Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1424 produits trouvés pour "Autophagie"
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Norswertianin
CAS :<p>Norswertianin, a xanthone, induces GBM cell differentiation and autophagy via oxidative stress and Akt/mTOR.</p>Formule :C13H8O6Couleur et forme :SolidMasse moléculaire :260.2ICT5040
CAS :<p>ICT5040 is a CXCR4 antagonist.</p>Formule :C10H8F3N3OSCouleur et forme :SolidMasse moléculaire :275.25SB-332235
CAS :<p>SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.</p>Formule :C13H10Cl3N3O4SCouleur et forme :SolidMasse moléculaire :410.66Autophagy-IN-C1
CAS :<p>Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea.</p>Formule :C29H28F6N4O2Couleur et forme :SolidMasse moléculaire :578.55Olacaftor
CAS :<p>Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).</p>Formule :C29H34FN3O4SCouleur et forme :SolidMasse moléculaire :539.66PF 750
CAS :<p>PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.</p>Formule :C22H23N3ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :345.44AMD 3465
CAS :<p>AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).</p>Formule :C24H38N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.60VUF11211
CAS :<p>VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.</p>Formule :C26H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.49AUTEN-67
CAS :<p>AUTEN-67 inhibits MTMR14, boosts autophagy, has antiaging/neuroprotective properties, and combats Huntington's disease onset/severity.</p>Formule :C23H14N4O6SCouleur et forme :SolidMasse moléculaire :474.45LV-320
CAS :<p>LV-320, potent ATG4B inhibitor; IC50: 24.5 μM, Kd: 16 μM. Blocks autophagy, stable, non-toxic, active in vivo. Useful for ATG4B research in cancer.</p>Formule :C29H26ClNO2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.11Antiproliferative agent-5
CAS :<p>Compound 4o inhibits gastric cancer growth, blocks G2/M cell cycle, induces ROS, and triggers autophagy. Used in anti-cancer studies.</p>Formule :C28H21BrN8OSCouleur et forme :SolidMasse moléculaire :597.49CXCR4 antagonist 9
CAS :<p>CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.</p>Formule :C21H27FN6Couleur et forme :SolidMasse moléculaire :382.48SA 47
CAS :<p>SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.</p>Formule :C17H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.41CXCR4 antagonist 8
CAS :<p>CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.</p>Formule :C21H26N6Couleur et forme :SolidMasse moléculaire :362.47ALLO-1
CAS :<p>ALLO-1, vital for autophagy, aids in engulfing paternal organelles by binding to worm LC3, LGG-1, via its LIR motif.</p>Formule :C17H15ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :314.77Obatoclax
CAS :<p>Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.</p>Formule :C20H19N3ODegré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :317.38Nicodicosapent
CAS :<p>Nicodicosapent is a fatty acid niacin conjugate that inhibits SREBP, a regulator of cholesterol metabolism.</p>Formule :C28H39N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.63STK683963
CAS :<p>STK683963 activates ATG4B, mediates redox regulation, and aids cancer research.</p>Formule :C12H8FN3O2SCouleur et forme :SolidMasse moléculaire :277.27LS2265
CAS :<p>LS2265, a fenofibrate derivative with a taurine modification, effectively induces the proliferation of peroxisomes in rat liver cells.</p>Formule :C19H20ClNO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.88AGN 205327
CAS :<p>AGN 205327 is a potent synthetic RAR agonist,showing selective RAR activation without RXR inhibition for retinoid research.</p>Formule :C24H26N2O3Degré de pureté :99.45% - 99.71%Couleur et forme :SolidMasse moléculaire :390.47HF51116
CAS :<p>HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.</p>Formule :C29H46N8OCouleur et forme :SolidMasse moléculaire :522.73CC214-2
CAS :<p>CC214-2: strong dual mTORC1/2 inhibitor, blocks autophagy, may shorten TB duration.</p>Formule :C20H25N5O3Couleur et forme :SolidMasse moléculaire :383.44AS1708727
CAS :<p>AS1708727 inhibits Foxo1, reducing blood sugar and triglycerides by altering gene expression.</p>Formule :C24H24Cl2N2O2Couleur et forme :SolidMasse moléculaire :443.37Aliskiren fumarate
CAS :<p>Oral renin inhibitor Aliskiren fumarate treats hypertension; IC50: 1.5 nM. Useful for cardiovascular and cancer cachexia research.</p>Formule :C34H57N3O10Couleur et forme :SolidMasse moléculaire :667.83Rimacalib
CAS :<p>Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).</p>Formule :C22H23FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.44Elliptinium acetate
CAS :<p>Elliptinium acetate (NSC 264137), a cytotoxic DNA intercalator for cancer research, targets L1210 cells.</p>Formule :C20H20N2O3Couleur et forme :SolidMasse moléculaire :336.38SA72
