IGF-1R
Les inhibiteurs d'IGF-1R sont des composés qui ciblent spécifiquement le récepteur du facteur de croissance analogue à l'insuline 1 (IGF-1R), une tyrosine kinase réceptrice impliquée dans la croissance, le développement et la survie cellulaires. La signalisation IGF-1R joue un rôle important dans la progression du cancer, ce qui rend ces inhibiteurs précieux pour la recherche en oncologie. Chez CymitQuimica, nous proposons des inhibiteurs d'IGF-1R pour soutenir vos recherches en biologie du cancer, endocrinologie et développement de thérapies ciblées.
106 produits trouvés pour "IGF-1R".
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MSDC-0602K
CAS :MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.Formule :C19H16KNO5SDegré de pureté :99.42%Couleur et forme :White SolidMasse moléculaire :409.5Ganitumab
CAS :Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.Degré de pureté :/ - > 95%Couleur et forme :Transparent LiquidMasse moléculaire :145.70 kDaRobatumumab
CAS :Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.Degré de pureté :96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :145.56 kDaGIP (3-42), human
CAS :Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.Formule :C214H324N58O63SDegré de pureté :95.73%Couleur et forme :SolidMasse moléculaire :4749.35HNMPA
CAS :HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.Formule :C11H11O4PDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :238.18Ref: TM-T21761
1mg48,00€2mg62,00€5mg88,00€1mL*10mM (DMSO)101,00€10mg137,00€25mg285,00€50mg427,00€100mg625,00€500mg1.324,00€NBI-31772
CAS :NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Formule :C17H11NO7Degré de pureté :99.79%Couleur et forme :Yellow SolidMasse moléculaire :341.27Teprotumumab
CAS :Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.Degré de pureté :SDS-PAGE:95.2%;SEC-HPLC:99.6%Couleur et forme :Transparent LiquidMasse moléculaire :145.62 kDaAZ7550 hydrochloride
CAS :AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formule :C27H32ClN7O2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :522.04ALK inhibitor 1
CAS :ALK inhibitor 1 is a selective ALK kinase inhibitor.Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :White SolidMasse moléculaire :562.48Ref: TM-T10285
1mg50,00€5mg110,00€1mL*10mM (DMSO)136,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€GIP (human) acetate
GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.Degré de pureté :98.65%Couleur et forme :SolidCixutumumab
CAS :Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impedingDegré de pureté :98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.32 kDaInsulin sensitizer C59
CAS :Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation.Formule :C16H18Cl2N2ODegré de pureté :99.98%Couleur et forme :White SolidMasse moléculaire :325.23Xenin-8
CAS :neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effectsFormule :C51H79N15O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1046.27Gastric Inhibitory Peptide (1-42) (porcine) TFA
Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.Formule :C225H342N60O66S·XCF3COOHCouleur et forme :White SolidMasse moléculaire :4975.55GIP (1-39)
CAS :Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.Formule :C210H316N56O61SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4633.21PQ401
CAS :PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formule :C18H16ClN3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :341.79Valanafusp alfa
CAS :Valanafusp alfa (AGT-181) is a fusion protein targeting HIR and IDUA for MPS I research.Couleur et forme :LiquidIGF-I (30-41)
CAS :IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).Formule :C51H83N19O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1266.34C-Peptide 2, rat
CAS :C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.Formule :C135H222N38O49Couleur et forme :SolidMasse moléculaire :3161.478Proinsulin C-peptide (human)
CAS :C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.Formule :C129H211N35O48Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3020.26Insulin Aspart
CAS :Insulin Aspart is a rapid-acting insulin analog with faster absorption than human insulin, improving postprandial glycemic control.Degré de pureté :99.86%Couleur et forme :White Solid[Pro3]-GIP (Mouse)
GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.Formule :C225H342N62O64SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4971.62AVE1642
AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidLDD39
LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.Formule :C55H59F2N11O6Couleur et forme :SolidMasse moléculaire :1008.12Insulin glulisine
CAS :Insulin glulisine (HMR 1964), a rapid-acting analogue, mimics human insulin; used in diabetes research.Formule :C258H384N64O78S6Couleur et forme :SolidMasse moléculaire :5822.57OI338
OI338 is an orally available, ultralong-acting insulin analogue.Formule :C260H403N65O84S6Couleur et forme :SolidMasse moléculaire :5971.76CPF-7
CAS :CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulationFormule :C118H193N33O32Couleur et forme :SolidMasse moléculaire :2586[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS :Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Formule :C72H110N19O33P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1862.67TLK19781
CAS :TLK19781 is an insulin receptor modulator.Formule :C33H24Cl2N4O13S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :883.73[D-Ala2]-GIP (human)
CAS :Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.Formule :C226H338N60O66SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4983.58cis-NVP-ADW742
CAS :NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Formule :C28H31N5OCouleur et forme :SolidMasse moléculaire :453.59Insulin α-chain (1-13)
CAS :Insulin alpha-chain peptide, amino acids 1-13, T cell-recognized, posttranslationally modified.Formule :C66H118N20O22S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1639.96IGF-1R inhibitor-2
CAS :IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.Formule :C24H24FN7O2Couleur et forme :SolidMasse moléculaire :461.501TAK-778
CAS :TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Formule :C24H28NO7PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.52GIP (1-30) amide,human
CAS :GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.Formule :C162H240N40O47SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3531.94WAY-270250
CAS :WAY-270250 is an IGF-1R/SRC inhibitor.Formule :C18H16N2O2Degré de pureté :99.97%Couleur et forme :Green SolidMasse moléculaire :292.33LAGIPRA peptide
LAGIPRA peptide is a long-acting agonist of GIP1R. It improves insulin sensitivity by enhancing glucose handling and reduces circulating branched-chain amino acids (BCAA) and keto acids. LAGIPRA peptide holds potential for research in type 2 diabetes.Proinsulin C-Peptide (55-89), human
CAS :Proinsulin, insulin's precursor, has A and B chains linked by a 31 amino acid C-peptide. Enzymes cleave it, yielding insulin and C-peptide.Formule :C153H259N49O52Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3616.99ZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Formule :C39H40N6O3Degré de pureté :98.34% - 99.32%Couleur et forme :Pink SolidMasse moléculaire :640.77GIP, human
CAS :Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.Formule :C226H338N60O66SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4983.6Acetyl Gastric Inhibitory Peptide (human)
CAS :Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.Formule :C228H340N60O67SCouleur et forme :SolidMasse moléculaire :5025.6Insulin peglispro
CAS :Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.Formule :C370H566N104O110S4Couleur et forme :SolidMasse moléculaire :8359.32(Pro3) GIP, human
CAS :(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.Formule :C226H338N60O64SCouleur et forme :SolidMasse moléculaire :4951.53DA-JC4
CAS :DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.Formule :C225H346N56O65Couleur et forme :SolidMasse moléculaire :4875.49Macupatide
CAS :Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.Couleur et forme :SolidGIP (1-30) amide, porcine TFA
GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.Couleur et forme :SolidXenin 8 acetate
Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family.Formule :C53H83N15O11Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :1106.32IGF-I (24-41)
CAS :IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.Formule :C88H133N27O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2017.16GIP (3-42), human acetate
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolismDegré de pureté :98%Couleur et forme :SolidINSR agonist 1
INSR agonist 1, an insulin receptor (INSR) agonist, effectively elevates INSR pY1355/1361 levels and exhibits synergistic effects with insulin.Formule :C36H47BrN4O6Couleur et forme :SolidMasse moléculaire :711.69
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