VEGFR
Les inhibiteurs du récepteur du facteur de croissance endothélial vasculaire (VEGFR) sont des composés qui bloquent la signalisation du VEGFR, un récepteur clé dans la voie VEGF, cruciale pour l'angiogenèse. Les inhibiteurs de VEGFR empêchent la formation de nouveaux vaisseaux sanguins qui fournissent des nutriments et de l'oxygène aux tumeurs, inhibant ainsi la croissance tumorale. Ces inhibiteurs sont largement utilisés en thérapie et en recherche contre le cancer pour étudier les mécanismes de l'angiogenèse et développer des traitements anticancéreux. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de VEGFR de haute qualité pour soutenir vos recherches en oncologie, biologie vasculaire et angiogenèse.
244 produits trouvés pour "VEGFR"
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Telatinib
CAS :Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.Formule :C20H16ClN5O3Degré de pureté :97.61% - 99.81%Couleur et forme :SolidMasse moléculaire :409.83Altiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :510.46SU5408
CAS :SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase.Formule :C18H18N2O3Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :310.35Ref: TM-T4026
1mg66,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg268,00€25mg492,00€50mg663,00€100mg858,00€500mg1.693,00€Gamabufotalin
CAS :Gamabufotalin, a Chansu bufadienolide, treats COX-2 diseases and cancer with high stability and low side effects.Formule :C24H34O5Degré de pureté :99.18% - 99.51%Couleur et forme :SolidMasse moléculaire :402.52Ref: TM-T4A2456
100mgÀ demander1mg84,00€1mL*10mM (DMSO)119,00€5mg178,00€10mg295,00€25mg497,00€50mg708,00€WHI-P180
CAS :WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formule :C16H15N3O3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :297.31SU 5402
CAS :SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Formule :C17H16N2O3Degré de pureté :98.91% - 99.64%Couleur et forme :Yellow-Green SolidMasse moléculaire :296.32SKLB 610
CAS :SKLB610, a novel multi-targeted inhibitor, inhibits angiogenesis-related tyrosine kinase VEGFR2, FGFR2, and PDGFR at a rate of 97%, 65%, and 55%, respectively,
Formule :C21H16F3N3O3Degré de pureté :99.33% - 99.83%Couleur et forme :SolidMasse moléculaire :415.37SU5204
CAS :SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFormule :C17H15NO2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :265.31Tivozanib
CAS :Tivozanib (KRN951) is an oral VEGFRs 1-3 inhibitor with potential antiangiogenic and cancer-fighting properties.Formule :C22H19ClN4O5Degré de pureté :98.08% - 99.67%Couleur et forme :SolidMasse moléculaire :454.86Ref: TM-T2456
2mg38,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg79,00€25mg135,00€50mg226,00€100mg405,00€200mg597,00€MAZ51
CAS :MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formule :C21H18N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :314.38AZD2932
CAS :AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.Formule :C24H25N5O4Degré de pureté :97.71% - 98.37%Couleur et forme :SolidMasse moléculaire :447.49AMG-47a
CAS :AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56Xanthatin
CAS :Xanthatin exhibits cytotoxic, antibacterial, antifungal properties, may treat NSCLC, and inhibits melanoma by targeting Wnt/β-catenin and angiogenesis.Formule :C15H18O3Degré de pureté :98.48% - 99.96%Couleur et forme :SolidMasse moléculaire :246.3Dovitinib lactate
CAS :Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).Formule :C24H27FN6O4Degré de pureté :99.54% - 99.77%Couleur et forme :SolidMasse moléculaire :482.51Ref: TM-T7104
5mg49,00€1mL*10mM (DMSO)54,00€10mg74,00€25mg122,00€50mg202,00€100mg339,00€200mg507,00€500mg800,00€AAL-993
CAS :AAL-993: VEGFR inhibitor; IC50: 130 nM (1), 23 nM (2), 18 nM (3); weak on other tyrosine kinases; antiangiogenic & antitumor.Formule :C20H16F3N3ODegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :371.36Ref: TM-T21593
1mg43,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg138,00€25mg260,00€50mg409,00€100mg605,00€500mg1.288,00€RAF265
CAS :RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formule :C24H16F6N6ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :518.41Ref: TM-T6296
1mg44,00€2mg59,00€5mg93,00€1mL*10mM (DMSO)94,00€10mg140,00€25mg253,00€50mg413,00€100mg605,00€NVP-BAW2881
CAS :NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.Formule :C22H15F3N4O2Degré de pureté :98.19% - 99.97%Couleur et forme :SolidMasse moléculaire :424.38Ref: TM-T3641
1mg34,00€2mg48,00€1mL*10mM (DMSO)69,00€5mg71,00€10mg109,00€25mg200,00€50mg324,00€100mg470,00€500mg1.054,00€SU5205
CAS :SU5205 is a VEGFR2 inhibitor.
