IGF-1R
Les inhibiteurs d'IGF-1R sont des composés qui ciblent spécifiquement le récepteur du facteur de croissance analogue à l'insuline 1 (IGF-1R), une tyrosine kinase réceptrice impliquée dans la croissance, le développement et la survie cellulaires. La signalisation IGF-1R joue un rôle important dans la progression du cancer, ce qui rend ces inhibiteurs précieux pour la recherche en oncologie. Chez CymitQuimica, nous proposons des inhibiteurs d'IGF-1R pour soutenir vos recherches en biologie du cancer, endocrinologie et développement de thérapies ciblées.
88 produits trouvés pour "IGF-1R"
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IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Couleur et forme :Lyophilized PowderMasse moléculaire :105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.HNMPA-(AM)3
CAS :<p>HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。</p>Formule :C20H23O10PDegré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :454.36IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Couleur et forme :Lyophilized PowderMasse moléculaire :80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.IGF1R/CD221 Protein, Mouse, Recombinant (His)
<p>IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Degré de pureté :> 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLCCouleur et forme :Lyophilized PowderMasse moléculaire :80.72+23.0 kDa (predicted); 110-140 kDa and 50-65 kDa, corresponding to the α subunit and β subunit respectively (reducing condition, due to glycosylation)IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Couleur et forme :Lyophilized PowderMasse moléculaire :105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.Ceritinib
CAS :<p>Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C28H36ClN5O3SDegré de pureté :98.52% - 99.77%Couleur et forme :SolidMasse moléculaire :558.14NVP-TAE 226
CAS :<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Formule :C23H25ClN6O3Degré de pureté :98.07% - 98.78%Couleur et forme :SolidMasse moléculaire :468.94GSK1838705A
CAS :<p>GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.</p>Formule :C27H29FN8O3Degré de pureté :98.89% - >99.99%Couleur et forme :SolidMasse moléculaire :532.57NVP-AEW541
CAS :<p>NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based</p>Formule :C27H29N5ODegré de pureté :98.7% - 99.86%Couleur et forme :SolidMasse moléculaire :439.55NVP-ADW742
CAS :<p>NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl</p>Formule :C28H31N5ODegré de pureté :96.14% - 98.70%Couleur et forme :SolidMasse moléculaire :453.58NT157
CAS :<p>NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.</p>Formule :C16H14BrNO5SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :412.26Ginsenoside Rg5
CAS :<p>Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.</p>Formule :C42H70O12Degré de pureté :98% - 99.65%Couleur et forme :SolidMasse moléculaire :767Insulin(cattle)
CAS :<p>Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.</p>Formule :C254H377N65O75S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5733.49NBI-31772 hydrate
<p>NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.</p>Formule :C17H13NO8Couleur et forme :SolidMasse moléculaire :372.82Linsitinib
CAS :<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Formule :C26H23N5ODegré de pureté :99.71% - ≥95%Couleur et forme :SolidMasse moléculaire :421.49AZD-3463
CAS :<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Formule :C24H25ClN6ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :448.95AG1024
CAS :<p>AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).</p>Formule :C14H13BrN2ODegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :305.17MID-1
CAS :<p>MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.</p>Formule :C12H11N3O4SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :293.3BRD7552
CAS :<p>BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.</p>Formule :C33H33N3O15Degré de pureté :>99.99% - ≥98%Couleur et forme :SolidMasse moléculaire :711.63Sari 59-801
CAS :Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Formule :C18H23N3O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :313.39
