Antibactérien

Mirosamicin is a macrolide antibiotic, it has antimicrobial effect against gram-positive bacteria, some gram-negative bacteria and mycoplasma.

Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

Aurein 2.5, an antimicrobial peptide with antibiotic properties, exhibits both antibacterial and antifungal activities [1] [2].

Antibacterial agent 49 (example 12) is a antibacterial agent.

Desotamide: an antibiotic cyclic hexapeptide targeting S. aureus, S. pneumoniae, and MRSE with MICs 16, 12.5, 32 μg/ml.

Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.

D13-9001, an antibiotic, inhibits AcrB and MexB with KDs of 1.15μM in E. coli and 3.57μM in P. aeruginosa.

Pleurocidin, an antibacterial peptide, originates from the skin secretions of the Winter Flounder (Pseudopleuronectes americanus) [1].

3-O-Methylellagic acid from Myrciaria cauliflora is anti-inflammatory, inhibits glucose transport, and kills Staph. Aureus at 32 μg/mL.

LeuRS-IN-1 is a leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity that inhibits M.tb LeuRS.

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.

6-C-Methylquercetin-3,4'-dimethyl ether is a flavonol derivative extracted from Bauhinia thonningii Schum leaves, displaying antibacterial effects on Gram-

PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.

Isepamicin (Sch 21420) is a strong aminoglycoside antibiotic, effective on Enterobacteriaceae and staphylococci, less so on other bacteria.

Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).

CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) shows antibacterial and antiparasitic activities against Chlamydia pneumoniae and

Colistin: polypeptide antibiotic for Gram-negative bacteria, including drug-resistant strains, but may cause nephrotoxicity.

LBM-415 is a peptide deformylase (PDF) inhibitor.

Efflux pump-IN-3 inhibits AcrB, potentiates antibiotics, and is non-toxic to membranes and nematodes.