FLT
Les inhibiteurs de la tyrosine kinase FLT (Fms-like) sont des composés qui ciblent les récepteurs FLT, impliqués dans la régulation de l'angiogenèse via la voie du VEGF (facteur de croissance endothélial vasculaire). Les récepteurs FLT jouent un rôle crucial dans le développement de nouveaux vaisseaux sanguins dans les tumeurs. L'inhibition des récepteurs FLT peut réduire efficacement l'angiogenèse et la croissance tumorale, ce qui rend ces inhibiteurs importants en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de FLT de haute qualité pour soutenir vos recherches en oncologie, biologie vasculaire et angiogenèse.
86 produits trouvés pour "FLT"
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FLT3-IN-3
CAS :FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.Formule :C27H38N8ODegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :490.64Ref: TM-T11298
1mg107,00€5mg259,00€1mL*10mM (DMSO)278,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€500mg2.717,00€MRX-2843
CAS :MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).Formule :C29H40N6ODegré de pureté :98.59% - 99.63%Couleur et forme :SolidMasse moléculaire :488.67Ref: TM-T16144
1mg58,00€5mg131,00€1mL*10mM (DMSO)140,00€10mg205,00€25mg408,00€50mg590,00€100mg840,00€FLT3-IN-23
FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effectsCouleur et forme :Odour SolidHSK205
HSK205 is a dual FLT3 and haspin inhibitor, exhibiting potent antitumor activity [1], with an IC50 of 0.187 nM for FLT3.Couleur et forme :Odour SolidFLT3/CHK1-IN-1
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantlyCouleur et forme :Odour SolidIRAK1/4/pan-FLT3 Kinase-IN-1
CAS :IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, demonstrating IC50 values of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. It exhibits favorable pharmacokinetic properties and holds promise for research in acute myeloid leukemia, with survival extension effects comparable to Gilteritinib.Formule :C21H26FN5O2Couleur et forme :SolidMasse moléculaire :399.46Emirodatamab
CAS :Emirodatamab (AMG-427) is an anti-FLT3/CD3 bispecific T-cell engager with an extended half-life. It can induce high cytotoxicity in primary AML progenitor cells and enhance FLT-3 expression. Combining Emirodatamab with anti-PD-1 antibodies increases T-cell dependent cytotoxicity (TDCC). This compound is under investigation for use in relapsed or refractory AML.Couleur et forme :LiquidPROTAC FLT-3 degrader 3
PROTACFLT-3degrader 3 (compound 35) is a PROTAC degrader of FLT. It exhibits antiproliferative activity, with an IC50 value of 7.55 nM in MV4-11 cells.Formule :C48H44Cl2N10O6Masse moléculaire :926.28223PF15 TFA
PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM.Formule :C46H50F3N13O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :969.97PROTAC FLT3/GSPT1/IKZF1/3 degrader-1
PROTACFLT3/GSPT1/IKZF1/3 degrader-1 is an FLT3 PROTAC degrader with DC50 = 1.2 nM. It functions as a molecular glue to degrade its brain substrates and exhibits antiproliferative activity against resistant acute myeloid leukemia (AML) cells, showing potential applications in AML research.Couleur et forme :Odour SolidFLT3-IN-24
FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase, with an IC50 of 7.94 nM. It also exhibits anti-proliferative effects on cells.Formule :C23H20N6O2SMasse moléculaire :444.13685FLT3/HDAC-IN-2
Compound 25h, also known as FLT3/HDAC-IN-2, is a dual inhibitor of FLT3/HDAC. It exhibits antiproliferative activity against MOLM-13 cells and is used in the study of acute myeloid leukemia.Couleur et forme :Odour Solid2-Butenamide
