AMPK
Les inhibiteurs de l'AMPK sont des composés qui ciblent et inhibent la Protéine Kinase Activée par l'AMP (AMPK), une enzyme jouant un rôle crucial dans l'homéostasie énergétique cellulaire. L'AMPK est activée en réponse à de faibles niveaux d'énergie dans les cellules et aide à réguler des processus tels que l'absorption du glucose, l'oxydation des acides gras et la biogenèse mitochondriale. Inhiber l'AMPK est important pour étudier son rôle dans les maladies métaboliques, le cancer et le vieillissement. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de l'AMPK pour soutenir vos recherches sur le métabolisme, l'oncologie et les maladies liées à l'âge.
161 produits trouvés pour "AMPK".
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Annaosanchun
CAS :Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Formule :C19H32O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :308.46ASP4132
CAS :ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Formule :C46H51F3N6O8S2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :937.06Ref: TM-T8432
1mg50,00€5mg114,00€10mg177,00€1mL*10mM (DMSO)185,00€25mg321,00€50mg482,00€100mg677,00€200mg928,00€HTH-01-015
CAS :HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).Formule :C26H28N8ODegré de pureté :98.38% - 99.70%Couleur et forme :Yellow SolidMasse moléculaire :468.55Ref: TM-T2374
1mg42,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg101,00€25mg200,00€50mg286,00€100mg385,00€Buformin hydrochloride
CAS :Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formule :C6H16ClN5Degré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :193.68PF-06409577
CAS :PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Formule :C19H16ClNO3Degré de pureté :95.17% - 98.21%Couleur et forme :SolidMasse moléculaire :341.79Ref: TM-T4427
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)71,00€10mg100,00€25mg200,00€50mg334,00€100mg537,00€200mg762,00€7-Methoxyisoflavone
CAS :7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).Formule :C16H12O3Degré de pureté :99.93% - 99.94%Couleur et forme :White SolidMasse moléculaire :252.26Methyl cinnamate
CAS :Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.Formule :C10H10O2Degré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :162.19Cimiracemoside C
CAS :Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.Formule :C35H56O9Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :620.81Karanjin
CAS :Karanjin, a flavonoid from karanja seeds, boosts GLUT4, AMPK in muscles, and triggers cancer cell apoptosis.Formule :C18H12O4Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :292.29Ref: TM-T2S0820
1mg46,00€1mL*10mM (DMSO)94,00€5mg96,00€10mg145,00€25mg259,00€50mg385,00€100mg557,00€200mg790,00€EX229
CAS :EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Formule :C24H18ClN3O3Degré de pureté :99.20% - 99.36%Couleur et forme :White SolidMasse moléculaire :431.87Ref: TM-TQ0028
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)80,00€10mg105,00€25mg210,00€50mg356,00€100mg535,00€A-769662
CAS :A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Formule :C20H12N2O3SDegré de pureté :97.52% - 99.58%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T2468
2mg37,00€5mg54,00€1mL*10mM (DMSO)56,00€10mg74,00€25mg135,00€50mg244,00€100mg440,00€500mg964,00€RGX-202
CAS :RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.Formule :C4H9N3O2Degré de pureté :99.67% - 99.8%Couleur et forme :SolidMasse moléculaire :131.13Chromium(III) acetate
CAS :Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.Formule :C2H3O2CrDegré de pureté :99.9%Couleur et forme :Green SolidMasse moléculaire :76.37Doxorubicin
CAS :Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formule :C27H29NO11Degré de pureté :99.31% - 99.73%Couleur et forme :Red Crystalline Solid SolidMasse moléculaire :543.52Asteltoxin
CAS :Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Formule :C23H30O7Couleur et forme :SolidMasse moléculaire :418.486AD1058
CAS :AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.Formule :C19H20N6O3SDegré de pureté :98.24%Couleur et forme :Yellow SolidMasse moléculaire :412.47Ref: TM-T200105
1mg66,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg222,00€25mg447,00€50mg685,00€100mg888,00€TMPA
CAS :TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formule :C21H32O6Degré de pureté :99.21%Couleur et forme :Yellow SolidMasse moléculaire :380.48Ref: TM-T13173
1mg75,00€5mg164,00€1mL*10mM (DMSO)167,00€10mg260,00€25mg440,00€50mg620,00€100mg964,00€PF-739
CAS :PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.Formule :C23H23ClN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.89ULK1-IN-2
CAS :ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.Formule :C19H16BrFN4O6Degré de pureté :99.07% - 99.97%Couleur et forme :SolidMasse moléculaire :495.26JJO-1
