Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
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SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Formule :C34H32FeO6Couleur et forme :SolidMasse moléculaire :592.46NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formule :C56H68ClN9O5S2Couleur et forme :SolidMasse moléculaire :1046.78Acridine homodimer
CAS :<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Formule :C38H42Cl2N6O2Couleur et forme :SolidMasse moléculaire :685.69Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formule :C115H145ClN18O31S2Zn2Couleur et forme :SolidMasse moléculaire :2505.83XL01126
<p>XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.</p>Formule :C50H64ClFN10O6S2Couleur et forme :SolidMasse moléculaire :1019.69p62-ZZ Ligand-Linker Conjugate 1
CAS :<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Formule :C31H42N2O6Couleur et forme :SolidMasse moléculaire :538.68Polyphemusin II-Derived Peptide
CAS :<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42Cisatracurium besylate
CAS :<p>Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration.</p>Formule :C53H72N2O12·2C6H5O3SDegré de pureté :97.89% - 99.85%Couleur et forme :White Or White Powder CategoryMasse moléculaire :1243.48TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Formule :C32H55N3O10SCouleur et forme :SolidMasse moléculaire :673.86RK-682 (calcium salt)
CAS :<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Formule :C42H74CaO10Couleur et forme :SolidMasse moléculaire :779.122Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Formule :C43H52N6O19P3Couleur et forme :SolidMasse moléculaire :1049.82AZD4721
CAS :<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formule :C27H31IN2O3Couleur et forme :SolidMasse moléculaire :558.45Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Formule :C40H47N3O8S2Couleur et forme :SolidMasse moléculaire :761.95Microcolin H
CAS :<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Formule :C38H63N5O9Couleur et forme :SolidMasse moléculaire :733.93Cy3-dCTP
<p>Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.</p>Formule :C43H51Li4N6O20P3S2Couleur et forme :SolidMasse moléculaire :1156.71MRT67307
CAS :<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formule :C26H36N6O2Degré de pureté :99.25% - 99.84%Couleur et forme :SolidMasse moléculaire :464.6DMTr-4'-CF3-5-Me-U-CED phosphoramidite
<p>DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.</p>Formule :C42H50F3N4O8PCouleur et forme :SolidMasse moléculaire :826.84PI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Couleur et forme :Odour SolidCXCR4 antagonist 1
CAS :<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69(3R,5S)-Fluvastatin
CAS :<p>(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.</p>Formule :C24H26FNO4Couleur et forme :SolidMasse moléculaire :411.47KRH-3955 hydrochloride
CAS :<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Formule :C28H48Cl3N7Couleur et forme :SolidMasse moléculaire :589.09MW-150 hydrochloride
CAS :<p>MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.</p>Formule :C24H24ClN5Couleur et forme :SolidMasse moléculaire :417.93Chlorotris(triphenylphosphine)copper
CAS :<p>Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.</p>Formule :C54H45ClCuP3Couleur et forme :SolidMasse moléculaire :885.86MeCY5-NHS ester triethylamine
<p>MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].</p>Formule :C42H56N4O10S2Couleur et forme :SolidMasse moléculaire :841.04Desethylamiodarone hydrochloride
CAS :<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formule :C23H26ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.72EB-42486
CAS :<p>EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.</p>Formule :C22H22N8ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :414.46Rapalink-1
CAS :<p>Rapalink-1 is an mTOR inhibitor that inhibits the mTORC1-4E-BP1 pathway in mice.</p>Formule :C91H138N12O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1784.14LY2510924
CAS :<p>LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).</p>Formule :C62H88N14O10Couleur et forme :SolidMasse moléculaire :1189.45Erlotinib-d6 hydrochloride
CAS :<p>Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.</p>Formule :C22H24ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.93Silibinin-d3
<p>Silibinin-d3 is the deuterium-labelled compound of silibinin, used for isotope tracing. Silibinin inhibit cancer cell proliferation and migration.</p>Formule :C25H22O10Couleur et forme :SolidMasse moléculaire :485.46Ponatinib-d8
CAS :<p>Ponatinib D8 is a deuterium-enriched, oral multi-kinase inhibitor (Abl, PDGFRα, VEGFR2, FGFR1, Src; IC50s: 0.37-5.4 nM).</p>Formule :C29H27F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.61ACT-1004-1239
CAS :<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Formule :C27H28F2N6O3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :522.55ATI-2341
CAS :<p>ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.</p>Formule :C104H178N26O25S2Couleur et forme :SolidMasse moléculaire :2256.82Levomepromazine
CAS :<p>Levomepromazine (Methotrimeprazine) is a Ca2+ release inducer with antiviral, anti-inflammatory, neuroprotective, sedative, and anti-nociceptive activities.</p>Formule :C19H24N2OSDegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :328.47CXCR2 antagonist 8
CAS :<p>CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.</p>Formule :C14H13N3O5Couleur et forme :SolidMasse moléculaire :303.27Motixafortide
CAS :<p>Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).</p>Formule :C97H144FN33O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2159.52Regorafenib-d3
CAS :<p>Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.</p>Formule :C21H15ClF4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.83Anti-LRRK2 Antibody (1C773)
<p>Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.</p>Couleur et forme :Odour LiquidGefitinib-d8
CAS :<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.</p>Formule :C22H24ClFN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.95Metformin-d6 hydrochloride
CAS :<p>Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.</p>Formule :C4H12ClN5Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :171.66Tetrahydrocurcumin D6
CAS :<p>Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4.</p>Formule :C21H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.45Manzamine A
CAS :<p>Manzamine A, from marine sponges, blocks GSK-3, halts cancer growth, prevents bacterial infections, and reduces tau phosphorylation.</p>Formule :C36H44N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.775PS372424 hydrochloride
CAS :<p>PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.</p>Formule :C33H45ClN6O4Degré de pureté :95.03%Couleur et forme :SolidMasse moléculaire :625.2Idelalisib D5
CAS :<p>Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.</p>Formule :C22H18FN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.45Ladarixin
CAS :<p>Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis.</p>Formule :C11H12F3NO6S2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :375.34Isoniazid-d4
CAS :<p>Isoniazid-d4 is a deuterium isotope marker for Isoniazid.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal.</p>Formule :C6H3D4N3OCouleur et forme :SolidMasse moléculaire :141.16Curcumin-d6
CAS :<p>Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a</p>Formule :C21H20O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.422Loperamide-d6 hydrochloride
CAS :<p>Loperamide D6 HCl: Deuterium-enriched opioid for diarrhea.</p>Formule :C29H34Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.54THZ-P1-2
CAS :<p>THZ-P1-2 is a PI5P4K inhibitor with anti-leukemic activity and can be used in the study of leukemia.</p>Formule :C31H29N7O2Couleur et forme :SolidMasse moléculaire :531.61
