Récepteur de l'histamine
Les récepteurs de l'histamine sont des GPCR qui médiatisent les effets de l'histamine, une amine biogène impliquée dans les réponses immunitaires, la sécrétion d'acide gastrique et la neurotransmission. Il existe quatre sous-types de récepteurs de l'histamine (H1, H2, H3 et H4), chacun jouant des rôles distincts dans les réactions allergiques, la fonction gastrique et l'activité du système nerveux central. Les antagonistes des récepteurs de l'histamine sont largement utilisés dans le traitement des allergies, des ulcères gastriques et du mal des transports. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de récepteurs de l'histamine de haute qualité pour soutenir vos recherches en immunologie, gastroentérologie et neuropharmacologie.
385 produits trouvés pour "Récepteur de l'histamine"
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Bamirastine
CAS :Bamirastine inhibits ligand binding to recombinant human histamine H1 receptor (rhH1R) with an IC50 value of 17.3 nM.Bamirastine has an inhibitory effect onFormule :C31H37N5O3Degré de pureté :96.68%Couleur et forme :SolidMasse moléculaire :527.66CP-66948
CAS :CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa.Formule :C13H20N6SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :292.4PF-03654764
CAS :PF-03654764, an oral H3 receptor blocker, Ki: human 1.2 nM, rat 7.9 nM, used with Fexofenadine for allergic rhinitis.Formule :C20H28F2N2ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :350.45Lavoltidine
CAS :Lavoltidine (Loxtidine) is potent and selective H2 receptor antagonist, oral and irreversible,inhibits gastric acid secretion, gastroesophageal reflux disease.Formule :C19H29N5O2Degré de pureté :98.30% - 98.36%Couleur et forme :SolidMasse moléculaire :359.47H3R-IN-1 Hydrochloride
CAS :H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .Formule :C19H24ClN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.86Propiomazine HCl
CAS :Propiomazine HCl is an analgesia adjunct.Formule :C20H25ClN2OSCouleur et forme :SolidMasse moléculaire :376.94Vapitadine dihydrochloride
CAS :Vapitadine dihydrochloride(R-129160 2HCl) is a novel, potent, selective and non-sedating compound with inhibitory effects on histamine H1.Formule :C17H22Cl2N4ODegré de pureté :98.28% - 99.30%Couleur et forme :SolidMasse moléculaire :369.29JNJ 10191584 maleate
CAS :JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM).Formule :C17H19ClN4O5Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :394.81Azatadine
CAS :Azatadine is histamine and cholinergic inhibitor (IC50: 6.5 nM and 10 nM, respectively).Formule :C20H22N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :290.4Impromidine
CAS :Impromidine is a highly potent and specific agonist of the histamine H2 receptor.Formule :C14H23N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.44VUF14862
CAS :VUF14862 is a robust and fatigue-resistant photoswitchable GPCR antagonist.Formule :C26H32N4O2Couleur et forme :SolidMasse moléculaire :432.56Sch 44643
CAS :Sch 44643 is an antagonist of platelet activating factor with oral activity.Formule :C25H22ClN3O2Couleur et forme :SolidMasse moléculaire :431.91UR-PI376
CAS :UR-PI376 is a selective histamine H4 receptor agonist with low H1/H2 activity and moderate H3 affinity.Formule :C17H22N6SCouleur et forme :SolidMasse moléculaire :342.46Brl 22321
CAS :Brl 22321 is a mast cell stabilizer.Formule :C12H9N3O2Couleur et forme :SolidMasse moléculaire :227.22BL 6341A
CAS :BL 6341A is related to Tumor data and H2-antagonists or anti-histaminsFormule :C9H14N8OS3Couleur et forme :SolidMasse moléculaire :346.46(R)-Azelastine
CAS :(R)-Azelastine, an antihistamine, reduces H1R, M1R, M3R levels and inhibits HNEpC growth.Formule :C22H24ClN3OCouleur et forme :SolidMasse moléculaire :381.9Aceprometazine
CAS :Aceprometazine (1664CB) is an antipsychotic which is orally active. Aceprometazine can be used in psychiatric disorders research, for example, depression [1].Formule :C19H22N2OSCouleur et forme :SolidMasse moléculaire :326.46Noberastine maleate
CAS :Noberastine maleate, a fast-acting furan-derived H1 antagonist, peaks at 4 hours with minimal CNS effects and maximal efficacy at 30 mg/day.Formule :C25H29N5O9Couleur et forme :SolidMasse moléculaire :543.53ROS 234 dioxalate