CAS :2-Butenamide, FLT3 inhibitor. Affordable Excellence: Reliable Quality You Can TrustFormule :C4H7NOCouleur et forme :SolidMasse moléculaire :85.1JAK3-IN-14
CAS :JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.Formule :C18H13N3ODegré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :287.32Ref: TM-T67754
1mg167,00€1mL*10mM (DMSO)358,00€5mg409,00€10mg595,00€25mg888,00€50mg1.234,00€100mg1.665,00€Pacritinib citrate
CAS :Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC 50 =23 nM) and the JAK2 V617F mutant (IC 50 =19 nM). It also targets FLT3 (IC 50 =22 nM) and the FLT3 D835Y mutant (IC 50 =6 nM). This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].Formule :C34H40N4O10Couleur et forme :SolidMasse moléculaire :664.7PF15
CAS :PF15, a PROTAC for FLT3-ITD, degrades FLT3 kinase. DC50: 76.7 nM; hinders FLT3-ITD+ cell growth; potential in leukemia.Formule :C44H49N13O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :855.943-Hydroxy Midostaurin
CAS :3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM inFormule :C35H30N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.648FLT3-IN-10
CAS :FLT3-IN-10, a potent FLT3 inhibitor, may treat FLT3-mutated AML.Formule :C15H11FN2ODegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :254.26Ref: TM-T9856
2mg35,00€1mL*10mM (DMSO)54,00€5mg56,00€10mg96,00€25mg172,00€50mg254,00€100mg360,00€200mg490,00€FLT3-ITD-IN-2
FLT3-ITD-IN-2 (Compound A1) is an inhibitor of the FLT3-ITD kinase, exhibiting an IC50 of 2.12 nM. It effectively suppresses the proliferation of the FLT3-dependent human AML cell line MOLM-13, with an IC50 of 25.65 nM. FLT3-ITD-IN-2 demonstrates antitumor activity against acute myeloid leukemia.Formule :C39H50N8O6Couleur et forme :SolidMasse moléculaire :726.86FLT3 Ligand-Linker Conjugate 1
CAS :FLT3 Ligand-Linker Conjugate 1 consists of an FLT3 ligand and a PROTAC linker that can recruit E3 ligase VHL. This conjugate is useful for synthesizing PROTAC RSS0680, a bifunctional compound designed for targeted protein degradation of kinases.Formule :C29H34N6O4S2Couleur et forme :SolidMasse moléculaire :594.748FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant.Formule :C24H22N6O2Couleur et forme :SolidMasse moléculaire :426.47FLT3-IN-20
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor, demonstrating IC50 values of 1 nM for FLT3-D835Y and 4 nM for FLT3-ITD.Formule :C28H33N7O2SCouleur et forme :SolidMasse moléculaire :531.67Anti-FLT1 Antibody (6K171)
Anti-FLT1 Antibody (6K171) is a Mouse antibody targeting FLT1. Anti-FLT1 Antibody (6K171) can be used in ELISA,ICC/IF.Couleur et forme :Odour LiquidAnti-VEGFR1/FLT-1 Antibody (9F18)
Anti-VEGFR1/FLT-1 Antibody (9F18) is a Rabbit antibody targeting VEGFR1/FLT-1. Anti-VEGFR1/FLT-1 Antibody (9F18) can be used in ELISA.Couleur et forme :Odour LiquidAnti-FLT1 Antibody (6S618)
Anti-FLT1 Antibody (6S618) is an antibody targeting FLT1. Anti-FLT1 Antibody (6S618) can be used in ELISA, IHC.Couleur et forme :Odour LiquidAnti-FLT1 Antibody (3W705)
Anti-FLT1 Antibody (3W705) is an antibody targeting FLT1. Anti-FLT1 Antibody (3W705) can be used in ELISA, WB, IHC, FCM.Couleur et forme :Odour LiquidFLT3-IN-16
CAS :FLT3-IN-16 is a potent FLT3 inhibitor (IC50 = 1.1 μM) for acute myeloid leukemia research.Formule :C15H15N3O2SDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :301.36Ref: TM-T9843
2mg34,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg86,00€25mg172,00€50mg260,00€100mg369,00€200mg487,00€BPR1K871
CAS :BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values ofFormule :C25H28ClN7O2SCouleur et forme :SolidMasse moléculaire :526.05FLT1 Protein, Human, Recombinant (aa 1-328, His)
