Récepteur cannabinoïde
Les récepteurs cannabinoïdes sont des GPCR qui médiatisent les effets des cannabinoïdes endogènes (endocannabinoïdes) et des phytocannabinoïdes, tels que ceux trouvés dans le cannabis. Les deux principaux types de récepteurs cannabinoïdes, CB1 et CB2, sont impliqués dans la régulation d'une large gamme de processus physiologiques, y compris la perception de la douleur, l'appétit, l'humeur et la fonction immunitaire. Les modulateurs des récepteurs cannabinoïdes ont un potentiel thérapeutique dans le traitement de conditions telles que la douleur chronique, l'épilepsie et la sclérose en plaques. Chez CymitQuimica, nous offrons une large gamme de modulateurs de récepteurs cannabinoïdes de haute qualité pour soutenir vos recherches en neuropharmacologie, gestion de la douleur et immunologie.
217 produits trouvés pour "Récepteur cannabinoïde"
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CB2R PAM
CAS :CB2R PAM, an oral drug, boosts CB2 receptor response to specific agonists, showing potential in neuropathic pain relief.Formule :C21H24BrFN2O2Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :435.33SCH-336
CAS :SCH-336: potent, selective CB2 agonist (Ki=1.8 nM, EC50=2 nM), orally active, 100x CB2 vs. CB1 preference, reduces leukocyte migration and eosinophilia.
Formule :C23H25NO8S3Degré de pureté :95.01%Couleur et forme :SolidMasse moléculaire :539.64PSB-CB5
CAS :PSB-CB5 (GPR18-IN-32)2 is a GRP18 antagonist with anti-inflammatory activity and can be used to study obesity and metabolic disorders.Formule :C20H17ClN2O2SDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :384.88AZD1940
CAS :AZD1940 (UNII-0J0035E9FT) is a high affinity CB(1)/CB(2) receptor agonist of the cannabinoid with oral activity. Application in the study of orofacial pain.Formule :C20H29F2N3O2SDegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :413.52Ref: TM-T30252
1mg130,00€5mg311,00€10mg535,00€25mg847,00€50mg1.169,00€100mg1.586,00€1mL*10mM (DMSO)344,00€JTE-907
CAS :JTE-907 是一种具有高度选择性和口服活性的 CB2 受体反向激动剂。JTE-907在体内展现出抗炎活性。Formule :C24H26N2O6Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :438.47Ref: TM-T19705
1mg52,00€5mg119,00€10mg177,00€25mg313,00€50mg465,00€100mg662,00€1mL*10mM (DMSO)142,00€AM-1235
CAS :AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.Formule :C24H21FN2O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :404.43O-2050
CAS :O-2050: strong CB1 antagonist (Ki 2.5 nM), CB2 inhibitor (Ki 0.2 nM); reduces mouse food intake, increases activity.Formule :C23H31NO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.56Heptadecanoyl ethanolamide
CAS :Heptadecanoyl ethanolamide, an endogenous cannabinoid, serves as a synthetic analog of PEA, featuring an odd-numbered (17-carbon) fatty acid chain [1].Formule :C19H39NO2Couleur et forme :SolidMasse moléculaire :313.52COR659
CAS :COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.Formule :C16H16ClNO3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :337.82Ref: TM-T36520
1mg38,00€5mg86,00€10mg123,00€25mg215,00€50mg299,00€100mg411,00€200mg560,00€1mL*10mM (DMSO)94,00€PF-03550096
CAS :PF-03550096, an orally active synthetic cannabinoid (CB), selectively binds to peripheral CB2 receptors with a Ki value of 7.9 nM, demonstrating analgesic activity [1].Formule :C19H28N4O4Couleur et forme :SolidMasse moléculaire :376.45URB447
CAS :URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].Formule :C25H21ClN2OCouleur et forme :SolidMasse moléculaire :400.9Tedalinab
CAS :Tedalinab is an effective and selective cannabinoid receptor 2 agonist.Formule :C19H21F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.39GW405833 hydrochloride
CAS :GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].Formule :C23H25Cl3N2O3Couleur et forme :SolidMasse moléculaire :483.822-Linoleoyl Glycerol
CAS :2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.Formule :C21H38O4Couleur et forme :SolidMasse moléculaire :354.531GSK494581A
CAS :GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.Formule :C27H28F2N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58PF 514273
CAS :PF 514273 is a CB1 receptor antagonist.Formule :C21H17Cl2F2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.28PSNCBAM-1
CAS :PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.Formule :C22H21ClN4ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :392.88Hemopressin(rat) TFA
CAS :Hemopressin(rat) TFA, a nonapeptide from hemoglobin α1-chain, selectively inhibits CB1 receptors and reduces inflammatory pain.Formule :C55H78F3N13O14Couleur et forme :SolidMasse moléculaire :1202.2811(Z),14(Z)-Eicosadienoic Acid Ethanolamide
CAS :11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide derivative of 11(Z),14(Z)-eicosadienoic acid.Formule :C22H41NO2Couleur et forme :SolidMasse moléculaire :351.57SAD-448
CAS :SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.Formule :C24H28N4O8SCouleur et forme :SolidMasse moléculaire :532.57O-2545 hydrochloride
CAS :O-2545 is a potent water-soluble central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist with Ki values of 1.5 and 0.32 nM, respectively. Typically, cannabinoid agonists are highly lipophilic and require solubilization through surfactant agents or binding to water miscible substances like albumin, Tween 80, or Emulphor for use. When dissolved in saline, O-2545 has shown high efficacy in mouse behavioral models, administered either intravenously or intracerebroventricularly.Formule :C26H36N2O2HClCouleur et forme :SolidMasse moléculaire :445Tricosanoyl Ethanolamide
