Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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Duvelisib
CAS :<p>Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.</p>Formule :C22H17ClN6ODegré de pureté :98.87% - 99.74%Couleur et forme :SolidMasse moléculaire :416.86PIK-75
CAS :<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formule :C16H14BrN5O4SDegré de pureté :98.52% - >99.99%Couleur et forme :SolidMasse moléculaire :452.28PD153035
CAS :<p>PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,</p>Formule :C16H14BrN3O2Degré de pureté :98.47% - 99.29%Couleur et forme :SolidMasse moléculaire :360.21Acalisib
CAS :<p>Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.</p>Formule :C21H16FN7ODegré de pureté :98.99% - ≥95%Couleur et forme :SolidMasse moléculaire :401.4Nazartinib
CAS :<p>Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (</p>Formule :C26H31ClN6O2Degré de pureté :98.63% - ≥95%Couleur et forme :Solid PowderMasse moléculaire :495.02Vacuolin-1
CAS :<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Formule :C26H24IN7ODegré de pureté :97.20% - 98.45%Couleur et forme :SolidMasse moléculaire :577.42HG-9-91-01
CAS :<p>HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and</p>Formule :C32H37N7O3Degré de pureté :96.86% - 99.71%Couleur et forme :SolidMasse moléculaire :567.68CZC24832
CAS :<p>CZC24832 is a selective inhibitor of PI 3-kinase γ.</p>Formule :C15H17FN6O2SDegré de pureté :99.08% - 99.12%Couleur et forme :SolidMasse moléculaire :364.4PD-089828
CAS :<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Formule :C18H18Cl2N6ODegré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :405.28Parsaclisib hydrochloride
CAS :<p>Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.</p>Formule :C20H23Cl2FN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.34COH-SR4
CAS :<p>COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.</p>Formule :C13H8Cl4N2ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :350.03RLY-2608
CAS :<p>RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.</p>Formule :C29H14ClF5N6O2Degré de pureté :98.62% - 98.7%Couleur et forme :SolidMasse moléculaire :608.91740 Y-P
CAS :<p>740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!</p>Formule :C141H222N43O39PS3Degré de pureté :98.3% - 99.87%Couleur et forme :SolidMasse moléculaire :3270.7Gefitinib hydrochloride
CAS :<p>Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.</p>Formule :C22H25Cl2FN4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :483.36CHIR 98024
CAS :<p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>Formule :C20H17Cl2N9O2Degré de pureté :96.74%Couleur et forme :SolidMasse moléculaire :486.31Cavutilide
CAS :<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formule :C22H26FN3O3Degré de pureté :99.82% - 99.85%Couleur et forme :SolidMasse moléculaire :399.458BMS-690514
CAS :<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Formule :C19H24N6O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :368.43Naquotinib mesylate
CAS :<p>Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR</p>Formule :C31H46N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.81Canertinib dihydrochloride
CAS :<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Formule :C24H27Cl3FN5O3Degré de pureté :99.13% - >99.99%Couleur et forme :SolidMasse moléculaire :558.86Almonertinib hydrochloride
CAS :<p>Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.</p>Formule :C30H36ClN7O2Degré de pureté :98.01% - 98.12%Couleur et forme :SolidMasse moléculaire :562.1Imgatuzumab
CAS :<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Couleur et forme :LiquidMasse moléculaire :145.0 (kDa)Depatuxizumab
CAS :<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Degré de pureté :95%Couleur et forme :LiquidElgemtumab
CAS :<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Degré de pureté :95%Couleur et forme :LiquidZalutumumab
CAS :<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Degré de pureté :95%Couleur et forme :LiquidIzalontamab
CAS :<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Degré de pureté :95%+ - 95%+Couleur et forme :LiquidBecotatug
CAS :<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Degré de pureté :95% - 95%Couleur et forme :LiquidAnbenitamab
CAS :<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Couleur et forme :LiquidPonezumab
CAS :<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Couleur et forme :LiquidFutuximab
CAS :<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Degré de pureté :95% - 95%Couleur et forme :LiquidZanidatamab
CAS :<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Couleur et forme :LiquidSerclutamab
CAS :<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Degré de pureté :98%Couleur et forme :Liquid1-Azakenpaullone
