CaSR
Le récepteur sensible au calcium (CaSR) est un GPCR qui joue un rôle essentiel dans le maintien de l'homéostasie du calcium en régulant la sécrétion de l'hormone parathyroïdienne et la réabsorption du calcium dans les reins. Le CaSR est également impliqué dans divers autres processus physiologiques, y compris le métabolisme osseux et la fonction vasculaire. Les modulateurs du CaSR sont utilisés dans le traitement de conditions telles que l'hyperparathyroïdie, l'ostéoporose et les maladies cardiovasculaires. Chez CymitQuimica, nous offrons une sélection de modulateurs de CaSR de haute qualité pour soutenir vos recherches sur le métabolisme du calcium, l'endocrinologie et la santé osseuse.
32 produits trouvés pour "CaSR"
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AC265347
CAS :<p>AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity for the study of neuroblastoma.</p>Formule :C17H17NOSDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :283.39Strontium ranelate
CAS :<p>Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis and can slow the course of osteoarthritis of the knee.</p>Formule :C12H6N2O8S·2SrDegré de pureté :98.97%Couleur et forme :Crystalline SolidMasse moléculaire :513.49Evocalcet
CAS :<p>Evocalcet (KHK7580) has an activating effect on the calcium-sensing receptor (CaSR).</p>Formule :C24H26N2O2Degré de pureté :98.88% - 99.68%Couleur et forme :SolidMasse moléculaire :374.48G-Glu-Val
CAS :<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Formule :C10H18N2O5Couleur et forme :SolidMasse moléculaire :246.26Upacicalcet HCl
<p>Upacicalcet HCl, a calcium mimetic, reduces blood PTH by targeting parathyroid receptors; treats secondary hyperparathyroidism.</p>Formule :C11H15Cl2N3O6SDegré de pureté :98.56%Couleur et forme :SoildMasse moléculaire :388.22Etelcalcetide
CAS :<p>Etelcalcetide (AMG 416), a synthetic peptide CaSR activator, treats secondary hyperparathyroidism in hemodialysis patients.</p>Formule :C38H73N21O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1048.26Poly-D-lysine hydrobromide (MW 150000-300000)
<p>Poly-D-lysine hydrobromide (MW 150000-300000) enhances neural cell adhesion in culture and acts as a calcium-sensing receptor agonist peptide in research.</p>Couleur et forme :Odour Solidγ-Glu-Abu TFA
<p>Gamma-Glu-AbuTFA is the TFA salt form of Gamma-Glu-Abu. This compound acts as an agonist for the calcium sensing receptor (CaSR), activating CaSR in HEK-293 cells with an EC50 of 0.21 μM.</p>Formule :C11H17F3N2O7Couleur et forme :SolidMasse moléculaire :346.26Poly-D-lysine hydrobromide (MW 1000-5000)
<p>Poly-D-lysine hydrobromide (PDLHB) (MW 1000-5000) is a synthetically produced polymeric substrate widely used in neural cell culture. Additionally, Poly-D-lysine hydrobromide acts as a CaSR agonist peptide.</p>Couleur et forme :Odour SolidCalcium-Sensing Receptor Antagonists I
CAS :<p>Calcium-Sensing Receptor Antagonists I functions as an antagonist to the parathyroid hormone receptors that sense calcium.</p>Formule :C23H24N2O2Couleur et forme :SolidMasse moléculaire :360.45NPS-2143 hydrochloride
CAS :<p>NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.</p>Formule :C24H25ClN2O2·HClDegré de pureté :99.38% - 99.67%Couleur et forme :SolidMasse moléculaire :445.38Etelcalcetide hydrochloride
CAS :<p>Etelcalcetide HCl, a synthetic peptide modulator of CaSR, lowers PTH in dialysis patients with secondary hyperparathyroidism.</p>Formule :C38H73N21O10S2HClDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1353.33NPS2390
CAS :<p>NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)</p>Formule :C19H21N3ODegré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :307.39Cinacalcet
CAS :<p>Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .</p>Formule :C22H22F3NDegré de pureté :99.48%Couleur et forme :Yellow OilMasse moléculaire :357.41TNCA
CAS :<p>TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.</p>Formule :C12H12N2O2Degré de pureté :97.33% - 97.73%Couleur et forme :SolidMasse moléculaire :216.24Cinacalcet hydrochloride
CAS :<p>Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-</p>Formule :C22H23ClF3NDegré de pureté :99.96% - >99.99%Couleur et forme :Off-White To Tan SolidMasse moléculaire :393.87γ-L-Glutamyl-L-alanine
CAS :<p>γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is the substrate of CRF21 (gamma-Glutamylcyclotransferase, GGCT).</p>Formule :C8H14N2O5Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :218.21Ligustroflavone
CAS :<p>Ligustroflavone (Nuezhenoside) has anti-inflammatory activity.</p>Formule :C33H40O18Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :724.66Gadolinium chloride
CAS :<p>Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist</p>Formule :Cl3GdDegré de pureté :98%Couleur et forme :White Crystalline SolidMasse moléculaire :263.61Poly-D-lysine hydrobromide (MW 30000-70000)
CAS :<p>Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is a peptide CaSR agonist that removes proteinase K-resistant PrP from SN56 neuroblastoma cells.</p>Formule :(C6H14N2O2)x·xHBrCouleur et forme :SolidMasse moléculaire :227.102Calhex 231 hydrochloride
CAS :<p>Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .</p>Formule :C25H28Cl2N2ODegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :443.41Tecalcet Hydrochloride
CAS :<p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>Formule :C18H23Cl2NODegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :340.29GSK3004774
CAS :<p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>Formule :C32H40N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.68(Rac)-Upacicalcet
CAS :<p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>Formule :C11H14ClN3O6SCouleur et forme :SolidMasse moléculaire :351.76NPS-2143
CAS :<p>NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.</p>Formule :C24H25ClN2O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :408.92Ronacaleret HCl
CAS :<p>Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.</p>Formule :C25H32ClF2NO4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :483.98Encaleret
CAS :<p>Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.</p>Formule :C29H33ClFNO4Couleur et forme :SolidMasse moléculaire :514.03CaSR antagonist-1
CAS :<p>CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation</p>Formule :C29H24FN3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.58Calindol hydrochloride
CAS :<p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>Formule :C21H21ClN2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :336.86H-Glu-Thr-OH
CAS :<p>H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).</p>Formule :C9H16N2O6Couleur et forme :SolidMasse moléculaire :248.23TAK-075
CAS :<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Formule :C36H46N4O4SCouleur et forme :SolidMasse moléculaire :630.84SB-423562
CAS :<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Formule :C26H32N2O4Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :436.54
