Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1424 produits trouvés pour "Autophagie"
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Nicardipine hydrochloride
CAS :<p>Nicardipine hydrochloride is a potent calcium channel blocker used to dilate cerebral and coronary vessels.</p>Formule :C26H30ClN3O6Degré de pureté :99.58% - 99.89%Couleur et forme :Yellow SolidMasse moléculaire :515.99Lapatinib Ditosylate
CAS :<p>Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).</p>Formule :C29H26ClFN4O4S·2C7H8O3SDegré de pureté :99.41%Couleur et forme :Yellow SolidMasse moléculaire :925.46AKOS037652256
CAS :<p>AKOS037652256 modulates TRPML, treating TRPML-linked diseases like lysosomal disorders, muscular dystrophy, neurodegeneration, and oxidative stress.</p>Formule :C24H26ClFN4O4S2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :553.07Fendiline hydrochloride
CAS :<p>Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.</p>Formule :C23H26ClNDegré de pureté :98.76% - 99.75%Couleur et forme :SolidMasse moléculaire :351.91NBDHEX
CAS :<p>NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).</p>Formule :C12H15N3O4SDegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :297.33Fluvastatin sodium
CAS :<p>Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol</p>Formule :C24H25FNNaO4Degré de pureté :98.54% - 99.56%Couleur et forme :Light Yellow Solid PowderMasse moléculaire :433.45Silmitasertib sodium salt
CAS :<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Formule :C19H11ClN3NaO2Degré de pureté :99.49% - 99.62%Couleur et forme :SolidMasse moléculaire :371.75Reserpine
CAS :<p>Reserpine, an alkaloid from Rauwolfia roots, depletes neurotransmitters, used in treating hypertension and psychosis, but side effects restrict use.</p>Formule :C33H40N2O9Degré de pureté :98.85% - 99.81%Couleur et forme :White Or Pale Buff To Slightly Yellowish Powder With A Bitter Taste (Ntp 1992)Masse moléculaire :608.68BIX 02565
CAS :<p>BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).</p>Formule :C26H30N6O2Degré de pureté :97.44% - 99.7%Couleur et forme :SolidMasse moléculaire :458.56Carboplatin
CAS :<p>Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.</p>Formule :C6H12N2O4PtDegré de pureté :98% - 99.72%Couleur et forme :White Crystalline PowderMasse moléculaire :371.25Irinotecan Hydrochloride
CAS :<p>Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.</p>Formule :C33H39ClN4O6Degré de pureté :98% - 99.94%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :623.14Loperamide hydrochloride
CAS :<p>Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.</p>Formule :C29H34Cl2N2O2Degré de pureté :99.91% - >99.99%Couleur et forme :Crystals Practically Insoluble In WaterMasse moléculaire :513.50Dihydroartemisinin
CAS :<p>Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!</p>Formule :C15H24O5Degré de pureté :98% - 99.41%Couleur et forme :White SolidMasse moléculaire :284.35Simvastatin
CAS :<p>Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.</p>Formule :C25H38O5Degré de pureté :98.54% - 99.13%Couleur et forme :SolidMasse moléculaire :418.57Hesperetin
CAS :<p>Hesperetin belongs to the flavanone class of flavonoids.</p>Formule :C16H14O6Degré de pureté :98.45% - 99.27%Couleur et forme :SolidMasse moléculaire :302.28Iohexol
CAS :<p>Iohexol, a contrast agent, has an osmolality of 322-844 mOsm/kg, 1.1-3 times blood plasma's.</p>Formule :C19H26I3N3O9Degré de pureté :99.61% - 99.89%Couleur et forme :White To Off-White Solid PowderMasse moléculaire :821.14Matrine
CAS :<p>Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.</p>Formule :C15H24N2ODegré de pureté :97.16% - >99.99%Couleur et forme :SolidMasse moléculaire :248.36Paclitaxel
CAS :<p>Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.</p>Formule :C47H51NO14Degré de pureté :98% - 99.92%Couleur et forme :White PowderMasse moléculaire :853.91Procainamide hydrochloride
CAS :<p>Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog</p>Formule :C13H21N3O·HClDegré de pureté :99.83% - 99.97%Couleur et forme :White To Slightly Yellow PowderMasse moléculaire :271.79Gimeracil
CAS :<p>Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.</p>Formule :C5H4ClNO2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :145.54Sulfamerazine
CAS :<p>Sulfamerazine (RP2632), a long-acting antibacterial, blocks dihydrofolic acid synthesis by competing with PABA.</p>Formule :C11H12N4O2SDegré de pureté :99.78%Couleur et forme :White Or Yellowish Crystalline PowderMasse moléculaire :264.30Pravastatin sodium