CAS :<p>1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.</p>Formule :C15H10BrN3ODegré de pureté :99.73%Couleur et forme :Tan SolidMasse moléculaire :328.16Icotinib
CAS :<p>Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.</p>Formule :C22H21N3O4Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :391.42IGF-1R modulator 1
CAS :<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formule :C22H17N3O4Couleur et forme :SolidMasse moléculaire :387.39lavendustin A
CAS :<p>lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.</p>Formule :C21H19NO6Degré de pureté :98%Couleur et forme :Off-White SolidMasse moléculaire :381.38GSK2292767
CAS :<p>GSK2292767 is a potent and selective PI3Kδ inhibitor.</p>Formule :C24H28N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.58ZM323881 hydrochloride
CAS :<p>ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.</p>Formule :C22H19ClFN3O2Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :411.86CNX-1351
CAS :<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Formule :C30H35N7O3SDegré de pureté :99.66% - 99.83%Couleur et forme :SolidMasse moléculaire :573.71Icotinib Hydrochloride
CAS :<p>Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.</p>Formule :C22H22ClN3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :427.88TAK-285
CAS :<p>TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.</p>Formule :C26H25ClF3N5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :547.96CAL-130
CAS :<p>CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formule :C23H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.47TCS 2002
CAS :<p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>Formule :C18H14N2O3SCouleur et forme :SolidMasse moléculaire :338.38MS 154N
CAS :<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45PI3K/mTOR Inhibitor-9
CAS :<p>PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).</p>Formule :C23H27N7O2Couleur et forme :SolidMasse moléculaire :433.51EGFR-IN-16
CAS :<p>EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.</p>Formule :C16H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.26NVP-CLR457
CAS :<p>NVP-CLR457 is an oral pan-class I PI3K inhibitor with dose-dependent antitumor activity.</p>Formule :C18H20F3N7O4Couleur et forme :SolidMasse moléculaire :455.39NU-7163
CAS :<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Formule :C18H17NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.33EGA
CAS :<p>EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.</p>Formule :C16H16BrN3ODegré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :346.22EGFR-IN-67
CAS :<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41DS21360717
CAS :<p>DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.</p>Formule :C21H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45DNA-PK-IN-1
CAS :<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Formule :C23H26N8O2Couleur et forme :SolidMasse moléculaire :446.5WR23
CAS :<p>WR23 is a piperidinylquinoxaline derivative and a phosphoinositide 3-kinase α (PI3Kα) inhibitor.</p>Formule :C19H18BrN3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.33LTURM-36
CAS :<p>LTURM-36 is a novel inhibitor of PI 3-kinase delta.</p>Formule :C22H18N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.39ZDWX-25
CAS :<p>ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.32MIPS-9922
CAS :<p>MIPS-9922: potent PI3Kβ inhibitor; prevents αIIbβ3 activation, platelet adhesion, and ADP-triggered aggregation.</p>Formule :C28H31F2N9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.6NSC81111
CAS :<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Formule :C19H16O4Couleur et forme :SolidMasse moléculaire :308.33Limertinib
CAS :<p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>Formule :C29H32ClN7O2Degré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :546.06GNE-293
CAS :<p>GNE-293 is a potent and selective PI3Kδ inhibitor.</p>Formule :C28H36N8O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.7PI-540
CAS :<p>PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).</p>Formule :C22H27N5O2SCouleur et forme :SolidMasse moléculaire :425.55DNA-PK-IN-3
CAS :<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Formule :C19H19N9OCouleur et forme :SolidMasse moléculaire :389.41PI3K-IN-6
CAS :<p>PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).</p>Formule :C17H14Cl2FN9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.26PI3Kδ/γ-IN-2
CAS :<p>PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy</p>Formule :C25H21ClN8OCouleur et forme :SolidMasse moléculaire :484.94GLPG3970
CAS :<p>GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.</p>Formule :C25H27F3N4O4Degré de pureté :99.60% - >99.99%Couleur et forme :SolidMasse moléculaire :504.5EGFR-IN-68
CAS :<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formule :C24H22N2OCouleur et forme :SolidMasse moléculaire :354.44EAI001
