Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
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HDAC10-IN-1
<p>HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.</p>Formule :C18H23N3O2Couleur et forme :SolidMasse moléculaire :313.39LRRK2-IN-2
CAS :<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Formule :C23H23Cl2F3N6O2Couleur et forme :SolidMasse moléculaire :543.37ACT-777991
CAS :<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48LRRK2-IN-16
CAS :<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441PARL-IN-1
<p>PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.</p>Formule :C40H58N6O7Couleur et forme :SolidMasse moléculaire :734.92DC-LC3in-D5
CAS :<p>DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.</p>Formule :C19H22Cl2N2O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :397.3ACT-672125
CAS :<p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>Formule :C25H25F3N10O2SCouleur et forme :SolidMasse moléculaire :586.59LC3B recruiter 1
CAS :<p>LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.</p>Formule :C14H10ClN3O2Couleur et forme :SolidMasse moléculaire :287.701CXCR4 antagonist 3
<p>CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.</p>Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Formule :C23H24F2N4O2SCouleur et forme :SolidMasse moléculaire :458.52Autophagy activator-1
CAS :<p>Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.</p>Formule :C25H32O8Couleur et forme :SolidMasse moléculaire :460.517CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36CXCR2/CCR7 antagonist-1
CAS :<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Formule :C23H27N3O5Couleur et forme :SolidMasse moléculaire :425.48Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12YOK-1304
CAS :<p>YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.</p>Formule :C28H35NO4Couleur et forme :SolidMasse moléculaire :449.58LRRK2-IN-4
CAS :<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99SCH 563705
CAS :<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48DCC-3116
CAS :<p>DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.</p>Formule :C26H36F3N7O2Degré de pureté :98.55%Couleur et forme :SoildMasse moléculaire :535.61Gepotidacin mesylate dihydrate
CAS :<p>Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.</p>Formule :C25H36N6O8SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :580.65Dusquetide
CAS :<p>Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.</p>Formule :C25H47N9O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.709VUF11207 trifluoroacetate salt
CAS :<p>VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.</p>Formule :C29H36F4N2O6Couleur et forme :SolidMasse moléculaire :584.609Pepstatin Ammonium
<p>Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM</p>Formule :C34H66N6O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :702.92Dihydrocelastrol
CAS :<p>Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE co</p>Formule :C29H40O4Couleur et forme :SolidMasse moléculaire :452.63FR 167653
CAS :<p>FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.</p>Formule :C24H20FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.51EIPA hydrochloride
CAS :<p>EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.</p>Formule :C11H19Cl2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.22CXCR4-IN-1
CAS :<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formule :C23H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.54VISTA-IN-2
CAS :<p>VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,</p>Formule :C23H23N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.45