CAS :<p>Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.</p>Formule :C23H35NaO7Degré de pureté :97.14%Couleur et forme :White Crystalline PowderMasse moléculaire :446.52Raloxifene hydrochloride
CAS :<p>Raloxifene HCl treats postmenopausal osteoporosis, acts as estrogen on bone/cholesterol, and blocks it in breast/uterus.</p>Formule :C28H28ClNO4SDegré de pureté :98% - 99.97%Couleur et forme :Light Yellow SolidMasse moléculaire :510.044Sulfisoxazole
CAS :<p>Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.</p>Formule :C11H13N3O3SDegré de pureté :99.87% - 99.98%Couleur et forme :White To Cream PowderMasse moléculaire :267.30Penfluridol
CAS :<p>Penfluridol (TLP-607) is a highly potent antipsychotic.</p>Formule :C28H27ClF5NODegré de pureté :98.9% - 99.87%Couleur et forme :Off-White To White Crystalline PowderMasse moléculaire :523.97Megestrol acetate
CAS :<p>Megestrol acetate (BDH1298) is an oral progestogen with anti-androgenic properties, used for endometrial and breast cancer, anorexia, and cachexia.</p>Formule :C24H32O4Degré de pureté :99.46% - 99.78%Couleur et forme :Crystalline SolidMasse moléculaire :384.51Naringin
CAS :<p>Naringin: flavanone glycoside with blood lipid-reducing, antioxidant, anticancer properties, inhibits cytochrome P450.</p>Formule :C27H32O14Degré de pureté :99.23%Couleur et forme :Beige Creamish Powder Solid Solid Particulate/PowderMasse moléculaire :580.53Triclosan
CAS :<p>Triclosan (Irgasan) is an antibacterial and antifungal agent.</p>Formule :C12H7Cl3O2Degré de pureté :99.63%Couleur et forme :White Solid CrystallineMasse moléculaire :289.54Metformin hydrochloride
CAS :<p>Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) is an AMPK activator. Metformin is used in type 2 diabetes research. Cost-effective and quality-assured.</p>Formule :C4H12ClN5Degré de pureté :97.53% - 99.97%Couleur et forme :White Or Almost White Crystals Solid CrystallineMasse moléculaire :165.63Deferoxamine Mesylate
CAS :<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Formule :C26H52N6O11SDegré de pureté :94.68% - 99.8%Couleur et forme :SolidMasse moléculaire :656.79Norepinephrine bitartrate monohydrate
CAS :<p>Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.</p>Formule :C8H11NO3·C4H6O6·H2ODegré de pureté :97.88% - ≥95%Couleur et forme :SolidMasse moléculaire :337.28Nimodipine
CAS :<p>Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.</p>Formule :C21H26N2O7Degré de pureté :99.64% - 99.79%Couleur et forme :SolidMasse moléculaire :418.44Lamotrigine
CAS :<p>Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.</p>Formule :C9H7Cl2N5Degré de pureté :99.76% - 99.95%Couleur et forme :White To Pale Cream-Colored Powder Crystals From Isopropanol SolidMasse moléculaire :256.09Clotrimazole
CAS :<p>Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.</p>Formule :C22H17ClN2Degré de pureté :99.89%Couleur et forme :Crystals SolidMasse moléculaire :344.84Erlotinib
CAS :<p>Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Formule :C22H23N3O4Degré de pureté :98.19% - 99.98%Couleur et forme :White To Off-White PowderMasse moléculaire :393.44Albendazole
CAS :<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Formule :C12H15N3O2SDegré de pureté :98.21% - 98.76%Couleur et forme :Colorless Crystals SolidMasse moléculaire :265.33Rhein
CAS :<p>Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.</p>Formule :C15H8O6Degré de pureté :99.04%Couleur et forme :Physical Description Yellow Needles (From Methanol) Or Yellow-Brown Powder (Ntp 1992)Masse moléculaire :284.226-Mercaptopurine
CAS :<p>6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.</p>Formule :C5H4N4SDegré de pureté :99.53% - 99.63%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :152.18Pregnenolone
CAS :<p>Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.</p>Formule :C21H32O2Degré de pureté :99.5% - >99.99%Couleur et forme :SolidMasse moléculaire :316.48Sodium salicylate
CAS :<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Formule :C7H5NaO3Degré de pureté :99.36% - 99.92%Couleur et forme :White Solid AmorphousMasse moléculaire :160.11Naproxen
CAS :<p>Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic</p>Formule :C14H14O3Degré de pureté :99.6% - 99.89%Couleur et forme :Crystals From Acetone-Hexane SolidMasse moléculaire :230.26Irinotecan hydrochloride trihydrate