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag.Degré de pureté :97.5%Couleur et forme :Lyophilized PowderMasse moléculaire :35.6 kDa (predicted)VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :85.1 kDa (predicted). Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.Ref: TM-TMPK-00451
5µg91,00€10µg150,00€20µg239,00€50µg471,00€100µg779,00€200µg1.410,00€500µg3.018,00€FLT1 Protein, Human, Recombinant (hFc)
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :61.1 kDa (predicted)Ref: TM-TMPY-00119
5µg85,00€10µg119,00€20µg192,00€50µg388,00€100µg655,00€200µg1.151,00€500µg2.777,00€VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :85.1 kDa (predicted). Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.FLT1 Protein, Human, Recombinant (aa 1-756, His)
FLT1 Protein, Human, Recombinant (aa 1-756, His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :83.7 kDa (predicted); 110-120 kDa (reducing condition, due to glycosylation)Ref: TM-TMPY-02108
5µg65,00€10µg94,00€20µg153,00€50µg291,00€100µg554,00€200µg827,00€500µg1.598,00€1mg3.278,00€FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :85.45 kDa (predicted); 113.32 kDa (reducing conditions)UNC2025 2HCl (1429881-91-3(free base))
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.Formule :C28H42Cl2N6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :549.62Ref: TM-T4419
1mg52,00€2mg77,00€5mg95,00€10mg163,00€1mL*10mM (DMSO)163,00€25mg306,00€50mg538,00€100mg767,00€Fostamatinib Disodium
CAS :Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.Formule :C23H24FN6O9P·2NaDegré de pureté :96.13% - 99.09%Couleur et forme :SolidMasse moléculaire :624.42Ref: TM-T2605
1mg44,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)110,00€10mg117,00€25mg210,00€50mg354,00€100mg530,00€500mg1.153,00€5'-Fluoroindirubinoxime
CAS :5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).Formule :C16H10FN3O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :295.27INE963
CAS :INE963: Potent against Pf 3D7 (EC50=6nM), clears parasites in <24h; effective on P. falciparum/vivax isolates (EC50=0.01-7nM).Formule :C19H26N6O2SDegré de pureté :99.08% - 99.45%Couleur et forme :SolidMasse moléculaire :402.51FLT3-IN-2
CAS :FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).Formule :C21H16ClF3N4Degré de pureté :97.57% - 98.53%Couleur et forme :SolidMasse moléculaire :416.83Ref: TM-T1938
1mg40,00€2mg52,00€5mg82,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg200,00€50mg333,00€100mg477,00€TCS 359
CAS :TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.Formule :C18H20N2O4SDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :360.43Pacritinib
CAS :Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formule :C28H32N4O3Degré de pureté :99.25% - 99.49%Couleur et forme :SolidMasse moléculaire :472.58HPK1-IN-2
CAS :HPK1-IN-2 is a strong, oral HPK1 inhibitor (IC50<0.05 μM), also blocking Lck, Flt3 kinases, with anticancer properties.Formule :C19H20N6OSDegré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :380.47Ref: TM-T9017
1mg73,00€5mg136,00€1mL*10mM (DMSO)161,00€10mg219,00€25mg365,00€50mg520,00€100mg692,00€200mg888,00€UNC2541
CAS :UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.Formule :C24H34FN7O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :471.57BPR1J-097
CAS :BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).Formule :C27H28N6O3SDegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :516.61BPR1J-097 hydrochloride (1327167-19-0(free base))
BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo.