CAS :ROS 234 dioxalate is a potent antagonist of H3(pKB of 9.46 for Guinea-pig ileum H3-receptor)Formule :C17H19N5O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.37Fenspiride-d5
CAS :Fenspiride-d5: internal standard for GC/LC-MS quantification, H1 antagonist, NSAID, anti-inflammatory, selective PDE4,5,3 inhibitor.Formule :C15H15D5N2O2Couleur et forme :SolidMasse moléculaire :265.36GSK-239512
CAS :GSK-239512 is an antagonist of H3 receptor and can be used in studies about the treatment of cognitive dysfunction in neurodegenerative disorders.Formule :C23H27N3O2Degré de pureté :99.62% - 99.74%Couleur et forme :SolidMasse moléculaire :377.48S-1-Propenyl-L-cysteine
CAS :S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensiveFormule :C6H11NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :161.22Dacemazine
CAS :Dacemazine is used to treat depression.Formule :C16H16N2OSCouleur et forme :SolidMasse moléculaire :284.38VUF14738
CAS :VUF14738 is a robust and fatigue-resistant photoswitchable GPCR antagonist.Formule :C25H32N4O2Couleur et forme :SolidMasse moléculaire :420.55Nedocromil
CAS :Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).Formule :C19H17NO7Degré de pureté :95% - 97.34%Couleur et forme :SolidMasse moléculaire :371.34Dothiepin HCl
CAS :Dothiepin HCl: TCA, SNRI, with antihistamine, antiadrenergic, anticholinergic, and sodium block properties.Formule :C19H22ClNSCouleur et forme :SolidMasse moléculaire :331.9FR-A 19
CAS :FR-A 19: Histamine H2 agonist, nanomolar inhibition of basophil histamine release; potent anti-allergic.Formule :C25H34Cl3F2N5Couleur et forme :SolidMasse moléculaire :548.93KY 234
CAS :KY 234 is a thromboxane synthetase antagonist.Formule :C33H35N5O2Couleur et forme :SolidMasse moléculaire :533.676(S)-Azelastine
CAS :(S)-Azelastine is an antihistamine reducing receptors H1R, M1R, M3R, and inhibiting HNEpC cell growth.Formule :C22H24ClN3OCouleur et forme :SolidMasse moléculaire :381.9VUF 8328
CAS :VUF 8328 is an agonist of histamine H(3) receptor.Formule :C7H12N4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :184.26ReN-1869
CAS :ReN-1869 is a novel selective histamine H(1) receptor antagonist with anti-neurogenic pain and anti-inflammatory activity for the study of neurological diseasesFormule :C24H27NO2Degré de pureté :99.83% - 99.98%Couleur et forme :SolidMasse moléculaire :361.48Immethridine dihydrobromide
CAS :Immethridine dihydrobromide is a histamine H3 receptor agonist.Formule :C9H11Br2N3Degré de pureté :97.61% - 98.14%Couleur et forme :SolidMasse moléculaire :321.01Proxyfan
CAS :Proxyfan is a high-affinity protean antagonist/agonist of H3 receptors from full agonist to full inverse agonist, depending on given tissue or brain region.Formule :C13H16N2ODegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :216.28DF-1111301
CAS :DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity.Formule :C15H25Cl2N3ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :334.29Noberastine
CAS :Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine activity.Formule :C17H21N5ODegré de pureté :99.72% - >99.99%Couleur et forme :SolidMasse moléculaire :311.38KP136
CAS :KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation).Formule :C16H18N4O3Degré de pureté :98.3% - 98.61%Couleur et forme :SolidMasse moléculaire :314.34JZP-361
CAS :JZP-361: selective MAGL inhibitor (IC50 = 46 nM); weaker on FAAH, hABHD6; anti-histamine; for asthma research.Formule :C22H20ClN5ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :405.88Pitolisant
CAS :Pitolisant is a potent and selective nonimidazole inverse agonist that acts on the recombinant human histamine H3 receptor with Ki of 0.16 nM.Formule :C17H26ClNODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :295.85Ref: TM-T60636
5mg46,00€10mg66,00€25mg114,00€50mg178,00€100mg295,00€500mg708,00€1mL*10mM (DMSO)49,00€KSK94
CAS :KSK94 is an H3 receptor antagonist that inhibits sigma-2 receptors , with a Ki value of 75.2 nM, and can be used to study injurious pain.Formule :C25H26N4ODegré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :398.5Impromidine hydrochloride
CAS :Impromidine hydrochloride is a very potent and specific histamine H2 receptor agonist for conducting cardiovascular studies.Formule :C14H26Cl3N7SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :430.83NP10679
