c-Fms
Les inhibiteurs de c-Fms ciblent le récepteur du facteur de stimulation des colonies-1 (c-Fms), une tyrosine kinase impliquée dans la régulation des macrophages et d'autres cellules immunitaires. La signalisation de c-Fms joue un rôle dans la prolifération, la différenciation et la survie de ces cellules. La dérégulation de c-Fms est associée à des maladies telles que le cancer, les conditions inflammatoires et l'ostéoporose. Chez CymitQuimica, nous proposons des inhibiteurs de c-Fms pour soutenir vos recherches en immunologie, oncologie et maladies inflammatoires.
108 produits trouvés pour "c-Fms"
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Lacnotuzumab
CAS :Lacnotuzumab (MCS110) is a humanized monoclonal antibody targeting CSF-1, which can be used in research on retinal diseases.Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :144.8 kDaMavrilimumab
CAS :Mavrilimumab (CAM 3001), a monoclonal antibody, blocks GM-CSF signaling, potentially reducing inflammation in rheumatoid arthritis.
Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :143.2 kDaEmactuzumab
CAS :Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has
Degré de pureté :SDS-PAGE:98.3%;SEC-HPLC:97.3%Couleur et forme :LiquidMasse moléculaire :144.4 kDaCSF1R-IN-1
CAS :CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.Formule :C25H20F3N5O2Degré de pureté :97.02% - 98.56%Couleur et forme :SolidMasse moléculaire :479.45Ref: TM-T10894
1mg88,00€5mg200,00€10mg309,00€25mg522,00€50mg747,00€100mg1.035,00€200mg1.378,00€1mL*10mM (DMSO)219,00€Edicotinib
CAS :Edicotinib (JNJ-527) is a blood-brain permeable, selective CSF-1R inhibitor, with lesser inhibitory effects on KIT and FLT3.Cost-effective and quality-assured.
Formule :C27H35N5O2Degré de pureté :98.58% - 99.72%Couleur et forme :SolidMasse moléculaire :461.6CSF1R-IN-2
CAS :CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Formule :C20H20FN7O2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :409.42PXB17
PXB17 inhibits CSF1R activation (IC50= 1.7 nM) by blocking the PI3K/AKT/mTORC1 signaling pathway. It is effective orally, significantly suppresses the growth of colorectal cancer (CRC), enhances the efficacy of PD-1 monoclonal antibodies (PD-1mAb), and reduces the recurrence of CRC tumors.Formule :C29H35N7O4Masse moléculaire :545.27505AMG-820
AMG-820 is a human antibody targeting CSF-1R, inhibiting the binding of ligands CSF1 and IL34, and preventing subsequent ligand-induced receptor activation. For AMG-820's isotype control, refer to [Human IgG2 kappa, Isotype Control].Couleur et forme :Odour LiquidSotuletinib hydrochloride
CAS :Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM),for ALS and TNBC.Formule :C20H23ClN4O3SDegré de pureté :98.812%Couleur et forme :SolidMasse moléculaire :434.94M4205
CAS :M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.Formule :C29H32N8ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :508.62Ref: TM-T9689
1mg50,00€5mg110,00€10mg170,00€25mg290,00€50mg414,00€100mg572,00€200mg772,00€1mL*10mM (DMSO)122,00€Plonmarlimab
CAS :Plonmarlimab(TJ003234) is an anti-GM-CSF monoclonal antibody with potential antiviral activity for the study of immune disorders and novel coronavirus infectionDegré de pureté :96.2% (SDS-PAGE); 95.4% (SEC-HPLC) - 96.2% (SDS-PAGE); 95.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.94 kDacFMS Receptor Inhibitor IV
CAS :cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
Formule :C22H26N4O2Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :378.47Gimsilumab
CAS :Gimsilumab (MORAb-022) is an anti-c-Fms humanized monoclonal antibody for the study of inflammation and hypoxemia caused by COVID-19.Degré de pureté :99.49% (SEC-HPLC) - 99.49% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.8 kDaEflapegrastim
CAS :Eflapegrastim: humanized IgG4 antibody and G-CSF that boosts neutrophils and shortens neutropenia.Couleur et forme :LiquidPyrithyldione
