DHFR
La dihydrofolate réductase (DHFR) est une enzyme qui joue un rôle crucial dans le cycle des folates, essentiel pour la synthèse, la réparation et la méthylation de l'ADN. Les inhibiteurs de la DHFR sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer et des maladies auto-immunes en raison de leur capacité à inhiber la prolifération cellulaire. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de la DHFR pour soutenir vos recherches en thérapie anticancéreuse, immunologie et biologie moléculaire.
30 produits trouvés pour "DHFR"
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P 218
CAS :P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.Formule :C18H25ClN4O4Degré de pureté :98.83%Couleur et forme :SoildMasse moléculaire :396.874-O-Methyldopamine hydrochloride
CAS :Compound PDK0318, with CAS No. 645-33-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0318 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C9H13NO2Couleur et forme :Slightly Beige Fluffy PowderMasse moléculaire :167.2DHFR-IN-16
DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.Formule :C32H34N4O4SMasse moléculaire :570.23008DHFR-IN-18
DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.Formule :C24H22ClN7Masse moléculaire :443.16252EGFR/DHFR-IN-1
EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR, with IC50 values of 0.151 µM and 0.541 µM, respectively. It induces cell cycle arrest in the G0-G1 and S phases.Formule :C24H26N4O5S2Masse moléculaire :514.13446DHFR-IN-21
DHFR-IN-21 (compound 5p) is an inhibitor of dihydrofolate reductase.Couleur et forme :Odour SolidDHFR-IN-20
DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4/8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1/S)PfDHFR.Couleur et forme :Odour SolidCB 3705
CAS :CB 3705 is a bio-active chemical.Formule :C21H21N5O6Couleur et forme :SolidMasse moléculaire :439.42EGFR/HER2/DHFR-IN-2
EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.Degré de pureté :98%Couleur et forme :Odour SolidDHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Couleur et forme :Odour SolidTH9028 TFA
TH9028 TFA is an effective MTHFD2 inhibitor (IC50=11 nM) that suppresses proliferation in HL-60 cells, AML cells, and T-ALL Jurkat cells.Formule :C18H19F3N12O7Degré de pureté :98.94% - 99.79%Masse moléculaire :572.42Anti-Dihydrofolate reductase Antibody (2V859)
Anti-Dihydrofolate reductase Antibody (2V859) is an antibody targeting Dihydrofolate reductase. Anti-Dihydrofolate reductase Antibody (2V859) can be used in ELISA, WB, IHC, IP.Couleur et forme :Odour LiquidWR99210 hydrochloride(47326-86-3 free base)
CAS :WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Formule :C14H19Cl4N5O2Degré de pureté :97.77% - 99.8%Couleur et forme :SolidMasse moléculaire :431.14Ref: TM-T17257L
1mg62,00€5mg132,00€1mL*10mM (DMSO)157,00€10mg200,00€25mg338,00€50mg497,00€100mg708,00€200mg954,00€Piritrexim isethionate
CAS :Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.Formule :C19H25N5O6SCouleur et forme :SolidMasse moléculaire :451.49WR99210
CAS :WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.Formule :C14H18Cl3N5O2Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :394.68Fanotaprim
CAS :Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.Formule :C19H22N8ODegré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :378.43Ref: TM-T36692
1mg50,00€2mg71,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg170,00€25mg318,00€50mg442,00€100mg627,00€200mg845,00€DHFR-IN-3
CAS :DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.Formule :C8H7BrN4Degré de pureté :99.521% - 99.65%Couleur et forme :SolidMasse moléculaire :239.07Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)
Key enzyme in folate metabolism.Couleur et forme :Lyophilized PowderMasse moléculaire :25.6 kDa (predicted)Ref: TM-TMPH-03535
5µg120,00€10µg195,00€20µg324,00€50µg489,00€100µg670,00€200µg964,00€500µg1.558,00€1mg2.277,00€Dihydrofolate reductase Protein, Human, Recombinant (His)
Key enzyme in folate metabolism.Couleur et forme :Lyophilized PowderMasse moléculaire :25.5 kDa (predicted)Ref: TM-TMPH-01224
5µg84,00€10µg120,00€20µg193,00€50µg290,00€100µg416,00€200µg631,00€500µg1.123,00€1mg1.700,00€Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
Key enzyme in folate metabolism.Couleur et forme :Lyophilized PowderMasse moléculaire :22.0 kDa (predicted)Ref: TM-TMPH-03581
5µg130,00€10µg211,00€20µg351,00€50µg520,00€100µg714,00€200µg1.027,00€500µg1.607,00€1mg2.350,00€(Rac)-Managlinat dialanetil
CAS :Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.Formule :C21H33N4O6PSDegré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :500.5510-Deazaaminopterin
CAS :10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.Formule :C20H21N7O5Couleur et forme :SolidMasse moléculaire :439.42Piritrexim
CAS :Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinomaFormule :C17H19N5O2Degré de pureté :98.50% - >99.99%Couleur et forme :SolidMasse moléculaire :325.37Clociguanil
CAS :Clociguanil has antimalarial activity.Formule :C12H15Cl2N5OCouleur et forme :SolidMasse moléculaire :316.19Aditoprime
CAS :Aditoprime (Aditoprim) is a selective bacterial DHFR inhibitor with strong nanomolar potency and broad-spectrum antibacterial activity.Formule :C15H21N5O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :303.36DHFR-IN-5
CAS :DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.Formule :C18H24N4O4Couleur et forme :SolidMasse moléculaire :360.41Talotrexin ammonium
CAS :Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.
Formule :C27H30N10O6Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :590.59Ref: TM-T64295
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€Phototrexate
CAS :Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).Formule :C20H19N7O5Couleur et forme :SolidMasse moléculaire :437.41Methotrexate-γ-aspartate
CAS :Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.Formule :C24H27N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :569.53DHFR-IN-4
CAS :DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.Formule :C18H21N5O2SDegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :371.46
