Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
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Dactolisib Tosylate
CAS :<p>Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR.</p>Formule :C37H31N5O4SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :641.74Acetazolamide sodium
CAS :<p>Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA) IX inhibitor used for indications such as epilepsy and altitude sickness.</p>Formule :C4H5N4NaO3S2Degré de pureté :99.71% - 99.87%Couleur et forme :SolidMasse moléculaire :244.23IT1t dihydrochloride
CAS :<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Formule :C21H36Cl2N4S2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :479.57Laduviglusib trihydrochloride
CAS :<p>Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.</p>Formule :C22H20Cl5N8Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :573.71AZD8797
CAS :<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Formule :C19H25N5OS2Degré de pureté :98.73% - 99.68%Couleur et forme :SolidMasse moléculaire :403.56Cysmethynil
CAS :<p>Cysmethynil is an indole-based Icmt inhibitor with antitumor activity, induces cell cycle arrest in G1 phase, and can be used for the study of solid tumors.</p>Formule :C25H32N2ODegré de pureté :99%Couleur et forme :SolidMasse moléculaire :376.53Rosolutamide
CAS :<p>Rosolutamide (ALZ-003) is a curcumin analog, an Nrf1 and Nrf2 activator.</p>Formule :C28H32O6Degré de pureté :95.48% - 99.15%Couleur et forme :SolidMasse moléculaire :464.55MTK458
CAS :<p>MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.</p>Formule :C17H15F3N4Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :332.32XRK3F2
CAS :<p>XRK3F2 inhibits p62-ZZ, counters MM's Runx2 suppression in vitro, and prompts bone growth and remodeling in vivo with tumors.</p>Formule :C23H24ClF2NO3Degré de pureté :98.75% - 98.91%Couleur et forme :SolidMasse moléculaire :435.89AC-73
CAS :<p>AC-73, an oral CD147 inhibitor, blocks ERK1/2/STAT3/MMP-2 pathway, reducing liver cancer progression and leukemia cell growth.</p>Formule :C21H21NO2Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :319.4Tin-protoporphyrin IX dichloride
CAS :<p>Tin-protoporphyrin IX inhibits HO-1, enhancing chemo efficacy in mouse PDAC.</p>Formule :C34H32Cl2N4O4SnDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :750.26CHIR-99021 HCl
CAS :<p>CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.</p>Formule :C22H19Cl3N8Degré de pureté :98.07% - 98.14%Couleur et forme :SolidMasse moléculaire :501.8FMK 9a
CAS :<p>FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.</p>Formule :C23H21FN2O3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :392.42Mavorixafor
CAS :<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Formule :C21H27N5Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :349.47Cytarabine hydrochloride
CAS :<p>Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.</p>Formule :C9H14ClN3O5Degré de pureté :98.46%Couleur et forme :White PowderMasse moléculaire :279.68CP-312
CAS :<p>CP-312 activates antioxidant defense, induces HMOX1, and shields human iPSC-derived cardiomyocytes from oxidative stress.</p>Formule :C16H12ClN3OS2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :361.87Cosalane
CAS :<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Formule :C45H60Cl2O6Degré de pureté :99.53% - 99.78%Couleur et forme :SolidMasse moléculaire :767.86GC7 Sulfate
CAS :<p>GC7 Sulfate blocks DHS, the sole enzyme activating eIF5A2, thus preventing eIF5A2 activation.</p>Formule :C8H22N4O4SDegré de pureté :99.85% - >99.99%Couleur et forme :SolidMasse moléculaire :270.35Elubrixin
CAS :<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Formule :C17H17Cl2FN4O4SDegré de pureté :98.65% - 99.78%Couleur et forme :SolidMasse moléculaire :463.31Apostatin-1
CAS :<p>Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.</p>Formule :C19H27N3OSDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :345.5KN-93 Phosphate
CAS :<p>KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase.Cost-effective and quality-assured.</p>Formule :C26H32ClN2O8PSDegré de pureté :99.58% - 99.93%Couleur et forme :SolidMasse moléculaire :599.03AGN 194078
CAS :<p>AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).</p>Formule :C22H23F2NO4Couleur et forme :SolidMasse moléculaire :403.42INT-767
CAS :<p>INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial function</p>Formule :C25H43NaO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.66CXCR2 antagonist 2
