GTPase
Les GTPases sont une famille d'enzymes qui hydrolysent le guanosine triphosphate (GTP) en guanosine diphosphate (GDP), jouant un rôle crucial dans les voies de transduction du signal, y compris celles médiées par les GPCR. Les GTPases agissent comme des interrupteurs moléculaires dans divers processus cellulaires, tels que la division cellulaire, la croissance et la différenciation. La dysrégulation de l'activité des GTPases est impliquée dans de nombreuses maladies, y compris le cancer et les troubles génétiques. Chez CymitQuimica, nous offrons une sélection de modulateurs de GTPase de haute qualité pour soutenir vos recherches en signalisation cellulaire, biologie du cancer et voies liées aux GPCR.
28 produits trouvés pour "GTPase".
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PT-129
PT-129 is a PROTAC degrader targeting the NTF2 domain of G3BP1/2, degrading stress granules in stressed cells, suppressing proliferation.Formule :C46H48N8O12SCouleur et forme :Yellow SolidMasse moléculaire :936.98RGS2-Galpha-q interaction-IN-1
RGS2–Galpha-q interaction-IN-1 (Compound AJ-3) is an inhibitor of the RGS2-Galpha-q interaction. It inhibits the growth of cancer cell lines that express RGS2 and has anti-cell migration properties.Formule :C30H30ClN7O3Couleur et forme :SolidMasse moléculaire :572.06Myristoylated ARF6 (2-13)
Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.Formule :C74H128N16O18Couleur et forme :SolidMasse moléculaire :1528.95925ART5537
ART5537 is a selective EXO1 inhibitor with an EC50 of 55 nM, an IC50 of 3.4 nM, and a Kd of 6.8 nM. It inhibits the homologous recombination (HR) process in HAP1 parental cells with an EC50 of 7.2 nM. The selectivity of ART5537 for the broad-spectrum nuclease superfamily members is over 200-fold higher. Its biological effects are entirely driven by EXO1 inhibition. ART5537 enhances sensitivity to ionizing radiation and exhibits synergism with Olaparib. It is applicable in research on breast and colon cancers.ARF6 (2-13)
CAS :ARF6 (2-13), a peptide with the sequence GKVLSKIFGNKE, acts as an inhibitor of ARF6 and can be utilized in endotoxemia research [1].Formule :C60H102N16O17Masse moléculaire :1319.55CID-1067700
CAS :CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).Formule :C18H18N2O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :390.477Exo-1
CAS :Exo-1 (Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate) is a synthetic compound that has been shown to affect the metabolism of various nutrients, asFormule :C15H12FNO3Degré de pureté :99.45%Couleur et forme :White SolidMasse moléculaire :273.2591BQU57
CAS :BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Formule :C16H13F3N4ODegré de pureté :97.45% - 98.72%Couleur et forme :SolidMasse moléculaire :334.2958CCG-50014
CAS :CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.Formule :C16H13FN2O2SDegré de pureté :98.53%Couleur et forme :White SolidMasse moléculaire :316.35Exo1
CAS :Exo1 is an inhibitor of the exocytic pathwayFormule :C15H12FNO3Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :273.26MLS-573151
CAS :MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formule :C21H19N3O2SDegré de pureté :98.80%Couleur et forme :White SolidMasse moléculaire :377.459NAV-2729
CAS :NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.Formule :C25H17ClN4O3Degré de pureté :98.91% - 99.57%Couleur et forme :Yellow SolidMasse moléculaire :456.88RBC8
CAS :RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.Formule :C25H20N4O3Degré de pureté :98.44% - 99.81%Couleur et forme :White SolidMasse moléculaire :424.4513ML-097
CAS :ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFormule :C14H11BrO3Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :307.139Dynamin inhibitory peptide Acetate
Dynamin inhibitory peptide Acetate is a peptide with the sequence Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro that inhibit the GTPase dynamin.Formule :C49H84N18O16Degré de pureté :97.28%Couleur et forme :SolidMasse moléculaire :1181.3Arf1-GEFs-IN-1
CAS :Arf1-GEFs-IN-1 is a potent and orally active inhibitor of ADP-ribosylation factor 1-guanine nucleotide exchange factors (Arf1-GEFs), exhibiting an IC50 value of 40 μM in CT26 cells. Primarily, Arf1-GEFs-IN-1 induces tumor regression by triggering anti-tumor immune responses rather than direct cytotoxicity. It effectively enhances CCL5 expression and demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 is applicable in colon cancer research.Formule :C19H18N6SMasse moléculaire :362.45QS11
CAS :QS11, a GTPase ARFGAP1, modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation.Formule :C36H33N5O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :567.68Bragsin1
CAS :Bragsin1 is a potent and selective and noncompetitive ArfGEF BRAG2 inhibitor, inhibits Arf GTPase activation(IC50 : 3 μM),and with anti-cancer activity.Formule :C11H6F3NO4Couleur et forme :SolidMasse moléculaire :273.1648CCG-2046
CAS :CCG-2046 is a chemical inhibitor targeting RGS4, demonstrating an inhibition concentration (IC50) of 4.3 μM for the interaction between RGS4 and Gαo signal.Formule :C11H10N4Couleur et forme :SolidMasse moléculaire :198.2239CCG-4986
CAS :CCG-4986 is the first small molecule RGS inhibitor reported that directly bound to an RGS protein.Formule :C13H11ClN2O5S2Couleur et forme :SolidMasse moléculaire :374.82