CAS :<p>SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH).</p>Formule :C21H26N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.44SX-517
CAS :<p>SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.</p>Formule :C19H16BFN2O3SCouleur et forme :SolidMasse moléculaire :382.22TN-14003
CAS :<p>TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.</p>Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42RNF5 inhibitor inh-02
CAS :<p>RNF5 inhibitor inh-02 is a selective inhibitor of the ubiquitin ligase RNF5/RMA1, which can significantly rescue F508del-CFTR cystic fibrosis (CF).</p>Formule :C23H20N4SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :384.5(S)-Hydroxychloroquine
CAS :<p>(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro.</p>Formule :C18H26ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.87IZCZ-3
CAS :<p>IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.</p>Formule :C46H49N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :715.93KRH-1636
CAS :<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Formule :C32H37N7O2Couleur et forme :SolidMasse moléculaire :551.68Autophagy inducer 4
CAS :<p>Autophagy inducer 4, a Magnolol-based Mannich derivative, is an anticancer agent that blocks cancer cell migration & is 76x more toxic to T47D cells.</p>Formule :C32H37NO6Couleur et forme :SolidMasse moléculaire :531.64PX20606 trans racemate
CAS :<p>PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).</p>Formule :C29H22Cl3NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :554.85Antitumor agent-81
CAS :<p>Antitumor agent-81, a P62-RNF168 agonist, reduces H2A ubiquitination, hinders DNA repair, and inhibits tumor growth.</p>Formule :C19H19N7O3Couleur et forme :SolidMasse moléculaire :393.4MPM-1
<p>MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.</p>Formule :C34H44F6N4O7Couleur et forme :SolidMasse moléculaire :734.73IT1t
CAS :<p>IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.</p>Formule :C21H34N4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.65Amsacrine
CAS :<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Formule :C21H19N3O3SDegré de pureté :99.2%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :393.46CUR5g
CAS :<p>CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells.</p>Formule :C22H20N2O2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :344.41Evogliptin
CAS :<p>Evogliptin (DA-1229) is an oral DPP4 inhibitor effective in reducing blood sugar and liver inflammation.</p>Formule :C19H26F3N3O3Couleur et forme :SolidMasse moléculaire :401.42ATG7-IN-3
CAS :<p>ATG7-IN-3, or compound 18, is an ATG7 inhibitor with a 0.048 μM IC50, blocking autophagy and LC3B puncta in H4 cells.</p>Formule :C11H16N6O5S2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :376.41Xantocillin
CAS :<p>Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway.</p>Formule :C18H12N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :288.3YM-155 hydrochloride
CAS :<p>Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits survivin promoter with an IC 50 of 0.54 nM[1].</p>Formule :C20H19ClN4O3Couleur et forme :SolidMasse moléculaire :398.85OSU-53
CAS :<p>OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.</p>Formule :C25H24F3N3O6S2Couleur et forme :SolidMasse moléculaire :583.6CCT128930
CAS :<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Formule :C18H20ClN5Degré de pureté :99.07% - 99.18%Couleur et forme :SolidMasse moléculaire :341.84FAAH inhibitor 1
CAS :<p>FAAH inhibitor 1 (Benzothiazole analog 3) is an effective FAAH inhibitor with an IC50 of 18 nM.</p>Formule :C24H23N3O3S3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :497.65(Rac)-BL-918
CAS :<p>(Rac)-BL-918 is the racemic form of BL-918. BL-918 is an effective activator of UNC-51-like kinase 1 (ULK1) (EC₅₀ = 24.14 nM), Parkinson's disease.</p>Formule :C23H15F8N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.44YOK-2204
CAS :<p>YOK-2204 is a ligand for the p62-ZZ domain and activates p62-dependent selective autophagy. It is also applicable in the design of AUTOTACs.</p>Formule :C28H35NO4Couleur et forme :SolidMasse moléculaire :449.58MRT-68601 HCl
CAS :<p>MRT-68601 HCl, a potent TBK1 (TANK-binding kinase-1), inhibits the formation of autophagosomes in lung cancer cells.</p>Formule :C25H34N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.58FKBP51F67V-selective antagonist Ligand2
CAS :<p>FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or</p>Formule :C43H56N2O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.91TUN-92046
