PDGFR
Les inhibiteurs du récepteur du facteur de croissance dérivé des plaquettes (PDGFR) sont des composés qui bloquent la signalisation du PDGFR, un récepteur impliqué dans la croissance cellulaire, la prolifération et l'angiogenèse. Le PDGFR joue un rôle significatif dans le développement des vaisseaux sanguins qui alimentent les tumeurs. Inhiber le PDGFR peut donc empêcher l'angiogenèse, ce qui rend ces inhibiteurs précieux en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de PDGFR de haute qualité pour soutenir vos recherches en oncologie, biologie vasculaire et angiogenèse.
126 produits trouvés pour "PDGFR"
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Linifanib
CAS :Formule :C21H18FN5ODegré de pureté :>95.0%(HPLC)(qNMR)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :375.41AG-1296
CAS :Formule :C16H14N2O2Degré de pureté :>98.0%(GC)Couleur et forme :White to Orange to Green powder to crystalMasse moléculaire :266.30PDGF R β/CD140b Protein, Human, Recombinant (His & Avi)
<p>PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :59 kDa (predicted). Due to glycosylation, the protein migrates to 78-115 kDa based on Tris-Bis PAGE result.PDGFRB Protein, Human, Recombinant (His), Biotinylated
<p>PDGFRB Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :57.6 kDa (predicted)PDGF R β/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated
<p>PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :59 kDa (predicted). Due to glycosylation, the protein migrates to 78-115 kDa based on Tris-Bis PAGE result.PDGF R β/CD140b Protein, Canine, Recombinant (His)
<p>PDGF R beta/CD140b Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :57.25 kDa (predicted). Due to glycosylation, the protein migrates to 70-100 kDa based on Tris-Bis PAGE result.PDGFRB Protein, Human, Recombinant (His)
<p>PDGFRB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :57.6 kDa (predicted); 95-100 kDa (reducing conditions)PDGFRB Protein, Human, Recombinant
<p>PDGFRB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 56.2 kDa and the accession number is P09619-1.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :56.2 kDa (predicted)PDGFRB Protein, Human, Recombinant (hFc)
<p>PDGFRB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :82.8 kDa (predicted)PD-161570
CAS :<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.51SU4312
CAS :<p>SU-4312 (DMBI) inhibits VEGFR & PDGFR (IC50: 0.8, 19.4 μM) and shields neurons from MPP(+)-induced damage by blocking nNOS.</p>Formule :C17H16N2ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :264.32PP121
CAS :<p>PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.</p>Formule :C17H17N7Degré de pureté :98.45% - 99.67%Couleur et forme :SolidMasse moléculaire :319.36Masitinib mesylate
CAS :<p>Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;</p>Formule :C29H34N6O4S2Degré de pureté :97.67% - 98.44%Couleur et forme :SolidMasse moléculaire :594.75TAK-593
CAS :<p>TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively).</p>Formule :C23H23N7O3Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :445.47Seralutinib
CAS :<p>Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.</p>Formule :C27H27N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :469.54Amuvatinib
CAS :<p>Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.</p>Formule :C23H21N5O3SDegré de pureté :99.38% - >99.99%Couleur et forme :SolidMasse moléculaire :447.51PD-089828
CAS :<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Formule :C18H18Cl2N6ODegré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :405.28Crenolanib
CAS :<p>Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).</p>Formule :C26H29N5O2Degré de pureté :98.40% - 99.73%Couleur et forme :SolidMasse moléculaire :443.54Vorolanib
CAS :<p>Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.</p>Formule :C23H26FN5O3Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :439.48Masitinib
CAS :<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Formule :C28H30N6OSDegré de pureté :97.56% - >99.99%Couleur et forme :SolidMasse moléculaire :498.64Avapritinib
CAS :<p>Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases.Cost-effective and quality-assured.</p>Formule :C26H27FN10Degré de pureté :96.59% - 99.7%Couleur et forme :SolidMasse moléculaire :498.56Nintedanib esylate
CAS :<p>Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β</p>Formule :C31H33N5O4·C2H6O3SDegré de pureté :99.43% - 99.96%Couleur et forme :SolidMasse moléculaire :649.76Multi-kinase inhibitor 1
CAS :<p>Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.</p>Formule :C20H17F3N4O3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :418.37Ki20227
