Récepteur opioïde
Les récepteurs opioïdes sont un groupe de récepteurs couplés aux protéines G qui médiatisent les effets des opioïdes endogènes et exogènes. Ces récepteurs jouent un rôle central dans la modulation de la douleur, la régulation de l'humeur et les comportements addictifs. Les agonistes et antagonistes des récepteurs opioïdes sont largement utilisés dans la gestion de la douleur et le traitement des dépendances, ainsi que dans la recherche sur les troubles neurologiques et psychiatriques. Chez CymitQuimica, nous offrons une sélection complète de modulateurs des récepteurs opioïdes de haute qualité pour soutenir vos recherches en neurobiologie, gestion de la douleur et thérapie contre les addictions.
297 produits trouvés pour "Récepteur opioïde"
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Clocinnamox mesylate
CAS :<p>Clocinnamox mesylate: irreversible μ-opioid blocker; Ki: 0.7 nM (mouse μ), 1.9 nM (δ), 5.7 nM (κ).</p>Formule :C30H33ClN2O7SCouleur et forme :SolidMasse moléculaire :601.11DALDA TFA
<p>DALDA TFA is a potent, μ-opioid receptor agonist exhibiting high selectivity and an affinity constant (K i) of 1.69 nM.</p>Formule :C30H45N9O5·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :611.74 (free base)Dynorphin B (1-13) (TFA)
<p>Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor .</p>Formule :C76H116N21F3O19Couleur et forme :SolidMasse moléculaire :1684.86KOR agonist 4
<p>KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.</p>Formule :C21H25N3Couleur et forme :SolidMasse moléculaire :319.44β-Endorphin, equine TFA
<p>β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3</p>Formule :C156H249F3N42O46SCouleur et forme :SolidMasse moléculaire :3537.96Akuammicine
CAS :<p>Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.</p>Formule :C20H22N2O2Couleur et forme :SolidMasse moléculaire :322.408Nociceptin(1-7)
CAS :<p>Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesia</p>Formule :C31H41N7O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :655.709[(pF)Phe4]Nociceptin(1-13)NH2
CAS :<p>Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.</p>Formule :C61H99FN22O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1399.6Ac-RYYRWK-NH2 TFA
CAS :<p>Ac-RYYRWK-NH2: potent, specific NOP receptor partial agonist with 0.071 nM affinity; no affinity for μ/κ/δ-opioid receptors.</p>Formule :C51H70F3N15O11Couleur et forme :SolidMasse moléculaire :1126.21ICI 174,864
CAS :<p>Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.</p>Formule :C38H53N5O7Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :691.87PL-017
CAS :<p>μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.</p>Formule :C29H37N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.64[Met5]-Enkephalin, amide
CAS :<p>[Met5]-Enkephalin, amide activates δ and ζ opioid receptors; has multiple forms and varying plasma levels.</p>Formule :C27H36N6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.68MT-7716 hydrochloride
CAS :<p>MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)</p>Formule :C27H29ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :477N-Acetyl-α-Endorphin
CAS :N-Acetyl-α-Endorphin is a chemical compound consisting of α-Endorphin that has been acetylated at the N-terminal.Formule :C79H122N18O27SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1787.98PIPE-3297
<p>PIPE-3297 (compound 25) is a selective kappa opioid receptor (KOR) agonist that activates the G protein signaling pathway with an EC50 of 1.1 nM and exhibits low β-arrestin-2 recruitment activity (10%). Additionally, PIPE-3297 promotes myelination and has anti-inflammatory properties.</p>Formule :C23H30N2OMasse moléculaire :350.23581[Nphe1]Nociceptin(1-13)NH2
