Aurora Kinase
Les inhibiteurs des kinases Aurora ciblent les kinases Aurora, une famille de kinases sérine/thréonine qui jouent un rôle crucial dans la régulation de la mitose. Ces kinases sont essentielles pour l'alignement correct des chromosomes, leur ségrégation et la cytokinèse pendant la division cellulaire. Une activité anormale des kinases Aurora peut entraîner une prolifération cellulaire incontrôlée et le cancer. En inhibant les kinases Aurora, ces composés peuvent induire un arrêt du cycle cellulaire et l'apoptose dans les cellules cancéreuses, ce qui en fait des outils précieux pour la recherche et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de kinases Aurora de haute qualité pour soutenir vos recherches sur la régulation du cycle cellulaire, la mitose et l'oncologie.
112 produits trouvés pour "Aurora Kinase"
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Aurora kinase inhibitor-3
CAS :Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formule :C21H18F3N5ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :413.4Ref: TM-T5524
1mg70,00€2mg95,00€5mg160,00€10mg250,00€25mg424,00€50mg612,00€100mg842,00€200mg1.159,00€1mL*10mM (DMSO)170,00€URMC-099
CAS :URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formule :C27H27N5Degré de pureté :99.32% - 99.98%Couleur et forme :SolidMasse moléculaire :421.54MLN8054 sodium
CAS :MLN8054 sodium is an Aurora A inhibitor.Formule :C25H14ClF2N4NaO2Couleur et forme :SolidMasse moléculaire :498.84Danusertib
CAS :<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formule :C26H30N6O3Degré de pureté :97.88% - 98.79%Couleur et forme :White PowderMasse moléculaire :474.55KW-2449
CAS :KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formule :C20H20N4ODegré de pureté :98.43% - 99.69%Couleur et forme :SolidMasse moléculaire :332.4JNJ-7706621
CAS :<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Formule :C15H12F2N6O3SDegré de pureté :99.1% - 99.85%Couleur et forme :SolidMasse moléculaire :394.36Palmatine chloride
CAS :Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formule :C21H22ClNO4Degré de pureté :97.9% - 99.47%Couleur et forme :SolidMasse moléculaire :387.86Palmatine
CAS :Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.Formule :C21H22NO4Degré de pureté :96.28% - 99.49%Couleur et forme :SolidMasse moléculaire :352.4XL228
CAS :XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formule :C22H31N9ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :437.54Ref: TM-T17267
1mg56,00€2mg78,00€5mg99,00€10mg149,00€25mg258,00€50mg393,00€100mg582,00€1mL*10mM (DMSO)110,00€Tozasertib
CAS :Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formule :C23H28N8OSDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :464.59PHA-680632
CAS :<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Formule :C28H35N7O2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :501.62GW779439X
CAS :GW779439X is an inhibitor of CDK.Formule :C22H21F3N8Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :454.45Ref: TM-T8866
1mg62,00€2mg87,00€5mg119,00€10mg188,00€25mg425,00€50mg625,00€100mg892,00€1mL*10mM (DMSO)131,00€AMG 900
CAS :AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Formule :C28H21N7OSDegré de pureté :98.4% - 99.51%Couleur et forme :SolidMasse moléculaire :503.58Ref: TM-T6380
1mg52,00€5mg97,00€10mg166,00€25mg303,00€50mg467,00€100mg682,00€500mg1.415,00€1mL*10mM (DMSO)105,00€CCT241736
CAS :CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Formule :C22H23Cl2N7Degré de pureté :96.2% - 99.81%Couleur et forme :SolidMasse moléculaire :456.37ENMD-2076
CAS :ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formule :C21H25N7Degré de pureté :97.63% - ≥95%Couleur et forme :SolidMasse moléculaire :375.47Barasertib-HQPA
CAS :<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Formule :C26H30FN7O3Degré de pureté :98.43% - 99.29%Couleur et forme :SolidMasse moléculaire :507.56SCH-1473759 hydrochloride
CAS :SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Formule :C20H27ClN8OSDegré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :463MK-5108
CAS :MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formule :C22H21ClFN3O3SDegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :461.94TAK-285
CAS :TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formule :C26H25ClF3N5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :547.96Ref: TM-T6039
1mg38,00€5mg80,00€10mg120,00€25mg216,00€50mg354,00€100mg512,00€200mg727,00€1mL*10mM (DMSO)96,00€GW843682X