CAS :<p>Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.</p>Formule :C33H45ClN4O9Degré de pureté :98.22% - >99.99%Couleur et forme :Pale Yellow To Yellow Crystalline PowderMasse moléculaire :677.18Pemetrexed
CAS :<p>Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).</p>Formule :C20H21N5O6Degré de pureté :98.1% - 99.92%Couleur et forme :Similar To White PowderMasse moléculaire :427.41Sophocarpine monohydrate
CAS :<p>Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formule :C15H22N2ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :246.35Motixafortide TFA(664334-36-5,Free)
<p>Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.</p>Formule :C99H145F4N33O21S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :2273.54GCN2iB
CAS :<p>GCN2iB is an ATP-competitive inhibitor of serine/threonine protein kinase, stress-responsive kinase (GCN2).Cost-effective and quality-assured.</p>Formule :C18H12ClF2N5O3SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :451.83Rutin
CAS :<p>Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and</p>Formule :C27H30O16Degré de pureté :95.66% - 97.19%Couleur et forme :SolidMasse moléculaire :610.52CXCR7 antagonist-1
CAS :<p>CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7.</p>Formule :C21H19FN6ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :390.41Bosutinib
CAS :<p>Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.</p>Formule :C26H29Cl2N5O3Degré de pureté :98.98% - 99.9%Couleur et forme :Yellowish-Orange Or Pink To Brownish Solid Solid PowderMasse moléculaire :530.45Triflupromazine hydrochloride
CAS :<p>Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.</p>Formule :C18H20ClF3N2SDegré de pureté :99.76% - 99.82%Couleur et forme :CrystalsMasse moléculaire :388.88Monacolin J
CAS :<p>Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.</p>Formule :C19H28O4Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :320.42LY2510924 acetate(1088715-84-7 free base)
<p>Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.</p>Formule :C64H91N13O13Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :1250.49AMG 487
CAS :<p>AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.</p>Formule :C32H28F3N5O4Degré de pureté :99.82% - 99.89%Couleur et forme :SolidMasse moléculaire :603.59VUF11207 fumarate
CAS :<p>VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).</p>Formule :C31H39FN2O8Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :586.65Dexamethasone
CAS :<p>Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.</p>Formule :C22H29FO5Degré de pureté :98% - 99.91%Couleur et forme :Crystals From Ether (Ntp 1992)Masse moléculaire :392.46Salicylic acid
CAS :<p>Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.</p>Formule :C7H6O3Degré de pureté :98.04% - 98.83%Couleur et forme :White Solid PowderMasse moléculaire :138.12VUF-11222
CAS :<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Formule :C25H31BrINDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :552.33ITIC
CAS :<p>"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."</p>Formule :C94H82N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1427.96vMIP-II (1-21) TFA
<p>vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.</p>Couleur et forme :Odour SolidBalixafortide
CAS :<p>Balixafortide (POL6326), a potent CXCR4 blocker with IC50 < 10 nM, mobilizes HSPCs and is anti-cancer, 1000x more selective than CXCR7.</p>Formule :C84H118N24O21S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1864.14ITIC-4F
CAS :<p>ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.</p>Formule :C94H78F4N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1499.92Autophagy Compound Library
<p>A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and</p>Couleur et forme :Odour SolidCalmodulin-Dependent Protein Kinase II (290-309)
CAS :<p>Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II</p>Formule :C103H185N31O24SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2273.83Balixafortide TFA (1051366-32-5 free base)
<p>Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.</p>Formule :C82H113N22F3O23S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1896.054-Amino-D-phenylalanine
CAS :<p>4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.</p>Formule :C9H12N2O2Couleur et forme :SolidMasse moléculaire :180.2EB-42486
CAS :<p>EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.</p>Formule :C22H22N8ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :414.46Tat-beclin 1 acetate
