Antibactérien

Antitubercular agent-11 (Compound 1e) is an antitubercular agent with a bulkier electron-donating group (Bu-t) that shows the best MIC value of 0.060 μg/mL [1].

Pks13-TE inhibitor 4 (compound 44) is a potent inhibitor from the thiazole series that effectively targets Pks13 to combat tuberculosis (TB) and addresses drug resistance.

844-TFM, a NBTI DNA gyrase blocker, IC50: 1.5 μM, kills Mycobacterium abscessus.

NDM-1 inhibitor-7 (Compound A8) is an NDM-1 inhibitor with an IC50 of 10.284 μM. It restores the ability of meropenem (MEM) to penetrate the cell wall of Gram-negative bacteria and effectively reinstates MEM's antibacterial activity against NDM-1 positive Escherichia coli. Moreover, NDM-1 inhibitor-7 demonstrates significant efficacy in both Galleria mellonella and murine peritonitis infection models.

Gougerotin is an inhibitor of protein synthesis.

Cefempidone (GR 50692) is a third-generation cephalosporin antibiotic. It exhibits antibacterial activity by inhibiting penicillin-binding proteins involved in the synthesis of bacterial cell walls.

OPC-167832: oral dprE1 inhibitor, IC50 0.258 μM, anti-tuberculosis, for Mycobacterium tuberculosis research.

Benzisothiazolone is an isothiazolinone fungicide that demonstrates growth inhibitory activity against Escherichia coli ATCC 8739 and yeast NCYC 1354. It is utilized in studies investigating growth inhibition models.

KKL-40 is a small-molecule inhibitor that targets the trans-translation process, effectively suppressing methicillin-sensitive and resistant Staphylococcus aureus (S. aureus) and other Gram-positive pathogens, including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. It works in synergy with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not show synergistic effects with other antibiotics such as daptomycin, kanamycin, or erythromycin. KKL-40 inhibits trans-translation, an extreme form of recoding, while being non-toxic to HeLa cells.

Tigemonam is a monobactam, a novel orally administered monobactam that protects against gram-negative aerobic bacterial pathogens. Cost-effective and quality-assured.

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.

Durlobactam sodium salt (ETX2514) have an IC50 values of 4, 14 and 190 nM against class A KPC-2, class C AmpC and class D OXA-24.Cost-effective and quality-assured.

Reutericyclin is a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri.

Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.

Ramifenazone is a drug of nonsteroidal anti-inflammatory.

Pulcherriminic acid, a cyclic dipeptide, chelates Fe3+, forms pulcherrimin, and has antimicrobial properties used in food, agriculture, and medicine.

N-(3-(Dimethylamino)propyl)tetradecanamide is a useful organic compound for research related to life sciences. The catalog number is T66531 and the CAS number is 45267-19-4.

Hexahydrohippuric acid is a useful organic compound for research related to life sciences. The catalog number is T65235 and the CAS number is 32377-88-1.

Sulfamonomethoxine sodium is a long-acting sulfonamide antibacterial agent utilized in blood kinetic studies; it inhibits dihydropteroate synthetase, thereby blocking folic acid synthesis [1].

Lenampicillin hydrochloride is an orally active prodrug of Ampicillin. Lenampicillin hydrochloride is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins. It is applied in the investigation of suppurative skin

Bacampicillin hydrochloride is an improved oral bioavailability penicillin antibiotic which is a prodrug of ampicillin.

Compound GK02084(SC) may have activity against the GTP site of Bs‐FtsZ.

Ciprofloxacin lactate is a useful organic compound for research related to life sciences. The catalog number is T66299 and the CAS number is 97867-33-9.

1-Naphthalenemethanol is a natural product for research related to life sciences. The catalog number is T67143 and the CAS number is 4780-79-4.

Phosalacine, isolated from Kitasatosporia phosalacinea, is a new herbicidal antibiotic that contains phosphinothricin.

Oleandomycin, a macrolide antibiotic structurally similar to Erythromycin, exhibits antimicrobial activity.

Cefetamet pivoxyl, a cephalosporin antibiotic, effectively inhibits 355 enteropathogens, including Gram-negative bacteria (ausgenommen Pseudomonas aeruginosa) and Legionella pneumophila [1].

1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66948 and the CAS number is 112811-72-0.

MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor used to study conditions linked to muscle wasting, encompassing both skeletal and cardiac muscle atrophy [1].

Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性，可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。

N-Butylthiophosphoric triamide is a useful organic compound for research related to life sciences. The catalog number is T65336 and the CAS number is 94317-64-3.

Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.

Pseudomonic acid C is the analogue of Pseudomonic Acid D which is an antibiotic agent from Pseudomonas fluorescens.

Ulifloxacin is a useful organic compound for research related to life sciences. The catalog number is T65577 and the CAS number is 112984-60-8.

Trans-Clopenthixol dihydrochloride ((E)-Clopenthixol dihydrochloride), an antibiotic without neuroleptic effects, has demonstrated in vitro efficacy against Pseudomonas aeruginosa and Plasmodium falciparum, as referenced in [1] [2].

Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.

Ethyl 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide is a useful organic compound for research related to life sciences. The catalog number is T65688 and the CAS number is 24683-26-9.

l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine.

Cefadroxil is a first generation aminocephalosporin with good patient compliance, a long-acting therapeutic effect, high solubility and relatively broad spectrum of anti-bacterial activity. Cefadroxil is also a substrate of the intestinal peptide transporter PepT1, which is primarily responsible for the drug's uptake across the apical membrane of small intestine.

2-Mercaptopyridine N-oxide sodium is a useful organic compound for research related to life sciences. The catalog number is T66776 and the CAS number is 3811-73-2.

CRS3123 (REP-3123) dihydrochloride is an orally active, fully synthetic antimicrobial agent that effectively inhibits Clostridioides difficile methionyl-tRNA synthetase (MetRS). CRS3123 dihydrochloride can be used in the study of Clostridioides difficile infection (CDI).

PqsR/LasR-IN-1 (Compound 2a) is a potent inhibitor of LasR and PqsR systems in P. aeruginosa. PqsR/LasR-IN-1 is also a inhibitor of hERG (IC50= 6.77 μM).

d-Atabrine hydrochloride is the active enantiomer of quinacrine and has anti-pr virus activity.

Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.