ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
146 produits trouvés pour "ALK".
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ALK-IN-26
CAS :ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Formule :C24H23NO3SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :405.51CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formule :C29H39ClN6O6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :635.17LDN-193189 2HCl
CAS :LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.Formule :C25H24Cl2N6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :479.4Ref: TM-T35348
5mg70,00€1mL*10mM (DMSO)74,00€10mg90,00€25mg138,00€50mg213,00€100mg318,00€500mg753,00€ALK inhibitor 1
CAS :ALK inhibitor 1 is a selective ALK kinase inhibitor.Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :White SolidMasse moléculaire :562.48Ref: TM-T10285
1mg50,00€5mg110,00€1mL*10mM (DMSO)136,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€ZX-29
CAS :ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formule :C23H28ClN7O3SDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :518.03Ref: TM-T13416
1mg96,00€5mg219,00€1mL*10mM (DMSO)250,00€10mg344,00€25mg587,00€50mg803,00€100mg1.063,00€200mg1.431,00€F-1
CAS :F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Formule :C22H27ClN8O3SDegré de pureté :97.66%Couleur et forme :SolidMasse moléculaire :519.02ALK inhibitor 2
CAS :ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formule :C23H28ClN7O3SDegré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :518.03MS4078
CAS :MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Formule :C45H52ClN9O8SDegré de pureté :98.74%Couleur et forme :Yellow SolidMasse moléculaire :914.47Ref: TM-T16153
1mg49,00€2mg66,00€5mg90,00€10mg152,00€1mL*10mM (DMSO)152,00€25mg260,00€50mg416,00€100mg615,00€Ascrinvacumab
CAS :Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.18%Couleur et forme :Transparent LiquidMasse moléculaire :150 kDaALK-IN-13
CAS :ALK-IN-13 is an ALK inhibitor.Formule :C29H39ClN7O2PCouleur et forme :SolidMasse moléculaire :584.1Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Degré de pureté :98%Couleur et forme :Odour SolidPROTAC ALK degrader-3
PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.Formule :C50H60ClN9O7SCouleur et forme :SolidMasse moléculaire :966.59Ceritinib-amide-C3-acid
CAS :Ceritinib-amide-C3-acid is a ligand-linker conjugate of a target protein. It consists of the protein ligand Ceritinib and a linker used for connecting an E3 ligase ligand. Ceritinib-amide-C3-acid is useful in the synthesis of [TD-004].Formule :C33H42ClN5O6SMasse moléculaire :672.24ALK5-IN-84
ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 for hALK5. Administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. This compound holds potential for research in developing inhalable ALK5 inhibitors.Formule :C20H20ClFN6OMasse moléculaire :414.86MS4077
CAS :MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).Formule :C55H72ClN9O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1134.73TL13-22
CAS :TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .Formule :C45H55ClN10O9SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :947.5dALK-3
dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.Formule :C39H45ClN7O5PCouleur et forme :SolidMasse moléculaire :758.245ALK/ROS1-IN-3
ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.Formule :C32H32N4O2Couleur et forme :SolidMasse moléculaire :504.25253INCB-000928
CAS :Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.Formule :C30H38N4O3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :502.65Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCPD-1224
CAS :CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Formule :C43H47ClN8O7SCouleur et forme :SolidMasse moléculaire :855.4LDN 193688
CAS :LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.Formule :C22H16N4ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :352.39ALKBH5-IN-5
CAS :ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formule :C13H13NO3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :231.25Ref: TM-T203011
5mg34,00€10mg46,00€1mL*10mM (DMSO)49,00€25mg84,00€50mg120,00€100mg178,00€200mg268,00€ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Formule :C29H32FN3OCouleur et forme :SolidMasse moléculaire :457.58Lys-PEG3-BA
CAS :Lys-PEG3-BA is a PROTAC degrader targeting EML4-ALK/EGFR, with DC50 values of 1.32 μM for H3122 cells (expressing EML4-ALK fusion protein) and 19.66 μM for H1975 cells (with EGFRL858R/T790M mutations). In vitro studies show that Lys-PEG3-BA can inhibit the proliferation of non-small cell lung cancer cells by modulating the ubiquitin-proteasome system. Lys-PEG3-BA is applicable for research related to non-small cell lung cancer.Formule :C38H57ClN9O7PMasse moléculaire :818.35ALK protein ligand-1
CAS :ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.Formule :C24H29ClN6O3SCouleur et forme :SolidMasse moléculaire :517.043TL13-112
CAS :TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formule :C49H60ClN9O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1002.57ALK2-IN-6