CAS :Tricosanoyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, has an ethanolamine metabolite whose significance remains to be established.Formule :C25H51NO2Couleur et forme :SolidMasse moléculaire :397.688Isopropyl dodec-11-enylfluorophosphonate
CAS :Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibitsFormule :C15H30FO2PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.37MCHB-1
CAS :MCHB-1, a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50= 0.52 nM), demonstrates high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively), distinguishing itself from similar benzimidazole compounds that significantly alleviate peripheral pain while minimizing central nervous system side effects in mice.Formule :C28H37N3O2Couleur et forme :SolidMasse moléculaire :447.623CB1 antagonist 1
CAS :CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, andFormule :C26H22Cl2N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.39Amauromine
CAS :Amauromine is a peripherally selective and potent cannabinoid receptor type 1 (CB1) receptor antagonist, a novel alkaloid with vasodilatory activity.Formule :C32H36N4O2Couleur et forme :SolidMasse moléculaire :508.65γ-Linolenoyl monoethanolamide
CAS :γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].Formule :C20H35NO2Couleur et forme :SolidMasse moléculaire :321.505CB 65
CAS :CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.Formule :C22H28ClN3O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :417.93(R)-Monlunabant
CAS :(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].Formule :C26H22ClF3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591CB1 inverse agonist 1
CAS :MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.Formule :C25H18Cl3N3O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :514.79Ref: TM-T10694
1mg50,00€5mg105,00€10mg155,00€25mg224,00€50mg314,00€100mg427,00€200mg577,00€1mL*10mM (DMSO)129,00€AM841
CAS :AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor.Formule :C26H39NO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.66Prostaglandin E2-1-glyceryl ester
CAS :Prostaglandin E2-1-glyceryl ester, a member of the Prostaglandin Glycerol Ester family, serves as an endocannabinoid ligand targeting the CB1 receptor. This compound triggers a swift and transient surge in intracellular free calcium levels [1] [2].Formule :C23H38O7Couleur et forme :SolidMasse moléculaire :426.55PSB-SB1202
CAS :PSB-SB1202 (Compound 21a), a phenyl coumarin compound, acts as a CB1/CB2 agonist. It demonstrates EC50 values of 56 and 14 nM and K i values of 32 and 49 nM for CB1 and CB2 receptors, respectively [1].Formule :C23H26O4Couleur et forme :SolidMasse moléculaire :366.45CB2R-IN-1
CAS :CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).Formule :C23H27F3N4O6S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.67CB-25
CAS :CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cellsFormule :C25H41NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.6CB-52
CAS :CB-52 acts as a neutral antagonist and ligand for the CB2 cannabinoid receptor [1].Formule :C26H43NO3Couleur et forme :SolidMasse moléculaire :417.62OMDM-5
CAS :OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Formule :C26H44N2O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :432.64Ref: TM-T12306
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)210,00€O-Arachidonoyl glycidol
CAS :O-Arachidonoyl glycidol (compound 1), a 2-arachidonoylglycerol (2-AG) analog, effectively inhibits the hydrolysis of cytosolic 2-oleoylglycerol (2-OG) with an IC50 value of 4.5 µM, and also blocks 2-OG and anandamide hydrolysis in membrane fractions with IC50 values of 19 µM and 12 µM, respectively [1].Formule :C23H36O3Couleur et forme :SolidMasse moléculaire :360.53GSK-554418A
CAS :GSK-554418A, a novel azaindole CB(2) agonists, is used for the treatment of chronic pain. It is efficacious in the acute model and the chronic joint pain model.Formule :C19H19ClN4O2Couleur et forme :SolidMasse moléculaire :370.83CAY10508
CAS :CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 µM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.Formule :C21H14Br2N2O2Couleur et forme :SolidMasse moléculaire :486.2GP 1a
CAS :GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.
Formule :C23H22Cl2N4ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :441.35GW 833972A
CAS :GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.
Formule :C18H14Cl2F3N5ODegré de pureté :99.93%Couleur et forme :SoildMasse moléculaire :444.24Bzo-poxizid
CAS :Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.40BAY 38-7271
CAS :BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).Formule :C20H21F3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.44AM8936
AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.Formule :C25H33NO3Couleur et forme :SolidMasse moléculaire :395.53CBR Agonist-2
CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.Formule :C27H27FN4OCouleur et forme :SolidMasse moléculaire :442.53PSB-KK1415
CAS :PSB-KK1415 is a selective agonist for the human orphan G protein-coupled receptor GPR18, with an EC50 of 19.1 nM.Formule :C24H23ClN6O2Masse moléculaire :462.93Cannabigerovarin
CAS :Cannabigerovarin (CBGV) is a compound categorized as a phytocannabinoid.Formule :C19H28O2Masse moléculaire :288.42Ac-Atovaquone
CAS :Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.Formule :C24H21ClO4Couleur et forme :SolidMasse moléculaire :408.87CBR Agonist-1
CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.Formule :C27H27FN4OCouleur et forme :SolidMasse moléculaire :442.53
