AMPK
Les inhibiteurs de l'AMPK sont des composés qui ciblent et inhibent la Protéine Kinase Activée par l'AMP (AMPK), une enzyme jouant un rôle crucial dans l'homéostasie énergétique cellulaire. L'AMPK est activée en réponse à de faibles niveaux d'énergie dans les cellules et aide à réguler des processus tels que l'absorption du glucose, l'oxydation des acides gras et la biogenèse mitochondriale. Inhiber l'AMPK est important pour étudier son rôle dans les maladies métaboliques, le cancer et le vieillissement. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de l'AMPK pour soutenir vos recherches sur le métabolisme, l'oncologie et les maladies liées à l'âge.
159 produits trouvés pour "AMPK"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
PF-06409577
CAS :<p>PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).</p>Formule :C19H16ClNO3Degré de pureté :95.17% - 98.21%Couleur et forme :SolidMasse moléculaire :341.797-Methoxyisoflavone
CAS :<p>7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).</p>Formule :C16H12O3Degré de pureté :99.93% - 99.94%Couleur et forme :SolidMasse moléculaire :252.26Methyl cinnamate
CAS :<p>Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.</p>Formule :C10H10O2Degré de pureté :99.88%Couleur et forme :Colorless To Pale Yellow Solid CrystallineMasse moléculaire :162.19Cimiracemoside C
CAS :<p>Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.</p>Formule :C35H56O9Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :620.81Karanjin
CAS :<p>Karanjin, a flavonoid from karanja seeds, boosts GLUT4, AMPK in muscles, and triggers cancer cell apoptosis.</p>Formule :C18H12O4Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :292.298-Chloroadenosine
CAS :<p>8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia.</p>Formule :C10H12ClN5O4Degré de pureté :98.75% - 99.84%Couleur et forme :SolidMasse moléculaire :301.69EX229
CAS :<p>EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.</p>Formule :C24H18ClN3O3Degré de pureté :99.20% - 99.36%Couleur et forme :SolidMasse moléculaire :431.87A-769662
CAS :<p>A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).</p>Formule :C20H12N2O3SDegré de pureté :97.52% - 99.58%Couleur et forme :SolidMasse moléculaire :360.39RGX-202
CAS :<p>RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.</p>Formule :C4H9N3O2Degré de pureté :99.67% - 99.8%Couleur et forme :SolidMasse moléculaire :131.13Doxorubicin
CAS :<p>Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.</p>Formule :C27H29NO11Degré de pureté :99.31%Couleur et forme :Red Crystalline Solid SolidMasse moléculaire :543.52Chromium(III) acetate
CAS :<p>Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.</p>Formule :C2H3O2CrDegré de pureté :99.9%Couleur et forme :Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InMasse moléculaire :76.37AD1058
CAS :<p>AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.</p>Formule :C19H20N6O3SDegré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :412.47Asteltoxin
CAS :<p>Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.</p>Formule :C23H30O7Couleur et forme :SolidMasse moléculaire :418.486TMPA
CAS :<p>TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.</p>Formule :C21H32O6Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :380.48AMPK activator 9
CAS :<p>AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.</p>Formule :C31H28F4N4O4Couleur et forme :SolidMasse moléculaire :596.57YM-53601 free base
CAS :<p>YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.</p>Formule :C21H21FN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.4ULK1-IN-2
CAS :<p>ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.</p>Formule :C19H16BrFN4O6Degré de pureté :99.25% - 99.25%Couleur et forme :SolidMasse moléculaire :495.26AMPK activator
CAS :<p>AMPK activator</p>Formule :C22H21FO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.4AMPK activator 8
CAS :<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Formule :C25H21ClN2O6Couleur et forme :SolidMasse moléculaire :480.9AMDE-1
CAS :<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Formule :C18H8ClF6N3Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :415.72AMPK activator 11
CAS :<p>AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-</p>Formule :C25H20N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.45LRRK2/NUAK1/TYK2-IN-1
CAS :<p>LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.</p>Formule :C20H11F3N6Couleur et forme :SolidMasse moléculaire :392.34Galegine hydrochloride
CAS :<p>Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.</p>Formule :C6H14ClN3Couleur et forme :SolidMasse moléculaire :163.65GL-V9
CAS :<p>GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.</p>Formule :C24H27NO5Couleur et forme :SolidMasse moléculaire :409.47SMTIN-T140
CAS :<p>SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.</p>Formule :C36H34BrClFN5OPDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :718.02IND 1316
CAS :<p>IND 1316 is an activator of AMP-activated protein kinase (AMPK).</p>Formule :C22H17NO3Couleur et forme :SolidMasse moléculaire :343.38AMPK activator 4
