AMPK
Les inhibiteurs de l'AMPK sont des composés qui ciblent et inhibent la Protéine Kinase Activée par l'AMP (AMPK), une enzyme jouant un rôle crucial dans l'homéostasie énergétique cellulaire. L'AMPK est activée en réponse à de faibles niveaux d'énergie dans les cellules et aide à réguler des processus tels que l'absorption du glucose, l'oxydation des acides gras et la biogenèse mitochondriale. Inhiber l'AMPK est important pour étudier son rôle dans les maladies métaboliques, le cancer et le vieillissement. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de l'AMPK pour soutenir vos recherches sur le métabolisme, l'oncologie et les maladies liées à l'âge.
170 produits trouvés pour "AMPK"
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ZLN024
CAS :ZLN024 is an activator of AMPK allosteric.Formule :C13H13BrN2OSDegré de pureté :99.751%Couleur et forme :SolidMasse moléculaire :325.22Ref: TM-T13411
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)178,00€Butylate
CAS :Butylate is a herbicide of thiocarbamate.Formule :C11H23NOSCouleur et forme :Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoistureMasse moléculaire :217.37MARK-IN-1
CAS :MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Formule :C22H23F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.53AMPK activator 7
CAS :AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.
Formule :C23H22F3N3O5Couleur et forme :SolidMasse moléculaire :477.43MARK-IN-2
CAS :MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formule :C18H18ClF2N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.88AMPK-α1β1γ1 activator 1
CAS :AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Formule :C25H24ClNO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.91Demethyleneberberine chloride
CAS :Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Formule :C19H18ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :359.8Ampkinone
CAS :Ampkinone is an indirect AMPK activator.Formule :C31H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.52AMPK-IN-1
CAS :AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formule :C24H18ClN3O3Couleur et forme :SolidMasse moléculaire :431.87PF-06679142
CAS :PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Formule :C20H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.3510Z-Hymenialdisine
CAS :Pan kinase inhibitorFormule :C11H10BrN5O2Degré de pureté :98%Couleur et forme :Light Yellow SolidMasse moléculaire :324.13MK-0626
CAS :MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formule :C22H24F2N6O2Degré de pureté :99.47% - >99.99%Couleur et forme :SolidMasse moléculaire :442.46Equisetin
CAS :Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.Formule :C22H31NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :373.49EGFR-IN-146
CAS :EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.Formule :C20H16N4Couleur et forme :SolidMasse moléculaire :312.368HDAC11-IN-2
CAS :HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.564NPC26
CAS :NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.Formule :C19H23N3O5S2Couleur et forme :SolidMasse moléculaire :437.533Galegine hemisulfate
CAS :Galegine hemisulfate, a guanidine derivative, aids in weight reduction in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human renal cell lines. Galegine hemisulfate also exhibits antibacterial activity, with a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.Formule :C6H15N3O4SCouleur et forme :SolidMasse moléculaire :225.27Aldometanib
CAS :Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.Formule :C27H43Cl2IN2Degré de pureté :99.32% - 99.55%Couleur et forme :SolidMasse moléculaire :593.46XMD-17-51 Trifluoroacetate
CAS :XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.Formule :C23H25F3N8O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :518.49AMPK activator C2
CAS :AMPK activator C2 is an AMPK allosteric activator.Formule :C7H6NO6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :231.1