CAS :<p>Competitive nociceptin receptor antagonist with pKi=8.4; no agonist activity; blocks nociceptin effects in vitro/in vivo.</p>Formule :C61H100N22O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1381.6SNC 80
CAS :<p>SNC 80, a non-peptide δ-opioid agonist (Ki=1.78 nM, IC50=2.73 nM), also targets μ-δ heteromers (EC50=52.8 nM), with analgesic and antidepressant potential.</p>Formule :C28H39N3O2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :449.63[DAla2, DArg6] Dynorphin A, (1-13) (porcine)
CAS :'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'Formule :C76H128N24O15Couleur et forme :SolidMasse moléculaire :1617.98CJ-15208
CAS :<p>CJ-15208: κ-opioid antagonist, IC50: 47 nM kappa, 260 nM mu, 2600 nM delta, reverses asimadoline effects in rabbits (ED50 1.3 µM).</p>Formule :C34H35N5O4Couleur et forme :SolidMasse moléculaire :577.67U-54494A hydrochloride
CAS :<p>U-54494A hydrochloride is a benzamide derivative related to kappa opioid receptor agonists. U-54494A hydrochloride has anticonvulsant activity.</p>Formule :C18H25Cl3N2OCouleur et forme :SolidMasse moléculaire :391.76Ac-RYYRWK-NH2
CAS :<p>Selective NOP receptor partial agonist peptide; Ki=0.71 nM; >4000 nM for μ, δ, κ receptors; boosts food intake in vivo.</p>Formule :C49H69N15O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1012.17Gluten Exorphin B5
CAS :<p>Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten.</p>Formule :C30H38N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.66Herkinorin
CAS :<p>Herkinorin: μ-opioid agonist with 100x μ-affinity, 50x less κ-affinity than Salvinorin A, from Salvia divinorum. Semi-synthetic from Salvinorin B.</p>Formule :C28H30O8Couleur et forme :SolidMasse moléculaire :494.53Dermorphin
CAS :<p>Dermorphin is agonist of μ-opioid receptor (MOR) agonist.</p>Formule :C40H50N8O10Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :802.87[Nphe1]Nociceptin(1-13)NH2 TFA
<p>[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.</p>Formule :C63H101F3N22O17Couleur et forme :SolidMasse moléculaire :1495.61Dynorphin B (1-13)
CAS :Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.Formule :C74H115N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1570.84β-Endorphin (rat)
CAS :<p>β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.</p>Formule :C157H254N42O44SCouleur et forme :SolidMasse moléculaire :3466.07CTAP
CAS :<p>Potent μ opioid antagonist, IC50 3.5 nM, 1200x selectivity over δ and somatostatin, brain-penetrant, active in vivo.</p>Formule :C51H69N13O11S2Degré de pureté :98%Couleur et forme :White Solid/PowderMasse moléculaire :1104.32Orphanin FQ(1-11)
CAS :<p>Nociceptin peptide fragment (1-11) with potent ORL1/KOR-3 receptor agonism (Ki = 55 nM), no opioid receptor affinity, and analgesic in mice.</p>Formule :C49H75N15O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1098.2Ro 64-6198
CAS :<p>Ro 64-6198: Nonpeptide, selective NOP agonist, high brain uptake, EC50=25.6 nM, 100x NOP>opioid affinity.</p>Formule :C26H31N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.54β-Naltrexamine dihydrochloride
CAS :<p>β-Naltrexamine dihydrochloride is an orally administered, irreversible opioid receptor antagonist. Its derivatives exhibit optimised subtype selectivity and can be used for pain research.</p>Formule :C20H28Cl2N2O3Degré de pureté :95.98%Couleur et forme :SoildMasse moléculaire :415.35Biphalin TFA
CAS :<p>Biphalin TFA is an opioid peptide analog that penetrates the blood-brain barrier (BBB) and encompasses two active enkephalin pharmacophores.</p>Formule :C46H56N10O10·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :909.00 (free base)CTOP
CAS :<p>Potent μ-receptor antagonist, Ki=0.96nM, ineffective at δ (>10,000nM). Alters behavior in vivo, boosts K+ currents in rat neurons in vitro, μ-independent.</p>Formule :C50H67N11O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1062.28Cebranopadol hemicitrate