Formule :C15H10FNODegré de pureté :99.62% - 99.67%Couleur et forme :SolidMasse moléculaire :239.24Foretinib
CAS :Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.Formule :C34H34F2N4O6Degré de pureté :98.07% - 99.68%Couleur et forme :SolidMasse moléculaire :632.65Ref: TM-T3113
2mg39,00€5mg57,00€10mg79,00€1mL*10mM (DMSO)79,00€25mg133,00€50mg207,00€100mg354,00€500mg848,00€Vorolanib
CAS :Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.Formule :C23H26FN5O3Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :439.48Ref: TM-T8491
1mg101,00€2mg142,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg340,00€25mg583,00€50mg842,00€100mg1.144,00€200mg1.521,00€Fruquintinib
CAS :Fruquintinib (HMPL-013) is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-Formule :C21H19N3O5Degré de pureté :98.84% - 99.89%Couleur et forme :SolidMasse moléculaire :393.39Ref: TM-T2656
2mg35,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg85,00€25mg117,00€50mg147,00€100mg250,00€500mg620,00€Orantinib
CAS :Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.Formule :C18H18N2O3Degré de pureté :98.92% - 99.52%Couleur et forme :SolidMasse moléculaire :310.35AG-13958
CAS :AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.Formule :C26H22FN7ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :467.5Ref: TM-T7493
1mg92,00€5mg250,00€1mL*10mM (DMSO)260,00€10mg385,00€25mg620,00€50mg893,00€100mg1.189,00€Motesanib
CAS :Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.Formule :C22H23N5ODegré de pureté :98% - 99.09%Couleur et forme :SolidMasse moléculaire :373.45Ref: TM-T2288
5mg34,00€1mL*10mM (DMSO)39,00€10mg49,00€25mg81,00€50mg114,00€100mg160,00€200mg230,00€500mg389,00€KRN-633
CAS :KRN-633 is an effective VEGFR inhibitor. The IC50s of KRN-633(KRN633) for VEGFR1, VEGFR2, and VEGFR3 is 170, 160 and 125 nM, respectively.Formule :C20H21ClN4O4Degré de pureté :99.53% - 99.73%Couleur et forme :SolidMasse moléculaire :416.86JI-101
CAS :JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets VEGFR-2, PDGFR-β, and EphB4.Formule :C22H20BrN5O2Degré de pureté :99.41% - 99.97%Couleur et forme :SolidMasse moléculaire :466.33Ilorasertib
CAS :Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formule :C25H21FN6O2SDegré de pureté :96.17% - 97.49%Couleur et forme :SolidMasse moléculaire :488.54Cediranib
CAS :Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.Formule :C25H27FN4O3Degré de pureté :97.21% - 99.94%Couleur et forme :SolidMasse moléculaire :450.51Ref: TM-T2500
2mg39,00€5mg59,00€1mL*10mM (DMSO)65,00€10mg87,00€25mg129,00€50mg168,00€100mg240,00€200mg439,00€500mg703,00€SCR-1481B1
CAS :SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitorFormule :C32H40ClF2N6O13PDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :821.12Ref: TM-T5349
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)102,00€10mg113,00€25mg200,00€50mg333,00€100mg495,00€Oglufanide
CAS :Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator,and inhibits vascular endothelial growth factor (VEGF).Formule :C16H19N3O5Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :333.34EOC317
CAS :EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).Formule :C27H26F5N7O3Degré de pureté :98.00% - 99.26%Couleur et forme :SolidMasse moléculaire :591.53SU5208
CAS :SU5208 (3-[(Thien-2-yl)methylene]-2-indolinone) is a compound with bioactivity.SU5208 inhibits vascular endothelial growth factor receptor-2 (VEGFR2).Formule :C13H9NOSDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :227.28Ref: TM-T22432
1mg44,00€5mg93,00€1mL*10mM (DMSO)95,00€10mg120,00€25mg203,00€50mg308,00€100mg432,00€200mg583,00€Linifanib
