PKA
La protéine kinase A (PKA) est une enzyme clé dans la cascade de signalisation des GPCR, activée par l'AMP cyclique (cAMP) en réponse à divers signaux extracellulaires. La PKA régule un large éventail de processus cellulaires, y compris le métabolisme, l'expression des gènes et la croissance cellulaire. La dérégulation de l'activité de la PKA est associée à diverses maladies, notamment le cancer, les troubles métaboliques et les affections cardiovasculaires. Les modulateurs de la PKA sont des outils précieux dans la recherche visant à comprendre les voies de signalisation des GPCR et à développer de nouvelles stratégies thérapeutiques. Chez CymitQuimica, nous offrons une sélection de modulateurs de PKA de haute qualité pour soutenir vos recherches en transduction de signal, régulation cellulaire et mécanismes des maladies.
48 produits trouvés pour "PKA"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
MR-L2
CAS :<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>Formule :C19H16Cl3FN4ODegré de pureté :98.09% - 98.94%Couleur et forme :SolidMasse moléculaire :441.71A-3 hydrochloride
CAS :<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Bucladesine sodium
CAS :<p>Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.</p>Formule :C18H23N5NaO8PDegré de pureté :96.56% - 99.76%Couleur et forme :White PowderMasse moléculaire :491.37JAK1/2/3 Inhibitor 1
CAS :<p>JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines</p>Formule :C6H2Cl2N2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :205.06Vasonatrin Peptide (VNP)
CAS :<p>Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activity</p>Formule :C123H198N36O36S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2865.37Fasudil
CAS :<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37KT5720
CAS :<p>KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).</p>Formule :C32H31N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.61PKG inhibitor peptide
CAS :<p>PKG inhibitor; mimics H2B phosphorylation site; Ki=86mM; blocks synthetic substrates, not histone phosphorylation; stops PKA activity on histones.</p>Formule :C38H74N18O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :943.12PKI(5-24)
CAS :<p>High affinity PKA inhibitor (Ki = 2.3 nM).</p>Formule :C76H129N31O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1925.057Gliotoxin
CAS :<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formule :C13H14N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.39Malantide
CAS :<p>Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.</p>Formule :C72H124N22O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.89Calcineurin substrate
CAS :<p>Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase.</p>Formule :C92H150N28O29Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2112.35CREBtide
CAS :<p>CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).</p>Formule :C73H129N29O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1716.99Kemptide Phospho-Ser5
<p>Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).</p>Formule :C32H62N13O12PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :851.89PKG Substrate
CAS :<p>PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).</p>Formule :C35H67N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :902.01Malantide TFA
<p>Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.</p>Formule :C74H125F3N22O23Couleur et forme :SolidMasse moléculaire :1747.91H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS :<p>H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].</p>Formule :C31H58N14O9Couleur et forme :SolidMasse moléculaire :770.88PKI (5-24),amide
CAS :<p>PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.</p>Formule :C94H149N33O30Couleur et forme :SolidMasse moléculaire :2221.4STAD 2
CAS :<p>STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap</p>Formule :C102H182N24O22Couleur et forme :SolidMasse moléculaire :2096.724Kemptide
CAS :<p>Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).</p>Formule :C32H61N13O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.91Kiss2 peptide acetate
<p>Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).</p>Formule :C63H84N16O12·xC2H4O2Couleur et forme :SolidMasse moléculaire :1257.44 (free base)PKA-IN-1
CAS :<p>PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study</p>Formule :C13H11N3ODegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :225.25AP-C2
CAS :<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Formule :C18H16N4SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :320.41PKA/AKAP-IN-2
CAS :<p>PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.</p>Formule :C17H17NO3Degré de pureté :99.82%Couleur et forme :SoildMasse moléculaire :283.32Aplithianines A
<p>Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM by</p>Degré de pureté :98%Couleur et forme :Odour SolidDT-3 acetate
<p>DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.</p>Formule :C152H258N52O28S·xC2H4O2Couleur et forme :SolidMasse moléculaire :3294.07 (free acid)CCG215022
CAS :<p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>Formule :C26H22FN7O3Degré de pureté :97.63% - 99.69%Couleur et forme :SolidMasse moléculaire :499.5Metadoxine
CAS :<p>Metadoxine (Metadoxil) is a neurotransmitter stimulant.</p>Formule :C8H11NO3·C5H7NO3Degré de pureté :99.19%Couleur et forme :Off-White PowderMasse moléculaire :298.29AT7867
CAS :<p>AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.</p>Formule :C20H20ClN3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :337.85Daphnetin
CAS :<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14HA-100
CAS :<p>HA-100 is an inhibitor of protein kinase</p>Formule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :Pale Yellow Crystalline SolidMasse moléculaire :277.34Iso-H7 dihydrochloride
CAS :<p>Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.</p>Formule :C14H19Cl2N3O2SDegré de pureté :99.53%Couleur et forme :White Crystalline SolidMasse moléculaire :364.29Bilobetin
CAS :<p>Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.</p>Formule :C31H20O10Degré de pureté :97.74% - 99.69%Couleur et forme :SolidMasse moléculaire :552.48Fasudil hydrochloride
CAS :<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formule :C14H18ClN3O2SDegré de pureté :99.54% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83PKG drug G1
CAS :<p>PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.</p>Formule :C13H11N3OSDegré de pureté :97.57% - 97.67%Couleur et forme :SolidMasse moléculaire :257.31AT13148
CAS :<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Formule :C17H16ClN3ODegré de pureté :98.04% - ≥95%Couleur et forme :SolidMasse moléculaire :313.78H-89 dihydrochloride
CAS :<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Formule :C20H20BrN3O2S·2HClDegré de pureté :98.22% - >99.99%Couleur et forme :SolidMasse moléculaire :519.28Staurosporine
CAS :<p>Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr</p>Formule :C28H26N4O3Degré de pureté :99.24% - 99.82%Couleur et forme :Off-White PowderMasse moléculaire :466.538-Bromo-cAMP sodium salt
CAS :<p>8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.</p>Formule :C10H10BrN5NaO6PDegré de pureté :98% - 99.94%Couleur et forme :Off-White PowderMasse moléculaire :430.08H-8 hydrochloride
CAS :<p>H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.</p>Formule :C12H17Cl2N3O2SDegré de pureté :99.93%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :338.256-Bn-cAMP
CAS :<p>6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.</p>Formule :C17H18N5O6PCouleur et forme :SolidMasse moléculaire :419.338-Chloro-cAMP sodium
CAS :<p>8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.</p>Formule :C10H10ClN5NaO6PCouleur et forme :SolidMasse moléculaire :385.638-MA-cAMP
CAS :<p>8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.</p>Formule :C11H15N6O6PCouleur et forme :SolidMasse moléculaire :358.25BGC201531
CAS :<p>BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.</p>Formule :C26H28N2O6SDegré de pureté :98.51% - 99.33%Couleur et forme :SolidMasse moléculaire :496.58Rp-cAMPS triethylammonium salt
CAS :<p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>Formule :C16H27N6O5PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.46FMP-API-1
CAS :<p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>Formule :C13H14N2O2Couleur et forme :SolidMasse moléculaire :230.2628-Br-cGMP-AM
CAS :<p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>Formule :C13H15BrN5O9PCouleur et forme :SolidMasse moléculaire :496.16PET-cGMP
CAS :<p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>Formule :C18H16N5O7PCouleur et forme :SolidMasse moléculaire :445.323