CAS :<p>TUN-92046 is a permeable alpha-ketoglutarate analog that blocks harmful autophagy in cardiomyopathy.</p>Formule :C7H10O5Degré de pureté :95.48% - 98.58%Couleur et forme :SolidMasse moléculaire :174.15Glaucocalyxin B
CAS :<p>Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).</p>Formule :C22H30O5Degré de pureté :99.13% - 99.35%Couleur et forme :SolidMasse moléculaire :374.47GPR35 agonist 1
CAS :<p>GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).</p>Formule :C10H4BrN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.07VUF5834
CAS :<p>VUF5834 is a full inverse agonist of CXCR3 N3.35A.</p>Formule :C31H41N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.69LRRK2-IN-10
CAS :<p>LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2</p>Formule :C20H15N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.37PS372424
CAS :<p>PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.</p>Formule :C33H44N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :588.74AZ10397767
CAS :<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Formule :C15H14ClFN4O2S2Couleur et forme :SolidMasse moléculaire :400.88FR 167653 free base
CAS :<p>FR 167653 is an oral p38 MAPK inhibitor for inflammation, trauma, ischemia relief; it suppresses TNF-α, IL-1β.</p>Formule :C24H18FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.43ROC-325
CAS :<p>ROC-325: orally active autophagy inhibitor with anticancer effects, induces kidney cancer cell death; selective action.</p>Formule :C28H27ClN4OSDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :503.06Sulfosuccinimidyl oleate
CAS :<p>Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.</p>Formule :C22H37NO7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.6SRT3190
CAS :<p>SRT3190 is an antagonist of CXCR2.</p>Formule :C18H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.53Ipsalazide
CAS :<p>Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.</p>Formule :C16H11N3Na2O6Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :387.25SCH 546738
CAS :<p>SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.</p>Formule :C23H31Cl2N7ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :492.45AL 8697
CAS :<p>AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.</p>Formule :C21H21F3N4ODegré de pureté :99.55% - 99.89%Couleur et forme :SolidMasse moléculaire :402.41(-)-Talarozole
CAS :<p>(-)-Talarozole is a potent retinoic acid metabolism inhibitor.</p>Formule :C21H23N5SCouleur et forme :SolidMasse moléculaire :377.51AGN 205728
CAS :<p>AGN 205728 is a potent and selective RARγ antagonist (Ki: 3 nM; IC95: 0.6 nM) and has no inhibition on RARα and RARβ.</p>Formule :C29H27NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.53GSK3-IN-3
CAS :<p>GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.</p>Formule :C24H35N3O4Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :429.55FC131
CAS :<p>CXCR4 antagonist</p>Formule :C36H47N11O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.83Dinoprost
CAS :<p>Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.</p>Formule :C20H34O5Degré de pureté :97.94% - 98.04%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :354.48ABTL-0812
CAS :<p>ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.</p>Formule :C18H32O3Couleur et forme :SolidMasse moléculaire :296.44K67
CAS :<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Formule :C29H30N2O7S2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :582.69(Rac)-AZD 6482
CAS :<p>(Rac)-AZD 6482 is the racemate of AZD 6482. AZD 6482 is a potent and selective inhibitor of p110β (IC50 of 0.69 nM).</p>Formule :C22H24N4O4Couleur et forme :SolidMasse moléculaire :408.45SR-17398
CAS :<p>SR-17398 is an inhibitor of Unc-51-Like Kinase 1 (ULK1) (IC50 = 22.4 uM).</p>Formule :C14H18N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.32Autophagy inducer 3
CAS :<p>Autophagy Inducer 3 triggers selective cancer cell death via autophagy, sparing healthy cells.</p>Formule :C24H43NO2Couleur et forme :SolidMasse moléculaire :377.6Evogliptin tartrate
CAS :<p>Evogliptin tartrate: Oral DPP-4 inhibitor, may treat atherosclerosis and diabetes.</p>Formule :C23H32F3N3O9Couleur et forme :SolidMasse moléculaire :551.51AC-55649
CAS :<p>AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.</p>Formule :C21H26O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :310.43MDK-6983
CAS :<p>MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.</p>Formule :C22H18Cl2N2O3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :429.3AMDE-1
CAS :<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Formule :C18H8ClF6N3Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :415.72SB02024
CAS :<p>SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.</p>Formule :C16H22F3N3O2Couleur et forme :SolidMasse moléculaire :345.36FAAH-IN-1
