PAFR
Le récepteur du facteur d'activation des plaquettes (PAFR) est un GPCR qui se lie au facteur d'activation des plaquettes (PAF), un puissant médiateur phospholipidique impliqué dans l'inflammation, la thrombose et les réactions allergiques. La signalisation du PAFR joue un rôle crucial dans les réponses immunitaires, la santé cardiovasculaire et la pathogenèse des maladies inflammatoires. La modulation de l'activité du PAFR est d'un grand intérêt dans le développement de thérapies anti-inflammatoires et antithrombotiques. Chez CymitQuimica, nous offrons une variété de modulateurs de PAFR de haute qualité pour soutenir vos recherches en immunologie, biologie cardiovasculaire et inflammation.
14 produits trouvés pour "PAFR"
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Kadsurenin C
CAS :Kadsurenin C (compound 1), a neolignan isolated from the aerial parts of Piper kadsura, exhibits anti-inflammatory properties and significant PAF (Platelet Activating Factor) antagonistic activity, with an IC50 value of 5.1 μM [1].Formule :C21H26O5Masse moléculaire :358.43Oxopurpureine
CAS :Oxopurpureine, classified as an oxoaporphine compound, functions to inhibit plant pathogens.Formule :C21H19NO6Masse moléculaire :381.38PAF C-18
CAS :PAF C-18 is a natural phospholipid molecule belonging to the platelet-activating factor (PAF) family,, involved in hemostasis and thrombosis by binding to PAFR.Formule :C28H58NO7PDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :551.74α-Bulnesene
CAS :α-Bulnesene, a novel PAF (platelet-activating factor) receptor antagonist, exhibits an IC50 of 17.62 μM. It can be isolated from patchouli. α-Bulnesene inhibits both PAF and arachidonic acid-induced aggregation of rabbit platelets.Formule :C15H24Couleur et forme :SolidMasse moléculaire :204.35PAF-AN-1
CAS :PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.Formule :C28H28N2O3Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :440.532-Acetylbenzoic acid
CAS :2-Acetylbenzoic acid outperforms 2-propionyloxybenzoic in hindering platelet function and PG synthesis; both similar in blocking PGI2 creation.Formule :C9H8O3Degré de pureté :99.62%Couleur et forme :Off-White SolidMasse moléculaire :164.16Tulopafant
CAS :Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.Formule :C25H19N3O2SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :425.5Methylcarbamyl PAF C-16
CAS :Methylcarbamyl PAF C-16 (Carbamyl-PAF) is a PAF analog with PAF agonistic properties, activating inflammation in pregnancy tissues and promoting preterm birth.Formule :C26H55N2O7PCouleur et forme :SolidMasse moléculaire :538.7Rocepafant
CAS :Rocepafant (LAU8080), a PAF antagonist, reduces neonatal rat brain damage and inhibits TNF-α toxicity in L929 cells.Formule :C26H23ClN6OS2Degré de pureté :97.31% - 98.95%Couleur et forme :SolidMasse moléculaire :535.08SDZ-62-434
CAS :SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity and may be used in the study of leukemia.Formule :C23H27Cl2N3Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :416.3948740 RP
CAS :48740 RP (RP 55779) is an antagonist of platelet-activating factor.Formule :C12H11N3OSDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :245.3Ref: TM-T10159
1mg356,00€5mg567,00€10mg907,00€25mg1.339,00€50mg1.815,00€100mg2.432,00€1mL*10mM (DMSO)567,00€Foropafant
CAS :Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM).Formule :C28H40N4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :464.71Apafant
CAS :Apafant (WEB 2086) is a PAF antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.Formule :C22H22ClN5O2SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :455.96ST-899
CAS :ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.Formule :C22H29BrClNO6Couleur et forme :SolidMasse moléculaire :518.83
