Hérisson/Smoothened
La voie de signalisation Hedgehog/Smoothened est une voie liée aux GPCR cruciale, impliquée dans le développement embryonnaire, la régénération des tissus et le maintien des cellules souches. Smoothened (SMO) est une protéine transmembranaire clé qui transduit les signaux des ligands Hedgehog (Hh) pour activer les cascades de signalisation en aval. La dérégulation de la voie Hedgehog/Smoothened est impliquée dans divers cancers et troubles du développement, en faisant une cible significative pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une gamme de modulateurs de haute qualité pour la voie Hedgehog/Smoothened afin de soutenir vos recherches en biologie du développement, oncologie et médecine régénérative.
49 produits trouvés pour "Hérisson/Smoothened"
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ALLO-2
CAS :ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.Formule :C18H12F3N5ODegré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :371.32Ref: TM-T14188
1mg60,00€5mg133,00€10mg200,00€25mg334,00€50mg475,00€100mg623,00€200mg858,00€1mL*10mM (DMSO)147,00€Dynarrestin
CAS :Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Formule :C22H23F2N3O2SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :431.5GANT 58
CAS :GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).Formule :C24H16N4SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :392.48SAG dihydrochloride
CAS :SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.Formule :C28H30Cl3N3OSDegré de pureté :99.57%Couleur et forme :SoildMasse moléculaire :562.98HSP70-IN-3
HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.Formule :C48H78N6O7SCouleur et forme :SolidMasse moléculaire :883.23GI-560192
CAS :GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Formule :C20H16N2O2Degré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :316.35Ref: TM-T64351
1mg85,00€5mg170,00€10mg250,00€25mg371,00€50mg522,00€100mg712,00€200mg954,00€1mL*10mM (DMSO)170,00€GLI1-IN-3
GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.Couleur et forme :Odour SolidHPP-9
HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BETFormule :C49H52N6O11Couleur et forme :SolidMasse moléculaire :900.97HL2-m5
CAS :HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.Formule :C70H101N15O24S3Couleur et forme :SolidMasse moléculaire :1632.83WAY-313170
CAS :WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Formule :C19H17ClN2O2S2Degré de pureté :97.92%Couleur et forme :SolidMasse moléculaire :404.93CUR61414 hydrochloride
CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.Formule :C31H43ClN4O5Degré de pureté :94.05%Couleur et forme :SolidMasse moléculaire :587.15SANT 2
CAS :SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Formule :C26H26ClN3O4Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :479.96MRT-10
CAS :MRT-10 is a Smoothened (Smo) receptor antagonist.
Formule :C24H23N3O5SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :465.52Sonidegib
CAS :Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.Formule :C26H26F3N3O3Degré de pureté :98% - 99.97%Couleur et forme :SolidMasse moléculaire :485.5JK184
CAS :JK184 is a potent Hedgehog (Hh) pathway inhibitor.
Formule :C19H18N4OSDegré de pureté :98.93% - 99.89%Couleur et forme :SolidMasse moléculaire :350.44Glasdegib
CAS :Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Formule :C21H22N6ODegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :374.44SANT-1
CAS :SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).Formule :C23H27N5Degré de pureté :99.93% - >99.99%Couleur et forme :SolidMasse moléculaire :373.49HhAntag
CAS :HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFormule :C24H23ClN4O3Degré de pureté :95.73%Couleur et forme :SolidMasse moléculaire :450.92Taladegib
CAS :Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.Formule :C26H24F4N6ODegré de pureté :98.75% - >99.99%Couleur et forme :SolidMasse moléculaire :512.5SAG hydrochloride (912545-86-9(free base))
CAS :SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Formule :C28H29Cl2N3OSDegré de pureté :99.19% - 99.97%Couleur et forme :SolidMasse moléculaire :526.52Ref: TM-T4211
1mg49,00€2mg65,00€5mg90,00€10mg114,00€25mg222,00€50mg334,00€100mg502,00€200mg717,00€1mL*10mM (DMSO)105,00€MRT-81
CAS :MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formule :C31H29N3O5SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :555.64Ref: TM-T9532
1mg48,00€5mg97,00€10mg145,00€25mg255,00€50mg368,00€100mg505,00€200mg692,00€1mL*10mM (DMSO)116,00€SAG
CAS :SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.