CAS :<p>FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.</p>Formule :C20H19ClN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.91GPP78
CAS :<p>GPP78: Strong Nampt inhibitor, IC50 3.0 nM, depletes NAD. Kills SH-SY5Y cells, IC50 3.8 nM via autophagy. Anti-cancer and anti-inflammatory.</p>Formule :C27H29N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.553HOI-BA-01
CAS :<p>3HOI-BA-01 is a mammalian targeting effective rapamycin activation inhibitor.</p>Formule :C19H15NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :337.33rac-NBI-74330
CAS :<p>rac-NBI-74330 is an effective and selective CXCR3 antagonist.</p>Formule :C32H27F4N5O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :605.58ACT-660602
CAS :<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Formule :C20H20F6N8OSCouleur et forme :SolidMasse moléculaire :534.48DK-1-49
CAS :<p>DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.</p>Formule :C28H31N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.71AMG 487 (S-enantiomer)
CAS :<p>AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.</p>Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59SR12418
CAS :<p>SR12418 is a specific synthetic ligand for REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. inhibits IL-17A expression in EL4 cells.</p>Formule :C31H30FNO3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :483.57VUF10132
CAS :<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Formule :C19H13BrCl4N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.03(R)-Hydroxychloroquine
CAS :<p>(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is an agent of synthetic antimalarial.</p>Formule :C18H26ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.87AC-73
CAS :<p>AC-73, an oral CD147 inhibitor, blocks ERK1/2/STAT3/MMP-2 pathway, reducing liver cancer progression and leukemia cell growth.</p>Formule :C21H21NO2Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :319.4Atg4B-IN-2
CAS :<p>Atg4B-IN-2 is an Atg4B inhibitor with anticancer activity that inhibits Atg4B and PLA2 and resists the anticancer activity of resistant prostate cancer drugs.</p>Formule :C21H30O3Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :330.46GC7 Sulfate
CAS :<p>GC7 Sulfate blocks DHS, the sole enzyme activating eIF5A2, thus preventing eIF5A2 activation.</p>Formule :C8H22N4O4SDegré de pureté :99.85% - >99.99%Couleur et forme :SolidMasse moléculaire :270.35NUCC-390
CAS :<p>NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.</p>Formule :C23H33N5ODegré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :395.54Rosolutamide
CAS :<p>Rosolutamide (ALZ-003) is a curcumin analog, an Nrf1 and Nrf2 activator.</p>Formule :C28H32O6Degré de pureté :95.48% - 99.15%Couleur et forme :SolidMasse moléculaire :464.55Apostatin-1
CAS :<p>Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.</p>Formule :C19H27N3OSDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :345.5CCT020312
CAS :<p>CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB.Cost-effective and quality-assured.</p>Formule :C31H30Br2N4O2Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :650.4CP-312
CAS :<p>CP-312 activates antioxidant defense, induces HMOX1, and shields human iPSC-derived cardiomyocytes from oxidative stress.</p>Formule :C16H12ClN3OS2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :361.87Acetazolamide sodium
CAS :<p>Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA) IX inhibitor used for indications such as epilepsy and altitude sickness.</p>Formule :C4H5N4NaO3S2Degré de pureté :99.71% - 99.87%Couleur et forme :SolidMasse moléculaire :244.23MAPK13-IN-1
CAS :<p>MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).</p>Formule :C20H23N5O2Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :365.43IT1t dihydrochloride
CAS :<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Formule :C21H36Cl2N4S2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :479.57Cysmethynil
CAS :<p>Cysmethynil is an indole-based Icmt inhibitor with antitumor activity, induces cell cycle arrest in G1 phase, and can be used for the study of solid tumors.</p>Formule :C25H32N2ODegré de pureté :99%Couleur et forme :SolidMasse moléculaire :376.53Laduviglusib trihydrochloride
CAS :<p>Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.</p>Formule :C22H20Cl5N8Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :573.71Elubrixin
CAS :<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Formule :C17H17Cl2FN4O4SDegré de pureté :98.65% - 99.78%Couleur et forme :SolidMasse moléculaire :463.31Dactolisib Tosylate
CAS :<p>Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR.</p>Formule :C37H31N5O4SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :641.74XRK3F2