CAS :<p>Cebranopadol hemicitrate is a NOP and opioid receptor agonist that targets human NOP, MOP, KOP, and δ-opioid peptide (DOP) receptors, with Ki/EC50 values of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, and 18 nM/110 nM, respectively. It is used in studies of acute and chronic pain.</p>Couleur et forme :Solid[DPro10] Dynorphin A (1-11)acetate,porcine
<p>[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM.</p>Formule :C65H107N21O15Degré de pureté :99.05%Couleur et forme :SoildMasse moléculaire :1422.7Nociceptin (1-13), amide
CAS :<p>Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain</p>Formule :C61H100N22O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1381.59UFP-101
CAS :<p>Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.</p>Formule :C82H138N32O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1908.19[Arg14,Lys15]Nociceptin
CAS :<p>Potent NOP agonist (EC50 = 1 nM), >875x selective vs opioid receptors; outperforms nociceptin in vivo, increases pain perception, reduces movement.</p>Formule :C82H137N31O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1909.18N-Desmethyl Loperamide
CAS :<p>N-Desmethyl Loperamide is the major metabolite of loperamide. It is also used as the precusor for radiolabelled loperamide.</p>Formule :C28H31ClN2O2Couleur et forme :SolidMasse moléculaire :463.01MT-7716 free base
CAS :<p>MT-7716: selective NOP agonist, potential in preventing alcohol abuse/relapse.</p>Formule :C27H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.54Neurotransmitter Receptor Compound Library
<p>A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；</p>Couleur et forme :Odour SolidBAM-22P
CAS :<p>Bovine adrenal medulla docosapeptide (BAM-22P) is a potent opioid agonist, derived from the proenkephalin A gene, which is present in the adrenal medulla.</p>Formule :C130H184N38O31S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2839.22TAN67
CAS :<p>TAN67 is the first effective selective non-peptide delta1 opioid receptor.</p>Formule :C23H26Br2N2OCouleur et forme :SolidMasse moléculaire :506.282Boc-ypgflt(O-tbu)
CAS :<p>Boc-ypgflt(O-tbu) is a delta-receptor-selective opioid antagonist.</p>Formule :C44H64N6O11Couleur et forme :SolidMasse moléculaire :853.01N-terminally acetylated Endomorphin-1
<p>N-terminally acetylated Endomorphin-1 is a modified Endomorphin-1.</p>Formule :C36H40N6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :652.74Opioid receptor agonist 1
<p>Opioid receptor agonist1 (Compound 2638-28) is an orally active opioid receptor agonist that shows strong affinity for MOR, DOR, and KOR, with Ki values of 5, 24, and 212 nM, respectively. It exhibits analgesic activity in both the mouse warm water tail-flick model and the acetic acid writhing model.</p>Formule :C32H45N5OCouleur et forme :SolidMasse moléculaire :515.73(Rac)-SNC80
CAS :<p>(Rac)-SNC80, a racemic δ-opioid agonist (K i 1.78 nM), shows potential for treating various headache disorders.</p>Formule :C28H39N3O2Couleur et forme :SolidMasse moléculaire :449.63DAMGO (TFA)
CAS :<p>DAMGO is a selective peptide agonist of the µ-opioid receptor .</p>Formule :C28H36F3N5O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61Deltorphin
CAS :<p>Deltorphin (Dermenkephalin) is Isolated from the skin of Phyllomedusa Sauvage. It also has an affinity to the opioid receptor.</p>Formule :C44H62N10O10S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :955.15AP-238
CAS :<p>AP-238 is a novel synthetic opioid (NSO) that acts as an agonist for the μ-opioid receptor (MOR), with an EC50 of 248 nM. Additionally, AP-238 exhibits analgesic properties.</p>Formule :C18H26N2OCouleur et forme :SolidMasse moléculaire :286.41
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