CAS :JJO-1 is a bi-quinoline activating all AMPK αβγ isoforms except γ3; it requires low ATP and is unaffected by γ mutations or β deletions.Formule :C19H13N3Couleur et forme :SolidMasse moléculaire :283.33AMPK activator
CAS :AMPK activatorFormule :C22H21FO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.4XMD-17-51
CAS :XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.Formule :C21H24N8ODegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :404.47AMPK activator 6
CAS :AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.Formule :C25H28O5Couleur et forme :SolidMasse moléculaire :408.49AMPK activator 9
CAS :AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Formule :C31H28F4N4O4Couleur et forme :SolidMasse moléculaire :596.57AMPK activator 12
CAS :AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Formule :C23H24BrNO2Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :426.35IND 1316
CAS :IND 1316 is an activator of AMP-activated protein kinase (AMPK).Formule :C22H17NO3Couleur et forme :SolidMasse moléculaire :343.38AMPK activator 8
CAS :AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Formule :C25H21ClN2O6Couleur et forme :SolidMasse moléculaire :480.9AMPK activator 11
CAS :AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-Formule :C25H20N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.45OSU-53
CAS :OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Formule :C25H24F3N3O6S2Couleur et forme :SolidMasse moléculaire :583.6AMPK activator 4
CAS :Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Formule :C24H21ClN2O3Degré de pureté :99.97% - 99.99%Couleur et forme :SolidMasse moléculaire :420.89Ref: TM-T62238
1mg86,00€5mg173,00€1mL*10mM (DMSO)203,00€10mg334,00€25mg563,00€50mg802,00€100mg1.099,00€500mg2.187,00€LRRK2/NUAK1/TYK2-IN-1
CAS :LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.Formule :C20H11F3N6Couleur et forme :SolidMasse moléculaire :392.34GL-V9
CAS :GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Formule :C24H27NO5Couleur et forme :SolidMasse moléculaire :409.47HL271
CAS :HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Formule :C13H17ClF3N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :351.76AMPK activator 1
CAS :AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).Formule :C32H33F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.62SMTIN-T140
CAS :SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Formule :C36H34BrClFN5OPDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :718.02ML753286
CAS :ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Formule :C20H25N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.43YM-53601 free base
CAS :YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Formule :C21H21FN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.4AMDE-1
CAS :AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.Formule :C18H8ClF6N3Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :415.72DK419
CAS :DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Formule :C16H8ClF6N3ODegré de pureté :99.63%Couleur et forme :White SolidMasse moléculaire :407.7AMPK-IN-3
CAS :AMPK-IN-3: potent, selective AMPK (α2/α1) & KDR inhibitor; IC50: 60.7/107/3820 nM; anticancer in K562 cells.Formule :C25H33N5O3Degré de pureté :97.25%Couleur et forme :SolidMasse moléculaire :451.56YLF-466D
CAS :YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Formule :C29H20ClNO3Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :465.93Ref: TM-T13368
1mg34,00€5mg79,00€1mL*10mM (DMSO)82,00€10mg111,00€25mg188,00€50mg269,00€100mg371,00€200mg512,00€PF-249
CAS :PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Formule :C17H16ClN3O3Degré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :345.78Ref: TM-T24626
1mg46,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg236,00€50mg344,00€100mg482,00€200mg662,00€AMPK-IN-1
CAS :AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formule :C24H18ClN3O3Couleur et forme :SolidMasse moléculaire :431.87MK-0626
CAS :MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formule :C22H24F2N6O2Degré de pureté :99.47% - >99.99%Couleur et forme :SolidMasse moléculaire :442.46AMPK activator 7
CAS :AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Formule :C23H22F3N3O5Couleur et forme :SolidMasse moléculaire :477.43PF-06679142
CAS :PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Formule :C20H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.35MARK-IN-2
CAS :MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formule :C18H18ClF2N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.88Butylate
CAS :Butylate is a herbicide of thiocarbamate.Formule :C11H23NOSCouleur et forme :SolidMasse moléculaire :217.37MARK-IN-1
CAS :MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Formule :C22H23F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.53MRT199665
CAS :MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.Formule :C28H31N5O2Couleur et forme :SolidMasse moléculaire :469.58
