PKA
La protéine kinase A (PKA) est une enzyme clé dans la cascade de signalisation des GPCR, activée par l'AMP cyclique (cAMP) en réponse à divers signaux extracellulaires. La PKA régule un large éventail de processus cellulaires, y compris le métabolisme, l'expression des gènes et la croissance cellulaire. La dérégulation de l'activité de la PKA est associée à diverses maladies, notamment le cancer, les troubles métaboliques et les affections cardiovasculaires. Les modulateurs de la PKA sont des outils précieux dans la recherche visant à comprendre les voies de signalisation des GPCR et à développer de nouvelles stratégies thérapeutiques. Chez CymitQuimica, nous offrons une sélection de modulateurs de PKA de haute qualité pour soutenir vos recherches en transduction de signal, régulation cellulaire et mécanismes des maladies.
61 produits trouvés pour "PKA"
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MR-L2
CAS :MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Formule :C19H16Cl3FN4ODegré de pureté :98.09% - 98.94%Couleur et forme :SolidMasse moléculaire :441.71Ref: TM-T12103
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)358,00€10mg500,00€25mg807,00€50mg1.099,00€100mg1.485,00€500mg2.962,00€A-3 hydrochloride
CAS :A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Ref: TM-T14069
1mg34,00€5mg63,00€10mg90,00€1mL*10mM (DMSO)95,00€25mg161,00€50mg260,00€100mg416,00€500mg888,00€Bucladesine sodium
CAS :Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.Formule :C18H23N5NaO8PDegré de pureté :96.56% - 99.76%Couleur et forme :White PowderMasse moléculaire :491.37RI-STAD-2
RI-STAD-2 is a high-affinity peptide that interferes with the regulatory subunit RI of protein kinase A (PKA). It disrupts the binding between A-kinase anchoring proteins (AKAPs) and PKA-RI by mimicking the α-helical domain of AKAPs, interacting with the dimerization/docking (D/D) domain of PKA-RI. This disruption affects the activity and intracellular localization of PKA. RI-STAD-2 is utilized in studying the role of AKAPs and PKA-RI interactions in pathological processes such as cardiovascular diseases and cancer.Formule :C109H181N25O35Masse moléculaire :2400.31519PKG inhibitor peptide
CAS :PKG inhibitor; mimics H2B phosphorylation site; Ki=86mM; blocks synthetic substrates, not histone phosphorylation; stops PKA activity on histones.Formule :C38H74N18O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :943.12Kemptide
CAS :Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).Formule :C32H61N13O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.91PKI(5-24)
CAS :High affinity PKA inhibitor (Ki = 2.3 nM).Formule :C76H129N31O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1925.057Gliotoxin
CAS :Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formule :C13H14N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.39(2S,4R)-DS89002333
(2S,4R)-DS89002333 is an enantiomer of DS89002333 and functions as an orally active PRKACA inhibitor, exhibiting an IC50 of 0.3 nM.Formule :C22H20ClF2N3O3Masse moléculaire :447.11613PKA Inhibitor Fragment (6-22) amide TFA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of cAMP-dependent protein kinase A (PKA).Formule :C82H131F3N28O26Degré de pureté :99.61% - 99.87%Couleur et forme :SolidMasse moléculaire :1982.08Vasonatrin Peptide (VNP)
CAS :Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activityFormule :C123H198N36O36S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2865.37Aplithianines A
Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM byDegré de pureté :98%Couleur et forme :Odour SolidMalantide
CAS :Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formule :C72H124N22O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.89Calcineurin substrate
CAS :Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase.Formule :C92H150N28O29Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2112.35CREBtide
CAS :CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Formule :C73H129N29O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1716.99Kemptide Phospho-Ser5
Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).Formule :C32H62N13O12PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :851.89PKG Substrate
CAS :PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).Formule :C35H67N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :902.01PKA/AKAP-IN-2
CAS :PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.Formule :C17H17NO3Degré de pureté :99.82%Couleur et forme :SoildMasse moléculaire :283.32Malantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Formule :C74H125F3N22O23Couleur et forme :SolidMasse moléculaire :1747.91H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS :H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].Formule :C31H58N14O9Couleur et forme :SolidMasse moléculaire :770.88AP-C2
CAS :AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Formule :C18H16N4SDegré de pureté :99.99%Couleur et forme :SoildMasse moléculaire :320.41PKI (5-24),amide
CAS :PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.Formule :C94H149N33O30Couleur et forme :SolidMasse moléculaire :2221.4PKA-IN-1