Formule :C27H29ClN6O3SDegré de pureté :98% - 98.54%Couleur et forme :SolidMasse moléculaire :553.07UNC2025
CAS :UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor.Formule :C28H40N6ODegré de pureté :99.53% - 99.74%Couleur et forme :SolidMasse moléculaire :476.664SC-203
CAS :4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity.Cost-effective and quality-assured.Formule :C33H38N8O4SDegré de pureté :99.52% - 99.84%Couleur et forme :SolidMasse moléculaire :642.77TAK-659 hydrochloride
CAS :TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM.Formule :C17H22ClFN6ODegré de pureté :99.28% - 99.82%Couleur et forme :SolidMasse moléculaire :380.85Gilteritinib hemifumarate
CAS :Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment ofFormule :C29H44N8O3C4H4O4Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :610.75KRN383
CAS :KRN383 inhibits ITD cell growth at ≤2.9 nM, erases ITD tumors in mice at 80 mg/kg dose, and may suit various treatment plans.Formule :C17H17N3O4Couleur et forme :SolidMasse moléculaire :327.33FLT3-IN-18
CAS :FLT3-IN-18: potent, selective FLT3 inhibitor, IC50 0.003 μM, induces apoptosis, G1 arrest, blocks FLT3/STAT5, potential in AML research.Formule :C26H36N8OCouleur et forme :SolidMasse moléculaire :476.62FLT3/D835Y-IN-1
CAS :FLT3/D835Y-IN-1, an oral FLT3 inhibitor (IC50: FLT3 - 0.26 nM, D835Y - 0.18 nM), shows anticancer potential in AML research.Formule :C22H21N5O3Couleur et forme :SolidMasse moléculaire :403.43AGL 2043
CAS :AGL 2043 is a potent, reversible, ATP-competitive inhibitor of type III receptor tyrosine kinases.Formule :C15H12N4SCouleur et forme :SolidMasse moléculaire :280.35MDK5466
CAS :MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.Formule :C21H23N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.49PDGFRα/FLT3-ITD-IN-1
CAS :PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively.Formule :C27H39N9OCouleur et forme :SolidMasse moléculaire :505.66BSc5371
CAS :BSc5371: Irreversible FLT3 inhibitor; Kds 0.83-5.8 nM for various FLT3 mutants including wild type.Formule :C24H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.6PDGFRα/FLT3-ITD-IN-3
CAS :PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to beFormule :C26H39N9Couleur et forme :SolidMasse moléculaire :477.65FLT3-IN-11
CAS :FLT3-IN-11, an oral FLT3 kinase inhibitor: potent, selective, IC50 - wild-type 7.22 nM, FLT3-D835Y 4.95 nM, anti-AML IC50 3.2 nM for MV4-11.Formule :C20H25F3N6OCouleur et forme :SolidMasse moléculaire :422.45HP1328
CAS :HP1328: potent FLT3/ITD inhibitor, reduces leukemia, extends survival in mice, belongs to benzoimidazole family.Formule :C23H23N3O3Couleur et forme :SolidMasse moléculaire :389.45TG-46
CAS :TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.Formule :C26H34N6O3SDegré de pureté :98.82% - 99.86%Couleur et forme :SolidMasse moléculaire :510.65AAE871
CAS :AAE871 is a type I FLT3 inhibitor.Formule :C24H34N8O2SCouleur et forme :SolidMasse moléculaire :498.64FLT3-IN-6
CAS :FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.Formule :C23H25N5O3Couleur et forme :SolidMasse moléculaire :419.48JNJ-47117096 hydrochloride
CAS :JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.Formule :C21H23ClN4O2Couleur et forme :SolidMasse moléculaire :398.89FLT3/ITD-IN-2
CAS :FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.Formule :C23H26F3N7O2Couleur et forme :SolidMasse moléculaire :489.49FLT3-IN-4
CAS :FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenousFormule :C23H25N7O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T11299
1mg87,00€5mg215,00€1mL*10mM (DMSO)235,00€10mg318,00€25mg510,00€50mg692,00€100mg888,00€500mg1.783,00€AXL-IN-13
