Récepteur du facteur de croissance des fibroblastes (FGFR)
Les inhibiteurs des récepteurs du facteur de croissance des fibroblastes (FGFR) sont des thérapies ciblées qui bloquent l'activité des FGFR, impliqués dans la prolifération cellulaire, la différenciation et l'angiogenèse. La signalisation FGFR contribue à la formation de nouveaux vaisseaux sanguins dans les tumeurs, favorisant leur croissance et leur survie. Inhiber les FGFR peut donc réduire l'angiogenèse et la progression tumorale. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de FGFR de haute qualité pour soutenir vos recherches en cancérologie, biologie du développement et angiogenèse.
170 produits trouvés pour "Récepteur du facteur de croissance des fibroblastes (FGFR)"
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PD168393
CAS :<p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>Formule :C17H13BrN4ODegré de pureté :99.13% - 99.83%Couleur et forme :SolidMasse moléculaire :369.22Lenvatinib mesylate
CAS :<p>Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.</p>Formule :C22H23ClN4O7SDegré de pureté :99.03% - 99.79%Couleur et forme :SolidMasse moléculaire :522.96SSR128129E
CAS :<p>SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.</p>Formule :C18H15N2O4·NaDegré de pureté :98.79% - ≥95%Couleur et forme :SolidMasse moléculaire :346.31H3B-6527
CAS :<p>H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.</p>Formule :C29H34Cl2N8O4Degré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :629.54Futibatinib
CAS :<p>Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.</p>Formule :C22H22N6O3Degré de pureté :97.66% - 99.44%Couleur et forme :SolidMasse moléculaire :418.45FGFR2-IN-3
CAS :<p>FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].</p>Formule :C28H24FN7O2Degré de pureté :99.63%Couleur et forme :SoildMasse moléculaire :509.53TG 100801
CAS :<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Formule :C33H30ClN5O3Degré de pureté :99.28% - 99.61%Couleur et forme :SolidMasse moléculaire :580.08CPL304110
CAS :<p>CPL304110: oral, selective FGFR 1-3 inhibitor; IC50 - FGFR1: 0.75nM, FGFR2: 0.5nM, FGFR3: 3.05nM.</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54FGFR3-IN-5
CAS :<p>FGFR3-IN-5: potent, selective FGFR3 inhibitor. IC50: 3 nM FGFR3, 44 nM FGFR2, 289 nM FGFR1. For cancer research.</p>Formule :C24H24FN7O3Couleur et forme :SolidMasse moléculaire :477.49MAX-40279 hydrochloride
CAS :<p>MAX-40279 HCl: potent FLT3/FGFR inhibitor; potential in AML research.</p>Formule :C22H24ClFN6OSCouleur et forme :SolidMasse moléculaire :474.98MAX-40279 hemifumarate
CAS :<p>MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.</p>Formule :C48H50F2N12O6S2Couleur et forme :SolidMasse moléculaire :993.12FGFR4-IN-11
CAS :<p>FGFR4-IN-11: selective, covalent FGFR4 inhibitor; IC50=2.1 nM; blocks FGF19 pathway; anticancer.</p>Formule :C29H29N5O5Couleur et forme :SolidMasse moléculaire :527.57FGFR3-IN-1
CAS :<p>FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).</p>Formule :C28H39N9O3SCouleur et forme :SolidMasse moléculaire :581.73SSR128129E free acid
CAS :<p>SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).</p>Formule :C18H16N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.33FGFR4-IN-5
CAS :<p>FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.</p>Formule :C23H23Cl2N5O5Couleur et forme :SolidMasse moléculaire :520.37FIIN-4
CAS :<p>FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.</p>Formule :C35H38N8O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :634.73FGFR-IN-9
<p>FGFR-IN-9: oral FGFR inhibitor, IC50: 17.1 nM (FGFR4 WT), 29.6 (FGFR3), 30.7 (V550L), 46.7 (FGFR2), 64.3 nM (FGFR1).</p>Formule :C25H28N6O3SCouleur et forme :SolidMasse moléculaire :492.59FGFR-IN-3
CAS :<p>FGFR-IN-3: potent, oral FGFR modulator, BBB-penetrating, neuroprotective, potential in neurodegeneration study.</p>Formule :C18H27F2N5O2Couleur et forme :SolidMasse moléculaire :383.44Derazantinib Racemate
CAS :<p>Derazantinib Racemate is an oral ATP competitive kinase inhibitor targeting FGFR1/2/3 (IC50s: 4.5/1.8/4.5 nM).</p>Formule :C29H29FN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.57SUN13837
CAS :<p>SUN13837, an oral FGFR modulator, crosses the BBB and shows neuroprotective promise.</p>Formule :C21H29N5O2Couleur et forme :SolidMasse moléculaire :383.49MAX-40279
