Récepteur de la dopamine
Les récepteurs de la dopamine sont un groupe de récepteurs couplés aux protéines G (GPCR) qui répondent au neurotransmetteur dopamine, jouant un rôle clé dans la régulation du mouvement, de la motivation, de la récompense et de plusieurs fonctions cognitives. Ces récepteurs sont divisés en familles de type D1 et de type D2, chacune ayant des fonctions et des profils pharmacologiques distincts. Les modulateurs des récepteurs de la dopamine sont largement étudiés pour leurs applications dans le traitement de la maladie de Parkinson, de la schizophrénie, de la dépendance et d'autres troubles neuropsychiatriques. Chez CymitQuimica, nous offrons une large gamme de modulateurs de récepteurs de la dopamine de haute qualité pour soutenir vos recherches en neurosciences, santé mentale et signalisation GPCR.
407 produits trouvés pour "Récepteur de la dopamine"
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A-437203
CAS :<p>A-437203 (Lu201640), selective D3 antagonist with Ki: D2-71nM, D3-1.6nM, D4-6220nM; based on 1H-pyrimidin-2-one scaffold.</p>Formule :C20H27F3N6OSDegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :456.53BP14979
CAS :<p>BP14979 is D3R-selective partial agonist.</p>Formule :C23H34N4O2Degré de pureté :98.29% - 99.73%Couleur et forme :SolidMasse moléculaire :398.54SK609 HCl
CAS :<p>SK609 HCl is a selective dopamine D3 receptor agonist. It also has atypical signaling properties.</p>Formule :C10H15Cl2NDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :220.14Remoxipride hydrochloride
CAS :<p>Remoxipride hydrochloride (Roxiam) is a selective antagonist of D2 receptor with IC50s of 1.57 μM, ＞100 μM and 42 μM for D2 receptor, D1 receptor and α1-</p>Formule :C16H24BrClN2O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :407.73CyPPA
CAS :<p>CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.</p>Formule :C16H23N5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :285.39Fananserin
CAS :<p>Fananserin: Oral 5-HT2A antagonist (Ki=0.37 nM, rat), blocks human D4 receptor (Ki=2.93 nM).</p>Formule :C23H24FN3O2SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :425.52CCG 203769
CAS :<p>CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.</p>Formule :C8H14N2O2SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :202.27Sonepiprazole
CAS :<p>Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociation</p>Formule :C21H27N3O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :401.52CY 208-243
CAS :<p>CY 208-243 is a selective dopamine D1 receptor agonist with anti-Parkinson disease activity.</p>Formule :C19H18N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :274.36Timiperone
CAS :<p>Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior.</p>Formule :C22H24FN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.51ABT-670
CAS :<p>ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.</p>Formule :C19H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.4SKF 81297
CAS :<p>SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].</p>Formule :C16H16ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :289.76FAUC-312
CAS :<p>FAUC-312 is a potent and selective agonist of the dopamine D4 receptor.</p>Formule :C21H26N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.46LY3154885
CAS :<p>LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).</p>Formule :C23H23Cl2N3O2Couleur et forme :SolidMasse moléculaire :444.35Quinpirole dihydrochloride
CAS :<p>Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.</p>Formule :C13H23Cl2N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.25Pentiapine
CAS :<p>Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.</p>Formule :C15H17N5SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :299.39AJ-76 hydrochloride
CAS :<p>AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) serves as a dopamine autoreceptor antagonist, exhibiting pK i values of 6.95 for hD3, 6.67 for hD4, 6.37 for hD2S, 6.21 for hD2L, and 6.07 for rD2 receptors, indicating its binding affinity strength across these receptor types.</p>Formule :C15H24ClNOCouleur et forme :SolidMasse moléculaire :269.81Carbidine dihydrochloride
CAS :<p>Carbidine, a gamma-carboline derivative, is an atypical antipsychotic that modulates dopamine release and tyrosine hydroxylase activity.</p>Formule :C13H20Cl2N2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :275.217UWA-101 hydrochloride
CAS :<p>UWA-101 hydrochloride is a selective, non-cytotoxic inhibitor of DAT/SERT, demonstrating EC50 values of 3.6 µM for DAT and 2.3 µM for SERT inhibition. It mitigates motor disorders and other side effects associated with dopaminergic agent use (e.g., L-DOPA) without exhibiting psychotropic effects. This compound is utilized in research focused on neurodegenerative conditions like Parkinson's disease [1] [2].</p>Formule :C13H18ClNO2Couleur et forme :SolidMasse moléculaire :255.74SB-414796
CAS :<p>SB-414796 is a selective antagonist of the dopamine D3 receptor.</p>Formule :C29H36N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :536.69Naxagolide free base