<p>Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1.</p>Degré de pureté :99.44%Couleur et forme :SoildAutophagy-IN-6
<p>Autophagy-IN-6 (compound 1u) is an inhibitor of lysosomal autophagy that induces the accumulation of the LC3-II protein. Additionally, it exhibits antiproliferative activity.</p>Formule :C28H43N3O3Couleur et forme :SolidMasse moléculaire :469.66TC14012 TFA
<p>TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .</p>Formule :C92H141F3N34O21S2Degré de pureté :96.31%Couleur et forme :SolidMasse moléculaire :2180.44Schisandrin A
CAS :<p>Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM</p>Formule :C24H32O6Degré de pureté :99.21% - 99.901%Couleur et forme :SolidMasse moléculaire :416.51ALA-A2 peptide
<p>ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.</p>Formule :C67H111N21O19SCouleur et forme :SolidMasse moléculaire :1546.79Sulfadiazine
CAS :<p>Sulfadiazine, a short-acting sulfonamide, blocks bacterial folic acid synthesis; used with pyrimethamine to treat toxoplasmosis in AIDS, newborns.</p>Formule :C10H10N4O2SDegré de pureté :99.32%Couleur et forme :White To Slightly Yellow Crystalline PowderMasse moléculaire :250.28AChE-IN-80
<p>AChE-IN-80 (Compound 1) is an inhibitor of acetylcholinesterase (AChE). It suppresses inflammation and reactive oxygen species (ROS) production in cultured neurons and microglia, induces autophagy, and prevents the spread of beta-amyloid (Aβ) fibrils. AChE-IN-80 exhibits antioxidant activity and neuroprotective effects, making it valuable for Alzheimer's disease research.</p>Formule :C11H14N2O2SCouleur et forme :SolidMasse moléculaire :238.306Chromomycin A2
CAS :<p>Chromomycin A2, from marine actinomycetes, halts B. subtilis and various cancer cells; promotes autophagy in melanoma.</p>Formule :C59H86O26Couleur et forme :SolidMasse moléculaire :1211.3DOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Formule :C58H78N16O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1223.34PBA-1105 TFA
<p>PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.</p>Formule :C41H49F3N2O8Couleur et forme :SolidMasse moléculaire :754.832Fasudil
CAS :<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37MRT67307
CAS :<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formule :C26H36N6O2Degré de pureté :99.25% - 99.84%Couleur et forme :SolidMasse moléculaire :464.6ML-SA5
CAS :<p>ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.Cost-effective and quality-assured.</p>Formule :C19H24ClN3O4S2Degré de pureté :99.16% - >99.99%Couleur et forme :SoildMasse moléculaire :457.99Elaiophylin
CAS :<p>Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.</p>Formule :C54H88O18Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1025.27Rimantadine
CAS :<p>Rimantadine (1-Rimantadine) (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 μM.</p>Formule :C12H21NDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :179.3Ezurpimtrostat
CAS :<p>Ezurpimtrostat targets fibrosis, cancer, autophagy, CTSB, CTSL, CTSD. (From patent WO2020048694 A1)</p>Formule :C25H31ClN4Couleur et forme :SolidMasse moléculaire :423.0Cyclic MKEY
CAS :<p>MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.</p>Formule :C113H174N28O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2532.89SJFα
CAS :<p>SJFα (SJF alpha) degrades p38α and p38δ and can be used in cancer research.</p>Formule :C59H67F2N7O11SDegré de pureté :95.25%Couleur et forme :SolidMasse moléculaire :1120.27TH152
CAS :<p>TH152 is a general reversible ligand for LC3/GABARAP with a dissociation constant (KD) of 2 µM. LC3/GABARAP is a protein associated with autophagy.</p>Formule :C22H23ClN4O4S2Couleur et forme :SolidMasse moléculaire :507.03Diquat dibromide
CAS :<p>Diquat dibromide is a water-soluble herbicide that causes rapid and profound systemic toxicity.Diquat dibromide induces acute kidney injury with high lethality.</p>Formule :C12H12Br2N2Degré de pureté :97.11% - 99%Couleur et forme :SolidMasse moléculaire :344.05CXCR7 modulator 1
CAS :<p>CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.</p>Formule :C48H57F2N7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.07PTX80
CAS :<p>PTX80 is an antagonist of p62, with an IC50 value of 31.18 nM. It has been shown to reduce tumor volume in a HCT116 colorectal cancer mouse xenograft model.</p>Formule :C26H26N4O3SCouleur et forme :SolidMasse moléculaire :474.58CXCL-CXCR1/2-IN-1
