c-Fms
Les inhibiteurs de c-Fms ciblent le récepteur du facteur de stimulation des colonies-1 (c-Fms), une tyrosine kinase impliquée dans la régulation des macrophages et d'autres cellules immunitaires. La signalisation de c-Fms joue un rôle dans la prolifération, la différenciation et la survie de ces cellules. La dérégulation de c-Fms est associée à des maladies telles que le cancer, les conditions inflammatoires et l'ostéoporose. Chez CymitQuimica, nous proposons des inhibiteurs de c-Fms pour soutenir vos recherches en immunologie, oncologie et maladies inflammatoires.
108 produits trouvés pour "c-Fms"
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Ki20227
CAS :<p>Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).</p>Formule :C24H24N4O5SDegré de pureté :98.97% - 99.88%Couleur et forme :SolidMasse moléculaire :480.54Vimseltinib
CAS :<p>Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).</p>Formule :C23H25N7O2Degré de pureté :99.05% - 99.57%Couleur et forme :SolidMasse moléculaire :431.49Sotuletinib
CAS :<p>Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor, >1000-fold selective against its closest receptor tyrosine kinase homologs.</p>Formule :C20H22N4O3SDegré de pureté :97.43% - 99.82%Couleur et forme :SolidMasse moléculaire :398.48AZ304
CAS :<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Formule :C27H25N5O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :451.52GW2580
CAS :<p>GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.</p>Formule :C20H22N4O3Degré de pureté :99.48% - >99.99%Couleur et forme :SolidMasse moléculaire :366.41PLX5622
CAS :<p>PLX5622 is a selective, orally active and blood-brain barrier permeable CSF1R inhibitor. PLX5622 induces elimination of microglia. Cost effective and quality assured.</p>Formule :C21H19F2N5ODegré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :395.41Linifanib
CAS :<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Formule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4Nampt-IN-1
CAS :<p>Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.</p>Formule :C20H25N3O5SDegré de pureté :99.28% - 99.4%Couleur et forme :SolidMasse moléculaire :419.49OSI-930
CAS :<p>OSI-930 is an oral c-Kit/VEGFR-2 inhibitor targeting tumor growth and angiogenesis.</p>Formule :C22H16F3N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :443.44Dovitinib
CAS :<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Formule :C21H21FN6ODegré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :392.43Anumigilimab
CAS :<p>Anumigilimab (CSL-324) is a fully human therapeutic anti-G-CSFR antibody with potential anti-tumor activity for the study of inflammation.</p>Degré de pureté :95.75% (SEC-HPLC) - 98.43% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :143.86 kDaLenzilumab
CAS :<p>Lenzilumab (KB 003) is a humanized GM-CSF neutralizing antibody for the study of COVID-19.</p>Degré de pureté :98.9% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.5% (SEC-HPLC)Couleur et forme :LiquidNamilumab
CAS :<p>Namilumab (AMG203) is a humanised IgG1 monoclonal antibody that neutralises GM-CSF. rheumatoid arthritis and active axial spondyloarthritis.</p>Degré de pureté :95%Couleur et forme :LiquidTrabikibart
CAS :<p>Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidCabiralizumab
CAS :<p>Cabiralizumab is an anti-CSF1R monoclonal antibody that enhances T cell infiltration, inhibits osteoclasts, and is used in RA and immune-oncology research.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidAnti-Mouse GM-CSF Antibody (MP1-22E9)
<p>Anti-Mouse GM-CSF Antibody is a rat-derived IgG2a isotype inhibitor that targets mouse granulocyte-macrophage colony-stimulating factor (GM-CSF).</p>Degré de pureté :98%Couleur et forme :Odour LiquidCSF1R-IN-19
CAS :<p>CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].</p>Formule :C20H27N7OCouleur et forme :SolidMasse moléculaire :381.47Sotuletinib dihydrochloride
CAS :<p>Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.</p>Formule :C20H24Cl2N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.4c-Fms-IN-9
CAS :<p>c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.</p>Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45Leustroducsin A
CAS :<p>Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.</p>Formule :C32H52NO10PCouleur et forme :SolidMasse moléculaire :641.73c-Fms-IN-7
CAS :<p>c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).</p>Formule :C26H24N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.57c-Fms-IN-8
CAS :<p>c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.</p>Formule :C27H30N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.54JNJ-28312141