CAS :<p>Naxagolide is a sustained release formulation. It is a dopamine agonist.</p>Formule :C15H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :247.33Dihydrexidine
CAS :<p>Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.</p>Formule :C17H17NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.32Z1078601926
CAS :<p>Z1078601926 is an allosteric inhibitor of the human dopamine transporter (hDAT) and exhibits a synergistic effect when combined with Nomifensine [1].</p>Formule :C14H19FN2OCouleur et forme :SolidMasse moléculaire :250.31Carmoxirole hydrochloride
CAS :<p>Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo.</p>Formule :C24H27ClN2O2Degré de pureté :99.37% - 99.62%Couleur et forme :SolidMasse moléculaire :410.94PW0464
CAS :<p>PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for neurological disorders.</p>Formule :C19H17F2N3O4Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :389.35LBT 999
CAS :<p>LBT 999 is used as a dopamine reuptake inhibitor.</p>Formule :C20H26FNO2Couleur et forme :SolidMasse moléculaire :331.42JNJ-37822681 dihydrochloride
CAS :<p>JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。</p>Formule :C17H19Cl2F5N4Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :445.26(+)-Dihydrexidine hydrochloride
CAS :<p>(+)-Dihydrexidine hydrochloride is an agonist of dopamine D1 receptor(EC50 of 72± 21 nM).</p>Formule :C17H18ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.78Brilaroxazine
CAS :<p>Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.</p>Formule :C22H25Cl2N3O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :450.36LY-368975
CAS :<p>LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.</p>Formule :C17H21NOSCouleur et forme :SolidMasse moléculaire :287.42SKF 81297 hydrobromide
CAS :<p>SKF 81297 hydrobromide, a selective agonist of the dopamine D1-like receptor，exhibits central activity and is widely used to study the neuromodulatory effects.</p>Formule :C16H17BrClNO2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :370.67CP-293019
CAS :<p>CP-293019 is a potent, selective antagonist of dopamine D4 receptor.</p>Formule :C19H22F2N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.44-Amino-PPHT Hydrobromide
CAS :<p>4-Amino-PPHT Hydrobromide is a precursor for fluorescent labeled Dopamine D2 receptors agonist.</p>Formule :C21H28N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.46PAOPA
CAS :<p>dopamine D2 receptor modulator</p>Formule :C11H18N4O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :254.29NMI 8739
CAS :<p>NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.</p>Formule :C30H41NO3Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :463.65Lumateperone
CAS :<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.5Dopamine D3 receptor antagonist-1
<p>Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeutic</p>Formule :C31H35Cl2N3O3Couleur et forme :SolidMasse moléculaire :568.53D4R antagonist-1
<p>Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.</p>Formule :C21H25F2NO2Couleur et forme :SolidMasse moléculaire :361.43CM699
CAS :<p>CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.</p>Formule :C24H29N3O2Couleur et forme :SolidMasse moléculaire :391.51Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Formule :C27H29N5OCouleur et forme :SolidMasse moléculaire :439.55D1R antagonist 1
CAS :<p>Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].</p>Formule :C22H26BrNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.35Dopamine D3 receptor antagonist-2
<p>Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.</p>Formule :C23H27Cl2N3O3Couleur et forme :SolidMasse moléculaire :464.38UNC10099984A
CAS :<p>UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.</p>Formule :C24H29Cl2N3O2Couleur et forme :SolidMasse moléculaire :462.41Neflumozide
CAS :<p>Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.</p>Formule :C22H23FN4O2Couleur et forme :SolidMasse moléculaire :394.44NMDAR antagonist 5
CAS :<p>NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.</p>Formule :C17H21N3Couleur et forme :SolidMasse moléculaire :267.369D4R antagonis-2
<p>Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.</p>Formule :C21H23ClF2N2O2Couleur et forme :SolidMasse moléculaire :408.87Lisuride
CAS :<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Formule :C20H26N4OCouleur et forme :SolidMasse moléculaire :338.45Cendifensine
CAS :<p>Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).</p>Formule :C14H17Cl2NOCouleur et forme :SolidMasse moléculaire :286.197Disulergine
CAS :<p>Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.</p>Formule :C17H24N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.46Dinoxyline
CAS :<p>Dinoxyline is a potent dopamine receptor agonist, with dissociation constants (Ki values) for D1, D2, D3, and D4 receptors being 7 nM, 6 nM, 5 nM, and 43 nM, respectively. It is utilized in neuroscience research.</p>Formule :C15H13NO3Couleur et forme :SolidMasse moléculaire :255.27