CAS :PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to studyFormule :C13H11N3ODegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :225.25STAD 2
CAS :STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFormule :C102H182N24O22Couleur et forme :SolidMasse moléculaire :2096.724Fasudil
CAS :Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37WAY-299562
CAS :WAY-299562 is a modulator that regulates the interaction between protein kinase A (PKA) and A-kinase anchoring proteins (AKAP).Formule :C16H13NO3Couleur et forme :SolidMasse moléculaire :267.28JAK1/2/3 Inhibitor 1
CAS :JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell linesFormule :C6H2Cl2N2SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :205.06KT5720
CAS :KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).Formule :C32H31N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.61DT-3 acetate
DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.Formule :C152H258N52O28S·xC2H4O2Couleur et forme :SolidMasse moléculaire :3294.07 (free acid)H-89 dihydrochloride
CAS :H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Formule :C20H20BrN3O2S·2HClDegré de pureté :98.22% - >99.99%Couleur et forme :SolidMasse moléculaire :519.28Ref: TM-T6250
5mg39,00€1mL*10mM (DMSO)52,00€10mg58,00€25mg106,00€50mg202,00€100mg344,00€200mg512,00€500mg815,00€AT13148
CAS :AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formule :C17H16ClN3ODegré de pureté :98.04% - ≥95%Couleur et forme :SolidMasse moléculaire :313.78Staurosporine
CAS :Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormule :C28H26N4O3Degré de pureté :99.24% - 99.82%Couleur et forme :Off-White PowderMasse moléculaire :466.53Ref: TM-T6680
1mg58,00€2mg82,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg234,00€50mg380,00€100mg565,00€500mg1.215,00€8-Bromo-cAMP sodium salt
CAS :8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Formule :C10H10BrN5NaO6PDegré de pureté :98% - 99.94%Couleur et forme :Off-White PowderMasse moléculaire :430.08Iso-H7 dihydrochloride
CAS :Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Formule :C14H19Cl2N3O2SDegré de pureté :99.53%Couleur et forme :White Crystalline SolidMasse moléculaire :364.29CCG215022
CAS :CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Formule :C26H22FN7O3Degré de pureté :97.63% - 99.69%Couleur et forme :SolidMasse moléculaire :499.5Ref: TM-T3498
1mg56,00€5mg114,00€1mL*10mM (DMSO)127,00€10mg178,00€25mg394,00€50mg655,00€100mg1.035,00€AT7867
CAS :AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.Formule :C20H20ClN3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :337.85Ref: TM-T6304
2mg42,00€5mg62,00€1mL*10mM (DMSO)62,00€10mg81,00€25mg128,00€50mg198,00€100mg296,00€200mg427,00€Daphnetin
CAS :Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14Bilobetin
CAS :Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Formule :C31H20O10Degré de pureté :97% - 99.69%Couleur et forme :SolidMasse moléculaire :552.48Ref: TM-T4S2128
1mg44,00€2mg66,00€5mg137,00€1mL*10mM (DMSO)177,00€10mg236,00€25mg403,00€50mg582,00€100mg800,00€PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Formule :C82H134N28O26Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :1928.11Ref: TM-T21674L
1mg90,00€2mg116,00€5mg166,00€10mg264,00€1mL*10mM (DMSO)432,00€25mg442,00€50mg645,00€100mg888,00€Fasudil dihydrochloride
CAS :Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Formule :C14H19Cl2N3O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :364.29Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :99.54% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83PKG drug G1
CAS :PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Formule :C13H11N3OSDegré de pureté :97.57% - 97.67%Couleur et forme :SolidMasse moléculaire :257.31CREBtide acetate(149155-45-3 free base)
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Formule :C75H133N29O21Degré de pureté :96.13%Couleur et forme :SolidMasse moléculaire :1777.07PKI 14-22 amide, myristoylated Acetate
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.Formule :C55H104N20O14Degré de pureté :96.34%Couleur et forme :SolidMasse moléculaire :1269.54Ref: TM-T21983L
1mg167,00€5mg363,00€10mg538,00€1mL*10mM (DMSO)695,00€25mg800,00€50mg1.071,00€100mg1.449,00€PKG inhibitor peptide TFA (82801-73-8 free base)
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).Formule :C40H75F3N18O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1057.13PKI (5-24) Acetate(99534-03-9 free base)
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).Formule :C96H152N32O33Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :2282.43PKG Substrate acetate(81187-14-6 free base)
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with aFormule :C37H71N17O13Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :962.08Hydroxyfasudil
CAS :Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formule :C14H17N3O3SDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :307.37Malantide acetate(86555-35-3 free base)
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptideFormule :C74H128N22O23Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1693.97HA-100
CAS :HA-100 is an inhibitor of protein kinaseFormule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :Pale Yellow Crystalline SolidMasse moléculaire :277.34