CAS :<p>MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.</p>Formule :C22H23FN6OSCouleur et forme :SolidMasse moléculaire :438.52Rogaratinib
CAS :<p>Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).</p>Formule :C23H26N6O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :466.56FGFR3-IN-2
CAS :<p>FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).</p>Formule :C28H39N9O4SCouleur et forme :SolidMasse moléculaire :597.73FGFR-IN-7
CAS :<p>FGFR-IN-7: Oral FGFR modulator, crosses blood-brain barrier, neuroprotective, phospholipidosis-resistant, useful for neurodegeneration study.</p>Formule :C16H21ClF2N4O2Couleur et forme :SolidMasse moléculaire :374.81ARQ 069
CAS :<p>ARQ 069 inhibits FGFR2 phosphorylation concentration-dependently (IC50: 9.7 µM), without affecting β-actin. Preferentially binds inactive FGFR1/2.</p>Formule :C18H15N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :273.33TG 100801 Hydrochloride
CAS :<p>TG 100801: prodrug for macular degeneration. TG 100572: inhibits kinases (VEGFRs, FGFRs, PDGFRβ, Src family), with varying IC50s.</p>Formule :C33H31Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.54FGFR2-IN-1
CAS :<p>FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used to study FGFR2-associated cancers.</p>Formule :C22H19N3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :357.41CP-547632 hydrochloride
CAS :<p>CP-547632 hydrochloride: oral VEGFR-2/FGF inhibitor (IC50: 11/9 nM), well-tolerated, antitumor.</p>Formule :C20H25BrClF2N5O3SCouleur et forme :SolidMasse moléculaire :568.86CAY10583
CAS :<p>CAY10583 is a selective BLT2 agonist that increases TGF-β1 and bFGF, promotes keratinocyte migration, accelerates wound healing in diabetic mice.</p>Formule :C25H25NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.47MAX-40279 hemiadipate
CAS :<p>MAX-40279 hemiadipate: Potent FLT3/FGFR inhibitor; potential in AML treatment. (Patent WO2021180032A1)</p>Formule :C50H56F2N12O6S2Couleur et forme :SolidMasse moléculaire :1023.19FGFR2-IN-2
CAS :<p>FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.</p>Formule :C23H22N4ODegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :370.45TG 100572
CAS :<p>TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2</p>Formule :C26H26ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.97Infigratinib phosphate
CAS :<p>Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and</p>Formule :C26H34Cl2N7O7PDegré de pureté :99.24% - 99.6%Couleur et forme :SolidMasse moléculaire :658.47PP58
CAS :<p>PP58 is an inhibitor of PDGFR, FGFR and Src family.</p>Formule :C22H19Cl2N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :456.32FGFR-IN-2
CAS :<p>FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54TG 100572 Hydrochloride
CAS :<p>TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.</p>Formule :C26H27Cl2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.43Sulfatinib
CAS :<p>Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to</p>Formule :C24H28N6O3SDegré de pureté :99.21% - >99.99%Couleur et forme :SolidMasse moléculaire :480.58FGFR-IN-4
CAS :<p>FGFR-IN-4 is a potent inhibitor of FGFR. FGFR-IN-4 has potential for cancer disease studies.</p>Formule :C24H21N7O2Couleur et forme :SolidMasse moléculaire :439.47SNIPER(TACC3)-11
CAS :<p>SNIPER(TACC3)-11 is a powerful FGFR3-TACC3 protein degrader, reducing its amount and hindering FGFR3-TACC3+ cancer cell growth.</p>Formule :C51H66N10O7S2Couleur et forme :SolidMasse moléculaire :995.26CP-547632 TFA
CAS :<p>CP-547632 TFA, an oral VEGFR-2 and FGF inhibitor, IC50: VEGFR-2 at 11 nM, FGF at 9 nM, shows antitumor activity.</p>Formule :C22H25BrF5N5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.43Infigratinib-Boc
CAS :<p>Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].</p>Formule :C29H35Cl2N7O5Couleur et forme :SolidMasse moléculaire :632.54FGFR4-IN-8
CAS :<p>FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.</p>Formule :C32H34Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.56FGFR-IN-11
CAS :<p>FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (</p>Formule :C28H29ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.01Resigratinib
CAS :<p>Resigratinib (KIN-3248) is an oral, irreversible pan-FGFR family protein inhibitor, covalently binds to and inhibits all four FGFR isoforms(FGFR1/2/3/4).</p>Formule :C26H27F2N7O3Degré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :523.53FGFR3-IN-6