CAS :AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.Formule :C34H41FN6O5Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :632.72FLT3/ITD-IN-3
CAS :FLT3/ITD-IN-3 (Compound 19) is a potent FLT3-ITD inhibitor with IC50 values: FLT3D835Y (0.3 nM), FLT3 (0.4 nM), inhibits AML cell proliferation.Formule :C22H26ClN7O2Couleur et forme :SolidMasse moléculaire :455.94PDGFRα/FLT3-ITD-IN-2
CAS :PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM).Formule :C28H41N9OCouleur et forme :SolidMasse moléculaire :519.68LBW242
CAS :LBW242: oral 3-mer Smac mimetic, IAP inhibitor, targets multiple myeloma, enhances TRAIL/chemo death in ovarian cancer, active on mutant FLT3 cells.Formule :C27H42N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.65FLT3-IN-12
CAS :FLT3-IN-12: potent, selective oral FLT3 inhibitor; FLT3-WT IC50: 1.48 nM, FLT3-D835Y: 2.87 nM; >1000x selective over c-KIT; anti-AML, IC50: 0.75 nM MV4-11.Formule :C21H23F3N6OCouleur et forme :SolidMasse moléculaire :432.44FLT3-IN-15
CAS :FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).Formule :C22H23ClFN5O2Couleur et forme :SolidMasse moléculaire :443.91GTP-14564
CAS :GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.Formule :C15H10N2ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :234.25UNC4203
CAS :UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.Formule :C30H44N6OCouleur et forme :SolidMasse moléculaire :504.71TAK-659
CAS :TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.Formule :C17H21FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.39SG3-179
CAS :SG3-179 is a BET inhibitor.Formule :C28H35ClFN7O3SCouleur et forme :SolidMasse moléculaire :604.14OTS447
CAS :OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .Formule :C27H32ClN3O2Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :466.02FLT3/ITD-IN-5
CAS :FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.Formule :C23H25N7O2Couleur et forme :SolidMasse moléculaire :431.49HPK1-IN-2 dihydrochloride
CAS :HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].Formule :C19H22Cl2N6OSCouleur et forme :SolidMasse moléculaire :453.39E6201
CAS :E6201, a dual kinase inhibitor, blocks MEK1/FLT3 and has anti-tumor/psoriasis effects with low IC50s: ERK2 (5.2 nM), JNK (91 nM), p38 MAPK (19 nM).Formule :C21H27NO6Couleur et forme :SolidMasse moléculaire :389.44JNJ-47117096
CAS :JNJ-47117096 is a potent and selective MELK inhibitor with an IC50 of 23 nM, and it also exhibits strong activity against Flt3 with an IC50 of 18 nM.Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.425TTT 3002
CAS :TTT 3002: oral FLT3 inhibitor for AML research, blocks D835 mutations, potent at 0.2 nM IC50.Formule :C27H23N5O3Couleur et forme :SolidMasse moléculaire :465.50Multi-kinase inhibitor 3
CAS :Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.Formule :C26H26N6O2Couleur et forme :SolidMasse moléculaire :454.52Multi-kinase inhibitor 4
CAS :Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.Formule :C25H24N6O2Couleur et forme :SolidMasse moléculaire :440.50FLT3/ITD-IN-1
FLT3/ITD-IN-1 inhibits FLT3-ITD with IC50s: 38.2 nM (FLT3) and 144.1 nM (ITD), and fights acute myeloid leukemia.Formule :C19H22N6O2Couleur et forme :SolidMasse moléculaire :366.42Lomonitinib
CAS :Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.Formule :C27H24N4O2Couleur et forme :SolidMasse moléculaire :436.505LT-850-166
LT-850-166 is a potent inhibitor of FLT3 and has shown efficacy in overcoming a wide range of FLT3 mutations.Formule :C30H29Cl2N7OCouleur et forme :SolidMasse moléculaire :574.5