CAS :NP10679 is a N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit that inhibits histamine H1, hERG channels, and CYPase.Formule :C23H26F3N3O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :449.47Clemastine
CAS :Clemastine (Meclastin) is an antagonist of the H1 receptor and exhibits anti-inflammatory effects.Formule :C21H26ClNODegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :343.89Bavisant
CAS :Bavisant (JNJ-31001074) is a selective and orally active Human H3 receptor antagonist.Formule :C19H27N3O2Degré de pureté :99.21% - 99.65%Couleur et forme :SolidMasse moléculaire :329.44Ref: TM-TQ0046
1mg43,00€5mg96,00€10mg134,00€25mg221,00€50mg325,00€100mg465,00€500mgÀ demander1mL*10mM (DMSO)94,00€Linetastine
CAS :Linetastine (TMK-688) inhibits 5-LOX, blocks leukotrienes, counters histamine; researched for asthma, atherosclerosis, ulcers.Formule :C35H40N2O6Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :584.7D18024
CAS :D18024 is a phthalazinonderivat with anti-allergic and anti-histamine effect.Formule :C29H31ClFN3ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :492.03Ref: TM-T10945
1mg349,00€5mg697,00€10mg888,00€25mg1.395,00€50mg1.783,00€100mg2.530,00€1mL*10mM (DMSO)880,00€Enerisant hydrochloride
CAS :Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteinsFormule :C22H31ClN4O3Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :434.96Abt-288
CAS :ABT-288 is a selective and potent H3 antagonist for the treatment of mild to moderate Alzheimer's dementia.Formule :C23H24N4ODegré de pureté :98.17% - 98.49%Couleur et forme :SolidMasse moléculaire :372.46KSK68
CAS :KSK68 is a sigma-1 and histamine H3 receptor antagonist with analgesic activity, inhibits H3 receptors and can be used to study pain.Formule :C23H28N2O2Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :364.48Efletirizine
CAS :Efletirizine (UCB-28754), a histamine blocker and 5-LO inhibitor, aids in topical allergy treatment.Formule :C21H24F2N2O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :390.42Antihistamine-1
CAS :Antihistamine-1 是能够渗透血脑屏障的 H1-抗组胺药 (Ki=6.9 nM), 它也是 CYP2D6 和 hERG 通道的抑制剂，其 IC50 值分别为 5.4 和 0.8 μM。Formule :C23H24FN5Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :389.47Eclazolast
CAS :Eclazolast (RHC 2871), a lipophilic anti-allergic, inhibits mast cell mediator release by affecting Fc(epsilon)RI-related processes, dose-dependently.Formule :C12H12ClNO4Degré de pureté :98.29% - 98.61%Couleur et forme :SolidMasse moléculaire :269.68Ref: TM-T25360
1mg112,00€5mg261,00€10mg396,00€25mg655,00€50mg888,00€100mg1.251,00€500mg2.493,00€1mL*10mM (DMSO)249,00€Irdabisant
CAS :Irdabisant (CEP-26401) is an H3R antagonist/inverse agonist, BBB permeable, with cognition-enhancing effects for schizophrenia/cognitive research.Formule :C18H23N3O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :313.39UCB-35440
CAS :UCB-35440, a 5-lipoxygenase inhibitor and a histamine H1 receptor antagonist, is used potentially for the treatment of dermatitis.Formule :C31H34ClN5O4Couleur et forme :SolidMasse moléculaire :576.09Meclizine N-oxide
CAS :Meclizine N-oxide, a metabolite of the histamine H1 receptor antagonist meclizine (1), also acts as a degradation product and potential impurity in commercial meclizine preparations (2).Formule :C25H27ClN2OCouleur et forme :SolidMasse moléculaire :407Levocabastine hydrochloride
CAS :Levocabastine HCl is an agent with antihistaminic activity.Formule :C26H30ClFN2O2Couleur et forme :SolidMasse moléculaire :456.98Quinotolast sodium
CAS :Quinotolast sodium inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner in the concentration range of 1-100 μg/mL.Formule :C17H12N6NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.312A-349821
CAS :A-349821 is an H3 receptor agonist radioligand.Formule :C28H35F3N2O5Couleur et forme :SolidMasse moléculaire :536.59CI-949
CAS :CI-949 inhibits LTC4/D4, histamine, TXB2 release (IC50: 0.5, 11.4, 0.1 μM).Formule :C20H20N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.41Ebrotidine
CAS :Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.Formule :C14H17BrN6O2S3Degré de pureté :97.519%Couleur et forme :SolidMasse moléculaire :477.42Minocromil
CAS :Minocromil is a new agent of Anti-asthmatic.Formule :C18H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.33GT-2331
CAS :GT-2331 is a histamine H3 receptor antagonist.Formule :C14H20N2Couleur et forme :SolidMasse moléculaire :216.32APD-916