CAS :<p>XRK3F2 inhibits p62-ZZ, counters MM's Runx2 suppression in vitro, and prompts bone growth and remodeling in vivo with tumors.</p>Formule :C23H24ClF2NO3Degré de pureté :98.75% - 98.91%Couleur et forme :SolidMasse moléculaire :435.89Tin-protoporphyrin IX dichloride
CAS :<p>Tin-protoporphyrin IX inhibits HO-1, enhancing chemo efficacy in mouse PDAC.</p>Formule :C34H32Cl2N4O4SnDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :750.26CHIR-99021 HCl
CAS :<p>CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.</p>Formule :C22H19Cl3N8Degré de pureté :98.07% - 98.14%Couleur et forme :SolidMasse moléculaire :501.8Cytarabine hydrochloride
CAS :<p>Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.</p>Formule :C9H14ClN3O5Degré de pureté :98.46%Couleur et forme :White PowderMasse moléculaire :279.68ITX5061
CAS :<p>ITX5061 is a type II inhibitor of p38 MAPK and scavenger receptor B1 (SRB1) antagonist for the study of hepatitis C virus infection.</p>Formule :C30H38ClN3O7SDegré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :620.16LRRK2-IN-7
CAS :<p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.</p>Formule :C24H26N6ODegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :414.5AZD8797
CAS :<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Formule :C19H25N5OS2Degré de pureté :98.73% - 99.68%Couleur et forme :SolidMasse moléculaire :403.56Mavorixafor
CAS :<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Formule :C21H27N5Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :349.47AZD8309
CAS :<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formule :C15H14F2N4O2S2Degré de pureté :98.35% - 99.67%Couleur et forme :SolidMasse moléculaire :384.42FMK 9a
CAS :<p>FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.</p>Formule :C23H21FN2O3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :392.42MTK458
CAS :<p>MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.</p>Formule :C17H15F3N4Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :332.32Cosalane
CAS :<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Formule :C45H60Cl2O6Degré de pureté :99.53% - 99.78%Couleur et forme :SolidMasse moléculaire :767.86DCAP
CAS :<p>DCAP, a broad-spectrum antibiotic, disrupts the membranes of both Gram-positive and Gram-negative bacteria. Additionally, it inhibits late-stage autophagy by blocking autophagolysosome maturation and interrupting autophagic flux [1].</p>Formule :C19H22Cl2N2O4Couleur et forme :SolidMasse moléculaire :413.3XIE62-1004
CAS :<p>XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62.</p>Formule :C23H25NO3·HClCouleur et forme :SolidMasse moléculaire :399.91p38-α MAPK-IN-1
CAS :<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Formule :C27H35N5O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :477.66CEPN
CAS :<p>6CEPN is a Cyclooxygenase-1 inhibitor that acts by suppressing colorectal cancer growth.</p>Formule :C23H18O5Couleur et forme :SolidMasse moléculaire :374.39CXCR4 antagonist 6
CAS :<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Formule :C21H30N6Couleur et forme :SolidMasse moléculaire :366.5Calmidazolium chloride
CAS :<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Formule :C31H23Cl7N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :687.7AEW541 HCl
CAS :<p>AEW541 (CAS# 475489-16-8) is a selective IGF-IR kinase inhibitor (IC50: IGF-IR=0.086μM, InsR=2.3μM), blocking IGF-I effects and colony formation.</p>Formule :C27H31Cl2N5OCouleur et forme :SolidMasse moléculaire :512.47Antitumor agent-82
<p>Antitumor agent-82: potent, anti-proliferative, induces autophagy via ATG5/ATG7.</p>Formule :C32H42N6Couleur et forme :SolidMasse moléculaire :510.72KN-93 Phosphate
CAS :<p>KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase.Cost-effective and quality-assured.</p>Formule :C26H32ClN2O8PSDegré de pureté :99.58% - 99.93%Couleur et forme :SolidMasse moléculaire :599.03RK-682
CAS :<p>RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases).</p>Formule :C21H36O5Couleur et forme :SolidMasse moléculaire :368.51AGN-195183
CAS :<p>AGN 195183: RARα agonist, Kd=3 nM, selective, no RARβ/γ effect, inhibits breast cancer cells, in Phase I/II clinical trials, non-irritant.</p>Formule :C22H22ClF2NO4Couleur et forme :SolidMasse moléculaire :437.86Di-N-desethyl amiodarone hydrochloride
CAS :<p>Di-N-desethyl Amiodarone hydrochloride, a metabolite of Amiodarone, functions as a potent inhibitor of the respiratory chain [1].</p>Formule :C21H22ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.67LY2955303
CAS :<p>LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).</p>Formule :C36H42N4O3Degré de pureté :98.56% - 99.85%Couleur et forme :SolidMasse moléculaire :578.74E6130
CAS :<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06(3R,5R)-Rosuvastatin
