Antibactérien

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

Biotin protein ligase-IN-1 (Compound Bio-9) is an inhibitor of biotin protein ligase (BPL) with a Kd of 7 nM. This compound exhibits antimicrobial activity, with minimum inhibitory concentration (MIC) values of 0.2 μM against Staphylococcus aureus (including MRSA and MSSA) and 20 μM against Mycobacterium tuberculosis.

Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.

S-6123: Oxazolidinone antimicrobial that blocks ribosomal protein synthesis, sparing DNA/RNA.

Tylosin lactate: a vet macrolide antibiotic; broad vs. Gram-positive, limited on Gram-negative; from Streptomyces fradiae.

Compound 5a: MICs of 25, 25, 50, 50 μg/mL vs. B. subtilis, S. aureus, P. aeruginosa, E. coli.

ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.

(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].

Desferriferribactin is a biogenetic precursor of pyoverdin.

Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.

PL-5, a synthetic cecropin-melittin hybrid peptide, prevents wound infection.

Ilicicolin B is a useful organic compound for research related to life sciences. The catalog number is T125288 and the CAS number is 22581-07-3.

Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.

Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

LL-BM123γ2 is an antimicrobial agent that exhibits activity against various microorganisms. It is utilized in research related to antimicrobial properties.

Enopeptin A: depsipeptide antibiotic with unique amino acids, combats Gram-positive/negative bacteria, not antifungal.

Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.

(-)-cis-Myrtanol, a terpenoid compound derived from Artemisia dracunculus, exhibits effective antimicrobial activity against harmful gut bacteria such as Bifidobacterium bifidum.

Emeguisin A, a depsidone from E. unguis, fights S. aureus, MRSA, C. neoformans (MIC 0.5 μg/ml), and P. falciparum (IC50 2.2 μM).

17-hydroxy Venturicidin A: Streptomyces-derived macrolide with antibiotic and antifungal properties.

Rubrosulphin is a toxic metabolite found in a number of fungi.

LF11 displays antimicrobial activity.

Contezolid acefosamil sodium (MRX-4) is an oral antibiotic for drug-resistant Gram-positive cSSTIs, with low myelosuppression and MAOI risks.

Urease, made by various bacteria, aids pathogen virulence and is key to Helicobacter pylori's stomach colonization.

Pazufloxacin (T-3761) is a broad-spectrum fluoroquinolone antibiotic effective against various infections, including strains resistant to other quinolones.

Antibacterial agent 41 (example 3) is a antibacterial agent.

Arylomycin B6 is a lipoglycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.

"Antibacterial Synergist 2 inhibits biofilms of S. enterica, S. aureus, P. aeruginosa, and C. albicans."

WU-FA-01, a hydrogenated WU-FA-00 derivative, has potent antibacterial effects on Gram-positive strains and anti-inflammatory properties.

D13-9001, an antibiotic, inhibits AcrB and MexB with KDs of 1.15μM in E. coli and 3.57μM in P. aeruginosa.

Bottromycin A2, an antibiotic from Streptomyces, halts protein synthesis and targets MRSA, VRE (MIC: 1, 0.5 μg/ml).

Tebipenem pivoxil HCl: oral antibiotic that targets PBPs to block bacterial cell wall synthesis.

Maximin 28, an antimicrobial peptide isolated from toad brain tissue, exhibits activity against various bacterial strains, including Staphylococcus aureus,

Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).

Bactenecin TFA, a 12-aa bovine peptide, disrupts membranes, stops bacterial/fungal growth, and hampers biofilms.

Isocryptomerin, from Selaginella tamariscina, is an antifungal that depolarizes membranes and has anticancer, antibacterial effects.

Aldgamycin G is a Macrolide antibiotic against Gram-positive bacteria isolated from Streptomyces avidinii.

Cis-β-Terpineol, a monoterpene derived from the aerial parts of Anthemis turcomanica, exhibits antibacterial activity as evidenced by studies on the stems,

Salvinolone is a natural product that can be used as a reference standard.

Dicloxacillin, a β-Lactam antibiotic, targets beta-lactamase bacteria like Staphylococcus aureus, defeating penicillin resistance.

Ro 09-1428, a parenteral cephalosporin, has high antipseudomonal activity.

Antitubercular agent-41是一种抗菌剂。

A 83016A is a kinamycin-type antibiotic.

Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.

Sirpefenicol (ZTS-00007928), a phenicol antibacterial for treating animal bacterial infections.

apo-Enterobactin is a derivative of Enterobactin, which is a bacterial iron carrier that facilitates iron absorption.