c-Met/HGFR
Les inhibiteurs de c-Met/HGFR ciblent le Récepteur du Facteur de Croissance des Hépatocytes (c-Met), une tyrosine kinase impliquée dans des processus cellulaires tels que la croissance, la motilité et la morphogenèse. La signalisation de c-Met est impliquée dans la progression du cancer, la métastase et la résistance aux thérapies. Inhiber c-Met peut perturber la croissance et la propagation des tumeurs, faisant de ces inhibiteurs des outils précieux dans la recherche sur le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de c-Met/HGFR pour soutenir vos recherches en oncologie, métastase et thérapies ciblées contre le cancer.
144 produits trouvés pour "c-Met/HGFR"
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Umikibart
Umikibart is a humanized IgG4κ antibody targeting HGF, with the corresponding isotype control being HumanIgG4(S228P) kappa, Isotype Control.Couleur et forme :Odour LiquidLMTK3-IN-1
CAS :Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.Formule :C18H11F3N4ODegré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :356.3Caveolin-1 (82-101) amide (human, mouse, rat)
CAS :Caveolin-1 (82-101) amide (human, mouse, rat), also known as Caveolin-1 scaffolding domain peptide, mitigates aging-related detrimental alterations in variousFormule :C124H170N28O29Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2516.85BMS-777607
CAS :BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.Formule :C25H19ClF2N4O4Degré de pureté :98.16% - 98.56%Couleur et forme :SolidMasse moléculaire :512.89Ref: TM-T2658
2mg59,00€5mg86,00€10mg135,00€25mg251,00€50mg388,00€100mg690,00€200mg1.034,00€500mg1.550,00€Antitumor agent-111
Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects.Formule :C34H29ClF2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :675.08c-Met-IN-18
C-Met-IN-18, an ATP-competitive type-III inhibitor, targets both wild-type (WT) and D1228V mutant c-MET with IC50 values of 0.013 µM and 0.20 µM, respectively.Formule :C21H15FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.37c-Met-IN-23
c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.Formule :C16H13N7OMasse moléculaire :319.11816PROTAC c-Met degrader-2
CAS :PROTACc-Met degrader-2 (PROTAC2) is a c-Met degrader developed using PROTAC technology, with a DC50 value of 50 nM.Formule :C51H50F2N6O13Couleur et forme :SolidMasse moléculaire :992.97Narnatumab
CAS :Narnatumab (IMC-RON8) is a humanized antibody targeting the macrophage-stimulating receptor (RON) with antitumor activity, used in advanced malignant solid tumors research.Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :145.8 kDaNorleual
CAS :Angiotensin IV analog, potent HGF/c-MET inhibitor (IC50=3 pM), halts MDCK cell growth and invasion, AT4 antagonist, impairs LTP, antiangiogenic.
Formule :C41H58N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.95SYN1143
CAS :SYN1143 (AMG-1) strongly inhibits RON & c-Met with IC50s: 9 & 4 nmol/L.Formule :C31H29FN4O5Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :556.58PF-04217903 methanesulfonate
CAS :PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).Formule :C20H20N8O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.49Norleual TFA
Norleual TFA, Ang IV analog, inhibits HGF/c-Met (IC50: 3 pM), blocks AT4, and has strong antiangiogenic effects.Formule :C43H59F3N8O9Masse moléculaire :888.97S49076
CAS :S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Formule :C22H22N4O4SDegré de pureté :95.35% - 97.4%Couleur et forme :SolidMasse moléculaire :438.5Ref: TM-T3274
1mg34,00€2mg44,00€5mg58,00€10mg93,00€25mg167,00€50mg260,00€100mg432,00€200mg618,00€1mL*10mM (DMSO)64,00€DS-1205
CAS :DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formule :C41H42FN5O7Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :735.8Ensartinib hydrochloride
CAS :Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormule :C26H29Cl4FN6O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :634.36Ref: TM-T22324
1mg54,00€5mg114,00€10mg177,00€25mg356,00€50mg580,00€100mg888,00€1mL*10mM (DMSO)158,00€NVP-BVU972
CAS :NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.Formule :C20H16N6Degré de pureté :97.24% - >99.99%Couleur et forme :SolidMasse moléculaire :340.38Ref: TM-T2680
2mg44,00€5mg74,00€10mg97,00€25mg178,00€50mg255,00€100mg359,00€200mg510,00€1mL*10mM (DMSO)84,00€AMG-208
CAS :AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.Formule :C22H17N5O2Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :383.4Capmatinib 2HCl
CAS :Capmatinib 2HCl (INC-280 2HCl), a c-MET inhibitor, is potent (IC50 = 0.13 nM), highly specific, and induces apoptosis in tumor cells.Formule :C23H19Cl2FN6ODegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :485.34Ref: TM-T4260
2mg34,00€5mg49,00€10mg64,00€25mg84,00€50mg92,00€100mg126,00€500mg303,00€1mL*10mM (DMSO)58,00€Ningetinib
CAS :Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formule :C31H29FN4O5Degré de pureté :99.95% - 99.98%Couleur et forme :SolidMasse moléculaire :556.58
