Récepteur du facteur de croissance des fibroblastes (FGFR)
Les inhibiteurs des récepteurs du facteur de croissance des fibroblastes (FGFR) sont des thérapies ciblées qui bloquent l'activité des FGFR, impliqués dans la prolifération cellulaire, la différenciation et l'angiogenèse. La signalisation FGFR contribue à la formation de nouveaux vaisseaux sanguins dans les tumeurs, favorisant leur croissance et leur survie. Inhiber les FGFR peut donc réduire l'angiogenèse et la progression tumorale. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de FGFR de haute qualité pour soutenir vos recherches en cancérologie, biologie du développement et angiogenèse.
170 produits trouvés pour "Récepteur du facteur de croissance des fibroblastes (FGFR)"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
PHA-680632
CAS :<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Formule :C28H35N7O2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :501.62Roblitinib
CAS :<p>Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.</p>Formule :C25H30N8O4Degré de pureté :97.27% - 99%Couleur et forme :SolidMasse moléculaire :506.56SU4984
CAS :<p>SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).</p>Formule :C20H19N3O2Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :333.38BLU9931
CAS :<p>BLU9931 is the first selective small molecule inhibitor of FGFR4.</p>Formule :C26H22Cl2N4O3Degré de pureté :96.958% - 99.85%Couleur et forme :SolidMasse moléculaire :509.38Heparan Sulfate
CAS :<p>Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG). Cost effective and quality assured.</p>Formule :C12H19NO20S3(monomer)Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.47(monomer)EOC317
CAS :<p>EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).</p>Formule :C27H26F5N7O3Degré de pureté :98.00% - 99.26%Couleur et forme :SolidMasse moléculaire :591.53Derazantinib
CAS :<p>Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formule :C29H29FN4ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :468.57GW786034B
CAS :<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98PRN1371
CAS :<p>PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).</p>Formule :C26H30Cl2N6O4Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :561.46FIIN-3
CAS :<p>FIIN-3 is an irreversible inhibitor of FGFR.</p>Formule :C34H36Cl2N8O4Degré de pureté :97.63% - 98.92%Couleur et forme :SolidMasse moléculaire :691.61Ponatinib
CAS :<p>Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively</p>Formule :C29H27F3N6ODegré de pureté :98% - 99.60%Couleur et forme :SolidMasse moléculaire :532.56S49076
CAS :<p>S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.</p>Formule :C22H22N4O4SDegré de pureté :95.35% - 97.4%Couleur et forme :SolidMasse moléculaire :438.5Gandotinib
CAS :<p>LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).</p>Formule :C23H25ClFN7ODegré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :469.94FGFR2-IN-3 hydrochloride
CAS :<p>FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.</p>Formule :C28H25ClFN7O2Couleur et forme :SolidMasse moléculaire :546.0Dovitinib lactate hydrate
CAS :<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Formule :C24H27FN6O4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :482.51KHS101 hydrochloride
CAS :<p>KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.</p>Formule :C18H22ClN5SDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :375.92Fisogatinib
CAS :<p>Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.</p>Formule :C24H24Cl2N4O4Degré de pureté :99.27% - ≥95%Couleur et forme :SolidMasse moléculaire :503.38Masitinib mesylate
CAS :<p>Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;</p>Formule :C29H34N6O4S2Degré de pureté :97.67% - 98.44%Couleur et forme :SolidMasse moléculaire :594.75KHS 101
CAS :<p>KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.</p>Formule :C18H21N5SDegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :339.46Ferulic acid sodium
CAS :<p>Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.</p>Formule :C10H9NaO4Degré de pureté :99.58%Couleur et forme :White Crystalline PowderMasse moléculaire :216.16S49076 HCl
CAS :<p>S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.</p>Formule :C22H18ClN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.85ON123300
CAS :<p>ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).</p>Formule :C24H27N7ODegré de pureté :99.22% - 99.53%Couleur et forme :SolidMasse moléculaire :429.52R1530
CAS :<p>R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.</p>Formule :C18H14ClFN4ODegré de pureté :98.422%Couleur et forme :SolidMasse moléculaire :356.78ODM-203