CAS :<p>Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.</p>Formule :C24H21ClN2O3Degré de pureté :99.46% - 99.65%Couleur et forme :SolidMasse moléculaire :420.89OSU-53
CAS :<p>OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.</p>Formule :C25H24F3N3O6S2Couleur et forme :SolidMasse moléculaire :583.6AMPK activator 1
CAS :<p>AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).</p>Formule :C32H33F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.62HL271
CAS :<p>HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.</p>Formule :C13H17ClF3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.76PF-739
CAS :<p>PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.</p>Formule :C23H23ClN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.89MARK-IN-4
CAS :<p>MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.</p>Formule :C21H23N7OSCouleur et forme :SolidMasse moléculaire :421.52AMPK activator 12
CAS :<p>AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.</p>Formule :C23H24BrNO2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :426.35AMPK activator 6
CAS :<p>AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.</p>Formule :C25H28O5Couleur et forme :SolidMasse moléculaire :408.49ML753286
CAS :<p>ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.</p>Formule :C20H25N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.43XMD-17-51
CAS :<p>XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.</p>Formule :C21H24N8ODegré de pureté :99.04%Couleur et forme :SoildMasse moléculaire :404.47DK419
CAS :<p>DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.</p>Formule :C16H8ClF6N3ODegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :407.7YLF-466D
CAS :<p>YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.</p>Formule :C29H20ClNO3Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :465.93PF-249
CAS :<p>PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.</p>Formule :C17H16ClN3O3Degré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :345.78AMPK-α1β1γ1 activator 1
CAS :<p>AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1</p>Formule :C25H24ClNO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.91Demethyleneberberine chloride
CAS :<p>Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-</p>Formule :C19H18ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :359.8Ampkinone
CAS :<p>Ampkinone is an indirect AMPK activator.</p>Formule :C31H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.52MARK-IN-1
CAS :<p>MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).</p>Formule :C22H23F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.53MARK-IN-2
CAS :<p>MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).</p>Formule :C18H18ClF2N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.88MRT199665
CAS :<p>MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.</p>Formule :C28H31N5O2Couleur et forme :SolidMasse moléculaire :469.58MK-0626
CAS :<p>MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.</p>Formule :C22H24F2N6O2Degré de pureté :99.47% - >99.99%Couleur et forme :SolidMasse moléculaire :442.46AMPK activator 7
CAS :<p>AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.</p>Formule :C23H22F3N3O5Couleur et forme :SolidMasse moléculaire :477.4310Z-Hymenialdisine
CAS :<p>Pan kinase inhibitor</p>Formule :C11H10BrN5O2Degré de pureté :98%Couleur et forme :Light Yellow SolidMasse moléculaire :324.13PF-06679142
CAS :<p>PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.</p>Formule :C20H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.35AMPK-IN-1
CAS :AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formule :C24H18ClN3O3Couleur et forme :SolidMasse moléculaire :431.87Butylate
CAS :<p>Butylate is a herbicide of thiocarbamate.</p>Formule :C11H23NOSCouleur et forme :Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoistureMasse moléculaire :217.37ZLN024
CAS :<p>ZLN024 is an activator of AMPK allosteric.</p>Formule :C13H13BrN2OSDegré de pureté :99.751%Couleur et forme :SolidMasse moléculaire :325.22EGFR-IN-146
CAS :<p>EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.</p>Formule :C20H16N4Couleur et forme :SolidMasse moléculaire :312.368NPC26
CAS :<p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>Formule :C19H23N3O5S2Couleur et forme :SolidMasse moléculaire :437.533Equisetin
CAS :<p>Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.</p>Formule :C22H31NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :373.49HDAC11-IN-2
CAS :<p>HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.</p>Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.564Aldometanib
CAS :<p>Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.</p>Formule :C27H43Cl2IN2Degré de pureté :99.32% - 99.55%Couleur et forme :SolidMasse moléculaire :593.46XMD-17-51 Trifluoroacetate
CAS :<p>XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.</p>Formule :C23H25F3N8O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :518.49AMPK activator C2
CAS :<p>AMPK activator C2 is an AMPK allosteric activator.</p>Formule :C7H6NO6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :231.1