CAS :Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4Ref: TM-T2514
5mg48,00€1mL*10mM (DMSO)50,00€10mg80,00€25mg119,00€50mg178,00€100mg259,00€200mg477,00€500mg772,00€GW786034B
CAS :Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98KI8751
CAS :KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.Formule :C24H18F3N3O4Degré de pureté :99.22% - 99.9%Couleur et forme :SolidMasse moléculaire :469.41Ref: TM-T2446
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg81,00€25mg147,00€50mg279,00€100mg447,00€200mg635,00€Vatalanib dihydrochloride
CAS :Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2/KDR.Formule :C20H15ClN4·2HClDegré de pureté :99.16%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :419.73Golvatinib
CAS :Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factorFormule :C33H37F2N7O4Degré de pureté :98.24% - ≥95%Couleur et forme :SolidMasse moléculaire :633.69Ref: TM-T6517
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)92,00€10mg96,00€25mg141,00€50mg187,00€100mg333,00€Ningetinib Tosylate
CAS :Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formule :C38H37FN4O8SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :728.79Ponatinib
CAS :Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormule :C29H27F3N6ODegré de pureté :98% - 99.60%Couleur et forme :SolidMasse moléculaire :532.56Cabozantinib S-malate
CAS :Cabozantinib S-malate (XL184) is the salt form of cabozantinib, an orally bioavailable, small molecule RTK inhibitor with potential antineoplastic activity.Formule :C32H30FN3O10Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :635.59SU5214
CAS :SU5214 is a modulator of tyrosine kinase signal transduction.Formule :C16H13NO2Degré de pureté :99.45% - 99.55%Couleur et forme :SolidMasse moléculaire :251.28UNC0064-12 hydrochloride (1430089-64-7(free base))
UNC0064-12 hydrochloride is an inhibitor of VEGFR2.Formule :C19H25ClN8Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :400.91Ref: TM-T2056L
1mg84,00€5mg168,00€1mL*10mM (DMSO)185,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€Toceranib Phosphate
CAS :Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.Formule :C22H28FN4O6PDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :494.45Ramucirumab
CAS :Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.Formule :C285H434N74O88S2Degré de pureté :98.2% (SDS-PAGE); 99.2% (SEC-HPLC) - 99.20%Couleur et forme :LiquidMasse moléculaire :143.77 kDaNingetinib
CAS :Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formule :C31H29FN4O5Degré de pureté :99.95% - 99.98%Couleur et forme :SolidMasse moléculaire :556.58Orobol
CAS :Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.Formule :C15H10O6Degré de pureté :98% - 98%Couleur et forme :SolidMasse moléculaire :286.24XL 999
CAS :Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）Formule :C26H28FN5ODegré de pureté :98.24% - 99.55%Couleur et forme :SolidMasse moléculaire :445.53Cabozantinib
CAS :Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).
Formule :C28H24FN3O5Degré de pureté :99.68% - 99.88%Couleur et forme :SolidMasse moléculaire :501.51BFH772
CAS :BFH772, a BAW2881 analogue, selectively inhibits VEGFR2 (IC50: 3 nM) and blocks RET, PDGFR, KIT phosphorylation (IC50: 30-160 nM).Formule :C23H16F3N3O3Degré de pureté :97.71% - 99.89%Couleur et forme :SolidMasse moléculaire :439.39Su1498
CAS :Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the VEGF receptor 2, having negligible activity at several other serine/threonine and tyrosine kinases.
Formule :C25H30N2O2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :390.52
