,00€LM-41
CAS :LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.Formule :C19H14FNO2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :307.32GSK-3 Inhibitor XIII
CAS :GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Formule :C18H15N5Degré de pureté :99.85% - 99.86%Couleur et forme :SolidMasse moléculaire :301.35Ref: TM-T78578
1mg106,00€5mg243,00€10mg437,00€25mg934,00€50mg1.283,00€100mg1.730,00€200mg2.337,00€1mL*10mM (DMSO)251,00€XL413 xHCl
CAS :BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215
Formule :C14H12ClN3O2·xHClDegré de pureté :99.37% - 99.67%Couleur et forme :SolidMasse moléculaire :326.18GSK-3β inhibitor 11
CAS :GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.
Formule :C20H15N3O4SDegré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :393.42IHMT-MST1-58
CAS :IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.
Formule :C21H22N6O3SDegré de pureté :98.31% - 99.92%Couleur et forme :SolidMasse moléculaire :438.5ABC1183
CAS :ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.
Formule :C18H14N4OSDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :334.39JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formule :C22H23FN4O3SDegré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :442.51GSK-3β inhibitor 2
CAS :GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50
Formule :C14H14N4O3SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :318.35ROCK2-IN-6 hydrochloride
CAS :ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formule :C26H22ClF2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.95BRD5648
CAS :BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Formule :C20H23N3ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :321.42TGFβ-IN-5
CAS :TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.Formule :C20H16N4Degré de pureté :99.29% - 99.62%Couleur et forme :SolidMasse moléculaire :312.37TP0427736
CAS :TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Formule :C14H10N4S2Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :298.39SWTX-143
CAS :SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptionalFormule :C19H18F3N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.36ML115
CAS :ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formule :C15H15ClN2O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :322.74Ref: TM-T35544
1mg95,00€5mg227,00€10mg359,00€25mg630,00€50mg882,00€100mg1.188,00€200mg1.596,00€500mg2.357,00€1mL*10mM (DMSO)251,00€Stafib-2
CAS :Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,
Formule :C28H26N2O12P2Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :644.46DT-6
CAS :DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing
Formule :C89H130N20O29S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2008.23TM2 TEAD inhibitor
CAS :TM2 TEAD inhibitor, a robust and reversible inhibitor of the TEA domain transcription factor, presents dual inhibitory concentrations (IC50) of 38 nM for TEAD4Formule :C26H33N3O3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :435.57ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases
Formule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5Myristoyl tetrapeptide-12
CAS :Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Formule :C32H63N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.89YAP-TEAD-IN-2
CAS :YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Formule :C25H24ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.923,7-DMF
CAS :3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formule :C17H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29ROCK-IN-1
CAS :ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFormule :C20H18FN3ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :335.37GNE-7883
CAS :GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.Formule :C28H29FN6O2Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :500.57Ref: TM-T78558
1mg116,00€5mg283,00€10mg455,00€25mg747,00€50mg1.026,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)310,00€Kartogenin sodium
CAS :Kartogenin (KGN) sodium acts as an inducer of chondrogenic tissue formation (EC 50: 100 nM). It promotes chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and modulating the CBFβ-RUNX1 transcriptional program. Additionally, Kartogenin sodium aids tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. It is extensively utilized in cell-free therapies for cartilage regeneration and protection, tendon-bone healing, wound healing, and limb development. The compound is also vital for cartilage repair, coordinating limb development, and osteoarthritis (OA) research [1] [2] [3] [4].Formule :C20H14NNaO3Couleur et forme :SolidMasse moléculaire :339.32PMMB-187
CAS :PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.Formule :C27H23BrN2O6S2Couleur et forme :SolidMasse moléculaire :615.52TEAD-IN-1
CAS :TEAD-IN-1 (Compound 2) is an effective inhibitor of TEAD auto-palmitoylation with an IC50 of 603 nM. It enhances the interaction between TEAD and VGLL4, while diminishing the interaction between YAP and TEAD. TEAD-IN-1 is applicable for cancer research.Formule :C15H20F2N2O3SCouleur et forme :SolidMasse moléculaire :346.393TEAD-IN-20
CAS :TEAD-IN-20 is a TEAD inhibitor with IC50 values of 0.021 μM in TEAD4 FRET and 0.044 μM in TEAD4 MCF7-Tead cell lines. It has potential applications in cancer research.Formule :C20H19F3N4O3Couleur et forme :SolidMasse moléculaire :420.39M3686
CAS :M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Formule :C21H18F3N5O2Couleur et forme :SolidMasse moléculaire :429.395CDD-1431
CAS :CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.Formule :C33H38N8O5SCouleur et forme :SolidMasse moléculaire :658.77YAP/TAZ inhibitor-3
CAS :YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.Formule :C21H18F3NO3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :389.37Ref: TM-T87651
1mg90,00€5mg215,00€10mg344,00€25mg695,00€50mg1.108,00€100mg1.791,00€200mg2.412,00€1mL*10mM (DMSO)236,00€TEAD-IN-10
CAS :TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].Formule :C15H14F3NOCouleur et forme :SolidMasse moléculaire :281.27(Rac)-SAG
CAS :(Rac)-SAG, an isoform of SAG, is a potent Smoothened (Smo) receptor agonist (EC₅₀ = 3 nM; Kd = 59 nM) that activates the Hedgehog signaling pathway and counteracts Cyclopamine's inhibition of Smo [1] [2] [3].Formule :C28H28ClN3OSCouleur et forme :SolidMasse moléculaire :490.06MYF-03-176
CAS :MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC₅₀ values of 47/32/71 nM. inhibits TEAD transcriptional activity and cancer cell growth, antitumour.Formule :C19H18F4N4O2Couleur et forme :SolidMasse moléculaire :410.37
