Récepteur de la dopamine
Les récepteurs de la dopamine sont un groupe de récepteurs couplés aux protéines G (GPCR) qui répondent au neurotransmetteur dopamine, jouant un rôle clé dans la régulation du mouvement, de la motivation, de la récompense et de plusieurs fonctions cognitives. Ces récepteurs sont divisés en familles de type D1 et de type D2, chacune ayant des fonctions et des profils pharmacologiques distincts. Les modulateurs des récepteurs de la dopamine sont largement étudiés pour leurs applications dans le traitement de la maladie de Parkinson, de la schizophrénie, de la dépendance et d'autres troubles neuropsychiatriques. Chez CymitQuimica, nous offrons une large gamme de modulateurs de récepteurs de la dopamine de haute qualité pour soutenir vos recherches en neurosciences, santé mentale et signalisation GPCR.
445 produits trouvés pour "Récepteur de la dopamine"
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LY3154885
CAS :LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).Formule :C23H23Cl2N3O2Couleur et forme :SolidMasse moléculaire :444.35Sonepiprazole
CAS :Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociationFormule :C21H27N3O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :401.52Quinpirole dihydrochloride
CAS :Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.Formule :C13H23Cl2N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.25CP-293019
CAS :CP-293019 is a potent, selective antagonist of dopamine D4 receptor.Formule :C19H22F2N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.4LY-368975
CAS :LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.Formule :C17H21NOSCouleur et forme :SolidMasse moléculaire :287.42Naxagolide free base
CAS :Naxagolide is a sustained release formulation. It is a dopamine agonist.Formule :C15H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :247.33PD 128907
CAS :PD 128907 - potent, selective dopamine D2/D3 agonist for researching receptor roles in the brain.Formule :C14H19NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :249.314-Amino-PPHT Hydrobromide
CAS :4-Amino-PPHT Hydrobromide is a precursor for fluorescent labeled Dopamine D2 receptors agonist.Formule :C21H28N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.46PW0464
CAS :PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for neurological disorders.Formule :C19H17F2N3O4Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :389.35Ref: TM-T36946
1mg160,00€5mg386,00€10mg635,00€25mg1.228,00€50mg1.839,00€100mg2.470,00€1mL*10mM (DMSO)425,00€LBT 999
CAS :LBT 999 is used as a dopamine reuptake inhibitor.Formule :C20H26FNO2Couleur et forme :SolidMasse moléculaire :331.42(+)-Dihydrexidine hydrochloride
CAS :(+)-Dihydrexidine hydrochloride is an agonist of dopamine D1 receptor(EC50 of 72± 21 nM).Formule :C17H18ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.78Pentiapine
CAS :Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.Formule :C15H17N5SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :299.39Ref: TM-T12405
1mg487,00€5mg753,00€10mg1.216,00€25mg1.691,00€50mg2.262,00€100mg3.068,00€1mL*10mM (DMSO)938,00€ABT-670
CAS :ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.Formule :C19H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.4SKF 81297
CAS :SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].Formule :C16H16ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :289.76SKF 81297 hydrobromide
CAS :SKF 81297 hydrobromide, a selective agonist of the dopamine D1-like receptor，exhibits central activity and is widely used to study the neuromodulatory effects.Formule :C16H17BrClNO2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :370.67AJ-76 hydrochloride
CAS :AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) serves as a dopamine autoreceptor antagonist, exhibiting pK i values of 6.95 for hD3, 6.67 for hD4, 6.37 for hD2S, 6.21 for hD2L, and 6.07 for rD2 receptors, indicating its binding affinity strength across these receptor types.Formule :C15H24ClNOCouleur et forme :SolidMasse moléculaire :269.81Carbidine dihydrochloride
CAS :Carbidine, a gamma-carboline derivative, is an atypical antipsychotic that modulates dopamine release and tyrosine hydroxylase activity.Formule :C13H20Cl2N2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :275.217UWA-101 hydrochloride
CAS :UWA-101 hydrochloride is a selective, non-cytotoxic inhibitor of DAT/SERT, demonstrating EC50 values of 3.6 µM for DAT and 2.3 µM for SERT inhibition. It mitigates motor disorders and other side effects associated with dopaminergic agent use (e.g., L-DOPA) without exhibiting psychotropic effects. This compound is utilized in research focused on neurodegenerative conditions like Parkinson's disease [1] [2].Formule :C13H18ClNO2Couleur et forme :SolidMasse moléculaire :255.74PAOPA
CAS :dopamine D2 receptor modulatorFormule :C11H18N4O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :254.29NMI 8739
CAS :NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.