CAS :<p>(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Formule :C22H28FN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.544E2RCat
CAS :<p>4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression</p>Formule :C22H14ClNO4S2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :455.93Beclin1-ATG14L interaction inhibitor 1
CAS :<p>Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.</p>Formule :C23H24N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.53INT-767
CAS :<p>INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial function</p>Formule :C25H43NaO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.66CXCR4 antagonist 7
CAS :<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Formule :C15H17N5O3Couleur et forme :SolidMasse moléculaire :315.33Ruxolitinib sulfate
CAS :<p>Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.</p>Formule :C17H20N6O4SCouleur et forme :SolidMasse moléculaire :404.45Gly-β-MCA
CAS :<p>Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.</p>Formule :C26H43NO6Degré de pureté :≥98.0%Couleur et forme :SolidMasse moléculaire :465.62Butylate
CAS :<p>Butylate is a herbicide of thiocarbamate.</p>Formule :C11H23NOSCouleur et forme :Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoistureMasse moléculaire :217.37CXCR2-IN-2
CAS :<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9(R,R)-CXCR2-IN-2
CAS :<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9TIQ-15
CAS :<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Formule :C23H32N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.53p38 MAPK-IN-1
CAS :<p>p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.</p>Formule :C21H14F2N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.35CXCR2 antagonist 3
CAS :<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Formule :C17H15FN2O4SCouleur et forme :SolidMasse moléculaire :362.38(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59BPO-27 racemate
CAS :<p>BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.</p>Formule :C26H18BrN3O6Degré de pureté :97.67% - 98.86%Couleur et forme :SolidMasse moléculaire :548.34Ladarixin Sodium
CAS :<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Formule :C11H12F3NNaO6S2Couleur et forme :SolidMasse moléculaire :398.32SR10067
CAS :<p>SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.</p>Formule :C31H31NO3Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :465.58Acitretin sodium
CAS :<p>Acitretin sodium is a second-generation, systemic retinoid. It is also has been used in the treatment of psoriasis.</p>Formule :C21H26NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.42AGN 194078
CAS :<p>AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).</p>Formule :C22H23F2NO4Couleur et forme :SolidMasse moléculaire :403.42Pentixafor
CAS :<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formule :C60H80N14O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1221.36Cisd2 agonist 1
CAS :<p>Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).</p>Formule :C14H13FN2O3SDegré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :308.33AGN 194310
CAS :<p>AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].</p>Formule :C28H24O2SCouleur et forme :SolidMasse moléculaire :424.55ATG12-ATG3 inhibitor 1
CAS :<p>ATG12-ATG3 Inhibitor 1 (compound 189) serves as a potent inhibitor of autophagy [1].</p>Formule :C18H17NO3SCouleur et forme :SolidMasse moléculaire :327.4EACC
CAS :<p>EACC inhibits Stx17, blocking autophagosome-lysosome fusion, and is a reversible autophagy inhibitor.</p>Formule :C13H11N3O6S2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :369.37NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Formule :C23H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.46SLLN-15
CAS :<p>SLLN-15: oral, potent autophagy enhancer; targets macroautophagy in TNBC.</p>Formule :C19H23N7Se2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.35CXCR2 antagonist 2
CAS :<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Formule :C17H17FN2O4SCouleur et forme :SolidMasse moléculaire :364.39SAFit2
CAS :<p>SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assured</p>Formule :C46H62N2O10Degré de pureté :98.16% - >99.99%Couleur et forme :SolidMasse moléculaire :802.99PHY34
CAS :<p>PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.</p>Formule :C30H30O12Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :582.55AZ PFKFB3 26
CAS :<p>AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.</p>Formule :C24H26N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :402.49CXCR2-IN-1
CAS :<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35GDC-0349