CAS :<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Formule :C14H8Cl2N4O3SDegré de pureté :99.4%Couleur et forme :SoildMasse moléculaire :383.21ATG16L1 stabilizer-1
<p>ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent stabilizer of ATG16L1 that enhances cellular autophagy (Autophagy). Regardless of the presence of FKBP12, it has an inhibitory EC50 value of 12.1 μM for ATG16L1. When used alone, ATG16L1 stabilizer-1 can induce GFP-LC3 puncta formation, with an EC50 value of 12.0 μM.</p>Formule :C45H62N14O5SCouleur et forme :SolidMasse moléculaire :911.13OsMo
<p>OsMo is a lysosomal-targeting hNEU1 inhibitor utilized in the study of myocardial injury.</p>Couleur et forme :Odour SolidBOLD-100 free base
CAS :<p>BOLD-100 (NKP-1339/IT-139) is a ruthenium anticancer agent that inhibits GRP78 and disrupts ER homeostasis, affecting lysosome function and autophagy.</p>Formule :C14H12Cl4N4RuCouleur et forme :SolidMasse moléculaire :479.15NI-0801
<p>NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.</p>Degré de pureté :97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :Odour LiquidMito-fisetin mF3
<p>Mito-fisetin mF3 (compund mito-fisetin mF3) is a potent anticancer and anti-aging therapeutic agent that targets mitochondria.</p>Formule :C52H42IO7PCouleur et forme :SolidMasse moléculaire :936.76XL01126
<p>XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.</p>Formule :C50H64ClFN10O6S2Couleur et forme :SolidMasse moléculaire :1019.69Salinomycin sodium salt
CAS :<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Formule :C42H69NaO11Degré de pureté :98.76% - 99.11%Couleur et forme :White Or Light Yellow Crystalline Powder With Special SmelMasse moléculaire :772.98BVT173187
CAS :<p>BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.</p>Formule :C14H10Cl3NO2Couleur et forme :SolidMasse moléculaire :330.59SJFδ
CAS :<p>SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].</p>Formule :C62H63F2N7O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1168.27Retinoic acid-d5
CAS :<p>Retinoic acid-d5: deuterium-labeled, natural RAR agonist (IC50: 14 nM), affects cell growth and development, inhibits Nrf2.</p>Formule :C20H28O2Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :305.47CZC-54252 hydrochloride
CAS :<p>CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.</p>Formule :C22H26Cl2N6O4SDegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :541.45SG31
<p>SG31 is a potent activator of autophagy, exerting its effects through the AMPK/ULK1-dependent pathway.</p>Formule :C26H37N6O8PCouleur et forme :SolidMasse moléculaire :592.58Pantoprazole Sodium Hydrate
CAS :<p>Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus</p>Formule :C16H14F2N3NaO4SH2ODegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :432.37CXM102
<p>CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.</p>Formule :C28H27NO3Couleur et forme :SolidMasse moléculaire :425.52MLCK inhibitor peptide 18
CAS :<p>Myosin light chain kinase inhibitor; IC50=50 nM; 4000x more selective over CaM kinase II; no PKA inhibition; cell-permeable.</p>Formule :C60H105N23O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1324.64Autophagy/REV-ERB-IN-1 hydrochloride
<p>Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.</p>Formule :C24H32Cl2F2N2Masse moléculaire :456.19106(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.</p>Formule :C27H32N8O5Masse moléculaire :548.24957Indomethacin-D4
CAS :<p>Indomethacin-D4 is a deuterium labeled Indomethacin.</p>Formule :C19H16ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.81ALX 40-4C
CAS :<p>ALX40-4C is a small peptide inhibitor of the chemokine receptor CXCR4 that can inhibit X4 strains of HIV-1.</p>Formule :C56H113N37O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1464.74PDEδ autophagic degrader 1
<p>PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.</p>Formule :C41H42Br2IN7O5Masse moléculaire :997.06589(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formule :C29H36N8O6Masse moléculaire :592.27578CXCL8 (54-72)
<p>CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.</p>Formule :C107H173N33O30Masse moléculaire :2400.30261(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formule :C33H42N8O7Masse moléculaire :662.31765(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formule :C30H39N5O6Masse moléculaire :565.29003Atorvastatin Sodium
CAS :<p>Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on</p>Formule :C33H34FN2NaO5Degré de pureté :99.88% - >99.99%Couleur et forme :SolidMasse moléculaire :580.63CCR7 antagonist 1