Formule :C28H28ClN3OSDegré de pureté :97.37% - 98.88%Couleur et forme :SolidMasse moléculaire :490.06Ciliobrevin A
CAS :Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Formule :C17H9Cl2N3O2Degré de pureté :98.54% - 99.57%Couleur et forme :SolidMasse moléculaire :358.18Ref: TM-T3156
2mg42,00€5mg59,00€10mg85,00€25mg168,00€50mg235,00€100mg331,00€200mg492,00€1mL*10mM (DMSO)69,00€HPI 1
CAS :HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Formule :C27H29NO6Degré de pureté :97.6%Couleur et forme :SolidMasse moléculaire :463.52Ref: TM-T22089
1mg47,00€2mg60,00€5mg92,00€10mg135,00€25mg217,00€50mg324,00€100mg472,00€500mg1.026,00€1mL*10mM (DMSO)107,00€Neurodazine
CAS :Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Formule :C27H21ClN2O3Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :456.925-LOX inhibitor
CAS :5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.Formule :C22H27N5O2Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :393.48MS-0022
CAS :MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.Formule :C21H16BrN3OCouleur et forme :SolidMasse moléculaire :406.28SMANT hydrochloride
CAS :SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Formule :C16H24BrClN2ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :375.733-epi-Vitamin D3
CAS :3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM inFormule :C27H44OCouleur et forme :SolidMasse moléculaire :384.64RUSKI-201 dihydrochloride
CAS :RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.Formule :C20H29Cl2N3OSCouleur et forme :SolidMasse moléculaire :430.43Hedgehog Antagonist VIII
CAS :Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Formule :C23H15ClF4N4O2Couleur et forme :SolidMasse moléculaire :490.84SMO-IN-3
CAS :SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.Formule :C27H25F4N3O2Couleur et forme :SolidMasse moléculaire :499.5RUSKI-201
CAS :RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.Formule :C20H27N3OSCouleur et forme :SolidMasse moléculaire :357.51SANT-2
CAS :SANT-2 is a potent inhibitor of Shh signaling pathway.Formule :C23H20ClN3O4Couleur et forme :SolidMasse moléculaire :437.88Hedgehog IN-3
CAS :Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].Formule :C18H13ClF3N5OCouleur et forme :SolidMasse moléculaire :407.78M-25
CAS :M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Formule :C23H29N3O2Couleur et forme :SolidMasse moléculaire :379.5LEQ-506
CAS :LEQ506, an oral Smoothened antagonist, may inhibit cancer growth by blocking the Hedgehog signaling pathway.Formule :C27H29N5OCouleur et forme :SolidMasse moléculaire :439.55SMO-IN-2
CAS :SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Formule :C25H25F4N5O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :503.49AZD8542
CAS :AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formule :C25H24N4O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :412.48Hedgehog IN-2
CAS :Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].Formule :C24H22N4O2Couleur et forme :SolidMasse moléculaire :398.46GSA-10
CAS :GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Formule :C26H30N2O5Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :450.53Hh-Ag1.5
CAS :Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Formule :C28H26ClF2N3OSDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :526.04Ref: TM-T24754
1mg120,00€5mg289,00€10mg447,00€25mg740,00€50mg1.044,00€100mg1.459,00€1mL*10mM (DMSO)334,00€Robotnikinin
CAS :Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.Formule :C25H27ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.95SAG 21k
CAS :SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Formule :C29H28ClF2N3O2SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :556.07TAK-441
CAS :TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Formule :C28H31F3N4O6Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :576.56IMP-1575
CAS :IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.Formule :C19H25N3OSMasse moléculaire :343.49MRT-92
CAS :MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.Formule :C33H34N4O5Couleur et forme :SolidMasse moléculaire :566.65BRD50837
CAS :BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).Formule :C26H32ClN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :550.07LAB687
CAS :LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.Formule :C26H23F3N2O3Couleur et forme :SolidMasse moléculaire :468.47
