Récepteur Sigma
Les récepteurs sigma sont des sites de liaison uniques qui, contrairement aux GPCR classiques, ne correspondent pas aux catégories traditionnelles des protéines réceptrices. Ils sont impliqués dans la modulation des systèmes de neurotransmetteurs et ont été associés à divers troubles neurologiques et psychiatriques. Les récepteurs sigma sont également associés à la survie cellulaire, et leurs ligands sont explorés pour des applications thérapeutiques dans la neuroprotection, le cancer et la gestion de la douleur. Chez CymitQuimica, nous offrons une sélection de modulateurs de récepteurs sigma de haute qualité pour soutenir vos recherches en neurosciences, oncologie et biologie des récepteurs.
46 produits trouvés pour "Récepteur Sigma"
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Roluperidone
CAS :<p>Roluperidone (CYR-101) is a novel cyclic amide derivative.</p>Formule :C22H23FN2O2Degré de pureté :96.46% - 97.77%Couleur et forme :SolidMasse moléculaire :366.43Glycerol phenylbutyrate
CAS :<p>Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).</p>Formule :C33H38O6Degré de pureté :98.54% - 99.74%Couleur et forme :SolidMasse moléculaire :530.65Blonanserin
CAS :<p>Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.</p>Formule :C23H30FN3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.5PD 144418 oxalate
CAS :<p>PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.</p>Formule :C20H24N2O5Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :372.42KB-5492 FA
<p>KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8</p>Formule :C24H32N2O8Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :476.52Sigma-1 receptor antagonist 4
<p>Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced</p>Formule :C22H26N2OCouleur et forme :SolidMasse moléculaire :334.45AB21 HCl
<p>AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.</p>Formule :C23H29ClN2ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :384.2AD186
<p>AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.</p>Formule :C22H28N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :320.47UKH-1114
CAS :<p>UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.</p>Formule :C22H24F3NOCouleur et forme :SolidMasse moléculaire :375.43S1R agonist 2 hydrochloride
<p>Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.</p>Formule :C21H28ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.91AB21 oxalate
<p>AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.</p>Formule :C25H30N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.52σ1 Receptor ligand 1
<p>σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.</p>Formule :C22H28N2O2Couleur et forme :SolidMasse moléculaire :352.47AD353
<p>AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.</p>Formule :C23H30N2O2Couleur et forme :SolidMasse moléculaire :366.5σ1R-IN-1
<p>σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.</p>Formule :C15H22N2Couleur et forme :SolidMasse moléculaire :230.35BD1063 dhydrochloride
CAS :<p>BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).</p>Formule :C13H20Cl4N2Degré de pureté :99.52% - ≥95%Couleur et forme :SolidMasse moléculaire :346.12Siramesine
CAS :<p>Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent</p>Formule :C30H31FN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.58σ1 Receptor antagonist-1
CAS :<p>σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.</p>Formule :C21H23NOSDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :337.48Cutamesine dihydrochloride
CAS :<p>Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.</p>Formule :C23H32N2O2·2HClDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :441.434-IBP
CAS :<p>4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .</p>Formule :C19H21IN2ODegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :420.29EST64454 hydrochloride
CAS :<p>EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.</p>Formule :C18H23ClF2N4O2Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :400.85Siramesine hydrochloride
CAS :<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>Formule :C30H32ClFN2ODegré de pureté :99.72% - >99.99%Couleur et forme :SolidMasse moléculaire :491.04PRE-084 hydrochloride
CAS :<p>PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).</p>Formule :C19H28ClNO3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :353.88BD 1008 dihydrobromide
CAS :<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Formule :C15H24Br2Cl2N2Degré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :463.08Dimemorfan phosphate
CAS :<p>Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.</p>Formule :C18H25N·H3O4PDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :353.4Blarcamesine hydrochloride
CAS :<p>Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).</p>Formule :C19H24ClNODegré de pureté :99.57% - 99.9%Couleur et forme :SolidMasse moléculaire :317.85BD-1047 dihydrobromide
CAS :<p>BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy</p>Formule :C13H22Br2Cl2N2Degré de pureté :98.13% - 99.39%Couleur et forme :SolidMasse moléculaire :437.04Blarcamesine
CAS :<p>Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.</p>Formule :C19H23NODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :281.39Ditolylguanidine
CAS :<p>Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).</p>Formule :C15H17N3Degré de pureté :98.42%Couleur et forme :White To Pinkish Solid PowderMasse moléculaire :239.32S1RA hydrochloride
CAS :<p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki ></p>Formule :C20H24ClN3O2Degré de pureté :98% - 99.84%Couleur et forme :SolidMasse moléculaire :373.87KB-5492 free base
CAS :<p>KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.</p>Formule :C23H30N2O6Degré de pureté :97.10% - 97.94%Couleur et forme :SolidMasse moléculaire :430.49Opipramol
CAS :<p>Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.</p>Formule :C23H29N3ODegré de pureté :99.84% - 99.98%Couleur et forme :SolidMasse moléculaire :363.5S1RA
CAS :<p>S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2</p>Formule :C20H23N3O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :337.42PD 144418
CAS :<p>PD 144418 displays potential antipsychotic activity.</p>Formule :C18H22N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.38Sigma-LIGAND-1
CAS :<p>Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.</p>Formule :C27H33NO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :435.56DuP 734
CAS :<p>DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].</p>Formule :C17H23BrFNOCouleur et forme :SolidMasse moléculaire :356.279NE-100 hydrochloride
CAS :<p>NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.</p>Formule :C23H34ClNO2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :391.98Sigma-1 receptor antagonist 3
CAS :<p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>Formule :C19H23ClFN3ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :363.86WLB-89462
CAS :<p>WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-</p>Formule :C21H29N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.49Sigma-1 receptor antagonist 2
CAS :<p>Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).</p>Formule :C20H26ClN3O2Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :375.89S1R agonist 1 hydrochloride
CAS :<p>S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated</p>Formule :C20H26ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.88Sigma-1 receptor antagonist 1
CAS :<p>Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.</p>Formule :C19H23Cl2N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :380.31BD-1047
CAS :<p>BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.</p>Formule :C13H20Cl2N2Couleur et forme :SolidMasse moléculaire :275.217UMB24
CAS :<p>UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.</p>Formule :C17H21N3Couleur et forme :SolidMasse moléculaire :267.37Sigma-2 Radioligand 2
CAS :<p>Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).</p>Formule :C23H28FN3O3Couleur et forme :SolidMasse moléculaire :413.49Sigma-1 receptor antagonist 6
CAS :<p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>Formule :C32H34N6Couleur et forme :SolidMasse moléculaire :502.65Opipramol dihydrochloride
CAS :<p>Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).</p>Formule :C23H31Cl2N3OCouleur et forme :SolidMasse moléculaire :436.418