CAS :<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Formule :C17H17FN2O4SCouleur et forme :SolidMasse moléculaire :364.39SR10067
CAS :<p>SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.</p>Formule :C31H31NO3Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :465.58CXCR2-IN-2
CAS :<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9DCAP
CAS :<p>DCAP, a broad-spectrum antibiotic, disrupts the membranes of both Gram-positive and Gram-negative bacteria. Additionally, it inhibits late-stage autophagy by blocking autophagolysosome maturation and interrupting autophagic flux [1].</p>Formule :C19H22Cl2N2O4Couleur et forme :SolidMasse moléculaire :413.3Ladarixin Sodium
CAS :<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Formule :C11H12F3NNaO6S2Couleur et forme :SolidMasse moléculaire :398.32Antitumor agent-82
<p>Antitumor agent-82: potent, anti-proliferative, induces autophagy via ATG5/ATG7.</p>Formule :C32H42N6Couleur et forme :SolidMasse moléculaire :510.72BPO-27 racemate
CAS :<p>BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.</p>Formule :C26H18BrN3O6Degré de pureté :97.67% - 98.86%Couleur et forme :SolidMasse moléculaire :548.34TIQ-15
CAS :<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Formule :C23H32N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.536CEPN
CAS :<p>6CEPN is a Cyclooxygenase-1 inhibitor that acts by suppressing colorectal cancer growth.</p>Formule :C23H18O5Couleur et forme :SolidMasse moléculaire :374.39AEW541 HCl
CAS :<p>AEW541 (CAS# 475489-16-8) is a selective IGF-IR kinase inhibitor (IC50: IGF-IR=0.086μM, InsR=2.3μM), blocking IGF-I effects and colony formation.</p>Formule :C27H31Cl2N5OCouleur et forme :SolidMasse moléculaire :512.47Gly-β-MCA
CAS :<p>Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.</p>Formule :C26H43NO6Degré de pureté :≥98.0%Couleur et forme :SolidMasse moléculaire :465.62(R,R)-CXCR2-IN-2
CAS :<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9(3R,5R)-Rosuvastatin
CAS :<p>(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Formule :C22H28FN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.54Butylate
CAS :<p>Butylate is a herbicide of thiocarbamate.</p>Formule :C11H23NOSCouleur et forme :Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoistureMasse moléculaire :217.37Ruxolitinib sulfate
CAS :<p>Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.</p>Formule :C17H20N6O4SCouleur et forme :SolidMasse moléculaire :404.45LY2955303
CAS :<p>LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).</p>Formule :C36H42N4O3Degré de pureté :98.56% - 99.85%Couleur et forme :SolidMasse moléculaire :578.74CXCR2 antagonist 3
CAS :<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Formule :C17H15FN2O4SCouleur et forme :SolidMasse moléculaire :362.38CXCR4 antagonist 6
CAS :<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Formule :C21H30N6Couleur et forme :SolidMasse moléculaire :366.5AGN-195183
CAS :<p>AGN 195183: RARα agonist, Kd=3 nM, selective, no RARβ/γ effect, inhibits breast cancer cells, in Phase I/II clinical trials, non-irritant.</p>Formule :C22H22ClF2NO4Couleur et forme :SolidMasse moléculaire :437.86XIE62-1004
CAS :<p>XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62.</p>Formule :C23H25NO3·HClCouleur et forme :SolidMasse moléculaire :399.91p38-α MAPK-IN-1
CAS :<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Formule :C27H35N5O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :477.6Acitretin sodium
CAS :<p>Acitretin sodium is a second-generation, systemic retinoid. It is also has been used in the treatment of psoriasis.</p>Formule :C21H26NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.42SLLN-15
CAS :<p>SLLN-15: oral, potent autophagy enhancer; targets macroautophagy in TNBC.</p>Formule :C19H23N7Se2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.35p38 MAPK-IN-1
CAS :<p>p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.</p>Formule :C21H14F2N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.35Cisd2 agonist 1
CAS :<p>Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).</p>Formule :C14H13FN2O3SDegré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :308.33ATG12-ATG3 inhibitor 1
CAS :<p>ATG12-ATG3 Inhibitor 1 (compound 189) serves as a potent inhibitor of autophagy [1].</p>Formule :C18H17NO3SCouleur et forme :SolidMasse moléculaire :327.4Calmidazolium chloride
CAS :<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Formule :C31H23Cl7N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :687.7