<p>CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.</p>Formule :C13H22N6OSMasse moléculaire :310.15758RCP168
<p>RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.</p>Formule :C365H585N105O95S5Masse moléculaire :8119.27766ALX 40-4C Trifluoroacetate
<p>Alx40-4C trifluoroacetate inhibits CXCR4 and is an APJ antagonist with IC50 of 2.9M.</p>Formule :C58H114F3N37O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1578.76PF-06835375
CAS :<p>PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).</p>Couleur et forme :LiquidAntitumor agent-133
<p>Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.</p>Formule :C27H24Br2N4O8Masse moléculaire :689.99609ATRA-biotin
CAS :<p>ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues.</p>Formule :C36H55N3O4SCouleur et forme :SolidMasse moléculaire :625.91Tigecycline hydrate
CAS :<p>Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.</p>Formule :C29H39N5O8·xH2OCouleur et forme :SolidSyntide 2
CAS :<p>Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).</p>Formule :C68H122N20O18Degré de pureté :98%Couleur et forme :Lyophilized SolidMasse moléculaire :1507.82(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formule :C31H41N5O6Masse moléculaire :579.30568AUTAC1
CAS :<p>AUTAC1 is a MetAP2-targeted autophagy-mediated degradator (AUTAC) that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.</p>Formule :C44H63FN8O11SDegré de pureté :99.45% - 99.45%Couleur et forme :SolidMasse moléculaire :931.08Cabergoline
CAS :<p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>Formule :C26H37N5O2Degré de pureté :97.69% - 99.86%Couleur et forme :White Crystalline SolidMasse moléculaire :451.6MRL828
<p>MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.</p>Formule :C46H51FN14O5SCouleur et forme :SolidMasse moléculaire :930.38716Biotin-16-UTP
CAS :<p>Biotin-16-UTP serves as an efficient substrate for RNA polymerase, capable of substituting UTP in vitro transcription reactions to facilitate RNA labeling [1].</p>Formule :C32H48Li4N7O19P3SCouleur et forme :SolidMasse moléculaire :987.51Indole-3-Glyoxylyl Chloride
CAS :<p>Indole-3-glyoxylyl chloride (3-Indoleglyoxylyl chloride) can be used in chemical synthesis, such as bisindolylmaleimide.</p>Formule :C10H6ClNO2Degré de pureté :99.72%Couleur et forme :Yellow To Orange Powder Or CrystalsMasse moléculaire :207.61LC3B recruiter 2
CAS :<p>LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.</p>Formule :C10H9ClN2O2Couleur et forme :SolidMasse moléculaire :224.644Polyphyllin G
CAS :<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Formule :C51H84O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1049.21Autophagy agonist-1
<p>Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.</p>Formule :C33H41N3O5Couleur et forme :SolidMasse moléculaire :559.7H1k
<p>H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that downregulates the expression of cell cycle protein B1.</p>Formule :C27H22N2ODegré de pureté :98.13%Couleur et forme :SoildMasse moléculaire :390.48Acetyl coenzyme A
CAS :<p>Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesis</p>Formule :C23H38N7O17P3SCouleur et forme :SolidMasse moléculaire :809.57Fumagilin-105
CAS :<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formule :C46H60N2O9Couleur et forme :SolidMasse moléculaire :784.98Autocamtide 2
CAS :<p>Autocamtide-2: Selective peptide for CaMKII, a CAMK Ser/Thr kinase.</p>Formule :C65H118N22O20Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :1527.77DB1113
CAS :<p>DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.</p>Formule :C59H68F3N13O6SCouleur et forme :SolidMasse moléculaire :1144.31SQA1
CAS :<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formule :C22H26N4O5Couleur et forme :SolidMasse moléculaire :426.47TRAF6 peptide
CAS :<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Formule :C145H238N34O44Couleur et forme :SolidMasse moléculaire :3161.64Microcolin H
CAS :<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Formule :C38H63N5O9Couleur et forme :SolidMasse moléculaire :733.93PBA-1105b
CAS :<p>PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.</p>Formule :C47H64N2O10Couleur et forme :SolidMasse moléculaire :817.02YTK-105
CAS :<p>YTK-105 is a ligand targeting autophagy that binds to p62.</p>Formule :C16H19NO2Degré de pureté :98.31%Couleur et forme :SoildMasse moléculaire :257.33Ch55-O-C3-NH2