CAS :<p>JNJ-28312141: oral CSF1R/FLT3 inhibitor, potential for treating acute myeloid leukemia, tumors, and bone events.</p>Formule :C26H32N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.57CSF1R-IN-4
CAS :<p>CSF1R-IN-4, a potent CSF-1R inhibitor, may impact TAM/glioma cell communication, with cancer research potential. (WO2021197276A1, compound 104)</p>Formule :C23H20N6O3Couleur et forme :SolidMasse moléculaire :428.44c-Fms-IN-10
CAS :<p>c-Fms-IN-10 is a thieno[3,2-d]pyrimidine derivative, an FMS kinase inhibitor with IC50 of 2 nM, exhibiting anti-tumor properties.</p>Formule :C22H19N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.5CSF1R-IN-13
CAS :<p>CSF1R-IN-13: potent cancer research CSF1R inhibitor impacting cell growth regulation.</p>Formule :C21H20N4O3Couleur et forme :SolidMasse moléculaire :376.41CSF1R-IN-8
CAS :<p>CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).</p>Formule :C24H22N4O4Couleur et forme :SolidMasse moléculaire :430.46CSF1R-IN-10
CAS :<p>CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).</p>Formule :C25H22N4O3Couleur et forme :SolidMasse moléculaire :426.47Leustroducsin C
CAS :<p>Leustroducsin C is an inducer of colony-stimulating factors CSF extracted from Streptomyces platensis SANK 60191.</p>Formule :C34H56NO10PCouleur et forme :SolidMasse moléculaire :669.78CSF1R-IN-14
CAS :<p>CSF1R-IN-14, an isoindolinone derivative, powerfully inhibits CSF1R, with potential in cancer research. See WO2019134662A1, compound 1.</p>Formule :C23H22F3N5OCouleur et forme :SolidMasse moléculaire :441.45CSF1R-IN-12
CAS :<p>CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.</p>Formule :C21H17F3N4OCouleur et forme :SolidMasse moléculaire :398.38CSF1R-IN-7
CAS :<p>CSF1R-IN-7 is a highly selective CSF-1R inhibitor with good brain penetration for treatment of diseases associated with microglia-mediated neuroinflammation.</p>Formule :C22H22N6O3Degré de pureté :99.41% - 99.93%Couleur et forme :SolidMasse moléculaire :418.45CSF1R-IN-9
CAS :<p>CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).</p>Formule :C26H26N4O2Couleur et forme :SolidMasse moléculaire :426.51CSF1R-IN-6
CAS :<p>CSF1R-IN-6, a compound, effectively inhibits macrophage CSF1R essential for survival and differentiation.</p>Formule :C20H18N8O3Couleur et forme :SolidMasse moléculaire :418.41c-Fms-IN-2
CAS :<p>c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).</p>Formule :C19H21N3O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :339.39ABD-295
CAS :<p>ABD-295, a biphenylsulfide derivative, inhibits osteoclasts and prevents bone loss in vitro and in vivo.</p>Formule :C17H19F2NO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.4c-Fms-IN-6
CAS :<p>c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).</p>Formule :C22H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.48IACS-9439
CAS :<p>IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM.</p>Formule :C23H26ClN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.02c-Fms-IN-1
CAS :<p>c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).</p>Formule :C22H27N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :393.48Chiauranib
CAS :<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47c-Fms-IN-3
CAS :<p>c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.</p>Formule :C23H30N6ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :406.52c-Fms-IN-13
CAS :<p>c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.</p>Formule :C22H26N4O2Degré de pureté :99.93% - 99.97%Couleur et forme :SolidMasse moléculaire :378.47Pimicotinib
CAS :<p>Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.</p>Formule :C22H24N6O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :420.46CSF1R-IN-3
CAS :<p>CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.</p>Formule :C30H38N8O4Degré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :574.67c-Fms-IN-14
CAS :<p>c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].</p>Formule :C26H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.51Axl/Mer/CSF1R-IN-2
CAS :<p>Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].</p>Formule :C24H22F3N5O5Couleur et forme :SolidMasse moléculaire :517.46Axl/Mer/CSF1R-IN-1
CAS :<p>Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds)</p>Formule :C25H24F3N5O5Couleur et forme :SolidMasse moléculaire :531.48Ataquimast
CAS :<p>Ataquimast is used in curing advanced receptor-positive breast cancer.</p>Formule :C11H14ClN3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :239.7JTE-952
CAS :<p>JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.</p>Formule :C30H34N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.6CSF1R-IN-5
CAS :<p>CSF1R-IN-5: Potent CSF1R inhibitor, may alter TAM/glioma inflammatory exchanges, potential cancer research tool. (WO2021197276A1, Compound 11)</p>Formule :C22H19N7O3Couleur et forme :SolidMasse moléculaire :429.43
