c-Fms
Les inhibiteurs de c-Fms ciblent le récepteur du facteur de stimulation des colonies-1 (c-Fms), une tyrosine kinase impliquée dans la régulation des macrophages et d'autres cellules immunitaires. La signalisation de c-Fms joue un rôle dans la prolifération, la différenciation et la survie de ces cellules. La dérégulation de c-Fms est associée à des maladies telles que le cancer, les conditions inflammatoires et l'ostéoporose. Chez CymitQuimica, nous proposons des inhibiteurs de c-Fms pour soutenir vos recherches en immunologie, oncologie et maladies inflammatoires.
104 produits trouvés pour "c-Fms"
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Mavrilimumab
CAS :Mavrilimumab (CAM 3001), a monoclonal antibody, blocks GM-CSF signaling, potentially reducing inflammation in rheumatoid arthritis.
Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :143.2 kDaLacnotuzumab
CAS :Lacnotuzumab (MCS110) is a humanized monoclonal antibody targeting CSF-1, which can be used in research on retinal diseases.Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :144.8 kDaCSF1R-IN-2
CAS :CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Formule :C20H20FN7O2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :409.42CSF1R-IN-1
CAS :CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.Formule :C25H20F3N5O2Degré de pureté :97.02% - 98.56%Couleur et forme :SolidMasse moléculaire :479.45Ref: TM-T10894
1mg88,00€5mg200,00€10mg309,00€25mg522,00€50mg747,00€100mg1.035,00€200mg1.378,00€1mL*10mM (DMSO)219,00€Emactuzumab
CAS :Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has
Degré de pureté :SDS-PAGE:98.3%;SEC-HPLC:97.3%Couleur et forme :LiquidMasse moléculaire :144.4 kDaEdicotinib
CAS :Edicotinib (JNJ-527) is a blood-brain permeable, selective CSF-1R inhibitor, with lesser inhibitory effects on KIT and FLT3.Cost-effective and quality-assured.
Formule :C27H35N5O2Degré de pureté :98.58% - 99.72%Couleur et forme :SolidMasse moléculaire :461.6Pyrithyldione
CAS :Pyrithyldione is a sedative-hypnotic agent known to potentially induce agranulocytosis.Formule :C9H13NO2Couleur et forme :SolidMasse moléculaire :167.21Adrixetinib TFA
Adrixetinib (TFA) is a protein tyrosine kinase inhibitor that possesses antineoplastic properties [1] [2] [3].Couleur et forme :Odour SolidCSF1R-IN-17
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM.Formule :C20H25N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.44Antifibrotic agent 1
Antifibrotic agent 1 is an orally active medication designed to treat idiopathic pulmonary fibrosis (IPF). It effectively mitigates IPF-related processes, including TGF-β-induced epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT), as well as profibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α, and Src family kinases (SFKs), while sparing VEGFR, FGFR, and Abl to minimize off-target toxicity. In a bleomycin (BLM)-induced pulmonary fibrosis mouse model, it demonstrates strong antifibrotic activity.Formule :C27H23ClN6O2Couleur et forme :SolidMasse moléculaire :498.1571PXB17
PXB17 inhibits CSF1R activation (IC50= 1.7 nM) by blocking the PI3K/AKT/mTORC1 signaling pathway. It is effective orally, significantly suppresses the growth of colorectal cancer (CRC), enhances the efficacy of PD-1 monoclonal antibodies (PD-1mAb), and reduces the recurrence of CRC tumors.Formule :C29H35N7O4Masse moléculaire :545.27505GENZ-882706(Raceme)
CAS :GENZ-882706(Raceme) is the racemate of GENZ-882706.Formule :C26H25N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.51M4205
CAS :M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.Formule :C29H32N8ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :508.62Ref: TM-T9689
1mg50,00€5mg110,00€10mg170,00€25mg290,00€50mg414,00€100mg572,00€200mg772,00€1mL*10mM (DMSO)122,00€Eflapegrastim
CAS :Eflapegrastim: humanized IgG4 antibody and G-CSF that boosts neutrophils and shortens neutropenia.Couleur et forme :LiquidSotuletinib hydrochloride
CAS :Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM),for ALS and TNBC.Formule :C20H23ClN4O3SDegré de pureté :98.812%Couleur et forme :SolidMasse moléculaire :434.94Gimsilumab
CAS :Gimsilumab (MORAb-022) is an anti-c-Fms humanized monoclonal antibody for the study of inflammation and hypoxemia caused by COVID-19.Degré de pureté :99.49% (SEC-HPLC) - 99.49% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.8 kDaOtilimab
CAS :Otilimab, a humanized monoclonal antibody, blocks GM-CSF to reduce inflammation and may treat severe COVID-19 pneumonia.
Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :142.22 kDaPLX647 dihydrochloride
CAS :PLX647 dihydrochloride: potent FMS/KIT inhibitor (IC50: 28/16 nM), highly selective, limited FLT3/KDR activity, oral use.Formule :C21H19Cl2F3N4Couleur et forme :SolidMasse moléculaire :455.31cFMS Receptor Inhibitor IV
CAS :cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
Formule :C22H26N4O2Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :378.47Anti-CSF1R Antibody (2I506)
Anti-CSF1R Antibody (2I506) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (2I506) can be used in ELISA.Couleur et forme :Odour Liquid
