c-Fms
Les inhibiteurs de c-Fms ciblent le récepteur du facteur de stimulation des colonies-1 (c-Fms), une tyrosine kinase impliquée dans la régulation des macrophages et d'autres cellules immunitaires. La signalisation de c-Fms joue un rôle dans la prolifération, la différenciation et la survie de ces cellules. La dérégulation de c-Fms est associée à des maladies telles que le cancer, les conditions inflammatoires et l'ostéoporose. Chez CymitQuimica, nous proposons des inhibiteurs de c-Fms pour soutenir vos recherches en immunologie, oncologie et maladies inflammatoires.
108 produits trouvés pour "c-Fms"
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PRN1371
CAS :PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Formule :C26H30Cl2N6O4Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :561.46Ref: TM-TQ0015
1mg77,00€2mg100,00€5mg166,00€10mg289,00€25mg492,00€50mg710,00€100mg973,00€1mL*10mM (DMSO)200,00€Sotuletinib
CAS :Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor, >1000-fold selective against its closest receptor tyrosine kinase homologs.Formule :C20H22N4O3SDegré de pureté :97.43% - 99.82%Couleur et forme :SolidMasse moléculaire :398.48Ref: TM-T6119
1mg37,00€5mg79,00€10mg111,00€25mg172,00€50mg216,00€100mg378,00€500mg868,00€1mL*10mM (DMSO)87,00€Ki20227
CAS :Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).Formule :C24H24N4O5SDegré de pureté :98.97% - 99.88%Couleur et forme :SolidMasse moléculaire :480.54Ref: TM-T4315
1mg44,00€5mg90,00€10mg145,00€25mg268,00€50mg439,00€100mg700,00€200mg954,00€1mL*10mM (DMSO)90,00€AZD7507
CAS :AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.Formule :C23H27FN6O3Degré de pureté :99.55% - 99.78%Couleur et forme :SolidMasse moléculaire :454.5Ref: TM-T14380
1mg50,00€5mg110,00€10mg161,00€25mg289,00€50mg419,00€100mg583,00€200mg787,00€1mL*10mM (DMSO)127,00€Vimseltinib
CAS :Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Formule :C23H25N7O2Degré de pureté :99.05% - 99.57%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T10652
1mg87,00€5mg178,00€10mg295,00€25mg505,00€50mg690,00€100mg888,00€1mL*10mM (DMSO)203,00€Linifanib
CAS :Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4Ref: TM-T2514
5mg48,00€10mg80,00€25mg119,00€50mg178,00€100mg259,00€200mg477,00€500mg772,00€1mL*10mM (DMSO)50,00€Edicotinib HCl
CAS :Edicotinib (JNJ-40346527), an oral CSF1R inhibitor, may block FMS autophosphorylation, impeding tumor cell growth.Formule :C27H36ClN5O2Couleur et forme :SolidMasse moléculaire :498.07cFMS Receptor Inhibitor II
CAS :cFMS Receptor Inhibitor II is a CSF1R kinase inhibitorFormule :C23H20N4ODegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :368.43Ref: TM-T5586
1mg49,00€2mg65,00€5mg97,00€10mg154,00€25mg255,00€50mg376,00€100mg547,00€1mL*10mM (DMSO)106,00€Pexidartinib
CAS :Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potentialFormule :C20H15ClF3N5Degré de pureté :98.34% - 99.45%Couleur et forme :SolidMasse moléculaire :417.81Ref: TM-T2115
5mg46,00€10mg58,00€25mg90,00€50mg114,00€100mg145,00€200mg192,00€500mg333,00€1mL*10mM (DMSO)49,00€Anumigilimab
CAS :Anumigilimab (CSL-324) is a fully human therapeutic anti-G-CSFR antibody with potential anti-tumor activity for the study of inflammation.Degré de pureté :95.75% (SEC-HPLC) - 98.43% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :143.86 kDaCerdulatinib hydrochloride
CAS :Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Formule :C20H28ClN7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :482Lenzilumab
CAS :Lenzilumab (KB 003) is a humanized GM-CSF neutralizing antibody for the study of COVID-19.Degré de pureté :98.9% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.81 kDaCabiralizumab
CAS :Cabiralizumab is an anti-CSF1R monoclonal antibody that enhances T cell infiltration, inhibits osteoclasts, and is used in RA and immune-oncology research.Degré de pureté :95% - 98.2% (SDS-PAGE); 98.1% (SEC-HPLC)Couleur et forme :LiquidNamilumab
CAS :Namilumab (AMG203) is a humanised IgG1 monoclonal antibody that neutralises GM-CSF. rheumatoid arthritis and active axial spondyloarthritis.Degré de pureté :95%Couleur et forme :LiquidTrabikibart
CAS :Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.Degré de pureté :95% - 95.6% (SDS-PAGE); 99.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.64 kDaCSF1R-IN-19
CAS :CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].Formule :C20H27N7OCouleur et forme :SolidMasse moléculaire :381.47c-Fms-IN-6
CAS :c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).Formule :C22H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.48c-Fms-IN-9
CAS :c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45Leustroducsin A
CAS :Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.Formule :C32H52NO10PCouleur et forme :SolidMasse moléculaire :641.73c-Fms-IN-7
CAS :c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).Formule :C26H24N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.57c-Fms-IN-8
CAS :c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.Formule :C27H30N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.54JNJ-28312141
CAS :JNJ-28312141: oral CSF1R/FLT3 inhibitor, potential for treating acute myeloid leukemia, tumors, and bone events.Formule :C26H32N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.57CSF1R-IN-4
