Antibactérien

<p>Metallo-β-lactamase-IN-11 (compound 5f), a potent inhibitor of Metallo-β-lactamases (MBLs), demonstrates efficacy against the bacterial metallophyllactamase</p>

<p>Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.</p>

<p>Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.</p>

<p>EDA-DA is a probe for labeling bacterial cell wall Peptidoglycan, crucial for division and shape.</p>

<p>Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins.</p>

<p>Ertapenem: injectable carbapenem with broad antimicrobial spectrum, resistant to many beta-lactamases.</p>

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>

<p>Azidocillin, a semi-synthetic oral β-lactam antibiotic, treats various bacterial infections including osteitis and septicemia.</p>

<p>Albothricin is a streptothricin antibiotic.</p>

<p>PF 5081090 has a wide range of applications in life science related research.</p>

<p>Julifloricine is an alkaloid isolated from Prosopis juliflora that has antimicrobial activity.</p>

<p>Monocerin, from F. larvarum, combats E. coli, B. megaterium, M. violaceum, C. fusca; kills C. erythrocephala; hinders S. halepense root growth.</p>

<p>Napyradiomycin A1, a fungal compound from C. rubra, has antimicrobial effects (MIC 1.56-12.5 μg/ml) and blocks estrogen receptors and mitochondrial enzymes.</p>

<p>Amythiamicin C is an antimicrobial antibiotic effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and also exhibits activity against Plasmodium falciparum (the causative agent of malaria).</p>

<p>Cefpirome: fourth-gen cephalosporin, broad-spectrum, inactivates penicillin-binding proteins in bacteria.</p>

<p>8-Methylsulfinyloctyl isothiocyanate: antimicrobial, inhibits plant growth, impairs COX-2 inflammation in macrophages.</p>

<p>Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.</p>

<p>Cephalexin: potent oral antibiotic, broad-spectrum against gram-positive/negative bacteria; treats pneumonia, strep throat, endocarditis.</p>

<p>Doxycycline hydrochloride (Hyclate) is a synthetic tetracycline derivative with similar antimicrobial activity.</p>

<p>Voxvoganan (LTX-109) trihydrochloride, a topical antimicrobial, demonstrates a high efficacy against S.</p>

<p>Antibacterial agent 163 (compound 1), a hydroxyquinoline derivative, potently inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1].</p>

<p>Arylomycin A4 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.</p>

<p>PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.</p>

<p>Almurtide: Muramyl dipeptide derivative with anti-inflammatory, anti-tumor properties, protects mice from Pseudomonas and Candida infections.</p>

<p>Sphinganine is a synthetic sphingolipid fungicide against C. glabrata and C. albicans; MFC 0.5 μg/ml. Used as an analysis standard.</p>

<p>Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.</p>

<p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>

<p>Maximin 5, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Betonicine, an l-alpha-amino acid, is in herbs, spices, pulses, and mainly urine.</p>

<p>Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.</p>

<p>Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A.</p>

<p>Actinoidin A is a glycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Maximin H3, an antimicrobial peptide from Chinese red belly toad Bombina maxima skin secretions, exhibits antimicrobial properties against Escherichia coli</p>

<p>Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.</p>

<p>Anthracen-1-amine exhibits inhibitory activity against Escherichia coli.</p>

<p>Vineomycin A1 (OS-4742 A1) is an antibiotic effective against Gram-positive bacteria, identified in *Streptomyces matensis* subsp. vineus. It has also demonstrated antitumor activity in mice and holds potential for research in skin fibrosis.</p>

<p>Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.</p>

<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>

<p>MRV03-070, acting as a biosynthetic precursor akin to precolibactin [1], is a colibactin-activating peptidase ClbP inhibitor with an inhibitory concentration (</p>

<p>Cethromycin (ABT-773) is an antibiotic of ketolide.</p>

<p>2,4-Diacetylphloroglucinol is a useful organic compound for research related to life sciences. The catalog number is T21619 and the CAS number is 2161-86-6.</p>

<p>Sirpefenicol (ZTS-00007928), a phenicol antibacterial for treating animal bacterial infections.</p>

<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>

<p>XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.</p>

<p>Lysobactin (katanosin B) is an antibiotic effective against S. aureus, S. pneumoniae, and blocks PG biosynthesis.</p>

<p>Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).</p>

<p>Aurein 5.2 is an antibiotic antimicrobial peptide [1].</p>

<p>Maximin H2, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory effects on a range</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>