Antibactérien

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.

Arugomycin is an anthracycline natural product that functions as an antibiotic effective against Gram-positive bacteria. It has the ability to intercalate into DNA, giving it potential as an antitumor agent.

Penicillin V: orally active antibiotic against Streptococci, C. difficile, and S. aureus; treats otitis, sinusitis, pharyngitis, tonsillitis.

Altromycin E is a new pluramycin-like antibiotic.

Funalenone, from A. niger, inhibits HIV-1 integrase, HIV replication, and MMP-1, also curbing S. aureus growth. Less toxic to human cells.

Pyrocoll, from Streptomyces, stops various bacteria and cancer cells; active against P. falciparum, T. rhodesiense.

'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).

PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.

Teixobactin is a recently described antibiotic .

Antibacterial agent 61 (example 27) is a antibacterial agent.

Antibacterial agent 35 is a compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, enhancing its antibacterial activity.

Farobin A, a natural compound, exhibits antibacterial, antioxidant, and anti-inflammatory properties. It is effective against Streptococcus mutans ATCC 25175 and Streptococcus sobrinus ATCC 33478. Additionally, Farobin A demonstrates anti-inflammatory activity by targeting cytokine IL-6 and TNF-α [1].

Antitubercular agent-9 exhibits potent activity against tuberculosis, demonstrating a minimum inhibitory concentration (MIC) range of 1.03-2.32 μM.

Antimicrobial agent-26 is a powerful antimicrobial that has demonstrated the ability to counteract antibiotic resistance in vitro [1].

Cefetamet is a potent antibiotic to treat respiratory and urinary tract infections.

Psoracorylifol C is a useful organic compound for research related to life sciences and the catalog number is T124015.

Collismycin A, from Streptomyces, has antibacterial, antiproliferative, and neuroprotective effects. It inhibits various cancer cells and is iron-complexing.

CAY10742: Oral oxadiazole antibiotic, combats Gram-positive bacteria & MRSA, effective against resistant strains, works in mouse models. MICs = 1-4 μg/ml.

Arylomycin B2 is an antibiotic and a potent inhibitor of signal peptidase I (SPase I), exhibiting activity against Gram-positive bacteria.

Flagelin 22, a bacterial flagellin fragment, serves as a potent elicitor for plants and algae.

Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.

Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity [1] .

Lymecycline is a semisynthetic antibiotic. It is related to TETRACYCLINE.

Lankacyclinol A is a Lankacidin antibiotic.

Ambazone hydrate has anti-cancer activity.

LAB 149202F is a bioactive chemical.

Clovibactin, a novel antibiotic, effectively eradicates drug-resistant bacterial pathogens and demonstrates no discernible resistance.

Antibacterial agent 59 (example 24) is a antibacterial agent.

Luteoreticulin, a nitro-containing bacterial metabolite first isolated from S. luteoreticuli, exhibits mosquitocidal activity against A. aegypti at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.

Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.

Atrovenetin is an antibiotic found in Penicillium species (antibiotic). It exhibits inhibitory activity against Bacillus subtilis and Staphylococcus aureus. Atrovenetin is also a potent antioxidant.

Adenoregulin (Dermaseptin b2), an antimicrobial peptide antibiotic, exhibits efficacy against both Gram-negative and Gram-positive bacteria, as well as yeast

Meleagrin: Penicillium-derived alkaloid, inhibits FabI and c-Met, targets breast cancer metastasis, antimicrobial.

KPC-2-IN-1, a boronic acid KPC-2 inhibitor (Ki 0.032 μM), boosts cefotaxime against KPC-2 E. coli; tolerable in HEK-293 cells.

CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor.

DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates

3′-Omethyl-5′-hydroxydiplacone (compound 2), a C-6-geranylflavonoid isolated from the ethanol extract of Paulownia tomentosa fruits, exhibits antibacterial

Cefalonium hydrate: a β-lactam antibiotic for bovine mastitis from Gram-positive bacteria, especially staphylococci, with marked effectiveness.

Corallopyronin A is an antibiotic that can be isolated from *Corallococcus coralloides* [1].

Carbazomycin D, from Streptomyces, fights fungi T. asteroides and T. mentagrophytes, M. tuberculosis, and is cytotoxic to various cells.

NagZ-IN-1 (Compound 11h) is a β-N-acetylglucosaminidase inhibitor with a Ki of 3.3 μM. It is applicable in antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.

Zelkovamycin, a cyclic peptide antibiotic, blocks X. oryzae, P. oryzae, S. aureus, A. laidlawii growth at 0.01-300 μg/ml concentration.

(±)-Heraclenol, a coumarin derivative isolated from the fruits of Angelica lucida, exhibits antibacterial properties [1].

Antibacterialagent 272 (Compound Z22) is a potential antibacterial agent that targets the DNA and DNA-topoisomerase II (DNA-Topo II) complex. It exhibits strong antibacterial activity, with a minimum inhibitory concentration (MIC) of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853. Antibacterialagent 272 binds by intercalating between DNA base pairs, disrupting the normal function of bacterial DNA, and is suitable for research into bacterial infectious diseases.

Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.

T3SS-IN-3 (compound F-24) serves as an inhibitor specific to the type III secretion system (T3SS), significantly reducing the transcription of the hrpY gene

Alliacol B is an antibiotic with mild antibacterial and antifungal properties. It can inhibit DNA synthesis in Ehrlich ascites carcinoma cells.

AA58 enhances Ceftazidime efficacy by lowering its MIC.

ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.

Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.

2,4,6-trichloroanisole inhibits the cell viability of CHO and C32 cell lines and apoptosis, antibacterial activity against Plasmodium falciparum.

