Antibactérien

F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.

Rivabazumab pegol, a pegylated Fab antibody targeting the PcrV protein, is utilized in phase II studies for chronic Pseudomonas aeruginosa infections [1].

AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.

A unique collection of xnum species of natural products with anti-infective activity for high throughput screening (HTS) and high content screening (HCS);

A unique collection of xnum antibacterial bioactive compounds, a powerful tool for antibacterial drug development;

Trimethoprim-D9 is the deuterated form of Trimethoprim. Trimethoprim (T1153) is a bacteriostatic antibiotic and an orally active inhibitor of dihydrofolate reductase. It shows activity against a variety of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim (T1153) is used in studies involving urinary tract infections, shigellosis, and Pneumocystis pneumonia.

Erythromycin-D6 is a deuterated form of Erythromycin (TMSM-1118). Erythromycin, produced by actinomycetes, is a macrolide antibiotic (antibiotic) known for its broad antimicrobial activity. It functions by binding to the 50S ribosomal subunit of bacteria, thereby inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and/or translocation reactions, without affecting nucleic acid synthesis.

CF3–K11 is a stable antibiotic exhibiting significant antibacterial activity. It is particularly effective against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA).

Puromycin-D3 is the deuterated form of Puromycin. Derived from the bacterium Streptomyces, Puromycin (T19978) belongs to the aminoglycoside class of antibiotics and acts as an inhibitor of protein synthesis.

Nonanoic acid-D2 is the deuterated form of Nonanoic acid, which is a naturally occurring saturated fatty acid with a nine-carbon structure. Nonanoic acid (T3947) significantly reduces bacterial translocation, enhances antimicrobial activity, and notably increases the secretion of porcine β-defensin 1 (pBD-1) and pBD-2.

DDC18-8A is an amphiphilic dendritic polymer known for its potent antimicrobial and antibiofilm properties.

Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (T1558) (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol (T1558) is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.

Sulfanilamide-D4 is the deuterated form of Sulfanilamide. Sulfanilamide (T0123) acts as an inhibitor of the bacterial enzyme dihydropteroate synthase, with an IC50 of 320 μM.

Puromycin-D3 dihydrochloride is the deuterated form of Puromycin dihydrochloride. Puromycin dihydrochloride (T2219) (CL13900 dihydrochloride) functions as an aminonucleoside antibiotic that inhibits protein synthesis.

trans-Cinnamic acid-D7 is the deuterated form of trans-Cinnamic acid (TMSM-2714). This compound functions as a fungicide with a minimum inhibitory concentration (MIC) of 250 μg/mL against the fish pathogen Aeromonas sobria (A. sobria, SY-AS1).

Urease-IN-15 (compound 5g) is a non-competitive inhibitor of urease, exhibiting an IC50 of 3.80 µM.

Cilagicin is a dodecapeptide lipid and serves as an antibiotic (antibiotic) effective against Gram-positive bacteria. It features a dual mechanism that targets polyisoprene phosphate binding, which helps to inhibit the development of resistance.

Cathelicidin-2 chicken is an antimicrobial peptide exhibiting potent bactericidal and fungicidal activity specifically against Salmonella strains isolated from chickens.

Antibacterialagent 216 (Compound 2a) is an antibacterial agent that demonstrates significant bactericidal activity when used in conjunction with INH and RIF. It shows notable in vitro anti-tuberculosis effects against Mtb H37Rv and MDR clinical isolates, making it useful for tuberculosis research.

WAY-329764 is an antibacterial agent.