CAS :APD-916, an H3 receptor antagonist, exhibits favorable pharmacokinetic properties. Oral administration of APD-916 has been demonstrated to enhance wakefulness in various animal models.Formule :C23H31NO3SCouleur et forme :SolidMasse moléculaire :401.56Embramine hydrochloride
CAS :Embramine hydrochloride is a monoethanolamine derivative utilized for its antihistaminic and anticholinergic properties [1].Formule :C18H23BrClNOCouleur et forme :SolidMasse moléculaire :384.74JNJ-28583867
CAS :JNJ-28583867 is an inhibitor of histamine H(3) receptor antagonist and serotonin reuptake.Formule :C24H32N2O2SCouleur et forme :SolidMasse moléculaire :412.59GSK-1004723
CAS :GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis.Formule :C39H49ClN4O2Couleur et forme :SolidMasse moléculaire :641.28Cipralisant
CAS :Cipralisant: H3 receptor antagonist (in vivo), agonist (in vitro, pKi 9.9), Ki 0.47 nM in rats, may treat ADHD.Formule :C14H20N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :216.32Hydroxydione
CAS :Hydroxydione, a neuroactive steroid with general anesthetic properties, is utilized in anesthesia-related research [1] [2].Formule :C21H32O3Couleur et forme :SolidMasse moléculaire :332.48Cipralisant maleate
CAS :Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.Formule :C18H24N2O4Couleur et forme :SolidMasse moléculaire :332.39H3 receptor antagonist 1
CAS :H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.Formule :C20H28F2N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.45Levocabastine
CAS :Levocarbastine: 2nd-gen H1 antagonist, treats allergic conjunctivitis, selective NTS2 neurotensin inhibitor.Formule :C26H29FN2O2Couleur et forme :SolidMasse moléculaire :420.52H4R antagonist 2
CAS :H4R Antagonist 2, a potent Furo[3,2-d]pyrimidine derivative, serves as a histamine H4 receptor antagonist and holds potential for research into rheumatoidFormule :C13H17N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :259.31ST-1006
CAS :ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.Formule :C16H20Cl2N6Degré de pureté :99.96% - 99.98%Couleur et forme :SolidMasse moléculaire :367.28Ref: TM-T34709
1mg86,00€5mg188,00€10mg299,00€25mg487,00€50mg600,00€100mg743,00€200mg990,00€1mL*10mM (DMSO)187,00€Enerisant
CAS :Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.Formule :C22H30N4O3Degré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :398.50Ref: TM-T67828
1mg49,00€2mg67,00€5mg102,00€10mg166,00€25mg339,00€50mg439,00€100mg610,00€200mg827,00€1mL*10mM (DMSO)111,00€H3R antagonist 1
CAS :H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).Formule :C19H23N3O3Couleur et forme :SolidMasse moléculaire :341.4Tixanox sodium
CAS :Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Formule :C15H9NaO5SCouleur et forme :SolidMasse moléculaire :324.28H3R antagonist 5
CAS :H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.Formule :C23H32N2O4Couleur et forme :SolidMasse moléculaire :400.511CI-624
CAS :CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.Formule :C8H8N2SCouleur et forme :SolidMasse moléculaire :164.228H1R ligand-1
CAS :H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.Formule :C19H23NOCouleur et forme :SolidMasse moléculaire :281.392Sitamaquine hydrochloride
CAS :Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.Formule :C21H35Cl2N3OCouleur et forme :SolidMasse moléculaire :416.43Arpromidine
CAS :Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.Formule :C21H25FN6Couleur et forme :SolidMasse moléculaire :380.462Nedocromil sodium
CAS :Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Formule :C19H17NNaO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.335Histamine H3 antagonist-1
CAS :Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].
Formule :C24H28F3N3O2Couleur et forme :SolidMasse moléculaire :447.49ONO-8809
CAS :ONO-8809: Thromboxane A2 antagonist, reduces airway hyperresponse, macrophage accumulation, and MMP-9 in SHRSP brains.Formule :C30H46BrNO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.66(R)-(-)-α-Methylhistamine dihydrochloride
CAS :R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.Formule :C6H13Cl2N3Couleur et forme :SolidMasse moléculaire :198.09Imetit dihydrobromide
CAS :Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).Formule :C6H12Br2N4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.06