CAS :CSF1R-IN-4, a potent CSF-1R inhibitor, may impact TAM/glioma cell communication, with cancer research potential. (WO2021197276A1, compound 104)Formule :C23H20N6O3Couleur et forme :SolidMasse moléculaire :428.44c-Fms-IN-10
CAS :c-Fms-IN-10 is a thieno[3,2-d]pyrimidine derivative, an FMS kinase inhibitor with IC50 of 2 nM, exhibiting anti-tumor properties.Formule :C22H19N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.5CSF1R-IN-13
CAS :CSF1R-IN-13: potent cancer research CSF1R inhibitor impacting cell growth regulation.Formule :C21H20N4O3Couleur et forme :SolidMasse moléculaire :376.41CSF1R-IN-8
CAS :CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).Formule :C24H22N4O4Couleur et forme :SolidMasse moléculaire :430.46CSF1R-IN-10
CAS :CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).Formule :C25H22N4O3Couleur et forme :SolidMasse moléculaire :426.47Leustroducsin C
CAS :Leustroducsin C is an inducer of colony-stimulating factors CSF extracted from Streptomyces platensis SANK 60191.Formule :C34H56NO10PCouleur et forme :SolidMasse moléculaire :669.78CSF1R-IN-14
CAS :CSF1R-IN-14, an isoindolinone derivative, powerfully inhibits CSF1R, with potential in cancer research. See WO2019134662A1, compound 1.Formule :C23H22F3N5OCouleur et forme :SolidMasse moléculaire :441.45CSF1R-IN-12
CAS :CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.Formule :C21H17F3N4OCouleur et forme :SolidMasse moléculaire :398.38CSF1R-IN-7
CAS :CSF1R-IN-7 is a highly selective CSF-1R inhibitor with good brain penetration for treatment of diseases associated with microglia-mediated neuroinflammation.Formule :C22H22N6O3Degré de pureté :99.41% - 99.93%Couleur et forme :SolidMasse moléculaire :418.45CSF1R-IN-9
CAS :CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).Formule :C26H26N4O2Couleur et forme :SolidMasse moléculaire :426.51CSF1R-IN-6
CAS :CSF1R-IN-6, a compound, effectively inhibits macrophage CSF1R essential for survival and differentiation.
Formule :C20H18N8O3Couleur et forme :SolidMasse moléculaire :418.41c-Fms-IN-2
CAS :c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).Formule :C19H21N3O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :339.39Ref: TM-T10775
1mg92,00€5mg241,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€1mL*10mM (DMSO)180,00€ABD-295
CAS :ABD-295, a biphenylsulfide derivative, inhibits osteoclasts and prevents bone loss in vitro and in vivo.Formule :C17H19F2NO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.4Sotuletinib dihydrochloride
CAS :Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.Formule :C20H24Cl2N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.4IACS-9439
CAS :IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM.Formule :C23H26ClN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.02c-Fms-IN-1
CAS :c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).Formule :C22H27N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :393.48Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.
Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47c-Fms-IN-3
CAS :c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.Formule :C23H30N6ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :406.52Ref: TM-T10649
1mg52,00€5mg105,00€10mg161,00€25mg264,00€50mg358,00€100mg522,00€1mL*10mM (DMSO)110,00€c-Fms-IN-13
CAS :c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.Formule :C22H26N4O2Degré de pureté :99.93% - 99.97%Couleur et forme :SolidMasse moléculaire :378.47Pimicotinib
CAS :Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.Formule :C22H24N6O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :420.46Ref: TM-T79157
1mg52,00€5mg111,00€10mg170,00€25mg329,00€50mg528,00€100mg843,00€1mL*10mM (DMSO)156,00€CSF1R-IN-3
CAS :CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.Formule :C30H38N8O4Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :574.67Ref: TM-T64066
1mg101,00€5mg245,00€10mg358,00€25mg665,00€50mg973,00€100mg1.395,00€1mL*10mM (DMSO)309,00€Ataquimast
CAS :Ataquimast is used in curing advanced receptor-positive breast cancer.Formule :C11H14ClN3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :239.7Ref: TM-T30190
1mg64,00€5mg129,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€1mL*10mM (DMSO)116,00€JTE-952
CAS :JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.Formule :C30H34N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.6c-Fms-IN-14
CAS :c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].Formule :C26H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.51Axl/Mer/CSF1R-IN-2
CAS :Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].Formule :C24H22F3N5O5Couleur et forme :SolidMasse moléculaire :517.46CSF1R-IN-5
CAS :CSF1R-IN-5: Potent CSF1R inhibitor, may alter TAM/glioma inflammatory exchanges, potential cancer research tool. (WO2021197276A1, Compound 11)Formule :C22H19N7O3Couleur et forme :SolidMasse moléculaire :429.43Axl/Mer/CSF1R-IN-1
CAS :Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds)Formule :C25H24F3N5O5Couleur et forme :SolidMasse moléculaire :531.48Adrixetinib
CAS :Adrixetinib is an inhibitor of protein tyrosine kinase with antineoplastic activity .Formule :C25H24F3N5O5Couleur et forme :SolidMasse moléculaire :531.48