CAS :GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Formule :C22H18F3N3O4SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :477.46BI-831266
CAS :BI-831266 is a potent and selective Aurora kinase B inhibitor.Formule :C27H38ClN7O2Couleur et forme :SolidMasse moléculaire :528.09RET-IN-19
CAS :RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Formule :C28H28N6O4SCouleur et forme :SolidMasse moléculaire :544.62Aurora Kinases-IN-2
CAS :Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Formule :C22H18ClN5O3Couleur et forme :SolidMasse moléculaire :435.86L 888607 Racemate
CAS :L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Formule :C19H15ClFNO2SCouleur et forme :SolidMasse moléculaire :375.84Ilorasertib hydrochloride
CAS :Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formule :C25H22ClFN6O2SDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :525SAR156497
CAS :SAR156497: selective Aurora A/B/C inhibitor; IC50: 0.5 nM (A), 1 nM (B), 3 nM (C); good metabolic stability; anti-tumoral without genetic specificity.Formule :C27H24N4O4Couleur et forme :SolidMasse moléculaire :468.5HOI-07
CAS :HOI-07 is a specific Aurora B inhibitor.Formule :C19H13NO4Couleur et forme :SolidMasse moléculaire :319.31OM-137
CAS :OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formule :C13H14N4O3SCouleur et forme :SolidMasse moléculaire :306.34Binucleine 2
CAS :Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Formule :C13H11ClFN5Couleur et forme :SolidMasse moléculaire :291.71Aurora Kinases-IN-3
CAS :Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formule :C20H16F3N3O4Couleur et forme :SolidMasse moléculaire :419.35VE-465
CAS :VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formule :C22H28N8OSCouleur et forme :SolidMasse moléculaire :452.58FAK/aurora kinase-IN-1
CAS :FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Formule :C23H24ClN7O3Couleur et forme :SolidMasse moléculaire :481.93Aurora A/PKC-IN-1
CAS :Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Formule :C16H14N6OSe2Couleur et forme :SolidMasse moléculaire :464.24Aurora kinase inhibitor-10
CAS :Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Formule :C21H19F5N6O4SCouleur et forme :SolidMasse moléculaire :546.47Aurora kinase inhibitor-9
CAS :Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.Formule :C19H17Cl2N3O4SCouleur et forme :SolidMasse moléculaire :454.33Tripolin A
CAS :<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Formule :C15H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.25Chiauranib
CAS :<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47CD532
CAS :CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formule :C26H25F3N8ODegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :522.52GRK6-IN-1
CAS :GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Formule :C22H23ClN6O2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :438.91Ref: TM-T62518
1mg57,00€5mg120,00€10mg188,00€25mg432,00€50mg747,00€100mg1.216,00€1mL*10mM (DMSO)133,00€AAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T10215
1mg57,00€5mg125,00€10mg182,00€25mg329,00€50mg495,00€100mg718,00€1mL*10mM (DMSO)138,00€TC-A 2317 hydrochloride
CAS :TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93GW814408X
CAS :GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formule :C19H16N6OMasse moléculaire :344.37Aurora kinase inhibitor-8
CAS :Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formule :C30H29N7O3Couleur et forme :SolidMasse moléculaire :535.6GSK2646264
CAS :<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formule :C24H26N2O2Couleur et forme :SolidMasse moléculaire :374.48Aurora Kinases-IN-4
CAS :Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formule :C26H28N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55GRK2 Inhibitor 2
CAS :GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.36LY3295668
CAS :LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formule :C24H26ClF2N5O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :489.95CCT129202
CAS :CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formule :C23H25ClN8OSDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :497.02Aurora A inhibitor 4
CAS :Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Formule :C22H23N5O3Masse moléculaire :405.45Tripolin B
CAS :Tripolin B is an ATP-competitive inhibitor of Aurora kinases, with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively. However, it exhibits no inhibitory effect within cells.Formule :C12H9N3OMasse moléculaire :211.22
