Récepteur cannabinoïde
Les récepteurs cannabinoïdes sont des GPCR qui médiatisent les effets des cannabinoïdes endogènes (endocannabinoïdes) et des phytocannabinoïdes, tels que ceux trouvés dans le cannabis. Les deux principaux types de récepteurs cannabinoïdes, CB1 et CB2, sont impliqués dans la régulation d'une large gamme de processus physiologiques, y compris la perception de la douleur, l'appétit, l'humeur et la fonction immunitaire. Les modulateurs des récepteurs cannabinoïdes ont un potentiel thérapeutique dans le traitement de conditions telles que la douleur chronique, l'épilepsie et la sclérose en plaques. Chez CymitQuimica, nous offrons une large gamme de modulateurs de récepteurs cannabinoïdes de haute qualité pour soutenir vos recherches en neuropharmacologie, gestion de la douleur et immunologie.
196 produits trouvés pour "Récepteur cannabinoïde"
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O-2050
CAS :<p>O-2050: strong CB1 antagonist (Ki 2.5 nM), CB2 inhibitor (Ki 0.2 nM); reduces mouse food intake, increases activity.</p>Formule :C23H31NO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.56GW405833 hydrochloride
CAS :<p>GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].</p>Formule :C23H25Cl3N2O3Couleur et forme :SolidMasse moléculaire :483.822-Linoleoyl Glycerol
CAS :<p>2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.</p>Formule :C21H38O4Couleur et forme :SolidMasse moléculaire :354.531CB1 inverse agonist 1
CAS :<p>MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.</p>Formule :C25H18Cl3N3O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :514.79Hemopressin(rat) TFA
CAS :<p>Hemopressin(rat) TFA, a nonapeptide from hemoglobin α1-chain, selectively inhibits CB1 receptors and reduces inflammatory pain.</p>Formule :C55H78F3N13O14Couleur et forme :SolidMasse moléculaire :1202.28CB-25
CAS :<p>CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cells</p>Formule :C25H41NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.6γ-Linolenoyl monoethanolamide
CAS :<p>γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].</p>Formule :C20H35NO2Couleur et forme :SolidMasse moléculaire :321.505Tedalinab
CAS :<p>Tedalinab is an effective and selective cannabinoid receptor 2 agonist.</p>Formule :C19H21F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.39Prostaglandin E2-1-glyceryl ester
CAS :<p>Prostaglandin E2-1-glyceryl ester, a member of the Prostaglandin Glycerol Ester family, serves as an endocannabinoid ligand targeting the CB1 receptor. This compound triggers a swift and transient surge in intracellular free calcium levels [1] [2].</p>Formule :C23H38O7Couleur et forme :SolidMasse moléculaire :426.55PSB-SB1202
CAS :<p>PSB-SB1202 (Compound 21a), a phenyl coumarin compound, acts as a CB1/CB2 agonist. It demonstrates EC50 values of 56 and 14 nM and K i values of 32 and 49 nM for CB1 and CB2 receptors, respectively [1].</p>Formule :C23H26O4Couleur et forme :SolidMasse moléculaire :366.45CB2R-IN-1
CAS :<p>CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).</p>Formule :C23H27F3N4O6S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.67CB-52
CAS :<p>CB-52 acts as a neutral antagonist and ligand for the CB2 cannabinoid receptor [1].</p>Formule :C26H43NO3Couleur et forme :SolidMasse moléculaire :417.62URB447
CAS :<p>URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].</p>Formule :C25H21ClN2OCouleur et forme :SolidMasse moléculaire :400.9Isopropyl dodec-11-enylfluorophosphonate
CAS :<p>Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibits</p>Formule :C15H30FO2PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.37Amauromine
CAS :<p>Amauromine is a peripherally selective and potent cannabinoid receptor type 1 (CB1) receptor antagonist, a novel alkaloid with vasodilatory activity.</p>Formule :C32H36N4O2Couleur et forme :SolidMasse moléculaire :508.65PSNCBAM-1
CAS :<p>PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.</p>Formule :C22H21ClN4ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :392.88PF 514273
CAS :<p>PF 514273 is a CB1 receptor antagonist.</p>Formule :C21H17Cl2F2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.28GSK494581A
CAS :<p>GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.</p>Formule :C27H28F2N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58GP 1a
CAS :<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Formule :C23H22Cl2N4ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :441.35GW 833972A
CAS :<p>GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.</p>Formule :C18H14Cl2F3N5ODegré de pureté :99.93%Couleur et forme :SoildMasse moléculaire :444.24MDA7
CAS :<p>MDA7 is a selective agonist of the cannabinoid receptor 2 (CB2), demonstrating an EC50 of 128 nM in human CB2 receptors and 67.4 nM in rat CB2 receptors. The compound exhibits good affinity for CB2 receptors, with Ki values of 422 nM for humans and 238 nM for rats. In rat models, MDA7 shows analgesic activity.</p>Formule :C22H25NO2Couleur et forme :SolidMasse moléculaire :335.439MDMB-FUBICA