CAS :<p>EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.</p>Formule :C19H15N3O2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :349.41PI3Kγ inhibitor 4
CAS :<p>PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM).</p>Formule :C20H24N4O4SCouleur et forme :SolidMasse moléculaire :416.49Nimotuzumab
CAS :<p>Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).</p>Degré de pureté :95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidMRT80
CAS :<p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>Formule :C15H15N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :281.31mTOR inhibitor-2
CAS :<p>mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).</p>Formule :C23H21N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.46SDZ281-977
CAS :<p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35(E/Z)-CP-724714
CAS :<p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>Formule :C27H27N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54AG-183
CAS :<p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>Formule :C13H8N4O3Couleur et forme :Brown SolidMasse moléculaire :268.23PI3Kα-IN-13
CAS :<p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>Formule :C21H19N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.41Nemiralisib
CAS :<p>Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.</p>Formule :C26H28N6ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :440.54PI4KIII β inhibitor 3
CAS :<p>PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).</p>Formule :C22H22N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.53TGX-155
CAS :<p>TGX-155 is a selective PI3K inhibitor.</p>Formule :C20H19FN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.37FT-1518
CAS :<p>FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.</p>Formule :C20H26N8ODegré de pureté :98.34% - 98.80%Couleur et forme :SolidMasse moléculaire :394.47Tarlox-TKI
CAS :<p>Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.</p>Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74AZD3458
CAS :<p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).</p>Formule :C20H23N3O4S2Couleur et forme :SolidMasse moléculaire :433.54RV-1729
CAS :<p>RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.</p>Formule :C39H39ClN8O5Couleur et forme :SolidMasse moléculaire :735.23BKI-1369
CAS :<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51RTC-5
CAS :<p>RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.</p>Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96CAL-130 Hydrochloride
CAS :<p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formule :C23H23ClN8OCouleur et forme :SolidMasse moléculaire :462.94EGFR-IN-50
CAS :<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Formule :C24H26BrN3O4S2Couleur et forme :SolidMasse moléculaire :564.51NSC114126
CAS :<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39JBJ-04-125-02
CAS :<p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61PIKfyve-IN-2
CAS :<p>PIKfyve-IN-2 is a potent inhibitor of the PIKfyve kinase, with potential applications in cancer and autoimmune disorder research [1].</p>Formule :C22H22N8OCouleur et forme :SolidMasse moléculaire :414.46BRD3731
CAS :<p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>Formule :C24H31N3OCouleur et forme :SolidMasse moléculaire :377.523F8
CAS :<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formule :C15H14N2O4Degré de pureté :98.14% - 98.25%Couleur et forme :SolidMasse moléculaire :286.28Epertinib
CAS :<p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02EGFR-IN-64
CAS :<p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.4(R)-PS210
CAS :<p>(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).</p>Formule :C19H15F3O5Couleur et forme :SolidMasse moléculaire :380.31GW 583340 dihydrochloride
CAS :<p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03FD2056
CAS :<p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>Formule :C23H17ClN6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.94EGFR-IN-89
CAS :<p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>Formule :C26H31FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64AMPK activator 12
CAS :<p>AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.</p>Formule :C23H24BrNO2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :426.35PI5P4Ks-IN-1
CAS :<p>PI5P4Ks-IN-1 (compound 7) is an active compound which engages PI5P4Kγ[1].</p>Formule :C20H17N3SCouleur et forme :SolidMasse moléculaire :331.43Antiproliferative agent-34
CAS :<p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>Formule :C27H27N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.55PIMPC
CAS :<p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>Formule :C21H19N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.41PI3Kγ inhibitor 7
CAS :<p>PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].</p>Formule :C31H25N9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.59