Antibiotic tan-592B is an antibiotic agent.

Xinjiachalcone A, from Glycyrrhiza inflata, kills H. pylori effectively (MIC: 12.5-50 μM, 17 strains).

cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.

Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.

Penicillin G Benzathine Tetrahydrate (Benzathine Benzylpenicillin Tetrahydrate) serves as an antibiotic effective against numerous bacterial infections [1].

Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.

Cephabacin M6 is a new cephem antibiotic isolated from bacterial.

Avibactam Tetrabutylammonium is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases covalent and reversible.

23-O-Demycinosyltylosin (23-DMT), an acyl derivative of tylosin, exhibits antibacterial activity [1].

Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.

Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.

Candicidin, a heptaene macrolide from S. griseus or A. levoris, treats candidiasis topically. Mainly candicidin D.

Amythiamicin B is a novel antimicrobial antibiotic.

DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.

NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) has antimicrobial activity, inhibits the proliferation of C. albicans, and is used in diabetes.

Mycophenolate Mofetil: Non-competitive, selective inhibitor of IMP dehydrogenase I/II, IC50: 39/27 nM.

ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.

Kapurimycin A2 is an antitumor antibiotics.

Ceratotoxins B, an antibacterial peptide, is produced by sexually mature females of Ceratitis capitata (medfly).

Telithromycin is a macrolide antibiotic and erythromycin derivative,70S bacterial ribosome, antimicrobial, respiratory infections,inhibits protein synthesis.

Antibacterial (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol from Atractylodes fights MRSA; MIC 4-32 µg/mL.

T-91825 (PPI-0903M), an active N-phosphono cephalosporin, is potent against various bacteria and stems from TAK-599.

3α-Akebonoic acid is a natural product isolated from Holboellia coriacea Diels with antitumor activity.

Carbomycin is a bioactive chemical against Borrelia burgdorferi persisters (lyme disease).

Desacetyl cefapirin, a cefapirin metabolite, combats E. coli, K. pneumoniae, P. mirabilis, S. aureus; MICs: 120, 24, 34, 0.42 μg/ml.

Neoabietic acid, from Pinus palustris resin, is acid-sensitive and has antibacterial properties.

AIP-II is a macrocyclic peptide signaling molecule produced by Staphylococcus aureus for quorum sensing. It binds to the AgrC-II receptor, regulating the expression of virulence genes within Staphylococcus aureus. Additionally, AIP-II acts as an antagonist to the AgrC-I receptor.

Kyotorphin is a Morphine-like dipeptide.

LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S.

Isouvaretin demonstrates potent antibacterial activity against B. subtilis and S. epidermidis.

Antituberculosis agent-7: active against P. mirabilis (MIC 31.25μM), A. niger (MIC 62.5μM), and M. tuberculosis (MIC 3.41μM).

Compound PDK0095, with CAS No. 1777-82-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0095 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Ethylnaphthalene exhibits antibacterial activity and can be used in biochemical experiments and drug synthesis.

Caprazene is a precursor molecule of semi-synthetic antibacterial antibiotics and an anti-mycobacterial compound used for tuberculosis and Mycobacterium avium complex infection research. It can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture.

Efflux pump-IN-2 is an AcrB inhibitor that boosts antibiotic effects and blocks Nile Red efflux, non-toxic to nematodes.

Guamecycline is a biochemical.

Agent 46 from patent WO2013030735A1, example 9, is a potent antibacterial with research potential.

Amythiamicin D is a thiopeptide antibiotic that effectively inhibits the growth of various Gram-positive bacteria, but it is ineffective against Gram-negative bacteria such as Escherichia coli.

Bombinin-Like Peptide (BLP-1) is an antimicrobial peptide from Bombina species.

Maximin H3, an antimicrobial peptide from Chinese red belly toad Bombina maxima skin secretions, exhibits antimicrobial properties against Escherichia coli

Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.

Saptomycin D, an antibiotic (antibiotic) isolated from the Streptomyces sp. HP530 strain, exhibits potent antitumor activity. It demonstrates strong inhibitory effects on Gram-positive bacteria and weaker inhibition against certain Gram-negative bacteria and yeasts. Additionally, Saptomycin D shows significant antitumor properties that make it a candidate for research in cancer therapy.

Sitafloxacin (DU6859a) is a potent fluoroquinolone, effective against a wide spectrum of bacteria and used for respiratory and urinary infections.

2,2-Dithiobis(Benzothiazole) inhibits MAPK8 and Pseudomonas aeruginosa and is commonly used as an accelerator in rubber and plastic synthesis.

Sedecamycin is a 17-membered macrolide antibiotic. It is used for treating swine dysentery.

Aurein 2.3, an antibiotic antimicrobial peptide, partially inhibits E. coli ATPase activity and suppresses cell growth [1] [2].

Aurodox is a biochemical.

Aibellin is a peptide antibiotic and serves as an effective and beneficial modulator of rumen fermentation.

PL-5, a synthetic cecropin-melittin hybrid peptide, prevents wound infection.

Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and

Aldgamycin E is a neutral macrolide antibiotic agent from culture filtrates of Streptomyces lavendulae. Methanolysis produces methyl algarosides A & B.

Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.

Cephamycin C (CepC) is a nontoxic β-lactam antibiotic. CepC stands out from other cephalosporins for its greater resistance to β-lactamases.

ONX-0914 (PR-957) TFA is a selective LMP7 inhibitor, blocking cytokines and arthritis progression, and reactivates HIV-1.

Arylomycin B4 is a lipidic hexapeptide antibiotic (antibiotic) targeting Gram-positive bacteria.