CAS :<p>MDMB-FUBICA is a potent agonist of the cannabinoid receptors and exhibits psychoactive properties. It can be utilized in e-cigarettes.</p>Formule :C23H25FN2O3Couleur et forme :SolidMasse moléculaire :396.455BNS808
CAS :<p>BNS808 is an orally active, selective CB1R antagonist with an IC50 of 0.8 nM, demonstrating significant selectivity for CB2R and minimal brain penetration. It is being studied for the treatment of obesity and related metabolic complications, such as metabolic dysfunction-associated steatotic liver disease (MASLD). BNS808 reduces drug exposure to the central nervous system, enhancing safety, and minimizes drug interactions through high plasma protein binding.</p>Formule :C25H20Cl3N3O3SCouleur et forme :SolidMasse moléculaire :548.869CB1/2 receptor-1
CAS :<p>CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.</p>Formule :C33H48O2Couleur et forme :SolidMasse moléculaire :476.73BAY 38-7271
CAS :<p>BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).</p>Formule :C20H21F3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.44GAT564
<p>GAT564, an allosteric CB1R modulator, shows EC50s of 87 nM (cAMP) & 320 nM (β-arrestin2) and lowers IOP effectively in glaucoma mice.</p>Formule :C20H16N2O2SCouleur et forme :SolidMasse moléculaire :348.42Bzo-poxizid
CAS :<p>Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.</p>Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.40HU-308
CAS :<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>Formule :C27H42O3Couleur et forme :SolidMasse moléculaire :414.62CB1/2 agonist 1
<p>Potent CB1/2 agonist 1; crosses blood-brain barrier; anti-inflammatory, analgesic; for multiple sclerosis research.</p>Formule :C21H24BrFN2O2Couleur et forme :SolidMasse moléculaire :435.33TM38837
CAS :<p>CB1 antagonist 4 is an inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. It can reduce body weight, improve plasma inflammatory markers, and enhance glucose homeostasis [1].</p>Formule :C27H20Cl2F3N7OCouleur et forme :SolidMasse moléculaire :586.40CB2 receptor antagonist 1
CAS :<p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>Formule :C28H47NO3Couleur et forme :SolidMasse moléculaire :445.68Taranabant
CAS :<p>Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.</p>Formule :C27H25ClF3N3O2Degré de pureté :99.06% - 99.06%Couleur et forme :SolidMasse moléculaire :515.96CBR Agonist-2
<p>CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.</p>Formule :C27H27FN4OCouleur et forme :SolidMasse moléculaire :442.53CBR Agonist-1
<p>CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.</p>Formule :C27H27FN4OCouleur et forme :SolidMasse moléculaire :442.53HU 433
CAS :<p>HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.</p>Formule :C27H42O3Couleur et forme :SolidMasse moléculaire :414.621'-Naphthoyl-2-methylindole
CAS :<p>1'-Naphthoyl-2-methylindole (Compound 88) acts as a cannabinoid mimic and an inhibitor of Win 55212-2, displaying a 34% inhibition of [3H]Win 55212-2 binding to cannabinoid receptors at a concentration of 3 μM.</p>Formule :C20H15NOCouleur et forme :SolidMasse moléculaire :285.34FDU-PB-22
CAS :<p>FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.</p>Formule :C26H18FNO2Couleur et forme :SolidMasse moléculaire :395.43MDA77
CAS :<p>MDA77 is a CB2 agonist with an EC50 value of 5.82 nM and exhibits no activity towards CB1.</p>Formule :C21H23N3O3Couleur et forme :SolidMasse moléculaire :365.43O-1269
CAS :<p>O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.</p>Formule :C22H22Cl3N3OCouleur et forme :SolidMasse moléculaire :450.79AB-FUBINACA 3-fluorobenzyl isomer
CAS :<p>AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.</p>Formule :C20H21FN4O2Couleur et forme :SolidMasse moléculaire :368.41AM8936
<p>AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.</p>Formule :C25H33NO3Couleur et forme :SolidMasse moléculaire :395.53(Rac)-Zevaquenabant
CAS :<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Formule :C25H21ClF3N5O2SCouleur et forme :SolidMasse moléculaire :547.98WIN 55,212-2 Mesylate
CAS :<p>WIN 55,212-2 Mesylate ((R)-(+)-WIN 55212) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. Cannabinoid analogue WIN 55,212-2 Mesylate exhibited a novel anticancer effect against human tumors.</p>Formule :C28H30N2O6SDegré de pureté :98% - 99.71%Couleur et forme :White To Off-White SolidMasse moléculaire :522.61AM-2232
CAS :<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Formule :C24H20N2ODegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :352.432-Arachidonoylglycerol
CAS :<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Formule :C23H38O4Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :378.55AEF0117
CAS :<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formule :C29H40O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :436.63Ref: TM-T79909
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