Antibactérien

<p>Benzylpenicillin, a penicillin derivative, treats infections using sodium or potassium salts. Effective against gram-positive bacteria and gram-negative cocci.</p>

SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.

Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.

Psicofuranine: a nucleoside antibiotic inhibiting GMP synthase and P. falciparum growth with an IC50 of 0.3 mM.

PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.

Antimicrobial agent-40 exhibits antibacterial activity against fungi, Gram-negative, and Gram-positive bacteria. It also shows anticancer properties, displaying significant cytotoxicity towards MCF-7 cells with an IC50 of 33.52 μM.

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases.

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

Sparsomycin is an antitumor antibiotic. It also inhibits protein synthesis in the 70S and 80S ribosomal systems.

<p>Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.</p>

Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.

Kitasamycin tartrate, a macrolide antibiotic produced by Streptomyces kitasatoensis, has a wide spectrum of antimicrobial activity.

Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.

Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.

ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.

Citrullinated LL-37 3cit is a host defense peptide with potent immunomodulatory and antimicrobial properties, demonstrating direct antiviral activity against

<p>Gramicidin B is a nonribosomal peptide with antibiotic properties [1].</p>

Amphipathic peptide LAH4 forms a-helix, binds phospholipid membranes, and shows in vitro transfection on par with commercial reagents.