Antibactérien

Ro 24-6778 is a dual action cephalosporin with antimicrobial activity.

Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics.

Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.

Enterocin Hybrid 1, an antibacterial agent, effectively inhibits Vancomycin-resistant Enterococcus faecium and Staphylococcus haemolyticus [1].

Antimicrobial agent-36 (Compound 8b) is an antimicrobial compound that significantly inhibits DNA gyrase with an IC50 value of 4.56 µM. It is also utilized in the preparation of nanoparticle drug formulations and can be employed in the research and development of new antibiotics.

Antibacterialagent 274 (Compound 18b) is an antibacterial agent that targets bacterial cell membranes, exhibiting a minimum inhibitory concentration (MIC) of 8 μg/mL against Acinetobacter baumannii ATCC 17978. It functions by disrupting membrane integrity, causing intracellular accumulation of ROS, which leads to DNA and protein leakage, thereby exerting its antibacterial effects. Antibacterialagent 274 is applicable in research on infections caused by Gram-negative bacteria.

Anti-MRSA agent 15 (Compound 9o10) exhibits antimicrobial activity, inhibiting methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 0.0625 μg/mL. It demonstrates low hemolytic activity and minimal cytotoxicity. Additionally, Anti-MRSA agent 15 shows anti-infection activity in mice.

Antibiotic LB 10517 is a catechol-substituted cephalosporin with a broad spectrum of antibacterial.

Trimethoprim hydrochloride: oral, broad-spectrum antibiotic, DHFR inhibitor, treats UTIs, shigellosis, pneumocystis pneumonia, may block Influenza A with zinc.

Polyphemusin II is an antimicrobial peptide isolated from the blood cells of the American horseshoe crab. It exhibits antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria, as well as fungi.

Lactoferricin B (4-14), bovine (TFA), a 4-14 residue peptide from lactoferrin, has broad-spectrum antimicrobial properties.

Plantaricin A, an antimicrobial peptide extracted from Lactobacillus plantarum, exhibits efficacy against bacteria [1].

Omiganan-FITC TFA, a peptide-FITC complex, has bactericidal/fungicidal properties for preventing catheter infections.

Antitubercular Agent-38, a derivative of Benzothiazinones (BTZs), demonstrates potent antituberculosis activity while maintaining low cardiac toxicity and

IN-2-LF, an inhibitor of lethal factor, also demonstrates inhibitory activity against furin, possessing an IC50 of 2 μM. Moreover, when used alongside D6R [1], IN-2-LF significantly enhances protection from anthrax lethal toxin.

Evybactin: a selective DNA gyrase inhibitor for Mycobacterium tuberculosis (MIC 0.25 µg/mL), first of its kind.

Cyclic L27-11 is a cyclic peptide analog antibiotic that exhibits potent antimicrobial activity against specific bacteria, particularly Pseudomonas sp. It is highly effective against Pseudomonas aeruginosa, demonstrating nanomolar-level antibacterial activity. The mechanism of action for Cyclic L27-11 involves interfering with the function of the bacterial outer membrane protein LptD, inhibiting the normal transport of lipopolysaccharide (LPS). This inhibition leads to the accumulation of membrane-like substances within the bacterial cell, adversely affecting bacterial survival. Consequently, Cyclic L27-11 is a promising candidate for antimicrobial agent development.

Bombinin H5, an antimicrobial peptide originating from the skin of the (moth) Bombina variegata [1], exhibits potent biocidal properties.

Antibacterial agent 140 chloride, a first-of-its-kind Ru-based AIEgen photosensitizer, shows promise in detecting and treating Gram-positive bacteria (G+).

Altertoxin III is a mutagenic agent that induces mutations in Salmonella typhimurium strains TA98, TA100, and TA1537. It is isolated from extracts of A. alternata strains that demonstrate mutagenic responses in the Ames Salmonella typhimurium test.

Grepafloxacin, an oral fluoroquinolone antibiotic, effectively treats respiratory infections, especially Streptococcus pneumoniae.

Bactenecin 7, an antibacterial peptide, demonstrates activity in inhibiting Enterobacter cloacae growth, with minimum inhibitory concentrations (MICs) ranging

Urease-IN-9 (Compound 1e), an urease inhibitor with an IC50 of 19.5 μM, effectively impedes the enzyme's activity [1].

Blasticidin A, from S. resistomycificus, inhibits A. parasiticus aflatoxin (IC50s: 0.25 μM) but not growth; also halts protein synthesis in S. cerevisiae.

Maximin 32, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus and Escherichia coli, with minimum inhibitory

Indolicidin acetate, a powerful antimicrobial peptide isolated from bovine neutrophil cytoplasmic granules, demonstrates significant effectiveness [1].

Antibacterial agent 138 effectively targets multi-drug resistant bacteria by inhibiting protein synthesis.

PR-39 TFA, a peptide, noncompetitively inhibits proteasomes, spurring angiogenesis and reducing inflammation and mouse myocardial infarct size.

DHFR-IN-9 (compound 8A), a dihydrofolate reductase (DHFR) inhibitor, impedes purine and thymidylate biosynthesis, pivotal in cell proliferation and growth.

Octaarginine is a cell-penetrating peptide (CPP) known for its membrane-translocating activity. CPP's inherent ability to enter cells makes it useful for delivering various membrane-impermeable bioactive agents intracellularly. Additionally, CPP is employed to transport antimicrobial agents into intracellular bacteria.

Saquayamycin D is a glycoside of aquayamycin.

Elastase-IN-3 ,with CAS No. 15015-57-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Elastase-IN-3 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

HSGN-218: non-cytotoxic, gut-specific antibiotic; effective against C. difficile (MIC 0.003-0.03 μg/ml); boosts survival in mice with C. difficile.

DprE1-IN-6 (Compound 56) is a DprE1 inhibitor with demonstrated anti-TB activity, exhibiting a minimum inhibitory concentration (MIC) of 1 μM against the Mtb

Maximin 49, an antimicrobial peptide, exhibits antibacterial activity against S.

LL-37 scrambled peptide acetate is a scrambled peptide of LL-37 and is often used as a negative control for LL-37 peptide.

Antibacterial agent 56 (example 22) is a antibacterial agent.

Maximin 42 is an antimicrobial peptide with antibacterial activity against S.

Antibacterial agent 165 (compound 3), a hydroxyquinoline derivative, effectively inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1], demonstrating

Api137 is an antimicrobial peptide that disrupts bacterial growth by blocking translation processes.

IDR-1: Antimicrobial peptide, combats Gram-positive/negative bacteria, modulates immunity, non-toxic, anti-inflammatory, regulates chemokines/cytokines.

Antibacterial agent 162 trifluoromethanesulfonate (compound 7), a dual-function molecule, demonstrates potent inhibitory effects on Staphylococcus aureus,

Ellagic acid 4-O-β-D-xylopyranoside, an ellagitannin found naturally, exhibits antimicrobial properties and acts as an inhibitor of xanthine oxidase, displaying

T3SS-IN-2 (Compound 2h) serves as an inhibitor of the type three secretion system (T3SS), with applications in bacterial infection research [1].

Agent 47 boosts Ceftazidime's efficacy, lowering its MIC as a potent adjunct antibacterial.

'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).

Benzoic acid (Standard) is a standard substance for quantitative analysis.Benzoic acid (Dracylic acid) is an aromatic alcohol and common additive.

Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].

Lysine hydroxamate is a bioactive chemical.

Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.