CAS :<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formule :C24H32N6O3Degré de pureté :96.00% - 98.17%Couleur et forme :SolidMasse moléculaire :452.55SW063058
CAS :<p>SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.</p>Formule :C22H15BrFIN2O2Couleur et forme :SolidMasse moléculaire :565.17CXCR7 modulator 2
CAS :<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68SCH 563705
CAS :<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48SORT1-IN-2
CAS :<p>SORT1-IN-2 (compound 6) is an inhibitor of SORT1.</p>Formule :C21H29N3O4Couleur et forme :SolidMasse moléculaire :387.47CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36Autophagy-IN-7
CAS :<p>Autophagy-IN-7 is an autophagy inhibitor for use in studying solid tumours.</p>Formule :C15H11N7Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :289.29ATG12-IN-1
CAS :<p>ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.</p>Formule :C23H15ClN4O2Couleur et forme :SolidMasse moléculaire :414.84CXCR2/CCR7 antagonist-1
CAS :<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Formule :C23H27N3O5Couleur et forme :SolidMasse moléculaire :425.48SHS206
<p>SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).</p>Formule :C14H7F6N3OCouleur et forme :SolidMasse moléculaire :347.22YOK-1304
CAS :<p>YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.</p>Formule :C28H35NO4Couleur et forme :SolidMasse moléculaire :449.58LRRK2-IN-4
CAS :<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99ST-539
CAS :<p>ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.</p>Formule :C30H31N3O4SCouleur et forme :SolidMasse moléculaire :529.65SH498
CAS :<p>SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.</p>Formule :C27H25F3N2O4Couleur et forme :SolidMasse moléculaire :498.49Anle138b-F105
CAS :<p>Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.</p>Formule :C36H37FN4O5Couleur et forme :SolidMasse moléculaire :624.7SYUIQ-5
CAS :<p>SYUIQ-5 is a ligand for G-quadruplex structures. It plays a role in stabilizing G-quadruplexes and inducing senescence. Additionally, SYUIQ-5 inhibits the activity of the c-myc gene promoter. By displacing TRF2 from telomeres, SYUIQ-5 induces telomeric damage, which triggers autophagy (autophagy) in cancer cells.</p>Formule :C20H22N4Couleur et forme :SolidMasse moléculaire :318.415LRRK2-IN-16
CAS :<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12(R)-SCH 546738
CAS :<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.42CXCR7 antagonist-1 hydrochloride
CAS :<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Formule :C21H20ClFN6OCouleur et forme :SolidMasse moléculaire :426.87HDAC10-IN-2
<p>HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.</p>Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Formule :C23H24F2N4O2SCouleur et forme :SolidMasse moléculaire :458.52CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4Autophagy activator-1
CAS :<p>Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.</p>Formule :C25H32O8Couleur et forme :SolidMasse moléculaire :460.517DC-LC3in-D5
CAS :<p>DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.</p>Formule :C19H22Cl2N2O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :397.3LC3B recruiter 1
CAS :<p>LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.</p>Formule :C14H10ClN3O2Couleur et forme :SolidMasse moléculaire :287.701ACT-672125
CAS :<p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>Formule :C25H25F3N10O2SCouleur et forme :SolidMasse moléculaire :586.59CXCR4 antagonist 10
CAS :<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36PARL-IN-1
<p>PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.</p>Formule :C40H58N6O7Couleur et forme :SolidMasse moléculaire :734.92ACT-777991
CAS :<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48LRRK2-IN-2
CAS :<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Formule :C23H23Cl2F3N6O2Couleur et forme :SolidMasse moléculaire :543.37HMG499
CAS :<p>HMG499 inhibits HMG-CoA reductase (IC50: 0.41μM), reduces statin-induced HMGCR, lowers cholesterol, and lessens atherosclerosis.</p>Formule :C33H54O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.78HDAC10-IN-1
<p>HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.</p>Formule :C18H23N3O2Couleur et forme :SolidMasse moléculaire :313.39Stauprimide
CAS :<p>Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.</p>Formule :C35H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.62DQ661
CAS :<p>DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.</p>Formule :C41H47Cl2N5O2Couleur et forme :SolidMasse moléculaire :712.75BRD1991
CAS :<p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55Z-FY-CHO
CAS :<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Formule :C26H26N2O5Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :446.5
