Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1424 produits trouvés pour "Autophagie"
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FDW028
CAS :<p>FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.</p>Formule :C22H24N6ODegré de pureté :98.73% - 99.55%Couleur et forme :SoildMasse moléculaire :388.47cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Formule :C31H51ClN7O14PSCouleur et forme :SolidMasse moléculaire :844.27Peptide R
CAS :<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formule :C39H59N13O8S2Couleur et forme :SolidMasse moléculaire :902.1Flavopiridol
CAS :<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Formule :C21H20ClNO5Degré de pureté :97.74% - 99.86%Couleur et forme :SolidMasse moléculaire :401.84STO-609 acetate
CAS :<p>STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the</p>Formule :C19H10N2O3·C2H4O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :374.35Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formule :C115H145ClN18O31S2Zn2Couleur et forme :SolidMasse moléculaire :2505.83Cy5.5-SE (DIPEA)
<p>Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.</p>Formule :C53H66N4O16S4Couleur et forme :SolidMasse moléculaire :1143.37Corydalmine hydrochloride
CAS :<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Formule :C20H24ClNO4Couleur et forme :SolidMasse moléculaire :377.86Fe-TMPyP
CAS :<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Formule :C44H36Cl5FeN8Couleur et forme :SolidMasse moléculaire :909.92Insecticidal agent 364
CAS :<p>Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.</p>Formule :C23H18N4O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :430.48Manzamine A hydrochloride
CAS :<p>Manzamine A hydrochloride: oral beta-carboline inhibiting GSK-3β & CDK-5; blocks autophagy in cancer; antimalarial; fights HSV-1.</p>Formule :C36H45ClN4OCouleur et forme :SolidMasse moléculaire :585.23CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>Biotin-11-dCTP
<p>Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .</p>Formule :C28H43Li3N7O16P3SCouleur et forme :SolidMasse moléculaire :879.49MRT 67307 dihydrochloride
CAS :<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formule :C26H38Cl2N6O2Degré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :537.53(S)-Sitagliptin phosphate
CAS :<p>(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.</p>Formule :C16H18F6N5O5PCouleur et forme :SolidMasse moléculaire :505.314Autophagy/REV-ERB-IN-1
<p>Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.</p>Formule :C24H30F2N2Masse moléculaire :384.23771Clionamine B
CAS :<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Formule :C27H45NO3Couleur et forme :SolidMasse moléculaire :431.65Tigecycline mesylate
CAS :<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formule :C30H43N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.75Hoechst 33342 analog trihydrochloride
CAS :<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Formule :C32H38Cl3N7Couleur et forme :SolidMasse moléculaire :627.05Erlotinib-13C6
CAS :<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Formule :C22H23N3O4Couleur et forme :SolidMasse moléculaire :399.397D-CopA3
CAS :<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formule :C96H184N30O18S2Couleur et forme :SolidMasse moléculaire :2110.81Desethylamiodarone hydrochloride
CAS :<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formule :C23H26ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formule :C27H31IN2O3Couleur et forme :SolidMasse moléculaire :558.45Autocamtide 2, amide
<p>Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.</p>Formule :C65H119N23O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1526.79p62-ZZ Ligand-Linker Conjugate 1
CAS :<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Formule :C31H42N2O6Couleur et forme :SolidMasse moléculaire :538.68Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Formule :C43H52N6O19P3Couleur et forme :SolidMasse moléculaire :1049.82Acridine homodimer
CAS :<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Formule :C38H42Cl2N6O2Couleur et forme :SolidMasse moléculaire :685.69AZD4721
CAS :<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55PHTPP-1304
CAS :<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formule :C51H50F6N4O7Couleur et forme :SolidMasse moléculaire :944.96Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Formule :C40H47N3O8S2Couleur et forme :SolidMasse moléculaire :761.95Nictide
CAS :<p>Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.</p>Formule :C123H193N45O28Couleur et forme :SolidMasse moléculaire :2750.13Tigecycline hydrochloride
CAS :<p>Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formule :C29H40ClN5O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :622.11Valproic acid sodium salt
CAS :<p>Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.</p>Formule :C8H15NaO2Degré de pureté :98.43% - 99.78%Couleur et forme :White PowderMasse moléculaire :166.2RK-682 (calcium salt)
CAS :<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Formule :C42H74CaO10Couleur et forme :SolidMasse moléculaire :779.122Desethyl chloroquine
CAS :<p>Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.</p>Formule :C16H22ClN3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :291.82TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Formule :C32H55N3O10SCouleur et forme :SolidMasse moléculaire :673.86NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formule :C56H68ClN9O5S2Couleur et forme :SolidMasse moléculaire :1046.78CX4338
CAS :<p>CX4338 is a CXCL8-mediated chemotaxis inhibitor.</p>Formule :C22H24N2OSCouleur et forme :SolidMasse moléculaire :364.50CXCR4 antagonist 1
CAS :<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69BRD4 degrader-5
<p>BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM). It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.</p>Formule :C35H42ClN7O2SCouleur et forme :SolidMasse moléculaire :660.27DMTr-4'-CF3-5-Me-U-CED phosphoramidite
<p>DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.</p>Formule :C42H50F3N4O8PCouleur et forme :SolidMasse moléculaire :826.84SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Formule :C34H32FeO6Couleur et forme :SolidMasse moléculaire :592.46MeCY5-NHS ester triethylamine
<p>MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].</p>Formule :C42H56N4O10S2Couleur et forme :SolidMasse moléculaire :841.04(3R,5S)-Fluvastatin
CAS :<p>(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.</p>Formule :C24H26FNO4Couleur et forme :SolidMasse moléculaire :411.47KRH-3955 hydrochloride
CAS :<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Formule :C28H48Cl3N7Couleur et forme :SolidMasse moléculaire :589.09MW-150 hydrochloride
CAS :<p>MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.</p>Formule :C24H24ClN5Couleur et forme :SolidMasse moléculaire :417.93Chlorotris(triphenylphosphine)copper
CAS :<p>Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.</p>Formule :C54H45ClCuP3Couleur et forme :SolidMasse moléculaire :885.86Hexidium iodide
CAS :<p>Hexidium iodide fluoresces, stains mammalian cells & gram-positive bacteria, and binds to DNA with EDTA. Excitation/emission: ~518/600 nm.</p>Formule :C25H28IN3Couleur et forme :SolidMasse moléculaire :497.424Desfluoro-ezetimibe
CAS :<p>Desfluoro-ezetimibe: a defluorinated ezetimibe impurity; a stable, potent cholesterol blocker and Nrf2 activator.</p>Formule :C24H22FNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.43Cytochalasin E
CAS :<p>Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.</p>Formule :C28H33NO7Degré de pureté :98%Couleur et forme :Crystals From Acetone-Hexane White PowderMasse moléculaire :495.56