CAS :Pyrithyldione is a sedative-hypnotic agent known to potentially induce agranulocytosis.Formule :C9H13NO2Couleur et forme :SolidMasse moléculaire :167.21PLX647 dihydrochloride
CAS :PLX647 dihydrochloride: potent FMS/KIT inhibitor (IC50: 28/16 nM), highly selective, limited FLT3/KDR activity, oral use.Formule :C21H19Cl2F3N4Couleur et forme :SolidMasse moléculaire :455.31Adrixetinib TFA
Adrixetinib (TFA) is a protein tyrosine kinase inhibitor that possesses antineoplastic properties [1] [2] [3].Couleur et forme :Odour SolidAntifibrotic agent 1
Antifibrotic agent 1 is an orally active medication designed to treat idiopathic pulmonary fibrosis (IPF). It effectively mitigates IPF-related processes, including TGF-β-induced epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT), as well as profibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α, and Src family kinases (SFKs), while sparing VEGFR, FGFR, and Abl to minimize off-target toxicity. In a bleomycin (BLM)-induced pulmonary fibrosis mouse model, it demonstrates strong antifibrotic activity.Formule :C27H23ClN6O2Couleur et forme :SolidMasse moléculaire :498.1571CSF1R-IN-17
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM.Formule :C20H25N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.44GENZ-882706(Raceme)
CAS :GENZ-882706(Raceme) is the racemate of GENZ-882706.Formule :C26H25N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.51Otilimab
CAS :Otilimab, a humanized monoclonal antibody, blocks GM-CSF to reduce inflammation and may treat severe COVID-19 pneumonia.
Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :142.22 kDaCSF1R Protein, Human, Recombinant (His & GST)
CSF1R Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Couleur et forme :Lyophilized PowderMasse moléculaire :76 kDa (predicted); 75 kDa (reducing conditions)Anti-CSF1R Antibody (8O797)
Anti-CSF1R Antibody (8O797) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (8O797) can be used in ELISA.Couleur et forme :Odour LiquidCSF1R Protein, Human, Recombinant (His & Avi)
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :57.4 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Anti-CSF1R Antibody-FITC (4Y587)
Anti-CSF1R Antibody-FITC (4Y587) is a FITC-conjugated Mouse antibody targeting CSF1R. Anti-CSF1R Antibody-FITC (4Y587) can be used in FCM.Couleur et forme :Odour LiquidAnti-CSF1R Antibody (5B661)
Anti-CSF1R Antibody (5B661) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (5B661) can be used in ELISA,ELISA(Cap).Couleur et forme :Odour LiquidAnti-CSF1R Antibody (1R707)
Anti-CSF1R Antibody (1R707) is a Rabbit antibody targeting CSF1R. Anti-CSF1R Antibody (1R707) can be used in ELISA.Couleur et forme :Odour LiquidAnti-CSF1R Antibody (2I506)
Anti-CSF1R Antibody (2I506) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (2I506) can be used in ELISA.Couleur et forme :Odour LiquidCSF1R Protein (Ala299-Glu512), Human, Recombinant (His)
CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :25.3 kDa (predicted)CSF1R Protein, Human, Recombinant (Domain I&II&III, His)
CSF1R Protein, Human, Recombinant (Domain I&II&III, His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :31.1 kDa (predicted)Anti-CSF1R Antibody (5C535)
Anti-CSF1R Antibody (5C535) is a Rabbit antibody targeting CSF1R. Anti-CSF1R Antibody (5C535) can be used in ELISA.Couleur et forme :Odour LiquidPLX647
CAS :PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).Formule :C21H17F3N4Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :382.38Ref: TM-T1925
2mg39,00€5mg57,00€10mg86,00€25mg127,00€50mg178,00€100mg264,00€200mg389,00€1mL*10mM (DMSO)60,00€CSF1R Protein (Met1-Glu512), Human, Recombinant (His)
CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Degré de pureté :SDS-PAGE: 97.7%; SEC-HPLC: 99.7%Couleur et forme :Lyophilized PowderMasse moléculaire :56 kDa (predicted); 85-95 kDa (reducing condition, due to glycosylation)CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :57.76 kDa (predicted); 82.52 kDa (reducing conditions)CSF1R Protein, Human, Recombinant