CAS :<p>Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).</p>Formule :C24H24N4O5SDegré de pureté :98.97% - 99.88%Couleur et forme :SolidMasse moléculaire :480.54Toceranib Phosphate
CAS :<p>Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.</p>Formule :C22H28FN4O6PDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :494.45Flumatinib
CAS :<p>Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.</p>Formule :C29H29F3N8ODegré de pureté :99.39% - 99.95%Couleur et forme :SolidMasse moléculaire :562.59Tyrphostin A9
CAS :<p>Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor</p>Formule :C18H22N2ODegré de pureté :98.21% - 99.87%Couleur et forme :Yellow SolidMasse moléculaire :282.38N-(p-Coumaroyl) serotonin
CAS :<p>N-(p-Coumaroyl) Serotonin, from safflower seeds, has antioxidant, antitumor properties and improves vascular health.</p>Formule :C19H18N2O3Degré de pureté :98.10% - 98.89%Couleur et forme :SolidMasse moléculaire :322.36SU 5402
CAS :<p>SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.</p>Formule :C17H16N2O3Degré de pureté :98.91% - 99.64%Couleur et forme :Yellow-Green SolidMasse moléculaire :296.32AZD2932
CAS :<p>AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.</p>Formule :C24H25N5O4Degré de pureté :97.71% - 98.37%Couleur et forme :SolidMasse moléculaire :447.49Sennoside B
CAS :<p>Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.</p>Formule :C42H38O20Degré de pureté :92.85% - 98.92%Couleur et forme :Light Yellow CrystalMasse moléculaire :862.74Dovitinib lactate hydrate
CAS :<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Formule :C24H27FN6O4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :482.51Dovitinib lactate
CAS :<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Formule :C24H27FN6O4Degré de pureté :99.54% - 99.77%Couleur et forme :SolidMasse moléculaire :482.51Cediranib
CAS :<p>Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.</p>Formule :C25H27FN4O3Degré de pureté :97.21% - 99.94%Couleur et forme :SolidMasse moléculaire :450.51Tandutinib
CAS :<p>Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3</p>Formule :C31H42N6O4Degré de pureté :99.45% - ≥98%Couleur et forme :White SolidMasse moléculaire :562.7ON123300
CAS :<p>ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).</p>Formule :C24H27N7ODegré de pureté :99.22% - 99.53%Couleur et forme :SolidMasse moléculaire :429.52Orantinib
CAS :<p>Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.</p>Formule :C18H18N2O3Degré de pureté :98.92% - 99.52%Couleur et forme :SolidMasse moléculaire :310.35Tyrphostin AG1296
CAS :<p>Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.</p>Formule :C16H14N2O2Degré de pureté :99.94% - >99.99%Couleur et forme :SolidMasse moléculaire :266.29SU4984
CAS :<p>SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).</p>Formule :C20H19N3O2Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :333.38JI-101
CAS :<p>JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets VEGFR-2, PDGFR-β, and EphB4.</p>Formule :C22H20BrN5O2Degré de pureté :99.41% - 99.97%Couleur et forme :SolidMasse moléculaire :466.33Ilorasertib
CAS :<p>Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).</p>Formule :C25H21FN6O2SDegré de pureté :96.17% - 97.49%Couleur et forme :SolidMasse moléculaire :488.54Imatinib
CAS :<p>Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit</p>Formule :C29H31N7ODegré de pureté :99.42% - 99.94%Couleur et forme :Off White PowderMasse moléculaire :493.6Telatinib
CAS :<p>Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.</p>Formule :C20H16ClN5O3Degré de pureté :97.61% - 99.81%Couleur et forme :SolidMasse moléculaire :409.83Methylnissolin
CAS :<p>Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.</p>Formule :C17H16O5Degré de pureté :99.68% - 99.98%Couleur et forme :SolidMasse moléculaire :300.31Regorafenib monohydrate
CAS :<p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>Formule :C21H17ClF4N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :500.83Lenvatinib mesylate
CAS :<p>Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.</p>Formule :C22H23ClN4O7SDegré de pureté :99.03% - 99.79%Couleur et forme :SolidMasse moléculaire :522.96Linifanib
CAS :<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Formule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4PD168393
CAS :<p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>Formule :C17H13BrN4ODegré de pureté :99.13% - 99.83%Couleur et forme :SolidMasse moléculaire :369.22GW786034B
CAS :<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98CHIR-124
CAS :<p>CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.</p>Formule :C23H22ClN5ODegré de pureté :96.33% - 98.35%Couleur et forme :SolidMasse moléculaire :419.91
