Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
E6130
CAS :<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06Beclin1-ATG14L interaction inhibitor 1
CAS :<p>Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.</p>Formule :C23H24N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.53CXCR4 antagonist 7
CAS :<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Formule :C15H17N5O3Couleur et forme :SolidMasse moléculaire :315.33Di-N-desethyl amiodarone hydrochloride
CAS :<p>Di-N-desethyl Amiodarone hydrochloride, a metabolite of Amiodarone, functions as a potent inhibitor of the respiratory chain [1].</p>Formule :C21H22ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.67EACC
CAS :<p>EACC inhibits Stx17, blocking autophagosome-lysosome fusion, and is a reversible autophagy inhibitor.</p>Formule :C13H11N3O6S2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :369.37AGN 194310
CAS :<p>AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].</p>Formule :C28H24O2SCouleur et forme :SolidMasse moléculaire :424.55NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Formule :C23H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.46RK-682
CAS :<p>RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases).</p>Formule :C21H36O5Couleur et forme :SolidMasse moléculaire :368.51(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59Pentixafor
CAS :<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formule :C60H80N14O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1221.364E2RCat
CAS :<p>4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression</p>Formule :C22H14ClNO4S2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :455.93SAFit2
CAS :<p>SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assured</p>Formule :C46H62N2O10Degré de pureté :98.16% - >99.99%Couleur et forme :SolidMasse moléculaire :802.99AZ PFKFB3 26
CAS :<p>AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.</p>Formule :C24H26N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :402.49PHY34
CAS :<p>PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.</p>Formule :C30H30O12Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :582.55CXCR2-IN-1
CAS :<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35GDC-0349
CAS :<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formule :C24H32N6O3Degré de pureté :96.00% - 98.17%Couleur et forme :SolidMasse moléculaire :452.55SORT1-IN-2
CAS :<p>SORT1-IN-2 (compound 6) is an inhibitor of SORT1.</p>Formule :C21H29N3O4Couleur et forme :SolidMasse moléculaire :387.47Z-FY-CHO
CAS :<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Formule :C26H26N2O5Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :446.5SW063058
CAS :<p>SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.</p>Formule :C22H15BrFIN2O2Couleur et forme :SolidMasse moléculaire :565.17LRRK2-IN-5
<p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>Formule :C24H26F2N4O2SCouleur et forme :SolidMasse moléculaire :472.55Acetylpepstatin
CAS :<p>Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.</p>Formule :C33H61N5O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :703.875SCH-900875
CAS :<p>SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).</p>Formule :C28H37ClN8O2Couleur et forme :SolidMasse moléculaire :553.10LRRK2-IN-3
CAS :<p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99EMU-116
CAS :<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formule :C25H35N5Couleur et forme :SolidMasse moléculaire :405.58SLW131
CAS :<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535Autophagy-lysosome activator-1
<p>Autophagy-lysosome Activator-1 (Compound F1) is an autophagy-lysosome stimulator that effectively induces the degradation of PD-L1 or VISTA in tumor cells.</p>Formule :C17H18N4O2Couleur et forme :SolidMasse moléculaire :310.35BRD5631
CAS :<p>BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.</p>Formule :C30H35N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.62Rosiglitazone sodium
CAS :<p>Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.</p>Formule :C18H18N3NaO3SCouleur et forme :SolidMasse moléculaire :379.41CXCR7 modulator 2
CAS :<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68CXCR4 modulator-1
CAS :<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49HDAC10-IN-2
<p>HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.</p>Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39SHS206
<p>SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).</p>Formule :C14H7F6N3OCouleur et forme :SolidMasse moléculaire :347.22ST-539
CAS :<p>ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.</p>Formule :C30H31N3O4SCouleur et forme :SolidMasse moléculaire :529.65CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36Autophagy-IN-7
CAS :<p>Autophagy-IN-7 is an autophagy inhibitor for use in studying solid tumours.</p>Formule :C15H11N7Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :289.29CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4HMG499
CAS :<p>HMG499 inhibits HMG-CoA reductase (IC50: 0.41μM), reduces statin-induced HMGCR, lowers cholesterol, and lessens atherosclerosis.</p>Formule :C33H54O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.78(R)-SCH 546738
CAS :<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.42SYUIQ-5
CAS :<p>SYUIQ-5 is a ligand for G-quadruplex structures. It plays a role in stabilizing G-quadruplexes and inducing senescence. Additionally, SYUIQ-5 inhibits the activity of the c-myc gene promoter. By displacing TRF2 from telomeres, SYUIQ-5 induces telomeric damage, which triggers autophagy (autophagy) in cancer cells.</p>Formule :C20H22N4Couleur et forme :SolidMasse moléculaire :318.415CXCR4 antagonist 10
CAS :<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36Anle138b-F105
CAS :<p>Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.</p>Formule :C36H37FN4O5Couleur et forme :SolidMasse moléculaire :624.7SH498
CAS :<p>SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.</p>Formule :C27H25F3N2O4Couleur et forme :SolidMasse moléculaire :498.49ATG12-IN-1
CAS :<p>ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.</p>Formule :C23H15ClN4O2Couleur et forme :SolidMasse moléculaire :414.84QW24
CAS :<p>QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer.</p>Formule :C27H28N2O4Couleur et forme :SolidMasse moléculaire :444.52BRD1991
CAS :<p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55DQ661
CAS :<p>DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.</p>Formule :C41H47Cl2N5O2Couleur et forme :SolidMasse moléculaire :712.75CXCR7 antagonist-1 hydrochloride
CAS :<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Formule :C21H20ClFN6OCouleur et forme :SolidMasse moléculaire :426.87Stauprimide
CAS :<p>Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.</p>Formule :C35H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.62CCX662
CAS :<p>CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.</p>Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69