CAS :<p>Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR.</p>Formule :C27H35NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.57LC3in-C42
<p>LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.</p>Couleur et forme :Odour SolidN6-Isopentenyladenosine
CAS :<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>Formule :C15H21N5O4Degré de pureté :97.13% - 99.69%Couleur et forme :SolidMasse moléculaire :335.36Bacilotetrin C analogue
<p>Bacilotetrin C analogue is a variant of Bacilotetrin C. It exhibits cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231, with an IC50 of 0.48 μM. This compound induces autophagy (autophagy) in tumor cells and possesses antitumor activity.</p>Formule :C44H76N6O10Couleur et forme :SolidMasse moléculaire :849.11Deoxy-thalidomide-Pip-C-PIP-boc
CAS :<p>Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.</p>Formule :C28H39N5O5Couleur et forme :SolidMasse moléculaire :525.64Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Couleur et forme :Odour SolidPF-543
CAS :<p>PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.</p>Formule :C27H31NO4SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :465.6Dusquetide TFA
<p>Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.</p>Formule :C27H48F3N9O7Couleur et forme :SolidMasse moléculaire :667.72HDAC6-IN-58
<p>HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).</p>Couleur et forme :Odour SolidFDW028
CAS :<p>FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.</p>Formule :C22H24N6ODegré de pureté :98.73% - 99.55%Couleur et forme :SoildMasse moléculaire :388.47cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Formule :C31H51ClN7O14PSCouleur et forme :SolidMasse moléculaire :844.27Peptide R
CAS :<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formule :C39H59N13O8S2Couleur et forme :SolidMasse moléculaire :902.1Flavopiridol
CAS :<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Formule :C21H20ClNO5Degré de pureté :97.74% - 99.86%Couleur et forme :SolidMasse moléculaire :401.84STO-609 acetate
CAS :<p>STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the</p>Formule :C19H10N2O3·C2H4O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :374.35Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formule :C115H145ClN18O31S2Zn2Couleur et forme :SolidMasse moléculaire :2505.83Cy5.5-SE (DIPEA)
<p>Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.</p>Formule :C53H66N4O16S4Couleur et forme :SolidMasse moléculaire :1143.37Corydalmine hydrochloride
CAS :<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Formule :C20H24ClNO4Couleur et forme :SolidMasse moléculaire :377.86Fe-TMPyP
CAS :<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Formule :C44H36Cl5FeN8Couleur et forme :SolidMasse moléculaire :909.92Insecticidal agent 364
CAS :<p>Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.</p>Formule :C23H18N4O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :430.48Manzamine A hydrochloride
CAS :<p>Manzamine A hydrochloride: oral beta-carboline inhibiting GSK-3β & CDK-5; blocks autophagy in cancer; antimalarial; fights HSV-1.</p>Formule :C36H45ClN4OCouleur et forme :SolidMasse moléculaire :585.23CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>Biotin-11-dCTP
<p>Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .</p>Formule :C28H43Li3N7O16P3SCouleur et forme :SolidMasse moléculaire :879.49MRT 67307 dihydrochloride
CAS :<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formule :C26H38Cl2N6O2Degré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :537.53(S)-Sitagliptin phosphate
CAS :<p>(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.</p>Formule :C16H18F6N5O5PCouleur et forme :SolidMasse moléculaire :505.314Autophagy/REV-ERB-IN-1
<p>Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.</p>Formule :C24H30F2N2Masse moléculaire :384.23771Clionamine B
CAS :<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Formule :C27H45NO3Couleur et forme :SolidMasse moléculaire :431.65Tigecycline mesylate
CAS :<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formule :C30H43N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.75Hoechst 33342 analog trihydrochloride
CAS :<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Formule :C32H38Cl3N7Couleur et forme :SolidMasse moléculaire :627.05Erlotinib-13C6
CAS :<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Formule :C22H23N3O4Couleur et forme :SolidMasse moléculaire :399.397D-CopA3
