Gamma-sécrétase
Les inhibiteurs de la gamma-sécrétase sont des composés qui ciblent le complexe enzymatique gamma-sécrétase, impliqué dans le clivage de la protéine précurseur amyloïde (APP) pour produire des peptides bêta-amyloïdes. Ces peptides peuvent s'agréger pour former des plaques amyloïdes, un signe distinctif de la maladie d'Alzheimer. En inhibant la gamma-sécrétase, ces composés visent à réduire la production de bêta-amyloïde et son accumulation dans le cerveau, faisant d'eux un élément clé de la recherche sur la maladie d'Alzheimer. Chez CymitQuimica, nous proposons des inhibiteurs de la gamma-sécrétase pour soutenir vos recherches en biologie de l'amyloïde, en thérapie de la maladie d'Alzheimer et en maladies neurodégénératives.
59 produits trouvés pour "Gamma-sécrétase"
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CB-103
CAS :<p>CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.</p>Formule :C15H18N2ODegré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :242.32Demcizumab
CAS :<p>Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.34 kDaBrontictuzumab
CAS :<p>Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.</p>Degré de pureté :98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Couleur et forme :LiquidRovalpituzumab
CAS :<p>Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.02 kDaBMS-906024
CAS :<p>BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.</p>Formule :C26H26F6N4O3Degré de pureté :99.88% - >99.99%Couleur et forme :SolidMasse moléculaire :556.5Navicixizumab
CAS :<p>Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.</p>Couleur et forme :LiquidSPL-707
CAS :<p>SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).</p>Formule :C27H28FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.54γ-Secretase modulator 10
CAS :<p>γ-Secretase modulator 10 is a novel γ-secretase modulator.</p>Formule :C25H23F3N4O2Couleur et forme :SolidMasse moléculaire :468.48CIA-1 (Free base)
CAS :<p>CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.</p>Formule :C17H19N3O2SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :329.42RBPJ Inhibitor-1
CAS :<p>RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell</p>Formule :C17H14FN3O2Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :311.31Notch 1 TFA
<p>Notch 1 TFA encodes a member of the NOTCH family of proteins.</p>Formule :C64H98N15F3O25S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1614.81SAHM1
CAS :<p>Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.</p>Formule :C94H162N36O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2196.58FRM-024
CAS :<p>FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of</p>Formule :C22H22ClN5O2Couleur et forme :SolidMasse moléculaire :423.9PSEN1-IN-2
<p>PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.</p>Formule :C20H18ClFN2O3SCouleur et forme :SolidMasse moléculaire :420.885β-Cholanic acid
CAS :<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Formule :C24H40O2Degré de pureté :98.91% - 99.89%Couleur et forme :SoildMasse moléculaire :360.57PSEN1-IN-1
<p>PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50</p>Formule :C20H19ClF3NO3SCouleur et forme :SolidMasse moléculaire :445.88Legumain inhibitor 1
CAS :<p>Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.</p>Formule :C23H25N5O4SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :467.54Enoticumab
CAS :<p>Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.</p>Degré de pureté :98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Couleur et forme :Liquidγ-secretase modulator 3
CAS :<p>Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.</p>Formule :C24H23FN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53IMR-1
CAS :<p>IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formule :C15H15NO5S2Degré de pureté :97.96% - 98.38%Couleur et forme :SolidMasse moléculaire :353.41LY900009
CAS :<p>LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.</p>Formule :C23H27N3O4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :409.48JI130
CAS :<p>JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.</p>Formule :C23H24N2O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :376.45FLI-06
CAS :FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Formule :C25H30N2O5Degré de pureté :99.81% - ≥98%Couleur et forme :SolidMasse moléculaire :438.52γ-secretase modulator 1 hydrochloride
CAS :<p>gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].</p>Formule :C24H25ClN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :453IMR-1A
CAS :<p>IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formule :C13H11NO5S2Degré de pureté :97.1% - 99.76%Couleur et forme :SolidMasse moléculaire :325.36MK-0752 Sodium
CAS :<p>Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.</p>Formule :C21H21ClF2NaO4SCouleur et forme :SolidMasse moléculaire :465.89RO7185876
CAS :<p>RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.</p>Formule :C25H28F3N7Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :483.532Dilpacimab