Formule :C30H41NO3Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :463.65Lumateperone
CAS :Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.59-Methyl-β-carboline
CAS :9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative, and anti-inflammatory properties. Its behavioral effects may be linked to hippocampal dopamine levels and the stimulation of dendritic and synaptic proliferation.Formule :C12H10N2Couleur et forme :SolidMasse moléculaire :182.221RS 12254
CAS :RS 12254 is a dopamine agonist and antihypertensive agent.Formule :C28H40N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.63Disulergine
CAS :Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.Formule :C17H24N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.46U91356
CAS :U91356 is an agonist of the dopamine receptors.Formule :C13H17N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :231.29Dopamine D3 receptor antagonist-1
Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeuticFormule :C31H35Cl2N3O3Couleur et forme :SolidMasse moléculaire :568.53D4R antagonist-1
Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.Formule :C21H25F2NO2Couleur et forme :SolidMasse moléculaire :361.43CM699
CAS :CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.Formule :C24H29N3O2Couleur et forme :SolidMasse moléculaire :391.51Dopamine D3 receptor ligand-1
Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:Formule :C27H29N5OCouleur et forme :SolidMasse moléculaire :439.55Dopamine D3 receptor antagonist-2
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.Formule :C23H27Cl2N3O3Couleur et forme :SolidMasse moléculaire :464.38NMDAR antagonist 5
CAS :NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Formule :C17H21N3Couleur et forme :SolidMasse moléculaire :267.369D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Formule :C21H23ClF2N2O2Couleur et forme :SolidMasse moléculaire :408.87Lisuride
CAS :Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.Formule :C20H26N4OCouleur et forme :SolidMasse moléculaire :338.45Cendifensine
CAS :Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).Formule :C14H17Cl2NOCouleur et forme :SolidMasse moléculaire :286.197LY3154207
CAS :LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.Formule :C24H29Cl2NO3Couleur et forme :SolidMasse moléculaire :450.4Dopamine D4 receptor ligand 3
CAS :Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.Formule :C28H31N3O5Couleur et forme :SolidMasse moléculaire :489.56D1R antagonist 1
CAS :Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].Formule :C22H26BrNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.35PD-147693
CAS :PD-147693 (compound II) is an active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, and it exhibits antipsychotic activity similar to CI-1007.Formule :C24H27NOCouleur et forme :SolidMasse moléculaire :345.477Neflumozide
CAS :Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.Formule :C22H23FN4O2Couleur et forme :SolidMasse moléculaire :394.44Quinagolide Free Base
CAS :Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.Formule :C20H33N3O3SCouleur et forme :SolidMasse moléculaire :395.56RG-15
CAS :RG-15 is an orally active dopamine receptor antagonist with high affinity for the human D2 receptor (pKi of 8.23) and human D3 receptor (pKi of 10.49). It inhibits dopamine-stimulated [35S]GTPγS binding with IC50 values of 21.2 nM in rat striatal membranes, 36.7 nM in mouse A9 cells expressing human D2L receptors, and 7.2 nM in CHO cells expressing human D3 receptors. RG-15 enhances dopamine turnover and synthesis in the striatum and olfactory bulb of mice, exhibiting antipsychotic activity.Formule :C25H32Cl2F3N5O2SCouleur et forme :SolidMasse moléculaire :594.52UNC10099984A
CAS :UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.Formule :C24H29Cl2N3O2Couleur et forme :SolidMasse moléculaire :462.413-Hydroxybenzylamine
CAS :3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.Formule :C7H9NOCouleur et forme :SolidMasse moléculaire :123.1556-Chloro-5-(2-chloroethyl)indolin-2-one
CAS :6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Formule :C10H9Cl2NOCouleur et forme :SolidMasse moléculaire :230.09GR 218,231
CAS :GR 218,231 is a selective antagonist of D3 dopamine receptor.Formule :C24H33NO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.59