CAS :<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formule :C96H184N30O18S2Couleur et forme :SolidMasse moléculaire :2110.81Desethylamiodarone hydrochloride
CAS :<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formule :C23H26ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formule :C27H31IN2O3Couleur et forme :SolidMasse moléculaire :558.45Autocamtide 2, amide
<p>Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.</p>Formule :C65H119N23O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1526.79p62-ZZ Ligand-Linker Conjugate 1
CAS :<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Formule :C31H42N2O6Couleur et forme :SolidMasse moléculaire :538.68Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Formule :C43H52N6O19P3Couleur et forme :SolidMasse moléculaire :1049.82Acridine homodimer
CAS :<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Formule :C38H42Cl2N6O2Couleur et forme :SolidMasse moléculaire :685.69AZD4721
CAS :<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55PHTPP-1304
CAS :<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formule :C51H50F6N4O7Couleur et forme :SolidMasse moléculaire :944.96Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Formule :C40H47N3O8S2Couleur et forme :SolidMasse moléculaire :761.95Nictide
CAS :<p>Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.</p>Formule :C123H193N45O28Couleur et forme :SolidMasse moléculaire :2750.13Tigecycline hydrochloride
CAS :<p>Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formule :C29H40ClN5O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :622.11Valproic acid sodium salt
CAS :<p>Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.</p>Formule :C8H15NaO2Degré de pureté :98.43% - 99.78%Couleur et forme :White PowderMasse moléculaire :166.2RK-682 (calcium salt)
CAS :<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Formule :C42H74CaO10Couleur et forme :SolidMasse moléculaire :779.122Desethyl chloroquine
CAS :<p>Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.</p>Formule :C16H22ClN3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :291.82TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Formule :C32H55N3O10SCouleur et forme :SolidMasse moléculaire :673.86NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formule :C56H68ClN9O5S2Couleur et forme :SolidMasse moléculaire :1046.78CX4338
CAS :<p>CX4338 is a CXCL8-mediated chemotaxis inhibitor.</p>Formule :C22H24N2OSCouleur et forme :SolidMasse moléculaire :364.50CXCR4 antagonist 1
CAS :<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69BRD4 degrader-5
<p>BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM). It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.</p>Formule :C35H42ClN7O2SCouleur et forme :SolidMasse moléculaire :660.27DMTr-4'-CF3-5-Me-U-CED phosphoramidite
<p>DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.</p>Formule :C42H50F3N4O8PCouleur et forme :SolidMasse moléculaire :826.84SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Formule :C34H32FeO6Couleur et forme :SolidMasse moléculaire :592.46MeCY5-NHS ester triethylamine
<p>MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].</p>Formule :C42H56N4O10S2Couleur et forme :SolidMasse moléculaire :841.04(3R,5S)-Fluvastatin
CAS :<p>(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.</p>Formule :C24H26FNO4Couleur et forme :SolidMasse moléculaire :411.47KRH-3955 hydrochloride
CAS :<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Formule :C28H48Cl3N7Couleur et forme :SolidMasse moléculaire :589.09MW-150 hydrochloride
CAS :<p>MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.</p>Formule :C24H24ClN5Couleur et forme :SolidMasse moléculaire :417.93Chlorotris(triphenylphosphine)copper
CAS :<p>Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.</p>Formule :C54H45ClCuP3Couleur et forme :SolidMasse moléculaire :885.86Hexidium iodide
CAS :<p>Hexidium iodide fluoresces, stains mammalian cells & gram-positive bacteria, and binds to DNA with EDTA. Excitation/emission: ~518/600 nm.</p>Formule :C25H28IN3Couleur et forme :SolidMasse moléculaire :497.424Desfluoro-ezetimibe
CAS :<p>Desfluoro-ezetimibe: a defluorinated ezetimibe impurity; a stable, potent cholesterol blocker and Nrf2 activator.</p>Formule :C24H22FNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.43Cytochalasin E
CAS :<p>Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.</p>Formule :C28H33NO7Degré de pureté :98%Couleur et forme :Crystals From Acetone-Hexane White PowderMasse moléculaire :495.56