CAS :<p>Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidTarlatamab
CAS :<p>"Tarlatamab (AMG-757), a BiTE antibody, targets DLL3, prevalent in SCLC tumors with scant normal tissue expression, and shows promise for SCLC research."</p>Couleur et forme :LiquidTarextumab
CAS :<p>Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.</p>Degré de pureté :95%Couleur et forme :Liquidγ-secretase modulator 1
CAS :<p>gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.</p>Formule :C24H24N4OSDegré de pureté :99.75% - 99.96%Couleur et forme :SolidMasse moléculaire :416.54JI051
CAS :JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formule :C22H24N2O3Degré de pureté :≥98% - ≥98.0%Couleur et forme :SolidMasse moléculaire :364.44BPN-15606
CAS :<p>BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.</p>Formule :C23H23FN6OCouleur et forme :SolidMasse moléculaire :418.47Yhhu-3792
CAS :<p>Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.</p>Formule :C24H24N4O2Couleur et forme :SolidMasse moléculaire :400.47ELN318463 racemate
CAS :<p>ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.</p>Formule :C19H20BrClN2O3SDegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :471.8γ-secretase modulator 2
CAS :<p>Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.</p>Formule :C25H22F4N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.47Aβ42-IN-2
CAS :<p>Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].</p>Formule :C24H26N6O2Degré de pureté :98.09% - 99.87%Couleur et forme :SolidMasse moléculaire :430.5ELN318463
CAS :<p>ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.</p>Formule :C19H20BrClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.8CIA-1 hcl(452087-38-6 Free base)
CAS :<p>CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of</p>Formule :C17H20ClN3O2SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :365.88γ-Secretase modulator 4
CAS :<p>γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.</p>Formule :C23H19FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.42tCFA15
CAS :<p>tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.</p>Formule :C24H44O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.61RR-11a analog
CAS :<p>RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).</p>Formule :C22H29N5O8Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :491.49γ-Secretase modulator 11
CAS :<p>5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and</p>Formule :C28H22F2N4O2Couleur et forme :SolidMasse moléculaire :484.5LY-411575 isomer 1
CAS :<p>LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.</p>Formule :C26H23F2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.48Aβ42-IN-1 free base
CAS :<p>Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091</p>Formule :C29H26N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.54RR-11a
CAS :<p>RR-11a is a synthetic enzyme Legumain inhibitor.</p>Formule :C24H28N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.51BMS-983970
CAS :<p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>Formule :C26H26F4N4O3Couleur et forme :SolidMasse moléculaire :518.5BT-GSI
<p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.</p>Formule :C26H46BrN5O10P2Couleur et forme :SolidMasse moléculaire :730.52Yhhu-3792 hydrochloride
CAS :<p>Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].</p>Formule :C24H25ClN4O2Couleur et forme :SolidMasse moléculaire :436.93BMS-932481
CAS :<p>BMS-932481 is a γ-secretase modulator.</p>Formule :C24H24FN7OCouleur et forme :SolidMasse moléculaire :445.49GSM-1
CAS :<p>GSM-1 is a modulator of γ-Secretase.</p>Formule :C26H31ClF3NO2Couleur et forme :SolidMasse moléculaire :481.98Gossypolone
CAS :<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Formule :C30H26O10Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :546.52γ-Secretase modulator 11 hydrochloride
CAS :<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Formule :C28H23ClF2N4O2Couleur et forme :SolidMasse moléculaire :520.96PF-06648671
CAS :<p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>Formule :C25H23ClF4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.92DAPM
CAS :<p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>Formule :C20H20F2N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :390.38BPN-15606 besylate
<p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>Formule :C29H29FN6O4SCouleur et forme :SolidMasse moléculaire :576.64Notch inhibitor 1
CAS :<p>Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.</p>Formule :C26H25F7N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.49Aβ42-IN-1
CAS :<p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formule :C29H27ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499HDAC6-IN-9
CAS :<p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>Formule :C19H16N2O3Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :320.34