CAS :<p>ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity</p>Formule :C26H21F2N5O2SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :505.54Alofanib
CAS :<p>Alofanib (RPT835) selectively inhibits FGFR2 in KATO III cells with IC50 <10 nM; doesn’t affect FGFR1/3 or FGF2-FGFR2 binding.</p>Formule :C19H15N3O6SDegré de pureté :99.53% - 99.81%Couleur et forme :SolidMasse moléculaire :413.4Danusertib
CAS :<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formule :C26H30N6O3Degré de pureté :97.88% - 98.79%Couleur et forme :White PowderMasse moléculaire :474.55KW-2449
CAS :<p>KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.</p>Formule :C20H20N4ODegré de pureté :98.43% - 99.69%Couleur et forme :SolidMasse moléculaire :332.4Nintedanib esylate
CAS :<p>Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β</p>Formule :C31H33N5O4·C2H6O3SDegré de pureté :99.43% - 99.96%Couleur et forme :SolidMasse moléculaire :649.76FIIN-2
CAS :<p>FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.</p>Formule :C35H38N8O4Degré de pureté :97.82% - 99.65%Couleur et forme :Crystalline SolidMasse moléculaire :634.73PD-089828
CAS :<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Formule :C18H18Cl2N6ODegré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :405.28LY2874455
CAS :<p>LY2874455 has been used in trials studying the treatment of Advanced Cancer.</p>Formule :C21H19Cl2N5O2Degré de pureté :97.22% - 99.46%Couleur et forme :SolidMasse moléculaire :444.31Erdafitinib
CAS :<p>Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.</p>Formule :C25H30N6O2Degré de pureté :97.00% - 99.07%Couleur et forme :SolidMasse moléculaire :446.54ASP5878
CAS :<p>ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.</p>Formule :C18H19F2N5O4Degré de pureté :99.8% - 99.89%Couleur et forme :SolidMasse moléculaire :407.37AZD4547
CAS :<p>AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.</p>Formule :C26H33N5O3Degré de pureté :99.37% - 99.88%Couleur et forme :SolidMasse moléculaire :463.57CHIR-98014
CAS :<p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>Formule :C20H17Cl2N9O2Degré de pureté :97.25% - 99.59%Couleur et forme :SolidMasse moléculaire :486.31PD173074
CAS :<p>PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.</p>Formule :C28H41N7O3Degré de pureté :98.15% - 98.21%Couleur et forme :Yellow SolidMasse moléculaire :523.67SU 5402
CAS :<p>SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.</p>Formule :C17H16N2O3Degré de pureté :98.91% - 99.64%Couleur et forme :Yellow-Green SolidMasse moléculaire :296.32FGFR4-IN-1
CAS :<p>FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).</p>Formule :C24H27N7O5Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :493.52PD-161570
CAS :<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.51SUN11602
CAS :<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Formule :C26H37N5O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :451.6Orantinib
CAS :<p>Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.</p>Formule :C18H18N2O3Degré de pureté :98.92% - 99.52%Couleur et forme :SolidMasse moléculaire :310.35Dovitinib
CAS :<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Formule :C21H21FN6ODegré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :392.43XL 999
CAS :<p>Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）</p>Formule :C26H28FN5ODegré de pureté :98.24% - 99.55%Couleur et forme :SolidMasse moléculaire :445.53Zoligratinib
CAS :<p>Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.</p>Formule :C20H16N6ODegré de pureté :95.28% - 99.51%Couleur et forme :SolidMasse moléculaire :356.38Infigratinib
CAS :<p>Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and</p>Formule :C26H31Cl2N7O3Degré de pureté :98% - 98.97%Couleur et forme :SolidMasse moléculaire :560.48DGY-06-116
CAS :<p>DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.</p>Formule :C32H33ClN8O2Degré de pureté :97.65%Couleur et forme :SolidMasse moléculaire :597.11PF 477736
CAS :<p>PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (</p>Formule :C22H25N7O2Degré de pureté :97.58% - 99.94%Couleur et forme :SolidMasse moléculaire :419.48ENMD-2076
CAS :<p>ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.</p>Formule :C21H25N7Degré de pureté :97.63% - ≥95%Couleur et forme :SolidMasse moléculaire :375.47Regorafenib
CAS :<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82Masitinib
CAS :<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Formule :C28H30N6OSDegré de pureté :97.56% - >99.99%Couleur et forme :SolidMasse moléculaire :498.64
