PDGFR
Les inhibiteurs du récepteur du facteur de croissance dérivé des plaquettes (PDGFR) sont des composés qui bloquent la signalisation du PDGFR, un récepteur impliqué dans la croissance cellulaire, la prolifération et l'angiogenèse. Le PDGFR joue un rôle significatif dans le développement des vaisseaux sanguins qui alimentent les tumeurs. Inhiber le PDGFR peut donc empêcher l'angiogenèse, ce qui rend ces inhibiteurs précieux en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de PDGFR de haute qualité pour soutenir vos recherches en oncologie, biologie vasculaire et angiogenèse.
127 produits trouvés pour "PDGFR"
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CHIR-124
CAS :CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.Formule :C23H22ClN5ODegré de pureté :96.33% - 98.35%Couleur et forme :SolidMasse moléculaire :419.91Ref: TM-T6350
1mg39,00€2mg49,00€5mg77,00€10mg99,00€25mg161,00€50mg227,00€100mg339,00€1mL*10mM (DMSO)82,00€Ponatinib
CAS :Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormule :C29H27F3N6ODegré de pureté :98% - 99.60%Couleur et forme :SolidMasse moléculaire :532.56Lenvatinib mesylate
CAS :Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Formule :C22H23ClN4O7SDegré de pureté :99.03% - 99.79%Couleur et forme :SolidMasse moléculaire :522.96PD168393
CAS :PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formule :C17H13BrN4ODegré de pureté :99.13% - 99.83%Couleur et forme :SolidMasse moléculaire :369.22Ref: TM-T6932
1mg37,00€2mg50,00€5mg63,00€10mg94,00€25mg146,00€50mg210,00€100mg294,00€1mL*10mM (DMSO)52,00€XL 999
CAS :Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）Formule :C26H28FN5ODegré de pureté :98.24% - 99.55%Couleur et forme :SolidMasse moléculaire :445.53Regorafenib Hydrochloride
CAS :Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Formule :C21H16Cl2F4N4O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :519.28Flumatinib mesylate
CAS :Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.Formule :C30H33F3N8O4SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :658.69Ref: TM-T7861
1mg34,00€5mg84,00€10mg126,00€25mg236,00€50mg371,00€100mg595,00€500mg1.234,00€1mL*10mM (DMSO)132,00€Nintedanib
CAS :Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/Formule :C31H33N5O4Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :539.62Regorafenib
CAS :Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82Ref: TM-T1792
5mg34,00€10mg49,00€25mg75,00€50mg90,00€100mg137,00€200mg175,00€500mg294,00€1mL*10mM (DMSO)54,00€NVP-ACC789
CAS :ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.
Formule :C21H17BrN4Degré de pureté :99.44% - 99.63%Couleur et forme :SolidMasse moléculaire :405.29Dovitinib
CAS :Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.
Formule :C21H21FN6ODegré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :392.43ENMD-2076
CAS :ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formule :C21H25N7Degré de pureté :97.63% - ≥95%Couleur et forme :SolidMasse moléculaire :375.47Toceranib
CAS :Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.Formule :C22H25FN4O2Degré de pureté :97.62%Couleur et forme :SolidMasse moléculaire :396.46PDGFR Tyrosine Kinase Inhibitor III
CAS :PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor thatFormule :C27H27N5O4Degré de pureté :99.50%Couleur et forme :SoildMasse moléculaire :485.53Ref: TM-T60108
5mg52,00€10mg78,00€25mg160,00€50mg225,00€100mg325,00€200mg445,00€1mL*10mM (DMSO)50,00€AC710
CAS :AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).Formule :C31H42N6O4Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :562.7Ansornitinib
CAS :Ansornitinib (ANG-3070) is a KDR and PDGF receptor inhibitor with antifibrotic activity for the study of diseases caused by abnormal or excessive fibrosis.Formule :C30H32N6O4Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :540.61E-4177
CAS :E-4177 is an angiotensin II type 1 receptor (AT1R) antagonist and can be used to study cardiovascular diseases.Formule :C24H21N3O2Degré de pureté :98.67% - 99.57%Couleur et forme :SolidMasse moléculaire :383.44DMPQ dihydrochloride
CAS :PDGFRβ inhibitorFormule :C16H16Cl2N2O2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :339.22AC710 Mesylate
CAS :AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).Formule :C32H46N6O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.81PDGFRα kinase inhibitor 1
CAS :PDGFRα kinase inhibitor 1 is a type II PDGFRα kinase inhibitor that inhibits both PDGFRα and PDGFRβ.Formule :C34H34N8O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :586.69Ref: TM-T12396
1mg144,00€2mg359,00€5mg308,00€10mgÀ demander25mg745,00€50mg982,00€1mL*10mM (DMSO)À demanderBMS-605541
CAS :BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).
Formule :C19H17F2N5OSDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :401.43SU16f
CAS :SU16f, a 3-substituted indolin-2-one, is a selective PDGFRβ inhibitor; IC50: 10 nM (PDGFRβ), 140 nM (PDGFR1), 2.29 μM (PDGFR2), halts GC cell growth.Formule :C24H22N2O3Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :386.44Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.
Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47Tyrphostin AG1433
CAS :Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).Formule :C16H14N2O2Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :266.29TG 100572 Hydrochloride
CAS :TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.Formule :C26H27Cl2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.432-Methyl-3-phenylquinoxaline
CAS :2-Methyl-3-phenylquinoxaline (compound 38) serves as an effective inhibitor of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK), exhibiting significant inhibitory activity against the full-length PDGFR kinase in intact cells (IC50 greater than 100 μM).Formule :C15H12N2Couleur et forme :SolidMasse moléculaire :220.27CMV-423
CAS :CMV-423 is an antiviral agent exhibiting effective in vitro activity against beta-herpesviruses, including Human Cytomegalovirus (HCMV), Human Herpesvirus 6 (HHV-6), and Human Herpesvirus 7 (HHV-7). It is utilized in antiviral research.Formule :C14H14ClN3OCouleur et forme :SolidMasse moléculaire :275.73