CAS :ALK2-IN-6 is a potent and selective ALK2 inhibitor with an IC50 of 9 nM. ALK2-IN-6 exhibits excellent brain permeability and effectively suppresses bone morphogenetic protein signaling across various preclinical cancer models for the treatment of diffuse intrinsic pontine glioma.Formule :C26H31N3O3Degré de pureté :99.97%Couleur et forme :Gray SolidMasse moléculaire :433.542-Keto Crizotinib
CAS :2-Keto Crizotinib is an active lactam metabolite of crizotinib.Formule :C21H20Cl2FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.32TL13-12
CAS :TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Formule :C45H53ClN10O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :961.49LAE-102
LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.Couleur et forme :Odour LiquidALK5 Inhibitor II (hydrochloride)
CAS :ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).Formule :C17H13N5·HClDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.8ALK-IN-9
CAS :ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Formule :C20H21FN6O3Couleur et forme :SolidMasse moléculaire :412.425ALK degrader 2
ALK degrader 2 is an orally active ALK degrader that reduces EML4-ALK protein levels (DC50= 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC50= 102 nM). It facilitates ALK degradation through the Hsp70 chaperone system and the ubiquitin-proteasome pathway. In H3122 cells, ALK degrader 2 causes significant cell cycle arrest at the S phase and induces apoptosis. Additionally, it demonstrates antitumor activity in mice with H3122 xenograft tumors. ALK degrader 2 is a useful compound in researching non-small cell lung cancer (NSCLC).Couleur et forme :Odour SolidTL13-110
CAS :Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Formule :C49H62ClN9O9SCouleur et forme :SolidMasse moléculaire :988.59ALK-IN-12
CAS :ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Formule :C24H30ClN6O2PCouleur et forme :SolidMasse moléculaire :500.97M4K2234
CAS :M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.Formule :C27H31FN4O2Degré de pureté :99.99%Couleur et forme :White SolidMasse moléculaire :462.56SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Formule :C43H49Cl2N10O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :919.79FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Couleur et forme :LiquidRef: TM-L1610
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderZilurgisertib fumarate
CAS :Zilurgisertib fumarate is a selective ALK2 inhibitor that modulates iron metabolism and improves anemia by inhibiting SMAD phosphorylation and hepcidin production.Formule :C30H38N4O3·xC4H4O4Degré de pureté :99.96%Couleur et forme :Yellow SolidMasse moléculaire :502.66 (free base)ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.Formule :C32H28F2N4O3Couleur et forme :SolidMasse moléculaire :554.586LDN-193189 Tetrahydrochloride
CAS :LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Formule :C25H26Cl4N6Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :552.33EW-7195
CAS :EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Formule :C23H18N8Degré de pureté :99.98%Couleur et forme :White SolidMasse moléculaire :406.44Ref: TM-T38752
1mg124,00€2mg177,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg507,00€25mg1.009,00€50mg1.648,00€100mg2.602,00€DMH-1
CAS :DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Formule :C24H20N4ODegré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :380.44Brigatinib
CAS :Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Formule :C29H39ClN7O2PDegré de pureté :97.18% - >99.99%Couleur et forme :White SolidMasse moléculaire :584.09Ref: TM-T3621
2mg34,00€5mg48,00€1mL*10mM (DMSO)62,00€10mg63,00€25mg92,00€50mg108,00€100mg158,00€200mg227,00€500mg385,00€A 77-01
CAS :A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formule :C18H14N4Degré de pureté :98.82% - ≥95%Couleur et forme :SolidMasse moléculaire :286.33Ref: TM-T2098
1mg40,00€2mg52,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg118,00€25mg200,00€50mg280,00€100mg394,00€200mg580,00€CH5424802 analog
CAS :CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formule :C28H30N4O2Degré de pureté :98.96%Couleur et forme :White SolidMasse moléculaire :454.56Ref: TM-T9224
1mg124,00€5mg271,00€1mL*10mM (DMSO)324,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€RepSox
CAS :RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formule :C17H13N5Degré de pureté :99.10% - 99.86%Couleur et forme :Gray SolidMasse moléculaire :287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€5-phenylthieno[2,3-d]pyrimidin-4-amine
CAS :5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Formule :C12H9N3SDegré de pureté :97%Couleur et forme :Yellow SolidMasse moléculaire :227.29Ref: TM-T50042
2mg43,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg90,00€25mg138,00€50mg200,00€100mg301,00€200mg432,00€AZD-3463
CAS :AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formule :C24H25ClN6ODegré de pureté :99.13% - 99.97%Couleur et forme :Cyan SolidMasse moléculaire :448.95
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