CAS :<p>FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>Formule :C25H23FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.5FGFR3-IN-7
CAS :<p>FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>Formule :C25H24FN9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.52FGFR4-IN-16
CAS :<p>FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].</p>Formule :C35H30Cl2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.56Irpagratinib
CAS :<p>Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.</p>Formule :C28H32F2N6O5Degré de pureté :99.08% - 99.38%Couleur et forme :SolidMasse moléculaire :570.59FIIN-1
CAS :<p>FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,</p>Formule :C32H39Cl2N7O4Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :656.6FGFR3-IN-4
CAS :<p>FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM.</p>Formule :C26H24ClN7OCouleur et forme :SolidMasse moléculaire :485.97FGFR4-IN-9
<p>FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.</p>Formule :C24H22ClF3N4O4Couleur et forme :SolidMasse moléculaire :522.9FGFR-IN-5
CAS :<p>FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.</p>Formule :C25H22N6O3Couleur et forme :SolidMasse moléculaire :454.48FGFR-IN-6
CAS :<p>FGFR-IN-6 (Compound 5) is an FGFR inhibitor.</p>Formule :C23H22N6O3Couleur et forme :SolidMasse moléculaire :430.46FGFR4-IN-6
<p>FGFR4-IN-6: covalent, reversible FGFR4 blocker, 5.4 nM IC50, good oral bioavailability, reduces Hep3B2.1-7 tumors in mice, low toxicity.</p>Formule :C31H33N7O4Couleur et forme :SolidMasse moléculaire :567.64E7090 succinate
CAS :<p>E7090 succinate inhibits FGFR1, FGFR2, and FGFR3 with IC50: 0.71, 0.50, 1.2 nM; less so FGFR4 at 120 nM.</p>Formule :C76H92N10O24Couleur et forme :SolidMasse moléculaire :1529.60FGFR1 inhibitor-6
<p>FGFR1 inhibitor-6, IC50: 16.31 nM, blocks cell cycle at pro-G1/G2/M and induces apoptosis.</p>Formule :C27H19N5O4S2Couleur et forme :SolidMasse moléculaire :541.6CEP-11981
CAS :<p>CEP-11981 is an orally active TIE2/pan-VEGFR inhibitor with broad tyrosine kinase inhibitory activity, antitumour and anti-angiogenic, refractory solid tumours.</p>Formule :C28H27N7ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :477.56FGFR4-IN-10
<p>FGFR4-IN-10 (compound 5a) is a potent, selective FGFR4 inhibitor with IC50 of 70.7 nM, sparing FGFR1-3.</p>Formule :C20H19F3N6O3Couleur et forme :SolidMasse moléculaire :448.4AZ8010
CAS :<p>AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.</p>Formule :C27H34N4O3Couleur et forme :SolidMasse moléculaire :462.58FGFR1 inhibitor-17
CAS :<p>FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.</p>Formule :C16H13ClN2O3Couleur et forme :SolidMasse moléculaire :316.739FGFR1 inhibitor-16
CAS :<p>FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.</p>Formule :C16H9N5O3SCouleur et forme :SolidMasse moléculaire :351.339FGFR1 inhibitor-15
CAS :<p>FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.</p>Formule :C17H13FN4OCouleur et forme :SolidMasse moléculaire :308.31FGFR2/3-IN-2
CAS :<p>FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.</p>Formule :C29H23FN6O3Couleur et forme :SolidMasse moléculaire :522.53TYRA-300
CAS :<p>TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.</p>Formule :C25H24Cl2N6O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :559.47FGFR-IN-16
CAS :<p>FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.</p>Formule :C30H27Cl2N7O4Couleur et forme :SolidMasse moléculaire :620.49FGFR-IN-15
<p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>Formule :C22H23N5O5SCouleur et forme :SolidMasse moléculaire :469.51FGFR4-IN-4
CAS :<p>FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.</p>Formule :C28H32Cl2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.5PNU-145156E
CAS :<p>PNU-145156E is a noncytotoxic molecule inhibiting growth and angiogenic factors, suppress tumor angiogenesis, support anti-angiogenic research strategies.</p>Formule :C45H40N10O17S4Couleur et forme :SolidMasse moléculaire :1121.12Fanregratinib
CAS :<p>Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.</p>Formule :C27H33ClN6O2Couleur et forme :SolidMasse moléculaire :509.04FGFR1 inhibitor-10
CAS :<p>FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.</p>Formule :C26H30F3N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.62
