Synthèse ADN/ARN
Les inhibiteurs de la synthèse de l'ADN et de l'ARN sont des composés qui interfèrent avec les processus de réplication et de transcription dans les cellules, empêchant ainsi la production de matériel génétique essentiel. Ces inhibiteurs peuvent cibler diverses enzymes et protéines impliquées dans la synthèse des acides nucléiques, ce qui en fait des outils précieux pour étudier les mécanismes de réplication, de transcription et de traduction. Ils sont également utilisés dans le développement de traitements contre les infections et le cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de la synthèse de l'ADN/ARN pour soutenir vos recherches en biologie moléculaire, virologie et développement thérapeutique.
794 produits trouvés pour "Synthèse ADN/ARN"
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Polθ-IN-7
CAS :Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.Formule :C28H35F3N6O2Couleur et forme :SolidMasse moléculaire :544.612iPAF1C
CAS :<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formule :C27H26BrFN4OCouleur et forme :SolidMasse moléculaire :521.425-Iminodaunorubicin hydrochloride
CAS :5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.Formule :C27H31ClN2O9Couleur et forme :SolidMasse moléculaire :563.00Tetrahydrouridine dihydrate
THU dihydrate, a potent CDA inhibitor, outperforms cytidine by blocking the enzyme's active site.Formule :C9H20N2O8Couleur et forme :SolidMasse moléculaire :284.26WRN inhibitor 12
CAS :WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12RAD51-IN-7
CAS :RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Formule :C25H31N5O4S2Couleur et forme :SolidMasse moléculaire :529.675-Fluorouridine 5'-phosphate
CAS :5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.Formule :C9H12FN2O9PCouleur et forme :SolidMasse moléculaire :342.172(E)-Antiviral agent 67
CAS :<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374T-2513 hydrochloride
CAS :T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Formule :C25H28ClN3O5Couleur et forme :SolidMasse moléculaire :485.96WRN inhibitor 7
CAS :<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Formule :C27H23N3O6Couleur et forme :SolidMasse moléculaire :485.49ART615
ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).Formule :C21H21F3N4O2Couleur et forme :SolidMasse moléculaire :418.41Uridine 3',5'-diphosphate
CAS :Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].Formule :C9H14N2O12P2Couleur et forme :SolidMasse moléculaire :404.1612(S)-HETE
CAS :<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47DHX9-IN-9
CAS :DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].Formule :C21H21ClFN5O3S2Couleur et forme :SolidMasse moléculaire :510ATIC-IN-2
CAS :<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Formule :C4H4N4O3SCouleur et forme :SolidMasse moléculaire :188.165VPC-80051
CAS :VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.Formule :C16H13F2N3OCouleur et forme :SolidMasse moléculaire :301.291Antimalarial agent 44
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.Formule :C37H37N5O7Couleur et forme :SolidMasse moléculaire :663.72(Rac)-Plevitrexed
CAS :(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53Zorubicin
CAS :<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Formule :C34H35N3O10Couleur et forme :SolidMasse moléculaire :645.66Eprociclovir Na
CAS :Eprociclovir Na (A-5021) is 15x stronger than acyclovir at inhibiting herpesviruses, showing promise for EHV1 and herpetic keratitis treatment.Formule :C11H14N5NaO3Couleur et forme :SolidMasse moléculaire :287.25DHX9-IN-19
CAS :<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Formule :C20H21ClN4O4S2Couleur et forme :SolidMasse moléculaire :480.988Deoxythymidine-5'-triphosphate-d15
CAS :Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Formule :C10H15Li2N2O14P3Couleur et forme :SolidMasse moléculaire :509.136-N-Hydroxylaminopurine
CAS :6-N-Hydroxylaminopurine is a base analog with mutagenic activity.Formule :C5H5N5OMasse moléculaire :151.13RNase L ligand 3
CAS :RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.Formule :C27H27N3OSCouleur et forme :SolidMasse moléculaire :441.59GR 122222X
CAS :GR 122222X is an inhibitor of topoisomerase II.Formule :C26H35N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.653′-Amino-2′,3′-dideoxy-CTP
CAS :3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.Formule :C9H17N4O12P3Couleur et forme :SolidMasse moléculaire :466.172,5-Di-tert-butyl-1,4-benzoquinone
CAS :2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.Formule :C14H20O2Couleur et forme :SolidMasse moléculaire :220.31LN-439A
CAS :LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.Formule :C24H26FN3O4Couleur et forme :SolidMasse moléculaire :439.48And1 degrader 1
CAS :And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.Formule :C26H27Cl2N3OCouleur et forme :SolidMasse moléculaire :468.42Epolactaene
CAS :Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.Formule :C21H27NO6Couleur et forme :SolidMasse moléculaire :389.44APE1-IN-3
CAS :APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.Formule :C17H16O4Couleur et forme :SolidMasse moléculaire :284.31Plevitrexed
CAS :Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.533'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite
CAS :3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.Formule :C41H50N9O3PCouleur et forme :SolidMasse moléculaire :747.87RAD51-IN-8
RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.Formule :C16H14Cl2FN3O2Couleur et forme :SolidMasse moléculaire :370.21RECTAS-2.0
CAS :<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.805Dencatistat
CAS :Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.Formule :C24H27N7O5SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :525.58HRO761
CAS :HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formule :C31H31ClF3N9O5Degré de pureté :98.74% - 99.62%Couleur et forme :SolidMasse moléculaire :702.08Ref: TM-T72107
1mg60,00€5mg125,00€10mg177,00€25mg296,00€50mg502,00€100mg803,00€500mg1.795,00€1mL*10mM (DMSO)822,00€CTPS1-IN-1
CAS :CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formule :C21H22N6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :486.57SR 11302
CAS :SR 11302 is an inhibitor of activator protein-1 (AP-1).Formule :C26H32O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :376.53Ref: TM-T23384
1mg87,00€5mg144,00€10mg216,00€25mg376,00€50mg620,00€100mg938,00€1mL*10mM (DMSO)159,00€Ethynylcytidine
CAS :Ethynylcytidine is a nucleoside antimetabolite.Formule :C11H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.245'-O-DMT-N6-ibu-dA
CAS :5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formule :C35H37N5O6Couleur et forme :SolidMasse moléculaire :623.715'-DMT-3'-TBDMS-ibu-rG
CAS :5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Formule :C41H51N5O8SiCouleur et forme :SolidMasse moléculaire :769.96NSC639828
CAS :NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formule :C18H13BrClN5O3Couleur et forme :SolidMasse moléculaire :462.69MitoE10
CAS :MitoE10 is an effective mitochondrial targeting antioxidant.Formule :C42H55O5PSCouleur et forme :SolidMasse moléculaire :702.92