CSF1R Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55.1 kDa and the accession number is P07333-1.Couleur et forme :Lyophilized PowderMasse moléculaire :55.1 kDa (predicted); 80-90 kDa (reducing condition, due to glycosylation)CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :57.4 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Ref: TM-TMPK-00415
5µg91,00€10µg150,00€20µg239,00€50µg471,00€100µg779,00€200µg1.410,00€500µg3.018,00€CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated
CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :83.04 kDa (predicted); 110.87 kDa (reducing conditions)CSF1R Protein, Human, Recombinant (mFc)
CSF1R Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :81.5 kDa (predicted)Ref: TM-TMPY-05264
1mg2.099,00€5µg47,00€10µg65,00€20µg94,00€50µg167,00€100µg334,00€200µg499,00€500µg1.046,00€CSF1R Protein, Human, Recombinant (hFc)
CSF1R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :81.2 kDa (predicted)Ref: TM-TMPY-05429
1mg2.931,00€5µg57,00€10µg90,00€20µg126,00€50µg244,00€100µg472,00€200µg691,00€500µg1.488,00€Anti-CSF1R Antibody (4Y587)
Anti-CSF1R Antibody (4Y587) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (4Y587) can be used in FCM.Couleur et forme :Odour LiquidCSF1R Protein, Cynomolgus, Recombinant (His)
M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :56.3 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Anti-CSF1R Antibody (7V18)
Anti-CSF1R Antibody (7V18) is a Rabbit antibody targeting CSF1R. Anti-CSF1R Antibody (7V18) can be used in ELISA.Couleur et forme :Odour LiquidSotuletinib
CAS :Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor, >1000-fold selective against its closest receptor tyrosine kinase homologs.Formule :C20H22N4O3SDegré de pureté :97.43% - 99.82%Couleur et forme :SolidMasse moléculaire :398.48Ref: TM-T6119
1mg37,00€5mg79,00€10mg111,00€25mg172,00€50mg216,00€100mg378,00€500mg868,00€1mL*10mM (DMSO)87,00€GW2580
CAS :GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.Formule :C20H22N4O3Degré de pureté :99.48% - >99.99%Couleur et forme :SolidMasse moléculaire :366.41Ki20227
CAS :Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).Formule :C24H24N4O5SDegré de pureté :98.97% - 99.88%Couleur et forme :SolidMasse moléculaire :480.54Ref: TM-T4315
1mg44,00€5mg90,00€10mg145,00€25mg268,00€50mg439,00€100mg700,00€200mg954,00€1mL*10mM (DMSO)90,00€Vimseltinib
CAS :Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Formule :C23H25N7O2Degré de pureté :99.05% - 99.57%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T10652
1mg87,00€5mg178,00€10mg295,00€25mg505,00€50mg690,00€100mg888,00€1mL*10mM (DMSO)203,00€PLX5622
CAS :PLX5622 is a selective, orally active and blood-brain barrier permeable CSF1R inhibitor. PLX5622 induces elimination of microglia. Cost effective and quality assured.Formule :C21H19F2N5ODegré de pureté :98% - 99.97%Couleur et forme :SolidMasse moléculaire :395.41Ref: TM-T7100
1mg43,00€5mg81,00€10mg118,00€25mg230,00€50mg385,00€100mg502,00€200mg710,00€1mL*10mM (DMSO)77,00€cFMS Receptor Inhibitor II
CAS :cFMS Receptor Inhibitor II is a CSF1R kinase inhibitorFormule :C23H20N4ODegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :368.43Ref: TM-T5586
1mg49,00€2mg65,00€5mg97,00€10mg154,00€25mg255,00€50mg376,00€100mg547,00€1mL*10mM (DMSO)106,00€PRN1371
CAS :PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Formule :C26H30Cl2N6O4Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :561.46Ref: TM-TQ0015
1mg77,00€2mg100,00€5mg166,00€10mg289,00€25mg492,00€50mg710,00€100mg973,00€1mL*10mM (DMSO)200,00€Dovitinib
CAS :Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.
Formule :C21H21FN6ODegré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :392.43
